Basic mechanisms of neurodegeneration: a critical update.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMC 3823450)

Published in J Cell Mol Med on January 11, 2010

Authors

Kurt A Jellinger1

Author Affiliations

1: Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria. kurt.jellinger@univie.ac.at

Associated clinical trials:

Phase IIa Randomized Placebo Controlled Trial: Mesenchymal Stem Cells as a Disease-modifying Therapy for iPD | NCT04506073

Articles citing this

Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease. PLoS One (2016) 1.43

Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells (2013) 1.24

Interaction between pathogenic proteins in neurodegenerative disorders. J Cell Mol Med (2012) 1.06

Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers. Biochemistry (2011) 1.00

Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. Oxid Med Cell Longev (2012) 0.96

Specificity and kinetics of alpha-synuclein binding to model membranes determined with fluorescent excited state intramolecular proton transfer (ESIPT) probe. J Biol Chem (2011) 0.94

Liposomal Antioxidants for Protection against Oxidant-Induced Damage. J Toxicol (2011) 0.90

Disruption of axonal transport in motor neuron diseases. Int J Mol Sci (2012) 0.89

Interaction between α-synuclein and other proteins in neurodegenerative disorders. ScientificWorldJournal (2011) 0.89

Proteomics of protein post-translational modifications implicated in neurodegeneration. Transl Neurodegener (2014) 0.86

Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Future Med Chem (2012) 0.86

Con: Can neuropathology really confirm the exact diagnosis? Alzheimers Res Ther (2010) 0.85

Tetanus toxin C-fragment: the courier and the cure? Toxins (Basel) (2010) 0.84

Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision Medicine. Int J Mol Sci (2016) 0.84

A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease. PLoS Genet (2015) 0.83

A novel mutation I215V in the PRNP gene associated with Creutzfeldt-Jakob and Alzheimer's diseases in three patients with divergent clinical phenotypes. J Neurol (2012) 0.83

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study. J Neural Transm (Vienna) (2014) 0.82

Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons. Acta Neuropathol Commun (2014) 0.82

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons. Mol Neurodegener (2011) 0.82

Supramolecular non-amyloid intermediates in the early stages of α-synuclein aggregation. Biophys J (2012) 0.82

Discriminatory Analysis of Biochip-Derived Protein Patterns in CSF and Plasma in Neurodegenerative Diseases. Front Aging Neurosci (2011) 0.81

Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process. J Biol Chem (2015) 0.80

Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Cell Death Differ (2015) 0.80

miR-16-1 promotes the aberrant α-synuclein accumulation in parkinson disease via targeting heat shock protein 70. ScientificWorldJournal (2014) 0.80

High-resolution conformation and backbone dynamics of a soluble aggregate of apomyoglobin119. Biophys J (2011) 0.78

Parkinson's Disease: Assay of Phosphorylated α-Synuclein in Skin Biopsy for Early Diagnosis and Association with Melanoma. Brain Sci (2016) 0.78

A network view on Parkinson's disease. Comput Struct Biotechnol J (2013) 0.78

Ethyl acetate extract of Wedelia chinensis inhibits tert-butyl hydroperoxide-induced damage in PC12 cells and D-galactose-induced neuronal cell loss in mice. BMC Complement Altern Med (2014) 0.76

Protection against 1,2-di-methylhydrazine-induced systemic oxidative stress and altered brain neurotransmitter status by probiotic Escherichia coli CFR 16 secreting pyrroloquinoline quinone. Curr Microbiol (2015) 0.76

Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. Mol Neurobiol (2016) 0.76

Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model. Sci Rep (2017) 0.75

Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget (2016) 0.75

Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease. Comput Struct Biotechnol J (2016) 0.75

Redox Imbalance and Viral Infections in Neurodegenerative Diseases. Oxid Med Cell Longev (2016) 0.75

MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis. Oxid Med Cell Longev (2017) 0.75

Multidirectional inhibition of cortico-hippocampal neurodegeneration by kolaviron treatment in rats. Metab Brain Dis (2017) 0.75

Articles cited by this

(truncated to the top 100)

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science (2006) 27.96

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med (2008) 17.09

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron (2004) 14.35

Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science (2009) 13.45

Adapting proteostasis for disease intervention. Science (2008) 13.22

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

The roles of intracellular protein-degradation pathways in neurodegeneration. Nature (2006) 9.77

Neurodegenerative diseases target large-scale human brain networks. Neuron (2009) 9.69

Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science (2004) 8.71

Tau suppression in a neurodegenerative mouse model improves memory function. Science (2005) 8.66

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet (2008) 8.51

A role for ubiquitin in selective autophagy. Mol Cell (2009) 8.43

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci (2007) 7.77

Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol (2009) 7.50

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature (2009) 6.99

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A (2009) 6.87

Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (2006) 6.47

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell (2009) 6.20

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16

Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem (2009) 5.76

Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci (2007) 5.72

Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol (2009) 5.61

The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol (2007) 5.59

Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol (2009) 5.47

Oxidative stress and neurodegeneration: where are we now? J Neurochem (2006) 5.44

Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol (2009) 5.41

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res (2008) 5.29

Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet (2009) 5.15

Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci (2004) 5.10

Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci (2005) 5.00

Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol (2009) 4.88

Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol (2008) 4.58

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (2009) 4.25

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med (2009) 4.11

Principles of ubiquitin and SUMO modifications in DNA repair. Nature (2009) 4.10

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09

Role of axonal transport in neurodegenerative diseases. Annu Rev Neurosci (2008) 4.09

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol (2009) 3.95

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci U S A (2009) 3.86

The emerging complexity of protein ubiquitination. Biochem Soc Trans (2009) 3.85

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis (2008) 3.84

Systemic inflammation and disease progression in Alzheimer disease. Neurology (2009) 3.79

ER stress and neurodegenerative diseases. Cell Death Differ (2006) 3.78

Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol (2009) 3.73

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol (2009) 3.55

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci U S A (2009) 3.47

Mechanisms of Disease: astrocytes in neurodegenerative disease. Nat Clin Pract Neurol (2006) 3.42

Debris clearance by microglia: an essential link between degeneration and regeneration. Brain (2008) 3.36

A network dysfunction perspective on neurodegenerative diseases. Nature (2006) 3.33

Mechanism of toxicity in rotenone models of Parkinson's disease. J Neurosci (2003) 3.30

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest (2008) 3.23

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation (2008) 3.19

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell (2009) 3.17

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17

Endoplasmic reticulum stress responses. Cell Mol Life Sci (2008) 3.11

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron (2008) 3.08

Molecular mechanisms of prion pathogenesis. Annu Rev Pathol (2008) 3.05

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci (2007) 3.02

Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications. Annu Rev Pathol (2006) 3.01

Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci (2007) 2.96

Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci (2009) 2.96

Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol (2009) 2.93

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest (2008) 2.91

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci (2009) 2.82

Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ (2009) 2.76

Axonal transport defects in neurodegenerative diseases. J Neurosci (2009) 2.74

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med (2008) 2.74

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu Rev Pharmacol Toxicol (2009) 2.70

Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem (2009) 2.70

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med (2009) 2.66

The ubiquitylation machinery of the endoplasmic reticulum. Nature (2009) 2.66

Polyglutamine neurodegeneration: protein misfolding revisited. Trends Neurosci (2008) 2.63

Glial reactions in Parkinson's disease. Mov Disord (2008) 2.62

Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta (2008) 2.60

Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science (2009) 2.60

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron (2004) 2.53

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction. Nat Rev Neurosci (2008) 2.51

Abeta40 inhibits amyloid deposition in vivo. J Neurosci (2007) 2.47

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J (2008) 2.43

MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol (2008) 2.39

Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies. Brain Res (2007) 2.38

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain (2008) 2.34

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation. J Neurochem (2007) 2.32

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci (2009) 2.31

Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature. Biochim Biophys Acta (2008) 2.29

New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev (2008) 2.28

Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J Neurosci (2008) 2.20

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci U S A (2009) 2.14