Published in Mol Cell on January 29, 2010
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Eukaryotic DNA replication origins: many choices for appropriate answers. Nat Rev Mol Cell Biol (2010) 2.56
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell (2011) 2.40
CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. Genes Dev (2010) 1.86
Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol Cell (2010) 1.83
Principles and concepts of DNA replication in bacteria, archaea, and eukarya. Cold Spring Harb Perspect Biol (2013) 1.79
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol Cell (2011) 1.77
A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands. Mol Cell (2015) 1.75
Uncoupling of sister replisomes during eukaryotic DNA replication. Mol Cell (2010) 1.73
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA. Nat Struct Mol Biol (2013) 1.66
How dormant origins promote complete genome replication. Trends Biochem Sci (2011) 1.60
Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. Nat Struct Mol Biol (2014) 1.59
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Proc Natl Acad Sci U S A (2012) 1.44
The nuts and bolts of ring-translocase structure and mechanism. Curr Opin Struct Biol (2011) 1.44
A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA. Genes Dev (2014) 1.40
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife (2014) 1.40
Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J Cell Biol (2011) 1.37
Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J (2012) 1.37
High degree of coordination and division of labor among subunits in a homomeric ring ATPase. Cell (2012) 1.35
Structure of the eukaryotic MCM complex at 3.8 Å. Nature (2015) 1.35
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'. Nucleic Acids Res (2010) 1.28
Helicase loading at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.26
Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J (2011) 1.25
Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev (2010) 1.24
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell (2011) 1.24
Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase. Mol Cell (2014) 1.23
Genomic instability in cancer. Cold Spring Harb Perspect Biol (2013) 1.23
Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function. Genes Dev (2014) 1.22
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21
CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication. Proc Natl Acad Sci U S A (2014) 1.18
The minichromosome maintenance replicative helicase. Cold Spring Harb Perspect Biol (2013) 1.16
Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell Rep (2013) 1.16
A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife (2014) 1.15
Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J (2012) 1.15
The architecture of a eukaryotic replisome. Nat Struct Mol Biol (2015) 1.15
Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J (2014) 1.14
BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork. Mol Cell (2014) 1.14
Regulation of DNA replication during development. Development (2012) 1.13
Repair of a DNA-protein crosslink by replication-coupled proteolysis. Cell (2014) 1.12
A viral packaging motor varies its DNA rotation and step size to preserve subunit coordination as the capsid fills. Cell (2014) 1.12
Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. Elife (2015) 1.12
The dynamics of replication licensing in live Caenorhabditis elegans embryos. J Cell Biol (2012) 1.11
Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Dev Biol (2010) 1.11
Chromosome Duplication in Saccharomyces cerevisiae. Genetics (2016) 1.11
Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding. Nucleic Acids Res (2011) 1.10
Multiple functions for Mcm2-7 ATPase motifs during replication initiation. Mol Cell (2014) 1.09
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat Struct Mol Biol (2016) 1.08
A structural framework for replication origin opening by AAA+ initiation factors. Curr Opin Struct Biol (2012) 1.06
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer. Mol Cancer (2011) 1.05
The mechanism of DNA replication termination in vertebrates. Nature (2015) 1.04
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate. Nat Commun (2016) 1.04
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated. Chromosoma (2014) 1.03
Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases. J Biol Chem (2011) 1.03
Thermococcus kodakarensis encodes three MCM homologs but only one is essential. Nucleic Acids Res (2011) 1.02
The contribution of dormant origins to genome stability: from cell biology to human genetics. DNA Repair (Amst) (2014) 1.01
GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding. J Biol Chem (2011) 1.00
Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload. J Cell Biol (2011) 1.00
Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J (2011) 1.00
The Cdc45·Mcm2-7·GINS protein complex in trypanosomes regulates DNA replication and interacts with two Orc1-like proteins in the origin recognition complex. J Biol Chem (2011) 1.00
Dormant origins, the licensing checkpoint, and the response to replicative stresses. Cold Spring Harb Perspect Biol (2012) 0.99
Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement. Proc Natl Acad Sci U S A (2015) 0.99
The replication initiation protein Sld2 regulates helicase assembly. J Biol Chem (2013) 0.99
Analysis of the crystal structure of an active MCM hexamer. Elife (2014) 0.98
New insights into replisome fluidity during chromosome replication. Trends Biochem Sci (2012) 0.98
Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication. Genes Cells (2013) 0.98
Replication stress: getting back on track. Nat Struct Mol Biol (2016) 0.97
The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplication. Genes (Basel) (2013) 0.97
Structure and evolutionary origins of the CMG complex. Chromosoma (2013) 0.96
Architectures of archaeal GINS complexes, essential DNA replication initiation factors. BMC Biol (2011) 0.96
Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress. J Biol Chem (2013) 0.96
Retracted The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. J Biol Chem (2014) 0.96
Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex. J Biol Chem (2011) 0.95
Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem (2011) 0.95
The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level. Mol Cell (2015) 0.95
Regulation of the cell division cycle in Trypanosoma brucei. Eukaryot Cell (2012) 0.94
Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proc Natl Acad Sci U S A (2012) 0.93
Mechanistic analysis of local ori melting and helicase assembly by the papillomavirus E1 protein. Mol Cell (2011) 0.93
Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. J Biol Chem (2015) 0.93
Activation of a human chromosomal replication origin by protein tethering. Nucleic Acids Res (2013) 0.92
DNA replication and homologous recombination factors: acting together to maintain genome stability. Chromosoma (2013) 0.92
Clamp loader ATPases and the evolution of DNA replication machinery. BMC Biol (2012) 0.92
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity. EMBO J (2016) 0.92
DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast. Mol Biol Cell (2012) 0.92
DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding. Nucleic Acids Res (2013) 0.92
The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain. Biol Direct (2010) 0.91
Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase. Proc Natl Acad Sci U S A (2015) 0.91
Activation of the MCM helicase from the thermophilic archaeon, Thermoplasma acidophilum by interactions with GINS and Cdc6-2. Extremophiles (2014) 0.90
Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest (2017) 0.90
Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc Natl Acad Sci U S A (2017) 0.90
Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif. J Biol Chem (2010) 0.90
Translocation and stability of replicative DNA helicases upon encountering DNA-protein cross-links. J Biol Chem (2013) 0.90
Structure of human Cdc45 and implications for CMG helicase function. Nat Commun (2016) 0.89
RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. G3 (Bethesda) (2016) 0.89
Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis. Cell Biosci (2012) 0.89
Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly. Genes Dev (2015) 0.89
Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Res (2015) 0.88
"The Octet": Eight Protein Kinases that Control Mammalian DNA Replication. Front Physiol (2012) 0.88
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci U S A (2006) 5.66
Pervasive combinatorial modification of histone H3 in human cells. Nat Methods (2007) 3.54
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev (2004) 2.73
Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature (2002) 2.61
DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding. EMBO J (2004) 2.29
Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. Mol Cell (2006) 2.11
Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res (2006) 2.09
Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. PLoS Genet (2011) 1.95
Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes Dev (2007) 1.95
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol Cell (2011) 1.77
Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem (2008) 1.58
Gene-specific characterization of human histone H2B by electron capture dissociation. J Proteome Res (2006) 1.53
Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes Dev (2004) 1.46
Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes Dev (2007) 1.23
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21
The minichromosome maintenance replicative helicase. Cold Spring Harb Perspect Biol (2013) 1.16
Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Dev Biol (2010) 1.11
Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase. J Biol Chem (2002) 1.09
Interpreting top-down mass spectra using spectral alignment. Anal Chem (2008) 1.08
Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II. J Cell Biol (2010) 1.08
CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex. J Biol Chem (2005) 0.97
Phylogenetic investigations of Antarctic notothenioid fishes (Perciformes: Notothenioidei) using complete gene sequences of the mitochondrial encoded 16S rRNA. Mol Phylogenet Evol (2004) 0.96
Mitochondrial DNA, morphology, and the phylogenetic relationships of Antarctic icefishes (Notothenioidei: Channichthyidae). Mol Phylogenet Evol (2003) 0.95
Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proc Natl Acad Sci U S A (2012) 0.93
humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. Curr Biol (2005) 0.84
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. Elife (2013) 0.83
Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Mol Cell Biol (2012) 0.83
Characterization of Chlamydomonas reinhardtii Core Histones by Top-Down Mass Spectrometry Reveals Unique Algae-specific Variants and Post-translational Modifications. J Proteome Res (2017) 0.75