Published in Biochemistry on September 19, 2011
Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep (2012) 1.75
Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae. BMC Microbiol (2013) 1.39
Flavoenzymes: versatile catalysts in biosynthetic pathways. Nat Prod Rep (2013) 1.23
Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. ACS Chem Biol (2013) 1.08
Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. J Am Chem Soc (2011) 1.06
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nat Chem Biol (2012) 1.04
Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk. Nat Chem Biol (2013) 1.02
Complexity generation during natural product biosynthesis using redox enzymes. Curr Opin Chem Biol (2012) 0.96
Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. PLoS One (2012) 0.88
Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans. Mar Drugs (2013) 0.85
Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. ACS Chem Biol (2013) 0.85
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus. Cell Microbiol (2014) 0.84
Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. J Am Chem Soc (2012) 0.84
Oxidative Cyclization in Natural Product Biosynthesis. Chem Rev (2016) 0.81
Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Mol Microbiol (2015) 0.80
An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins. Chem Biol (2013) 0.79
A novel C2H2 transcription factor that regulates gliA expression interdependently with GliZ in Aspergillus fumigatus. PLoS Genet (2014) 0.78
Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Org Lett (2014) 0.77
Epigenetic modifier induced enhancement of fumiquinazoline C production in Aspergillus fumigatus (GA-L7): an endophytic fungus from Grewia asiatica L. AMB Express (2017) 0.75
Haenamindole and fumiquinazoline analogs from a fungicolous isolate of Penicillium lanosum. J Antibiot (Tokyo) (2016) 0.75
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res (2005) 21.68
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (2005) 8.55
Protein identification and analysis tools in the ExPASy server. Methods Mol Biol (1999) 6.31
Fusion PCR and gene targeting in Aspergillus nidulans. Nat Protoc (2006) 4.22
To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes. Trends Biochem Sci (2006) 1.81
Oxidation of amines by flavoproteins. Arch Biochem Biophys (2009) 1.49
Cottoquinazoline A and cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor. J Nat Prod (2009) 1.43
Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus. Eukaryot Cell (2008) 1.41
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Genes and molecules involved in Aspergillus fumigatus virulence. Rev Iberoam Micol (2005) 1.40
Metabolomics of Aspergillus fumigatus. Med Mycol (2008) 1.36
What's in a covalent bond? On the role and formation of covalently bound flavin cofactors. FEBS J (2009) 1.35
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis. Biochemistry (2010) 1.33
Protein glycosylation pathways in filamentous fungi. Glycobiology (2008) 1.28
Anthranilate-activating modules from fungal nonribosomal peptide assembly lines. Biochemistry (2010) 1.25
The growing VAO flavoprotein family. Arch Biochem Biophys (2008) 1.16
Aryl-alcohol oxidase protein sequence: a comparison with glucose oxidase and other FAD oxidoreductases. Biochim Biophys Acta (2000) 1.09
Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant. Planta (2001) 1.08
New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus, Aspergillus versicolor LCJ-5-4. Org Lett (2011) 1.01
Subcellular localization and biochemical comparison of cytosolic and secreted cytokinin dehydrogenase enzymes from maize. J Exp Bot (2009) 0.97
Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-(2)H2)benzylamine: nitrogen rehybridization and CH bond cleavage are not concerted. J Am Chem Soc (2011) 0.96
Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry (2011) 0.96
Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes. Plant Cell Physiol (2005) 0.95
Oxepinamides A-C and fumiquinazolines H--I: bioactive metabolites from a marine isolate of a fungus of the genus Acremonium. Chemistry (2000) 0.94
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chem Rev (2006) 7.69
Antibiotics for emerging pathogens. Science (2009) 7.39
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Genetics and assembly line enzymology of siderophore biosynthesis in bacteria. Microbiol Mol Biol Rev (2002) 5.12
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature (2011) 4.84
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Precision proteomics: the case for high resolution and high mass accuracy. Proc Natl Acad Sci U S A (2008) 4.00
A monovalent streptavidin with a single femtomolar biotin binding site. Nat Methods (2006) 3.89
Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol (2011) 3.80
Non-heme Fe(IV)-oxo intermediates. Acc Chem Res (2007) 3.55
Pervasive combinatorial modification of histone H3 in human cells. Nat Methods (2007) 3.54
Proteoform: a single term describing protein complexity. Nat Methods (2013) 3.48
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. Nat Chem Biol (2007) 3.33
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4. Anal Chem (2006) 3.08
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. Nature (2005) 2.91
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83
New antibiotics from bacterial natural products. Nat Biotechnol (2006) 2.72
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood (2010) 2.71
The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A (2008) 2.71
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A (2006) 2.63
Decoding protein modifications using top-down mass spectrometry. Nat Methods (2007) 2.62
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
BluB cannibalizes flavin to form the lower ligand of vitamin B12. Nature (2007) 2.53
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature (2006) 2.52
How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol (2006) 2.45
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Mol Cell Biol (2007) 2.43
Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature (2008) 2.39
Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry. J Am Chem Soc (2004) 2.36
ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry. Nucleic Acids Res (2007) 2.35
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
Mass spectrometric characterization of human histone H3: a bird's eye view. J Proteome Res (2006) 2.29
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. J Biol Chem (2008) 2.28
Nature's inventory of halogenation catalysts: oxidative strategies predominate. Chem Rev (2006) 2.24
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A (2009) 2.22
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry (2006) 2.22
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A (2007) 2.22
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase. Proc Natl Acad Sci U S A (2005) 2.12
Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res (2006) 2.09
Halogenation strategies in natural product biosynthesis. Chem Biol (2008) 2.08
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J (2009) 2.05
Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res (2006) 2.04
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proc Natl Acad Sci U S A (2005) 2.03
ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry. Nucleic Acids Res (2004) 2.03
Vancomycin assembly: nature's way. Angew Chem Int Ed Engl (2003) 1.99
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.98
Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. ACS Chem Biol (2007) 1.94
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chem Biol (2002) 1.90
A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.89
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry. Mol Cell Proteomics (2005) 1.86
Web and database software for identification of intact proteins using "top down" mass spectrometry. Anal Chem (2003) 1.85
Labeling proteins with small molecules by site-specific posttranslational modification. J Am Chem Soc (2004) 1.84
Tissue-specific expression and post-translational modification of histone H3 variants. J Proteome Res (2008) 1.84
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains. Nat Struct Biol (2002) 1.82
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis. Proc Natl Acad Sci U S A (2005) 1.82
Site-specific protein labeling by Sfp phosphopantetheinyl transferase. Nat Protoc (2006) 1.82
Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nat Chem (2011) 1.82
Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.80
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76
Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis. Chem Biol (2002) 1.75
A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines. Nature (2007) 1.74
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry (2007) 1.69
Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. Biochemistry (2009) 1.69
Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. J Am Chem Soc (2013) 1.69
Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation. Nat Chem Biol (2007) 1.68
Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature (2008) 1.66
A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome. J Am Soc Mass Spectrom (2009) 1.65
Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. Anal Chem (2002) 1.63
Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chem Biol (2004) 1.61
Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers. Anal Chem (2007) 1.60
The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria. Science (2010) 1.59
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proc Natl Acad Sci U S A (2005) 1.58
Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem (2008) 1.58
Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation. Mol Cell Proteomics (2006) 1.57
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proc Natl Acad Sci U S A (2002) 1.57
Proteome analysis of hepatocellular carcinoma by two-dimensional difference gel electrophoresis: novel protein markers in hepatocellular carcinoma tissues. Mol Cell Proteomics (2007) 1.57
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proc Natl Acad Sci U S A (2006) 1.56
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat Prod Rep (2008) 1.56
An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol (2012) 1.56
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chem Biol (2012) 1.55