Published in EMBO J on February 01, 1986
Dominant negative mutants of the Cdc2 kinase uncouple cell division from iterative plant development. EMBO J (1995) 3.92
cdc2a expression in Arabidopsis is linked with competence for cell division. Plant Cell (1993) 3.86
Cell cycle regulation of the human cdc2 gene. EMBO J (1992) 3.69
Isolation and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea mays. Proc Natl Acad Sci U S A (1991) 2.72
Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (1986) 2.66
The Arabidopsis functional homolog of the p34cdc2 protein kinase. Plant Cell (1991) 2.44
Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe. Mol Cell Biol (1987) 2.13
Cloning and characterisation of the S. pombe rad15 gene, a homologue to the S. cerevisiae RAD3 and human ERCC2 genes. Nucleic Acids Res (1992) 2.13
Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe. Nucleic Acids Res (1991) 2.12
The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe. EMBO J (1991) 1.94
Structure and developmental expression of the chicken CDC2 kinase. EMBO J (1989) 1.80
Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene. Nucleic Acids Res (1991) 1.66
Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle. Mol Cell Biol (1990) 1.54
Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor. Mol Cell Biol (1993) 1.53
Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle. Proc Natl Acad Sci U S A (1992) 1.45
Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes. Mol Cell Biol (1990) 1.45
Localization and properties of a silencing element near the mat3-M mating-type cassette of Schizosaccharomyces pombe. Genetics (1999) 1.30
Activation of the p34 CDC2 protein kinase at the start of S phase in the human cell cycle. Mol Biol Cell (1992) 1.08
Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards. Adv Exp Med Biol (2008) 0.96
Histone transcription in cell cycle mutants of fission yeast. EMBO J (1987) 0.87
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene (1985) 213.67
Genetic control of cell size at cell division in yeast. Nature (1975) 7.74
Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature (1981) 5.98
Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet (1982) 5.17
Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes. Nature (1984) 4.74
Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene. EMBO J (1985) 3.87
Functionally homologous cell cycle control genes in budding and fission yeast. Nature (1982) 3.78
Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases. Gene (1984) 3.50
Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics (1980) 3.42
Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1981) 3.07
Controls over the timing of DNA replication during the cell cycle of fission yeast. Exp Cell Res (1977) 2.27
Mutants altered in the control co-ordinating cell division with cell growth in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet (1978) 2.03
Isolation of cell size mutants of a fission yeast by a new selective method: characterization of mutants and implications for division control mechanisms. J Bacteriol (1981) 1.97
The nucleotide sequences of the 5S rRNAs of four mushrooms and their use in studying the phylogenetic position of basidiomycetes among the eukaryotes. Nucleic Acids Res (1983) 1.89
A control acting over the initiation of DNA replication in the yeast Schizosaccharomyces pombe. J Cell Sci (1979) 1.38
Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products. Nature (1983) 1.23
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol (1991) 33.90
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature (1989) 11.90
Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet (1976) 9.64
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature (1987) 8.87
cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell (1986) 8.82
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell (1987) 8.76
Genetic control of cell size at cell division in yeast. Nature (1975) 7.74
Questionnaire on the perceptions of patients about total hip replacement. J Bone Joint Surg Br (1996) 7.44
Questionnaire on the perceptions of patients about total knee replacement. J Bone Joint Surg Br (1998) 7.20
Animal cell cycles and their control. Annu Rev Biochem (1992) 6.60
Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell (1988) 6.29
The fission yeast cdc18+ gene product couples S phase to START and mitosis. Cell (1993) 6.25
Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature (1981) 5.98
Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell (1990) 5.42
Regulation of p34cdc2 protein kinase during mitosis. Cell (1989) 5.33
Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet (1982) 5.17
The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation. Cell (1986) 4.73
Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev (1992) 4.62
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature (1991) 4.60
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J (1991) 4.59
The roles of individual polyoma virus early proteins in oncogenic transformation. Nature (1982) 4.57
The Cdt1 protein is required to license DNA for replication in fission yeast. Nature (2000) 4.46
Substrates for p34cdc2: in vivo veritas? Cell (1990) 4.34
Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division. Exp Cell Res (1977) 4.31
Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. EMBO J (1991) 4.04
Growth in cell length in the fission yeast Schizosaccharomyces pombe. J Cell Sci (1985) 3.99
A controlled trial of zidovudine in primary human immunodeficiency virus infection. N Engl J Med (1995) 3.89
Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet (1981) 3.87
Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene. EMBO J (1985) 3.87
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. Cell (1987) 3.82
Functionally homologous cell cycle control genes in budding and fission yeast. Nature (1982) 3.78
Questionnaire on the perceptions of patients about shoulder surgery. J Bone Joint Surg Br (1996) 3.72
p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase. EMBO J (1989) 3.70
Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines. Proc Natl Acad Sci U S A (1983) 3.65
Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Nature (1994) 3.56
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Cell (1994) 3.52
Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J Virol (1996) 3.48
cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin. J Cell Biol (1997) 3.46
Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics (1980) 3.42
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J (1997) 3.38
Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford) (2004) 3.38
Cohesin Rec8 is required for reductional chromosome segregation at meiosis. Nature (1999) 3.35
p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell (1995) 3.29
Epidemiology of hip and knee pain and its impact on overall health status in older adults. Rheumatology (Oxford) (2004) 3.22
CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast. Cell (2000) 3.21
tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell. Cell (1997) 3.15
Cell cycle regulation in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Annu Rev Cell Biol (1991) 3.14
Dephosphorylation and activation of Xenopus p34cdc2 protein kinase during the cell cycle. Nature (1989) 3.12
Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation. Cell (1989) 3.05
A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group. N Engl J Med (1995) 3.04
Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring. J Cell Sci (1996) 3.01
Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis. J Cell Sci (1988) 2.96
Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature (1998) 2.95
Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein. Nature (1988) 2.88
Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast. Nature (1990) 2.86
A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts. Cell (1990) 2.84
Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells. Mol Cell Biol (1989) 2.75
Fission yeast Schizosaccharomyces pombe correctly excises a mammalian RNA transcript intervening sequence. Nature (1985) 2.74
The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. Cell (1990) 2.73
Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+. Nature (1988) 2.71
Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase. Science (1990) 2.63
Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Plasmid (1986) 2.58
A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J (1996) 2.58
A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet (1996) 2.54
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Cell (1995) 2.48
Coupling M phase and S phase: controls maintaining the dependence of mitosis on chromosome replication. Cell (1991) 2.47
The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol Gen Genet (1986) 2.46
Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis (1996) 2.44
Expression of the SV40 promoter in fission yeast: identification and characterization of an AP-1-like factor. Cell (1988) 2.44
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage (2010) 2.39
Effects of HIV disease on lipid, glucose and insulin levels: results from a large antiretroviral-naive cohort. HIV Med (2005) 2.33
Periodic transcription as a means of regulating gene expression during the cell cycle: contrasting modes of expression of DNA ligase genes in budding and fission yeast. EMBO J (1986) 2.29
Controls over the timing of DNA replication during the cell cycle of fission yeast. Exp Cell Res (1977) 2.27
Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle. J Cell Biol (1995) 2.26
Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle. Proc Natl Acad Sci U S A (1998) 2.20
A fission yeast RCC1-related protein is required for the mitosis to interphase transition. EMBO J (1994) 2.15
cut11(+): A gene required for cell cycle-dependent spindle pole body anchoring in the nuclear envelope and bipolar spindle formation in Schizosaccharomyces pombe. Mol Biol Cell (1998) 2.11
Prevalence and incidence of adults consulting for shoulder conditions in UK primary care; patterns of diagnosis and referral. Rheumatology (Oxford) (2005) 2.07
Uncontrolled septation in a cell division cycle mutant of the fission yeast Schizosaccharomyces pombe. J Bacteriol (1979) 2.06
Schizosaccharomyces pombe and Saccharomyces cerevisiae: a look at yeasts divided. Cell (1986) 2.06
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat Genet (1998) 2.04
Mutants altered in the control co-ordinating cell division with cell growth in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet (1978) 2.03
Construction and functional characterization of polyomavirus genomes that separately encode the three early proteins. J Virol (1984) 2.02
Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: implications for cdc2+ protein structure and function. Mol Gen Genet (1989) 2.02
suc1 is an essential gene involved in both the cell cycle and growth in fission yeast. EMBO J (1986) 1.99
The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population. Osteoarthritis Cartilage (2005) 1.99
Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med (2007) 1.95
Regulation of cell polarity by microtubules in fission yeast. J Cell Biol (1998) 1.88
Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth. EMBO J (1994) 1.87
Evidence for coinfection by multiple strains of human immunodeficiency virus type 1 subtype B in an acute seroconvertor. J Virol (1995) 1.85
How fission yeast fission in the middle. Cell (1996) 1.81
DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. J Cell Sci (1995) 1.79
Cell cycle control genes in fission yeast and mammalian cells. Trends Genet (1988) 1.77
twine, a cdc25 homolog that functions in the male and female germline of Drosophila. Cell (1992) 1.77
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev (1996) 1.75
Control of the higher eukaryote cell cycle by p34cdc2 homologues. Biochim Biophys Acta (1989) 1.74
Pre-meiotic S phase is linked to reductional chromosome segregation and recombination. Nature (2001) 1.71
Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia. J Infect Dis (1999) 1.70