Published in J Cell Biol on February 06, 2006
PML nuclear bodies. Cold Spring Harb Perspect Biol (2010) 2.44
Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol (2008) 1.59
PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins. J Cell Biol (2006) 1.12
Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. PLoS Pathog (2011) 1.10
A novel function for p53: regulation of growth cone motility through interaction with Rho kinase. J Neurosci (2009) 1.05
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. EMBO Rep (2008) 1.00
Nuclear polyglutamine-containing protein aggregates as active proteolytic centers. J Cell Biol (2008) 0.93
Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model. Mol Ther Methods Clin Dev (2014) 0.93
Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias. Brain Res Bull (2011) 0.84
AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity. J Neurosci (2013) 0.83
Efficient induction of nuclear aggresomes by specific single missense mutations in the DNA-binding domain of a viral AP-1 homolog. J Biol Chem (2011) 0.81
CRMP5-associated GTPase (CRAG) protein protects neuronal cells against cytotoxicity of expanded polyglutamine protein partially via c-Fos-dependent activator protein-1 activation. J Biol Chem (2011) 0.81
TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. Nat Commun (2016) 0.81
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene (2015) 0.78
Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model. J Mol Neurosci (2012) 0.77
The PIKE homolog Centaurin gamma regulates developmental timing in Drosophila. PLoS One (2014) 0.76
Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma. Mol Vis (2010) 0.76
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
Structure and function in the nucleus. Science (1998) 6.26
Biological and biochemical properties of human rasH genes mutated at codon 61. Cell (1986) 5.05
Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A (2000) 2.00
Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases? Neuron (1997) 1.91
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell (2000) 1.88
Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies. Am J Hum Genet (1998) 1.64
Endothelin: a novel peptide in the posterior pituitary system. Science (1990) 1.51
Beyond the Qs in the polyglutamine diseases. Genes Dev (2001) 1.41
Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. EMBO J (2002) 1.32
Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain. J Biol Chem (2000) 1.31
Critical role of collapsin response mediator protein-associated molecule CRAM for filopodia and growth cone development in neurons. Mol Biol Cell (2004) 1.09
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch. Hum Mol Genet (2000) 0.98
Adenovirus-mediated expression of mutant DRPLA proteins with expanded polyglutamine stretches in neuronally differentiated PC12 cells. Preferential intranuclear aggregate formation and apoptosis. Hum Mol Genet (1999) 0.98
PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases. Neurobiol Dis (2003) 0.96
Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA). Cytogenet Genome Res (2003) 0.88
A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro. J Biochem (2005) 0.80
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell (2008) 10.49
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat Neurosci (2011) 7.37
Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90
Age-associated elongation of the ascending aorta in adults. JACC Cardiovasc Imaging (2008) 2.80
A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J (2006) 2.52
CD38 is critical for social behaviour by regulating oxytocin secretion. Nature (2007) 2.44
Interrelationships among noninvasive measures of postischemic macro- and microvascular reactivity. J Appl Physiol (1985) (2008) 2.29
Habitual exercise and arterial aging. J Appl Physiol (1985) (2008) 2.19
Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension. Hypertension (2004) 2.17
Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J (2003) 2.13
Illuminating cell-cycle progression in the developing zebrafish embryo. Proc Natl Acad Sci U S A (2009) 1.88
The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res (2005) 1.85
Synergistic relationship between changes in the pulse wave velocity and changes in the heart rate in middle-aged Japanese adults: a prospective study. J Hypertens (2010) 1.80
Unfavorable effects of resistance training on central arterial compliance: a randomized intervention study. Circulation (2004) 1.73
Association between central elastic artery stiffness and cerebral perfusion in deep subcortical gray and white matter. Am J Hypertens (2011) 1.71
Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. Eur J Cancer (2008) 1.58
Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation. J Cell Biol (2011) 1.56
Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol (2002) 1.55
Central artery stiffness, neuropsychological function, and cerebral perfusion in sedentary and endurance-trained middle-aged adults. J Hypertens (2013) 1.50
Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. J Biol Chem (2003) 1.46
A new device for automatic measurements of arterial stiffness and ankle-brachial index. Am J Cardiol (2003) 1.46
Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res (2009) 1.42
Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res (2003) 1.41
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. J Biol Chem (2004) 1.41
Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance. J Appl Physiol (1985) (2002) 1.38
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem (2005) 1.37
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res (2010) 1.35
Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. EMBO J (2002) 1.32
Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release. Neuropharmacology (2007) 1.31
A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. J Biol Chem (2005) 1.28
Arterial stiffness and declines in individuals with normal renal function/early chronic kidney disease. Atherosclerosis (2010) 1.24
NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers. J Biol Chem (2004) 1.23
Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. Int J Cancer (2006) 1.23
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature (2010) 1.21
Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men. J Appl Physiol (1985) (2003) 1.20
Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J Physiol (2002) 1.19
Greater age-related reductions in central arterial compliance in resistance-trained men. Hypertension (2003) 1.19
MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2. Mol Cell (2013) 1.18
Enzymic and structural characterization of nepenthesin, a unique member of a novel subfamily of aspartic proteinases. Biochem J (2004) 1.17
Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. J Cell Biol (2009) 1.15
Effects of high intensity resistance training on arterial stiffness and wave reflection in women. Am J Hypertens (2005) 1.15
Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness. Eur Heart J (2003) 1.15
Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron (2013) 1.10
Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proc Natl Acad Sci U S A (2011) 1.09
Critical role of collapsin response mediator protein-associated molecule CRAM for filopodia and growth cone development in neurons. Mol Biol Cell (2004) 1.09
The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta. J Biol Chem (2005) 1.09
Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis. Blood (2006) 1.08
Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation. Mol Biol Cell (2009) 1.07
Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans. Hypertens Res (2007) 1.06
Protein tyrosine kinase, syk: a key player in phagocytic cells. J Biochem (2009) 1.06
Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up. J Appl Physiol (1985) (2002) 1.06
Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils. J Biol Chem (2006) 1.05
Insulin sensitivity as a mediator of the relationship between BMI and working memory-related brain activation. Obesity (Silver Spring) (2010) 1.05
The effects of strength training on central arterial compliance in middle-aged and older adults. Eur J Cardiovasc Prev Rehabil (2008) 1.04
Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells. Cancer Sci (2010) 1.04
Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood (2002) 1.04
Functional, biochemical, and chromatographic characterization of the complete [Ca2+]i oscillation-inducing activity of porcine sperm. Dev Biol (2005) 1.03
Influence of regular exercise on age-related changes in arterial elasticity: mechanistic insights from wall compositions in rat aorta. Can J Appl Physiol (2003) 1.02
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res (2010) 1.02
Distal shift of arterial pressure wave reflection sites with aging. Hypertension (2010) 1.02
Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. J Biol Chem (2009) 1.02
Resistance training increases basal limb blood flow and vascular conductance in aging humans. J Appl Physiol (1985) (2006) 1.02
Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J (2003) 1.02
Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem Biophys Res Commun (2003) 1.01
Resistance training and arterial compliance: keeping the benefits while minimizing the stiffening. J Hypertens (2006) 1.01
Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability. Arch Pathol Lab Med (2008) 1.01
Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells (2008) 1.00
Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. Am J Physiol Heart Circ Physiol (2002) 1.00
Preliminary assessment of an automatic screening device for peripheral arterial disease using ankle-brachial and toe-brachial indices. Blood Press Monit (2011) 1.00
CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J Biol Chem (2010) 1.00
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. EMBO Rep (2008) 1.00
Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. J Neurosci (2013) 0.99
How much exercise is required to reduce blood pressure in essential hypertensives: a dose-response study. Am J Hypertens (2003) 0.99
Reduction in alpha-adrenergic receptor-mediated vascular tone contributes to improved arterial compliance with endurance training. Int J Cardiol (2008) 0.99
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci (2007) 0.99
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol (2005) 0.99
Subclinical atherosclerosis is related to lower neuronal viability in middle-aged adults: a 1H MRS study. Brain Res (2010) 0.98
Continuous smoking and progression of arterial stiffening: a prospective study. J Am Coll Cardiol (2010) 0.98
Proteolytic processing of phospholipase Czeta and [Ca2+]i oscillations during mammalian fertilization. Dev Biol (2007) 0.98
Arterial compliance of rowers: implications for combined aerobic and strength training on arterial elasticity. Am J Physiol Heart Circ Physiol (2005) 0.98
Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase. J Biol Chem (2003) 0.97
Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Blood (2003) 0.97
Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol Cell Biol (2003) 0.96
A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein. Mitochondrion (2010) 0.96
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. PLoS One (2013) 0.96
Oncogene-mediated human lung epithelial cell transformation produces adenocarcinoma phenotypes in vivo. Cancer Res (2011) 0.96