Published in J Neurosci on July 10, 2013
Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. Sci Signal (2015) 1.56
Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol (2016) 1.38
Phosphoinositides regulate ion channels. Biochim Biophys Acta (2014) 1.09
Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity. J Biol Chem (2013) 1.06
Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. J Gen Physiol (2015) 1.06
Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol (2014) 0.97
Regulation of transient receptor potential channels by the phospholipase C pathway. Adv Biol Regul (2013) 0.90
Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. Neuron (2015) 0.86
Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels. J Gen Physiol (2015) 0.86
Phosphoinositide regulation of TRPV1 revisited. Pflugers Arch (2015) 0.84
TRPV1: A Target for Rational Drug Design. Pharmaceuticals (Basel) (2016) 0.82
Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. J Gen Physiol (2015) 0.81
Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies. Pharmaceuticals (Basel) (2016) 0.78
Differential regulation of proton-sensitive ion channels by phospholipids: a comparative study between ASICs and TRPV1. PLoS One (2015) 0.78
Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron (2016) 0.77
Agonist-dependence of functional properties for common nonsynonymous variants of human transient receptor potential vanilloid 1. Pain (2016) 0.76
Phosphoinositide signaling in somatosensory neurons. Adv Biol Regul (2015) 0.76
Effect of ThermaCare HeatWraps and Icy Hot Cream/Patches on Skin and Quadriceps Muscle Temperature and Blood Flow. J Chiropr Med (2016) 0.75
Osmotic activation of a Ca(2+)-dependent phospholipase C pathway that regulates ∆N TRPV1-mediated currents in rat supraoptic neurons. Physiol Rep (2017) 0.75
A molecular determinant of phosphoinositide affinity in mammalian TRPV channels. Sci Rep (2016) 0.75
Integrating TRPV1 Receptor Function with Capsaicin Psychophysics. Adv Pharmacol Sci (2016) 0.75
Phospholipase C δ4 regulates cold sensitivity in mice. J Physiol (2016) 0.75
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16
The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron (1998) 13.03
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26
Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev (2000) 5.13
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron (2003) 4.46
Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science (1998) 4.34
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci (2005) 4.00
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron (2007) 3.48
PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science (2012) 3.05
Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. Neuron (1999) 2.83
The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci (1997) 2.73
Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron (2007) 2.70
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A (2003) 2.58
Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol (2006) 2.58
Dual regulation of TRPV1 by phosphoinositides. J Neurosci (2007) 2.48
Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats. Pflugers Arch (1996) 2.45
Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 2.28
The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels. J Clin Invest (2010) 2.16
Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. J Biol Chem (1999) 2.08
Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 1.97
Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. J Biol Chem (2004) 1.89
Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89
Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. J Biol Chem (2004) 1.88
Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem (2005) 1.86
Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. J Biol Chem (2008) 1.83
Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell (2007) 1.77
TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron (2013) 1.73
Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell (2008) 1.52
Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival? Clin J Pain (2008) 1.47
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron (2010) 1.44
Determinants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1. J Biol Chem (2008) 1.37
Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. J Biol Chem (2009) 1.36
Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels. Cell Calcium (2004) 1.33
Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc (2009) 1.27
Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptides (2004) 1.26
Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol (2009) 1.22
Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby. J Physiol (2008) 1.19
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin. J Physiol (2005) 1.18
Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J Physiol (2011) 1.16
Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction. Science (2001) 1.13
Mechanism of Ca(2+)-dependent desensitization in TRP channels. Channels (Austin) (2008) 1.03
Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J Biol Chem (2008) 1.01
Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate. Am J Physiol Cell Physiol (2008) 1.00
Pharmacology of phosphoinositides, regulators of multiple cellular functions. Curr Pharm Des (2001) 0.98
Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. J Biol Chem (2012) 0.93
A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate. J Neurosci (2011) 0.92
Dynamic changes in phosphoinositide levels control ion channel activity. Pflugers Arch (2007) 0.91
Phosphoinositide sensitivity of ion channels, a functional perspective. Subcell Biochem (2012) 0.89
The latest phospholipase C, PLCeta, is implicated in neuronal function. Trends Biochem Sci (2005) 0.88
Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain (2011) 0.86
Complex regulation of capsaicin on intracellular second messengers by calcium dependent and independent mechanisms in primary sensory neurons. Neurosci Lett (2012) 0.80
RFa-related peptides are algogenic: evidence in vitro and in vivo. Eur J Neurosci (2004) 0.80
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell (2008) 10.49
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat Neurosci (2011) 7.37
Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. J Cell Biol (2006) 3.56
Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron (2002) 3.37
Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90
Dual regulation of TRPV1 by phosphoinositides. J Neurosci (2007) 2.48
Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. J Biol Chem (2004) 1.89
Illuminating cell-cycle progression in the developing zebrafish embryo. Proc Natl Acad Sci U S A (2009) 1.88
The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment. Mol Cell (2002) 1.74
Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J Neurosci (2010) 1.66
Inorganic polyphosphate modulates TRPM8 channels. PLoS One (2009) 1.64
Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation. J Cell Biol (2011) 1.56
Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol (2002) 1.55
Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. J Biol Chem (2003) 1.46
Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res (2009) 1.42
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. J Biol Chem (2004) 1.41
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem (2005) 1.37
Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release. Neuropharmacology (2007) 1.31
A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. J Biol Chem (2005) 1.28
Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J Physiol (2011) 1.16
Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proc Natl Acad Sci U S A (2011) 1.09
The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta. J Biol Chem (2005) 1.09
A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. J Cell Biol (2006) 1.07
Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity. J Biol Chem (2013) 1.06
Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells. Cancer Sci (2010) 1.04
Functional, biochemical, and chromatographic characterization of the complete [Ca2+]i oscillation-inducing activity of porcine sperm. Dev Biol (2005) 1.03
Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂. FASEB J (2011) 1.02
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res (2010) 1.02
Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J (2003) 1.02
Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J Biol Chem (2008) 1.01
Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels. Channels (Austin) (2007) 1.01
Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells (2008) 1.00
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci (2007) 0.99
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol (2005) 0.99
Proteolytic processing of phospholipase Czeta and [Ca2+]i oscillations during mammalian fertilization. Dev Biol (2007) 0.98
Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol Cell Biol (2003) 0.96
Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. J Biol Chem (2009) 0.94
Regulation of TRPM8 channel activity. Mol Cell Endocrinol (2011) 0.94
Evidence that activation of Src family kinase is not required for fertilization-associated [Ca2+]i oscillations in mouse eggs. Reproduction (2004) 0.94
MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and beta-actin at membrane microdomains. J Cell Physiol (2009) 0.93
Lack of phospholipase C-delta1 induces skin inflammation. Biochem Biophys Res Commun (2007) 0.92
PIASy-mediated repression of the Ets-1 is independent of its sumoylation. Biochem Biophys Res Commun (2006) 0.90
Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development. FASEB J (2007) 0.89
Sorcin regulates excitation-contraction coupling in the heart. J Biol Chem (2003) 0.89
PIASy controls ubiquitination-dependent proteasomal degradation of Ets-1. Biochem J (2007) 0.89
Phosphoinositide sensitivity of ion channels, a functional perspective. Subcell Biochem (2012) 0.89
Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport. Mol Pharmacol (2008) 0.88
Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth. J Biol Chem (2010) 0.88
Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem Biophys Res Commun (2011) 0.88
Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes (2011) 0.86
The newcomer in the integrin family: integrin α9 in biology and cancer. Adv Biol Regul (2012) 0.86
Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels. Biol Reprod (2009) 0.85
Repression of E1AF transcriptional activity by sumoylation and PIASy. Biochem Biophys Res Commun (2007) 0.84
Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. J Biol Chem (2011) 0.83
Roles of phospholipase C isozymes in organogenesis and embryonic development. Physiology (Bethesda) (2009) 0.83
Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochem Pharmacol (2013) 0.82
Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channels. J Biol Chem (2013) 0.82
Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun (2012) 0.82
Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. Biochem Biophys Res Commun (2004) 0.82
GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice. J Neurochem (2010) 0.81
β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. Gastroenterology (2011) 0.81
Male-specific sterility caused by the loss of CR16. Genes Cells (2007) 0.80
A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro. J Biochem (2005) 0.80
Phospholipase C-eta2 is highly expressed in the habenula and retina. Gene Expr Patterns (2010) 0.80
Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice. Neurobiol Dis (2013) 0.78
Software for precise tracking of cell proliferation. Biochem Biophys Res Commun (2011) 0.77
Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane. Adv Enzyme Regul (2010) 0.77
Calcium fluxes cause nuclear shrinkage and the translocation of phospholipase C-delta1 into the nucleus. Neurosci Lett (2010) 0.76
Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9. Mamm Genome (2008) 0.76
Physiological functions of phospholipase Cδ1 and phospholipase Cδ3. Adv Biol Regul (2013) 0.76
Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors. Cancer Sci (2014) 0.76
Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant. PLoS One (2012) 0.76
Phospholipase Cdelta4 associates with glutamate receptor interacting protein 1 in testis. J Biochem (2005) 0.75
Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C. J Biochem (2006) 0.75
Signal termination: how many different ways can you hit the brakes in biological systems? Acta Physiol (Oxf) (2012) 0.75
Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation. J Biol Chem (2011) 0.75
[Physiological functions of phospholipase Cdelta]. Seikagaku (2005) 0.75
Expression and characterization of a pleckstrin homology domain in phospholipase C, PLC-eta1. Protein Expr Purif (2007) 0.75
[The role of the phosphoinositide metabolism in epidermis]. Seikagaku (2014) 0.75