Published in Proc Natl Acad Sci U S A on February 03, 2006
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest (2007) 1.48
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation (2008) 1.20
Calcium signaling in vertebrate embryonic patterning and morphogenesis. Dev Biol (2007) 1.14
SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol (2006) 1.10
Chromogranin B regulates calcium signaling, nuclear factor kappaB activity, and brain natriuretic peptide production in cardiomyocytes. Circ Res (2008) 1.08
TSLP signaling network revealed by SILAC-based phosphoproteomics. Mol Cell Proteomics (2012) 1.04
Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling. Mol Cell Biol (2010) 1.02
Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease. Dev Dyn (2009) 0.98
The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice. J Biol Chem (2010) 0.97
The role of SH3BP2 in the pathophysiology of cherubism. Orphanet J Rare Dis (2012) 0.95
Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. J Biol Chem (2008) 0.93
Stem cells and calcium signaling. Adv Exp Med Biol (2012) 0.92
Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol Cell Biol (2012) 0.86
Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations. Neurochem Res (2011) 0.85
Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R. J Mol Cell Cardiol (2010) 0.82
Low-dose dasatinib rescues cardiac function in Noonan syndrome. JCI Insight (2016) 0.80
The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease. Semin Cell Dev Biol (2014) 0.77
A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma. Oncotarget (2016) 0.77
Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes. Front Physiol (2016) 0.75
Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Hepatol Commun (2016) 0.75
Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97
Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature (1997) 9.99
Calcium oscillations increase the efficiency and specificity of gene expression. Nature (1998) 9.19
NFAT signaling: choreographing the social lives of cells. Cell (2002) 8.17
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet (2001) 6.96
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci (2003) 6.24
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res (2003) 5.30
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet (2003) 5.16
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature (1998) 4.93
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
The transcription factor NF-ATc is essential for cardiac valve formation. Nature (1998) 4.14
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell (2004) 3.71
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med (2004) 3.55
Crystal structure of the tyrosine phosphatase SHP-2. Cell (1998) 3.48
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J (1997) 3.27
Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. Am J Dis Child (1968) 3.05
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev Cell (2005) 2.93
Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun (2004) 2.86
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell (2004) 2.82
PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Am J Hum Genet (2002) 2.81
NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J (2003) 2.24
Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet (2000) 2.07
Noonan syndrome. An update and review for the primary pediatrician. Clin Pediatr (Phila) (1994) 2.03
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol (2004) 1.53
Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol Cell Biol (2000) 1.38
Spectral analysis of calcium oscillations. Sci STKE (2004) 1.28
Germ-line and somatic PTPN11 mutations in human disease. Eur J Med Genet (2005) 1.27
The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. Nat Genet (2000) 1.27
SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol (2004) 1.21
Signal transduction of a tissue interaction during embryonic heart development. Cell Regul (1990) 1.06
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. J Biol Chem (2003) 1.01
SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1. J Biol Chem (2004) 0.94
Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol (2002) 4.37
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A (2006) 3.74
The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell (2013) 3.27
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science (2012) 3.01
Protein tyrosine phosphatase function: the substrate perspective. Biochem J (2007) 2.17
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest (2004) 2.00
Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol (2011) 1.93
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab (2006) 1.76
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nat Neurosci (2010) 1.74
Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. J Biol Chem (2005) 1.74
Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology (2007) 1.73
Altered trafficking and stability of polycystins underlie polycystic kidney disease. J Clin Invest (2014) 1.71
Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812. J Biol Chem (2004) 1.60
The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamwork. Sci STKE (2006) 1.54
Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem (2002) 1.53
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol (2004) 1.53
c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem (2007) 1.52
Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium. J Clin Invest (2006) 1.47
O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metab (2012) 1.46
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem (2004) 1.42
Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A (2007) 1.41
Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis. J Biol Chem (2008) 1.40
Phosphoproteomic screen identifies potential therapeutic targets in melanoma. Mol Cancer Res (2011) 1.38
Nucleoplasmic calcium is required for cell proliferation. J Biol Chem (2007) 1.34
Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes (2005) 1.33
Three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor at 24 A resolution. EMBO J (2002) 1.27
Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Proc Natl Acad Sci U S A (2008) 1.26
Distinct intracellular calcium transients in neurites and somata integrate neuronal signals. J Neurosci (2002) 1.24
Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells. Antioxid Redox Signal (2006) 1.22
SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol (2004) 1.21
A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. J Biol Chem (2008) 1.20
The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation. Mol Cell Biol (2005) 1.14
Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation. Proc Natl Acad Sci U S A (2007) 1.13
Ca2+ oscillations induced by testosterone enhance neurite outgrowth. J Cell Sci (2006) 1.11
SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol (2006) 1.10
Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Proc Natl Acad Sci U S A (2006) 1.10
Elevated testosterone induces apoptosis in neuronal cells. J Biol Chem (2006) 1.09
Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J Endocrinol (2009) 1.08
Chromogranin B regulates calcium signaling, nuclear factor kappaB activity, and brain natriuretic peptide production in cardiomyocytes. Circ Res (2008) 1.08
Role of MKP-1 in osteoclasts and bone homeostasis. Am J Pathol (2009) 1.07
Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors. Circ Res (2012) 1.06
A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel. J Biol Chem (2003) 1.05
Organic cation permeation through the channel formed by polycystin-2. J Biol Chem (2005) 1.05
Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells. FEBS Lett (2005) 1.05
Dihydropyridine receptors as voltage sensors for a depolarization-evoked, IP3R-mediated, slow calcium signal in skeletal muscle cells. J Gen Physiol (2003) 1.05
Regulation of the inositol 1,4,5-trisphosphate receptor type I by O-GlcNAc glycosylation. J Neurosci (2007) 1.04
Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions. Cell Mol Life Sci (2012) 1.03
Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Proc Natl Acad Sci U S A (2010) 1.03
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes. Endocrinology (2005) 1.01
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. J Biol Chem (2003) 1.01
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. J Clin Invest (2009) 1.01
Physiological signaling specificity by protein tyrosine phosphatases. Physiology (Bethesda) (2009) 1.01
Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol Cell Biol (2002) 0.99
Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell Calcium (2005) 0.98
Calcium signaling and polycystin-2. Biochem Biophys Res Commun (2004) 0.97
Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. J Neurosci (2005) 0.97
Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem (2011) 0.96
Na,K-ATPase signal transduction triggers CREB activation and dendritic growth. Proc Natl Acad Sci U S A (2009) 0.96
Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2. Am J Physiol Renal Physiol (2009) 0.96
MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy. FASEB J (2010) 0.96
Activation of the inositol 1,4,5-trisphosphate receptor by the calcium storage protein chromogranin A. J Biol Chem (2002) 0.95
Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J Mol Cell Cardiol (2013) 0.95
The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. Mol Biol Cell (2012) 0.94
Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation. J Immunol (2005) 0.94
Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation. J Biol Chem (2008) 0.93
Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells. Diabetes (2006) 0.93
Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. J Neurosci Res (2007) 0.92
Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating. J Biol Chem (2012) 0.90
Calcium signaling in the nucleus. Can J Physiol Pharmacol (2006) 0.90
Functional coupling of chromogranin with the inositol 1,4,5-trisphosphate receptor shapes calcium signaling. J Biol Chem (2004) 0.89
Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5. J Clin Invest (2013) 0.89
Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy. Med Sci Sports Exerc (2013) 0.88
MAP kinase phosphatase-1--a new player at the nexus between sarcopenia and metabolic disease. Aging (Albany NY) (2010) 0.88
JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. J Biol Chem (2009) 0.87
Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. Mol Cell Biol (2013) 0.86
Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol Cell Biol (2012) 0.86
Mitogen-activated protein kinase phosphatase-1 - a potential therapeutic target in metabolic disease. Expert Opin Ther Targets (2010) 0.85
Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding. Cell Calcium (2009) 0.85
Isoform-specific regulation of the inositol 1,4,5-trisphosphate receptor by O-linked glycosylation. J Biol Chem (2011) 0.85
Testosterone increases GLUT4-dependent glucose uptake in cardiomyocytes. J Cell Physiol (2013) 0.85
Prevention of paclitaxel-induced peripheral neuropathy by lithium pretreatment. FASEB J (2012) 0.84
Calcium, calpains, and cardiac hypertrophy: a new link. Circ Res (2009) 0.84
Methanethiosulfonate ethylammonium block of amine currents through the ryanodine receptor reveals single pore architecture. J Biol Chem (2003) 0.84
InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1. Biochem J (2004) 0.83
Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons. J Neurosci (2009) 0.83
SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem (2007) 0.83
A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart. Mol Ther (2012) 0.83
Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel. J Biol Chem (2011) 0.83
Analysis of protein tyrosine phosphatases and substrates. Curr Protoc Mol Biol (2010) 0.83
Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R. J Mol Cell Cardiol (2010) 0.82
Inositol 1,4,5-trisphosphate receptor movement is restricted by addition of elevated levels of O-linked sugar. Cell Calcium (2007) 0.82
The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function. FASEB J (2014) 0.81
High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells. Biochem Biophys Res Commun (2011) 0.81
Signaling microdomains: InsP(3) receptor localization takes on new meaning. Neuron (2002) 0.81