Published in J Proteome Res on February 01, 2006
Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature (2011) 4.84
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Decoding protein modifications using top-down mass spectrometry. Nat Methods (2007) 2.62
High throughput characterization of combinatorial histone codes. Mol Cell Proteomics (2009) 2.52
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Mol Cell Biol (2007) 2.43
Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 2.29
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. J Biol Chem (2008) 2.28
One-pot shotgun quantitative mass spectrometry characterization of histones. J Proteome Res (2009) 2.13
Tissue-specific expression and post-translational modification of histone H3 variants. J Proteome Res (2008) 1.84
Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers. Anal Chem (2007) 1.60
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Breaking the histone code with quantitative mass spectrometry. Expert Rev Proteomics (2011) 1.39
Accurate mass measurements in proteomics. Chem Rev (2007) 1.36
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Analysis of intact protein isoforms by mass spectrometry. J Biol Chem (2011) 1.15
Analysis of histones in Xenopus laevis. II. mass spectrometry reveals an index of cell type-specific modifications on H3 and H4. J Biol Chem (2008) 1.12
Robust methods for purification of histones from cultured mammalian cells with the preservation of their native modifications. Nucleic Acids Res (2009) 1.06
Liquid chromatography mass spectrometry profiling of histones. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 1.00
The Promise of Proteomics for the Study of ADP-Ribosylation. Mol Cell (2015) 0.98
Mass spectrometry-based strategies for characterization of histones and their post-translational modifications. Expert Rev Proteomics (2007) 0.98
Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics. Int J Mol Sci (2013) 0.97
Comparing and combining capillary electrophoresis electrospray ionization mass spectrometry and nano-liquid chromatography electrospray ionization mass spectrometry for the characterization of post-translationally modified histones. Mol Cell Proteomics (2013) 0.96
Expression and functionality of histone H2A variants in cancer. Oncotarget (2014) 0.95
Identification of lysine 37 of histone H2B as a novel site of methylation. PLoS One (2011) 0.94
High resolution electron transfer dissociation studies of unfractionated intact histones from murine embryonic stem cells using on-line capillary LC separation: determination of abundant histone isoforms and post-translational modifications. Mol Cell Proteomics (2010) 0.94
Progress in Top-Down Proteomics and the Analysis of Proteoforms. Annu Rev Anal Chem (Palo Alto Calif) (2016) 0.94
Mass spectrometry based proteomics, background, status and future needs. Protein Cell (2012) 0.94
Data processing algorithms for analysis of high resolution MSMS spectra of peptides with complex patterns of posttranslational modifications. Mol Cell Proteomics (2009) 0.93
The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components. Mol Cell Proteomics (2013) 0.93
Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster. Nucleic Acids Res (2011) 0.92
Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression. Mol Cell Proteomics (2015) 0.92
Identification and interrogation of combinatorial histone modifications. Front Genet (2013) 0.91
Global amine and acid functional group modification of proteins. Anal Chem (2008) 0.90
Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia. Proteomics (2009) 0.90
Analysis of Histone Modifications from Tryptic Peptides of Deuteroacetylated Isoforms. Int J Mass Spectrom (2012) 0.89
Quantitative analysis of histone modifications: formaldehyde is a source of pathological n(6)-formyllysine that is refractory to histone deacetylases. PLoS Genet (2013) 0.88
The ChroP approach combines ChIP and mass spectrometry to dissect locus-specific proteomic landscapes of chromatin. J Vis Exp (2014) 0.87
Unraveling the histone's potential: a proteomics perspective. Epigenetics (2008) 0.86
Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a. J Am Soc Mass Spectrom (2010) 0.86
Revealing histone variant induced changes via quantitative proteomics. Crit Rev Biochem Mol Biol (2011) 0.86
Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis. Nucleic Acids Res (2013) 0.86
Post-translational modifications of the histone variant H2AZ. Stem Cell Res (2013) 0.85
Global histone profiling by LC-FTMS after inhibition and knockdown of deacetylases in human cells. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.84
Mass spectrometry-based detection and assignment of protein posttranslational modifications. ACS Chem Biol (2015) 0.84
Mass spectrometric analysis of histone proteoforms. Annu Rev Anal Chem (Palo Alto Calif) (2014) 0.83
Combining genomic and proteomic approaches for epigenetics research. Epigenomics (2013) 0.83
Middle-Down and Top-Down Mass Spectrometric Analysis of Co-occurring Histone Modifications. Curr Protoc Protein Sci (2014) 0.82
Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior? J Proteome Res (2010) 0.80
Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry. Curr Opin Chem Biol (2016) 0.78
Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations. Expert Rev Proteomics (2015) 0.77
A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants. J Mass Spectrom (2013) 0.77
Transimination of quinone imines: a mechanism for embedding exogenous redox activity into the nucleosome. Chem Res Toxicol (2012) 0.76
Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry. J Proteome Res (2015) 0.75
Extracting histones for the specific purpose of label-free MS. Proteomics (2016) 0.75
MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones. Epigenetics Chromatin (2017) 0.75
Recent Achievements in Characterizing the Histone Code and Approaches to Integrating Epigenomics and Systems Biology. Methods Enzymol (2017) 0.75
Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature (2011) 4.84
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell (2010) 4.24
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
Precision proteomics: the case for high resolution and high mass accuracy. Proc Natl Acad Sci U S A (2008) 4.00
A monovalent streptavidin with a single femtomolar biotin binding site. Nat Methods (2006) 3.89
Pervasive combinatorial modification of histone H3 in human cells. Nat Methods (2007) 3.54
Proteoform: a single term describing protein complexity. Nat Methods (2013) 3.48
Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4. Anal Chem (2006) 3.08
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
Functional CpG methylation system in a social insect. Science (2006) 2.95
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood (2010) 2.71
Decoding protein modifications using top-down mass spectrometry. Nat Methods (2007) 2.62
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Mol Cell Biol (2007) 2.43
Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry. J Am Chem Soc (2004) 2.36
ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry. Nucleic Acids Res (2007) 2.35
Mass spectrometric characterization of human histone H3: a bird's eye view. J Proteome Res (2006) 2.29
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. J Biol Chem (2008) 2.28
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry (2006) 2.22
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J (2009) 2.05
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proc Natl Acad Sci U S A (2005) 2.03
ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry. Nucleic Acids Res (2004) 2.03
Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry. Mol Cell Proteomics (2005) 1.86
Web and database software for identification of intact proteins using "top down" mass spectrometry. Anal Chem (2003) 1.85
Tissue-specific expression and post-translational modification of histone H3 variants. J Proteome Res (2008) 1.84
Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.80
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72
Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. J Am Chem Soc (2013) 1.69
A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome. J Am Soc Mass Spectrom (2009) 1.65
Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. Anal Chem (2002) 1.63
Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chem Biol (2004) 1.61
Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers. Anal Chem (2007) 1.60
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proc Natl Acad Sci U S A (2005) 1.58
Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem (2008) 1.58
Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation. Mol Cell Proteomics (2006) 1.57
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proc Natl Acad Sci U S A (2006) 1.56
Gene-specific characterization of human histone H2B by electron capture dissociation. J Proteome Res (2006) 1.53
Oncogene-induced cellular senescence elicits an anti-Warburg effect. Proteomics (2013) 1.50
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47
Construction of a hybrid quadrupole/Fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa. J Am Soc Mass Spectrom (2004) 1.46
"Proteotyping": population proteomics of human leukocytes using top down mass spectrometry. Anal Chem (2008) 1.46
Modifications of H3 and H4 during chromatin replication, nucleosome assembly, and histone exchange. J Biol Chem (2006) 1.42
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. Chem Biol (2008) 1.41
Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa. Anal Chem (2010) 1.40
Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail. J Biol Chem (2007) 1.40
Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. Nat Prod Rep (2006) 1.39
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair. J Mol Cell Biol (2013) 1.37
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc Natl Acad Sci U S A (2008) 1.36
Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence. Mol Cell Proteomics (2013) 1.33
Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval. J Proteome Res (2009) 1.33
New and automated MSn approaches for top-down identification of modified proteins. J Am Soc Mass Spectrom (2005) 1.33
On the scalability and requirements of whole protein mass spectrometry. Anal Chem (2011) 1.31
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. J Am Chem Soc (2012) 1.29
A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol (2009) 1.29
The multiple facets of histone H4-lysine 20 methylation. Biochem Cell Biol (2009) 1.28
Mass spectrometry-based discovery of circadian peptides. Proc Natl Acad Sci U S A (2008) 1.27
Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. ACS Chem Biol (2011) 1.27
Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila. Mol Cell Proteomics (2006) 1.26
Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem (2006) 1.26
Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS. Proc Natl Acad Sci U S A (2004) 1.26
Using ProSight PTM and related tools for targeted protein identification and characterization with high mass accuracy tandem MS data. Curr Protoc Bioinformatics (2007) 1.26
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry (2006) 1.24
Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry. Anal Chem (2011) 1.23
Evaluation of the compact high-field orbitrap for top-down proteomics of human cells. J Proteome Res (2012) 1.22
Detection and localization of protein modifications by high resolution tandem mass spectrometry. Mass Spectrom Rev (2005) 1.22
Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry. Anal Chem (2006) 1.22
Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol (2007) 1.21
Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster. J Am Chem Soc (2006) 1.20
Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. Biochemistry (2005) 1.19
A protease for 'middle-down' proteomics. Nat Methods (2012) 1.19
Molecular-level description of proteins from saccharomyces cerevisiae using quadrupole FT hybrid mass spectrometry for top down proteomics. Anal Chem (2004) 1.18
Fourier-transform mass spectrometry for automated fragmentation and identification of 5-20 kDa proteins in mixtures. Electrophoresis (2002) 1.18
The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput. Mol Biosyst (2010) 1.16
Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale. Proteomics (2010) 1.16
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc (2009) 1.16
Top down proteomics of human membrane proteins from enriched mitochondrial fractions. Anal Chem (2013) 1.15
Analysis of intact protein isoforms by mass spectrometry. J Biol Chem (2011) 1.15
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry (2011) 1.15
Electron capture dissociation and 13C,15N depletion for deuterium localization in intact proteins after solution-phase exchange. Anal Chem (2003) 1.14
Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. J Am Chem Soc (2005) 1.14
Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. Biochemistry (2007) 1.13
Kinetics of re-establishing H3K79 methylation marks in global human chromatin. J Biol Chem (2010) 1.13
The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. J Am Chem Soc (2006) 1.13
Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. Biochemistry (2005) 1.13
Neuropeptidomics of the supraoptic rat nucleus. J Proteome Res (2008) 1.13