Published in Biochemistry on September 20, 2005
Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids. Biochim Biophys Acta (2010) 3.62
Tight regulation of unstructured proteins: from transcript synthesis to protein degradation. Science (2008) 3.48
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
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Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics (2008) 2.50
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Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proc Natl Acad Sci U S A (2008) 2.00
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices. Nat Struct Mol Biol (2007) 1.98
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Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators. Structure (2010) 1.89
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Expanding the proteome: disordered and alternatively folded proteins. Q Rev Biophys (2011) 1.60
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Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
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Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. Structure (2012) 1.47
Intrinsically disordered and pliable Starmaker-like protein from medaka (Oryzias latipes) controls the formation of calcium carbonate crystals. PLoS One (2014) 1.43
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The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome. J Biomed Biotechnol (2010) 1.16
Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins. Proc Natl Acad Sci U S A (2007) 1.16
Protein disorder in the human diseasome: unfoldomics of human genetic diseases. BMC Genomics (2009) 1.11
Shifts in the host range of a promiscuous plasmid through parallel evolution of its replication initiation protein. ISME J (2010) 1.07
Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein. Proc Natl Acad Sci U S A (2014) 1.06
Large-scale prediction of long disordered regions in proteins using random forests. BMC Bioinformatics (2009) 1.05
Effects of HMGN variants on the cellular transcription profile. Nucleic Acids Res (2011) 1.05
Analysis of structured and intrinsically disordered regions of transmembrane proteins. Mol Biosyst (2009) 1.05
Archaic chaos: intrinsically disordered proteins in Archaea. BMC Syst Biol (2010) 1.05
Nanoimaging for protein misfolding and related diseases. J Cell Biochem (2006) 1.05
Ebola virus VP30 is an RNA binding protein. J Virol (2007) 1.04
Wiggle-predicting functionally flexible regions from primary sequence. PLoS Comput Biol (2006) 1.03
Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II? Protein Sci (2010) 1.02
Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR. J Mol Biol (2008) 1.01
Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions. BMC Genomics (2008) 1.01
The importance of being flexible: the case of basic region leucine zipper transcriptional regulators. Curr Protein Pept Sci (2009) 1.01
Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Chem Rev (2014) 1.00
Functional advantages of dynamic protein disorder. FEBS Lett (2015) 0.98
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev (2014) 0.98
Quantitative relation between intermolecular and intramolecular binding of pro-rich peptides to SH3 domains. Biophys J (2006) 0.97
Structure of the nucleocapsid-binding domain from the mumps virus polymerase; an example of protein folding induced by crystallization. J Mol Biol (2008) 0.97
Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder. PLoS Comput Biol (2012) 0.97
What macromolecular crowding can do to a protein. Int J Mol Sci (2014) 0.96
Evidence for the concerted evolution between short linear protein motifs and their flanking regions. PLoS One (2009) 0.96
Intrinsically disordered regions of p53 family are highly diversified in evolution. Biochim Biophys Acta (2013) 0.96
N-terminal domains of DELLA proteins are intrinsically unstructured in the absence of interaction with GID1/gibberellic acid receptors. J Biol Chem (2010) 0.95
MFSPSSMpred: identifying short disorder-to-order binding regions in disordered proteins based on contextual local evolutionary conservation. BMC Bioinformatics (2013) 0.94
Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept. Expert Rev Proteomics (2010) 0.93
The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices. Protein Sci (2011) 0.93
Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition. PLoS One (2012) 0.93
Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300. J Biol Chem (2016) 0.93
The intrinsically disordered N-terminal region of AtREM1.3 remorin protein mediates protein-protein interactions. J Biol Chem (2012) 0.92
Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating. Pflugers Arch (2012) 0.91
Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1. Proteins (2009) 0.91
Slow, reversible, coupled folding and binding of the spectrin tetramerization domain. Biophys J (2012) 0.91
MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change. J Biol Chem (2010) 0.90
Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins. J Biol Chem (2016) 0.90
Resilience of death: intrinsic disorder in proteins involved in the programmed cell death. Cell Death Differ (2013) 0.90
Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications. Front Cell Dev Biol (2015) 0.89
Disordered flanks prevent peptide aggregation. PLoS Comput Biol (2008) 0.89
Phosphorylation of intrinsically disordered regions in remorin proteins. Front Plant Sci (2012) 0.88
Backbone dynamics of the 18.5 kDa isoform of myelin basic protein reveals transient alpha-helices and a calmodulin-binding site. Biophys J (2008) 0.88
Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Mol Biosyst (2013) 0.88
Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus. J Biol Chem (2012) 0.88
Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase. Biochemistry (2007) 0.88
Conformation of the EPEC Tir protein in solution: investigating the impact of serine phosphorylation at positions 434/463. Biophys J (2007) 0.88
Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytes. J Biol Chem (2012) 0.86
Protein disorder is positively correlated with gene expression in Escherichia coli. J Proteome Res (2008) 0.86
Disordered proteinaceous machines. Chem Rev (2014) 0.86
Coupled folding-binding in a hydrophobic/polar protein model: impact of synergistic folding and disordered flanks. Biophys J (2012) 0.86
Intrinsic disorder and protein multibinding in domain, terminal, and linker regions. Mol Biosyst (2010) 0.85
Modeling disordered regions in proteins using Rosetta. PLoS One (2011) 0.85
Retro-MoRFs: identifying protein binding sites by normal and reverse alignment and intrinsic disorder prediction. Int J Mol Sci (2010) 0.85
Intrinsically semi-disordered state and its role in induced folding and protein aggregation. Cell Biochem Biophys (2013) 0.85
Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway. Biochemistry (2011) 0.85
Correlations between predicted protein disorder and post-translational modifications in plants. Bioinformatics (2014) 0.84
Induced secondary structure and polymorphism in an intrinsically disordered structural linker of the CNS: solid-state NMR and FTIR spectroscopy of myelin basic protein bound to actin. Biophys J (2009) 0.84
Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome. PeerJ (2013) 0.84
Disorder predictors also predict backbone dynamics for a family of disordered proteins. PLoS One (2011) 0.83
Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses. Genome Biol Evol (2013) 0.83
The arginine-rich RNA-binding motif of HIV-1 Rev is intrinsically disordered and folds upon RRE binding. Biophys J (2013) 0.83
Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. Chem Rev (2016) 0.82
DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. Biomed Res Int (2014) 0.82
Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus. J Biol Chem (2011) 0.82
The Pathway Tools software. Bioinformatics (2002) 14.89
The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res (2004) 8.23
TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86
Intrinsic disorder in cell-signaling and cancer-associated proteins. J Mol Biol (2002) 5.64
Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J (2005) 5.36
DisProt: the Database of Disordered Proteins. Nucleic Acids Res (2006) 4.46
Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33
Function and structure of inherently disordered proteins. Curr Opin Struct Biol (2008) 4.19
Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu Rev Biophys (2008) 3.98
Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
Length-dependent prediction of protein intrinsic disorder. BMC Bioinformatics (2006) 3.70
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids. Biochim Biophys Acta (2010) 3.62
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res (2004) 3.59
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling. J Mol Recognit (2005) 3.57
Analysis of molecular recognition features (MoRFs). J Mol Biol (2006) 3.40
Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. J Clin Invest (2011) 3.28
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI). Cancer Immunol Immunother (2007) 3.16
Exploiting heterogeneous sequence properties improves prediction of protein disorder. Proteins (2005) 3.14
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest (2005) 3.11
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
Tumour immunity: effector response to tumour and role of the microenvironment. Lancet (2008) 2.94
"MIATA"-minimal information about T cell assays. Immunity (2009) 2.90
Predicting intrinsic disorder from amino acid sequence. Proteins (2003) 2.74
Flavors of protein disorder. Proteins (2003) 2.72
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
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Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms. Proc Natl Acad Sci U S A (2006) 2.57
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics (2008) 2.50
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Evolutionary rate heterogeneity in proteins with long disordered regions. J Mol Evol (2002) 2.46
Comparing and combining predictors of mostly disordered proteins. Biochemistry (2005) 2.45
Protein flexibility and intrinsic disorder. Protein Sci (2004) 2.33
Assessing protein disorder and induced folding. Proteins (2006) 2.33
Predicting intrinsic disorder in proteins: an overview. Cell Res (2009) 2.24
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Optimizing long intrinsic disorder predictors with protein evolutionary information. J Bioinform Comput Biol (2005) 2.20
Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum (2008) 2.15
A bimodal distribution of two distinct categories of intrinsically disordered structures with separate functions in FG nucleoporins. Mol Cell Proteomics (2010) 2.09
DisProt: a database of protein disorder. Bioinformatics (2004) 1.99
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem (2001) 1.99
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res (2007) 1.92
Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils. Chem Biol (2004) 1.91
EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming. J Biol Chem (2006) 1.91
Disorder and sequence repeats in hub proteins and their implications for network evolution. J Proteome Res (2006) 1.87
Harmonization of immune biomarker assays for clinical studies. Sci Transl Med (2011) 1.84
Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression. Eur J Immunol (2009) 1.81
Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity (2005) 1.81
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Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions. Blood (2003) 1.78
Malleable machines take shape in eukaryotic transcriptional regulation. Nat Chem Biol (2008) 1.76
D²P²: database of disordered protein predictions. Nucleic Acids Res (2012) 1.75
Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J Biol Chem (2007) 1.74
New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol (2006) 1.74
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest (2009) 1.71
Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry (2002) 1.71
TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder. Protein Pept Lett (2008) 1.70
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry (2006) 1.68
Melan-A/MART-1-specific CD8 T cells: from thymus to tumor. Trends Immunol (2002) 1.68
Introducing protein intrinsic disorder. Chem Rev (2014) 1.66
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A (2007) 1.65
Composition Profiler: a tool for discovery and visualization of amino acid composition differences. BMC Bioinformatics (2007) 1.64
Harmonization guidelines for HLA-peptide multimer assays derived from results of a large scale international proficiency panel of the Cancer Vaccine Consortium. Cancer Immunol Immunother (2009) 1.63
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A (2009) 1.61
Alternative splicing of intrinsically disordered regions and rewiring of protein interactions. Curr Opin Struct Biol (2013) 1.61
Do viral proteins possess unique biophysical features? Trends Biochem Sci (2008) 1.60
Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen. Proc Natl Acad Sci U S A (2008) 1.59
Rational drug design via intrinsically disordered protein. Trends Biotechnol (2006) 1.57