Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.

PubWeight™: 4.77‹?› | Rank: Top 1%

🔗 View Article (PMC 1235314)

Published in Am J Hum Genet on July 06, 2001

Authors

D H Blackwood1, A Fordyce, M T Walker, D M St Clair, D J Porteous, W J Muir

Author Affiliations

1: University Department of Psychiatry, Royal Edinburgh Hospital; and University of Edinburgh, Medical Genetics Section, Molecular Medicine Centre, Edinburgh, United Kingdom. dblackwood@ed.ac.uk

Articles citing this

(truncated to the top 100)

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34

Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76

The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet (2005) 4.02

Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull (2005) 3.93

Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A (2002) 3.34

Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophr Bull (2006) 2.92

Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci (2011) 2.89

Rethinking psychosis: the disadvantages of a dichotomous classification now outweigh the advantages. World Psychiatry (2007) 2.82

Mapping translocation breakpoints by next-generation sequencing. Genome Res (2008) 2.73

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron (2009) 2.72

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A (2005) 2.68

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci (2009) 2.55

Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited. J Am Acad Child Adolesc Psychiatry (2009) 2.49

The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders. Genetics (2002) 2.37

Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31

The genetic deconstruction of psychosis. Schizophr Bull (2007) 2.25

The psychiatric GWAS consortium: big science comes to psychiatry. Neuron (2010) 2.15

Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron (2010) 2.08

GSK-3: Functional Insights from Cell Biology and Animal Models. Front Mol Neurosci (2011) 1.99

Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies. J Clin Invest (2009) 1.87

Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. Am J Psychiatry (2010) 1.82

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Proc Natl Acad Sci U S A (2009) 1.76

Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull (2009) 1.71

Genetics of psychosis; insights from views across the genome. Hum Genet (2009) 1.68

A genome wide search for alcoholism susceptibility genes. Am J Med Genet B Neuropsychiatr Genet (2004) 1.68

Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. Eur J Neurosci (2008) 1.67

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron (2011) 1.67

Neurophysiological endophenotypes across bipolar and schizophrenia psychosis. Schizophr Bull (2008) 1.61

eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia? Schizophr Bull (2007) 1.57

Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron (2011) 1.57

Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Mol Psychiatry (2010) 1.49

Preattentional and attentional cognitive deficits as targets for treating schizophrenia. Psychopharmacology (Berl) (2004) 1.47

Schizophrenia genetics: where next? Schizophr Bull (2011) 1.42

DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends Mol Med (2011) 1.34

Modeling cognitive endophenotypes of schizophrenia in mice. Trends Neurosci (2009) 1.32

Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families. Am J Hum Genet (2004) 1.29

Predisposition locus for major depression at chromosome 12q22-12q23.2. Am J Hum Genet (2003) 1.29

Finding schizophrenia genes. J Clin Invest (2005) 1.28

DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology (2010) 1.27

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. Biol Psychol (2007) 1.21

Prepulse inhibition and genetic mouse models of schizophrenia. Behav Brain Res (2009) 1.20

Association of variants in DISC1 with psychosis-related traits in a large population cohort. Arch Gen Psychiatry (2009) 1.19

Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness. Proc Natl Acad Sci U S A (2013) 1.18

Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients. Biol Psychiatry (2011) 1.18

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness. J Physiol (2007) 1.15

Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. Front Genet (2012) 1.15

Questions about DISC1 as a genetic risk factor for schizophrenia. Mol Psychiatry (2013) 1.14

A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci U S A (2005) 1.14

Genetic models of schizophrenia and bipolar disorder: overlapping inheritance or discrete genotypes? Eur Arch Psychiatry Clin Neurosci (2005) 1.13

DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness. ACS Chem Neurosci (2011) 1.13

Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. Schizophr Bull (2006) 1.12

Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol (2012) 1.11

Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS One (2012) 1.11

NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett (2008) 1.11

Characterization of complex chromosomal rearrangements by targeted capture and next-generation sequencing. Genome Res (2011) 1.10

Personalized medicine in psychiatry: problems and promises. BMC Med (2013) 1.09

A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. Am J Hum Genet (2009) 1.08

A population genetic approach to mapping neurological disorder genes using deep resequencing. PLoS Genet (2011) 1.07

Brain vs behavior: an effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia. Schizophr Bull (2012) 1.06

Revitalizing psychiatric therapeutics. Neuropsychopharmacology (2014) 1.05

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits. Mol Psychiatry (2013) 1.05

DISC1 in schizophrenia: genetic mouse models and human genomic imaging. Schizophr Bull (2010) 1.04

Involvement of long noncoding RNAs in diseases affecting the central nervous system. RNA Biol (2012) 1.04

Functional role of adult hippocampal neurogenesis as a therapeutic strategy for mental disorders. Neural Plast (2012) 1.03

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Mol Psychiatry (2011) 1.01

DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse (2011) 0.99

Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry (2009) 0.98

Insoluble DISC1-Boymaw fusion proteins generated by DISC1 translocation. Mol Psychiatry (2010) 0.98

Schizophrenia: neural mechanisms for novel therapies. Mol Med (2003) 0.98

Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders. Curr Top Behav Neurosci (2012) 0.97

A role for WNT/β-catenin signaling in the neural mechanisms of behavior. J Neuroimmune Pharmacol (2012) 0.97

Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Hum Mol Genet (2010) 0.97

Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia. Neurobiol Dis (2012) 0.97

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins. Hum Mol Genet (2012) 0.97

Application of electroencephalography to the study of cognitive and brain functions in schizophrenia. Schizophr Bull (2007) 0.96

DISC1: a key lead in studying cortical development and associated brain disorders. Neuroscientist (2013) 0.96

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders. Neuropsychopharmacology (2015) 0.96

Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging. Hum Mol Genet (2013) 0.95

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. Mol Psychiatry (2014) 0.94

Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies. Prion (2012) 0.93

Emerging epigenetic mechanisms of long non-coding RNAs. Neuroscience (2013) 0.91

Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings. Schizophr Bull (2006) 0.91

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking. Hum Mol Genet (2013) 0.91

Postmortem brain: an underutilized substrate for studying severe mental illness. Neuropsychopharmacology (2013) 0.91

Impairment in functional capacity as an endophenotype candidate in severe mental illness. Schizophr Bull (2011) 0.91

Mouse models of gene-environment interactions in schizophrenia. Neurobiol Dis (2013) 0.90

Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia. PLoS One (2013) 0.90

Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder. Expert Opin Ther Targets (2014) 0.89

DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders. Front Behav Neurosci (2013) 0.88

Selective hyper-responsiveness of the interferon system in major depressive disorders and depression induced by interferon therapy. PLoS One (2012) 0.88

Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet (2014) 0.88

Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs. Front Behav Neurosci (2011) 0.88

Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia. Front Synaptic Neurosci (2014) 0.87

New frontiers in animal research of psychiatric illness. Methods Mol Biol (2012) 0.87

Resting EEG in psychosis and at-risk populations--a possible endophenotype? Schizophr Res (2014) 0.87

Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism. Am J Med Genet B Neuropsychiatr Genet (2007) 0.87

Does disrupted-in-schizophrenia (DISC1) generate fusion transcripts? Mol Psychiatry (2008) 0.87

Articles cited by this

A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry (1978) 12.65

Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet (2000) 7.16

The global burden of disease, 1990-2020. Nat Med (1998) 6.50

Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science (2000) 4.42

Association within a family of a balanced autosomal translocation with major mental illness. Lancet (1990) 3.94

Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet (2001) 3.73

Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Arch Gen Psychiatry (1993) 2.71

A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet (1999) 2.15

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci U S A (1999) 1.96

Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum Mol Genet (2000) 1.77

P300 topography differs in schizophrenia and manic psychosis. Biol Psychiatry (1999) 1.37

Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. Biol Psychiatry (2000) 1.30

Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch Gen Psychiatry (1991) 1.27

No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families. Nature (1989) 1.21

Linkage and associated studies of schizophrenia. Am J Med Genet (2000) 1.16

Long-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder. Psychol Med (1991) 1.15

Identification of neural circuits underlying P300 abnormalities in schizophrenia. Psychophysiology (1999) 1.07

Searching high and low: a review of the genetics of bipolar disorder. Bipolar Disord (2000) 1.06

Auditory P300 event-related potentials and neuropsychological performance in schizophrenia and bipolar affective disorder. Biol Psychiatry (1995) 1.05

Event-related potential correlates of impaired selective attention in children at high risk for schizophrenia. Biol Psychiatry (1992) 1.05

Altered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia. Correlations with memory and P300. Br J Psychiatry (1999) 1.03

A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish. Am J Hum Genet (1996) 1.03

P300, a state and a trait marker in schizophrenia. Lancet (2000) 1.00

Segregation analysis of complex phenotypes: an application to schizophrenia and auditory P300 latency. Psychiatr Genet (1994) 1.00

Genetic influence on auditory information processing in schizophrenia: P300 in monozygotic twins. Biol Psychiatry (1999) 0.98

Linkage analysis of fifty-seven microsatellite loci to bipolar disorder. Neuropsychopharmacology (1993) 0.98

Do schizophrenia and affective disorder share susceptibility genes? Schizophr Res (1999) 0.95

Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia. Electroencephalogr Clin Neurophysiol (1994) 0.89

Articles by these authors

Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet (2000) 7.16

Whole-genome association study of bipolar disorder. Mol Psychiatry (2008) 6.80

Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry (2011) 4.16

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry (2008) 3.85

The DISC locus in psychiatric illness. Mol Psychiatry (2007) 3.46

SUSPECTS: enabling fast and effective prioritization of positional candidates. Bioinformatics (2006) 2.96

WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A (2001) 2.79

Splinkerettes--improved vectorettes for greater efficiency in PCR walking. Nucleic Acids Res (1995) 2.51

Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax (2007) 1.93

Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. Mol Psychiatry (2001) 1.81

High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered. Genomics (1992) 1.74

A locus for bipolar affective disorder on chromosome 4p. Nat Genet (1996) 1.67

A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Ther (1996) 1.49

Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. J Med Genet (2003) 1.46

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Mol Psychiatry (2005) 1.41

A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D. Cancer Res (2000) 1.39

Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens. Nat Genet (1995) 1.37

Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol Cell Neurosci (2004) 1.35

Control of the flux in the arginine pathway of Neurospora crassa. Modulations of enzyme activity and concentration. Biochem J (1981) 1.35

Intracranial time-resolved contrast-enhanced MR angiography at 3T. AJNR Am J Neuroradiol (2006) 1.31

Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder. Psychiatr Genet (2001) 1.30

Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch Gen Psychiatry (1991) 1.27

Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder. Mol Psychiatry (2008) 1.27

Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. Genomics (2000) 1.23

Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population. Mol Psychiatry (2006) 1.23

Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome. Proc Natl Acad Sci U S A (1985) 1.22

CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse. Am J Physiol (1994) 1.20

Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene. J Neurochem (1999) 1.18

Molecular and physical arrangements of human DNA in HRAS1-selected, chromosome-mediated transfectants. Mol Cell Biol (1986) 1.17

Control of the flux in the arginine pathway of Neurospora crassa. The flux from citrulline to arginine. Biochem J (1980) 1.16

Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett (2005) 1.15

Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum. Gene Ther (1998) 1.14

'Pfropfschizophrenie' revisited. Schizophrenia in people with mild learning disability. Br J Psychiatry (1998) 1.14

Rethinking the genetic architecture of schizophrenia. Psychol Med (2010) 1.13

Sendai virus-mediated CFTR gene transfer to the airway epithelium. Gene Ther (2007) 1.13

Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO J (1996) 1.13

Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. Am J Med Genet B Neuropsychiatr Genet (2005) 1.13

Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol Psychiatry (2006) 1.12

Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. J Immunol (2001) 1.11

Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2005) 1.11

HRAS1-selected chromosome transfer generates markers that colocalize aniridia- and genitourinary dysplasia-associated translocation breakpoints and the Wilms tumor gene within band 11p13. Proc Natl Acad Sci U S A (1987) 1.11

Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study. Ann Hum Genet (2001) 1.10

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung. Gene Ther (2011) 1.10

A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. Mol Psychiatry (2004) 1.08

Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Mol Psychiatry (2005) 1.07

Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression. Mamm Genome (1994) 1.06

Auditory P300 event-related potentials and neuropsychological performance in schizophrenia and bipolar affective disorder. Biol Psychiatry (1995) 1.05

Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder. Mol Psychiatry (2006) 1.05

Altered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia. Correlations with memory and P300. Br J Psychiatry (1999) 1.03

Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11. Genomics (1988) 1.02

Central and peripheral fusiform aneurysms six years after left atrial myxoma resection. J Neurol Neurosurg Psychiatry (2003) 1.02

Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatr Genet (1996) 1.02

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site. Mol Cell Neurosci (2005) 1.01

Nuts and bolts of psychiatric genetics: building on the Human Genome Project. Trends Genet (2001) 1.01

Non-viral vectors in cystic fibrosis gene therapy: progress and challenges. Trends Biotechnol (2004) 1.00

Segregation analysis of complex phenotypes: an application to schizophrenia and auditory P300 latency. Psychiatr Genet (1994) 1.00

Definition and refinement of a region of loss of heterozygosity at 11q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis. Cancer Res (1996) 0.99

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A (1999) 0.98

Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level. Br J Cancer (1988) 0.97

Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Mol Psychiatry (2011) 0.96

Detecting QTLs for uni- and bipolar disorder using a variance component method. Psychiatr Genet (1999) 0.96

A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. Proc Natl Acad Sci U S A (2008) 0.96

Some principles and practices of genetic biobanking studies. Eur Respir J (2009) 0.95

False aneurysm of the profunda femoris artery following nail and plate fixation of an intertrochanteric fracture. Report of a case. J Bone Joint Surg Br (1968) 0.95

Association of DISC1 variants with age of onset in a population-based sample of recurrent major depression. Mol Psychiatry (2012) 0.94

Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. Neurotox Res (2004) 0.94

BARX2 induces cadherin 6 expression and is a functional suppressor of ovarian cancer progression. Cancer Res (2001) 0.94

Selection for precise chromosomal targeting of a dominant marker by homologous recombination. Science (1989) 0.94

The experiences of adults with intellectual disabilities and their carers in general hospitals: a focus group study. J Intellect Disabil Res (2008) 0.94

Gene mapping and physical arrangements of human chromatin in transformed, hybrid cells: fluorescent and autoradiographic in situ hybridization compared. Somat Cell Mol Genet (1986) 0.93

Hitch-hiking from HRAS1 to the WAGR locus with CMGT markers. Nucleic Acids Res (1988) 0.93

GWAS for psychiatric disease: is the framework built on a solid foundation? Mol Psychiatry (2009) 0.93

The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia. Mol Psychiatry (2001) 0.92

Neuropsychological and P300 abnormalities in schizophrenics and their relatives. Psychol Med (1993) 0.91

A 6.9-Mb high-resolution BAC/PAC contig of human 4p15.3-p16.1, a candidate region for bipolar affective disorder. Genomics (2001) 0.91

Correlation between nasal potential difference measurements, genotype and clinical condition in patients with cystic fibrosis. Eur Respir J (1997) 0.91

Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide. Hum Gene Ther (2001) 0.91

Heritability of chronic pain in 2195 extended families. Eur J Pain (2012) 0.90

Identification of genes from a schizophrenia-linked translocation breakpoint region. Genomics (2001) 0.90

Chromosomal abnormalities and mental illness. Mol Psychiatry (2003) 0.90