Published in J Immunol on February 15, 2006
Thymic emigration revisited. J Exp Med (2007) 2.60
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity (2008) 2.16
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med (2008) 1.86
A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change. J Immunol (2008) 0.97
Central tolerance: what have we learned from mice? Semin Immunopathol (2008) 0.97
The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla. J Immunol (2009) 0.84
Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection. PLoS Comput Biol (2013) 0.84
Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J Immunol (2011) 0.84
Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules. Immunogenetics (2008) 0.82
Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold. Proc Natl Acad Sci U S A (2012) 0.81
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity (2007) 9.26
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol (2009) 4.28
Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature (2005) 3.81
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity (2009) 2.99
Tracking epitope-specific T cells. Nat Protoc (2009) 2.96
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol (2003) 2.47
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity (2006) 2.23
The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr Biol (2006) 2.20
Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science (2012) 2.01
Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity (2008) 1.95
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 1.93
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol (2013) 1.88
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. J Exp Med (2008) 1.86
Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers. Immunity (2009) 1.84
Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation. J Immunol (2011) 1.84
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation. J Cell Biol (2012) 1.64
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol (2013) 1.61
Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells. Immunity (2012) 1.59
Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A (2011) 1.52
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48
Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines. J Immunol (2008) 1.45
Ezrin and moesin function together to promote T cell activation. J Immunol (2009) 1.44
MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major. J Exp Med (2004) 1.40
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38
CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity. J Immunol (2003) 1.37
Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. J Leukoc Biol (2003) 1.30
Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun (2007) 1.26
Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest (2011) 1.23
Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol (2008) 1.23
WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol Cell Biol (2007) 1.21
Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations. J Immunol (2010) 1.18
HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. J Leukoc Biol (2005) 1.18
Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med (2014) 1.17
Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. Immunol Rev (2012) 1.15
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res (2013) 1.12
Asymmetric B cell division in the germinal center reaction. Science (2011) 1.10
Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire. Proc Natl Acad Sci U S A (2009) 1.09
De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov (2013) 1.07
B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation. J Immunol (2014) 1.07
Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. PLoS Pathog (2011) 1.07
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells. J Immunol (2010) 1.07
Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol (2011) 1.07
Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. J Exp Med (2002) 1.07
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood (2009) 1.03
Doxycycline alters metabolism and proliferation of human cell lines. PLoS One (2013) 1.01
Mechanism and regulatory function of CpG signaling via scavenger receptor B1 in primary B cells. J Biol Chem (2009) 0.98
A tumor-associated glycoprotein that blocks MHC class II-dependent antigen presentation by dendritic cells. J Immunol (2004) 0.97
Further analysis of the T-cell subsets and pathways of murine cardiac allograft rejection. Am J Transplant (2003) 0.96
The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop. Blood (2013) 0.96
Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis. J Neurovirol (2004) 0.95
Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii. J Cell Sci (2006) 0.95
Multiple eicosanoid-activated nonselective cation channels regulate B-lymphocyte adhesion to integrin ligands. Am J Physiol Cell Physiol (2005) 0.93
Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance. J Clin Invest (2003) 0.92
Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection. J Immunol (2006) 0.92
Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity. J Autoimmun (2010) 0.91
The role of dendritic cells in multiple sclerosis. Curr Neurol Neurosci Rep (2007) 0.89
Antigen presentation by keratinocytes directs autoimmune skin disease. Proc Natl Acad Sci U S A (2003) 0.89
Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice. Eur J Immunol (2012) 0.89
Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress. J Virol (2013) 0.89
Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. J Immunol (2005) 0.87
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. J Exp Med (2014) 0.87
Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol (2013) 0.86
Mechanisms of hypotonicity-induced calcium signaling and integrin activation by arachidonic acid-derived inflammatory mediators in B cells. J Immunol (2005) 0.85
The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla. J Immunol (2009) 0.84
B-lymphocyte calcium influx. Immunol Rev (2009) 0.84
A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. J Virol (2014) 0.83
Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation. J Immunol (2003) 0.83
Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response. Xenotransplantation (2004) 0.83
Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. J Exp Med (2013) 0.83
Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death. Immunol Lett (2011) 0.82
CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs. J Immunol (2012) 0.82
Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold. Proc Natl Acad Sci U S A (2012) 0.81
HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. J Lipid Res (2008) 0.81
Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells. J Biol Chem (2013) 0.81
Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice. PLoS One (2010) 0.78
Inflammatory arthritis--an exciting confluence of human and animal research. Immunol Rev (2010) 0.77
Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus. J Clin Invest (2014) 0.77
Immunology. Fueling function over expansion in T cells. Science (2013) 0.75
Stemming the tide of rejection. Nat Med (2002) 0.75
Bruton's Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model. Transplantation (2016) 0.75
An increased frequency of autoantibody-inducing CD4+ T cells in pre-diseased lupus-prone mice. Int Immunol (2004) 0.75
Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. Res Sq (2020) 0.75
Invariant chain and the MHC class II cytoplasmic domains regulate localization of MHC class II molecules to lipid rafts in tumor cell-based vaccines. J Immunol (2004) 0.75
Costimulation in resistance to infection and development of immune pathology: lessons from toxoplasma. Immunol Res (2003) 0.75
Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2. bioRxiv (2020) 0.75
Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. medRxiv (2020) 0.75