Published in J Biol Chem on January 23, 2006
One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol (2008) 4.54
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SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates. J Biol Chem (2011) 1.16
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Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD. J Biol Chem (2010) 0.95
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Role of malectin in Glc(2)Man(9)GlcNAc(2)-dependent quality control of α1-antitrypsin. Mol Biol Cell (2011) 0.90
Modulation of the unfolded protein response by the human hepatitis B virus. Front Microbiol (2014) 0.90
Activation of ERAD pathway by human hepatitis B virus modulates viral and subviral particle production. PLoS One (2012) 0.89
The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein. J Biol Chem (2013) 0.89
Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP. Mol Biol Cell (2013) 0.89
Characterization of early EDEM1 protein maturation events and their functional implications. J Biol Chem (2011) 0.88
EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. J Cell Biol (2014) 0.86
Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway. J Cell Biol (2015) 0.83
A Golgi-localized mannosidase (MAN1B1) plays a non-enzymatic gatekeeper role in protein biosynthetic quality control. J Biol Chem (2014) 0.83
Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD. Glycoconj J (2008) 0.83
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Endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins and mutant P23H rhodopsin in photoreceptor cells. Adv Exp Med Biol (2012) 0.80
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The class I α1,2-mannosidases of Caenorhabditis elegans. Glycoconj J (2012) 0.78
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A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins. J Biol Chem (2016) 0.77
EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog. PLoS One (2014) 0.76
Varicella-Zoster Virus Infectious Cycle: ER Stress, Autophagic Flux, and Amphisome-Mediated Trafficking. Pathogens (2016) 0.76
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The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search. Int J Mol Sci (2017) 0.75
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Quality control of glycoprotein folding and ERAD: the role of N-glycan handling, EDEM1 and OS-9. Histochem Cell Biol (2016) 0.75
Evolution of protein N-glycosylation process in Golgi apparatus which shapes diversity of protein N-glycan structures in plants, animals and fungi. Sci Rep (2017) 0.75
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Modulation of activity by Arg407: structure of a fungal alpha-1,2-mannosidase in complex with a substrate analogue. Acta Crystallogr D Biol Crystallogr (2008) 0.75
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A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell (2003) 4.99
Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res (2004) 3.59
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin. Science (2003) 3.28
Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. J Clin Invest (2011) 3.28
ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER. Science (2008) 3.18
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"MIATA"-minimal information about T cell assays. Immunity (2009) 2.90
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol (2006) 2.76
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. Nat Cell Biol (2006) 2.37
Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum (2008) 2.15
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. Mol Biol Cell (2008) 2.14
Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One (2011) 2.01
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
Ypt11 functions in bud-directed transport of the Golgi by linking Myo2 to the coatomer subunit Ret2. Curr Biol (2008) 1.93
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem (2008) 1.88
Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong alpha1-antitrypsin by human ER mannosidase I. J Biol Chem (2003) 1.86
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Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. J Biol Chem (2008) 1.77
Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis. Mol Biol Cell (2006) 1.77
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Biochemical characterization of the prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B complex. J Biol Chem (2009) 1.74
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Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women. J Gastroenterol (2005) 1.71
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest (2009) 1.71
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Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A (2009) 1.61
Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen. Proc Natl Acad Sci U S A (2008) 1.59
The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens. J Biol Chem (2008) 1.57
Rational drug design via intrinsically disordered protein. Trends Biotechnol (2006) 1.57
EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Mol Cell (2009) 1.56
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Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection. Mol Biol Cell (2009) 1.55
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity (2013) 1.51
Improving protein order-disorder classification using charge-hydropathy plots. BMC Bioinformatics (2014) 1.50
Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Mol Biol Cell (2007) 1.49
Human M-ficolin is a secretory protein that activates the lectin complement pathway. J Immunol (2005) 1.49
Mechanism and components of endoplasmic reticulum-associated degradation. J Biochem (2009) 1.48
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans. J Biol Chem (2009) 1.47
Transcriptional profiling of Caulobacter crescentus during growth on complex and minimal media. J Bacteriol (2004) 1.46
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Heat shock cognate protein 70 is involved in rotavirus cell entry. J Virol (2002) 1.37
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EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin. Genes Cells (2006) 1.25
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