Pharmacogenetic tools for the development of target-oriented cognitive-enhancing drugs.

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Published in NeuroRx on January 01, 2006

Authors

José A Apud1, Daniel R Weinberger

Author Affiliations

1: Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Health and Human Services, Bethesda, Maryland 20892, USA. apudj@mail.nih.gov

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Neural mechanisms of selective visual attention. Annu Rev Neurosci (1995) 24.99

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A (2001) 9.42

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (1996) 7.26

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet (2004) 5.70

Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature (1995) 5.63

Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry (1986) 4.34

Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A (2003) 4.21

Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem (1958) 4.16

Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry (1995) 4.10

Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A (1998) 3.99

Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study. Am J Psychiatry (2002) 3.89

A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Brain Res Rev (1997) 3.80

Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology (2002) 3.79

Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex (2000) 3.37

Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry (1992) 3.02

Dopaminergic role in stimulant-induced wakefulness. J Neurosci (2001) 2.91

Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci (2002) 2.69

Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry (2000) 2.68

Selection, integration, and conflict monitoring; assessing the nature and generality of prefrontal cognitive control mechanisms. Neuron (2004) 2.50

Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature (1997) 2.46

Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neurosci (2002) 2.46

Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am J Psychiatry (2001) 2.45

Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc Natl Acad Sci U S A (1996) 2.40

Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism. Arch Gen Psychiatry (1998) 2.28

Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex. J Neurosci (2000) 2.18

Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry (1999) 2.17

Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl) (2002) 2.17

Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. Psychopharmacology (Berl) (1994) 2.09

Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function. Biol Psychiatry (1999) 2.08

Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology (Berl) (1997) 2.08

Effects of bromocriptine on human subjects depend on working memory capacity. Neuroreport (1997) 2.00

The role of the regulatory enzymes of catecholamine synthesis in Parkinson's disease. Neurology (1992) 1.99

The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophr Bull (1999) 1.99

Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. J Comp Neurol (2001) 1.95

3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model. J Neurochem (1994) 1.94

Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation. Science (2000) 1.91

Catechol-O-methyl transferase: pharmacological aspects and physiological role. Pharmacol Rev (1975) 1.79

The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task. J Neurophysiol (1994) 1.76

Cognition in schizophrenia: impairments, determinants, and functional importance. Psychiatr Clin North Am (2005) 1.63

Effects of dextroamphetamine on cognitive performance and cortical activation. Neuroimage (2000) 1.63

Human liver catechol-O-methyltransferase pharmacogenetics. Clin Pharmacol Ther (1990) 1.60

Catecholamine regulation of the prefrontal cortex. J Psychopharmacol (1997) 1.59

Selective activation of mesocortical DA system by stress. Nature (1976) 1.56

The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia. Biol Psychiatry (1999) 1.56

Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology (1998) 1.54

Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia. Brain Res Brain Res Rev (2000) 1.51

Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. Eur J Neurosci (2002) 1.51

Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits. Proc Natl Acad Sci U S A (2001) 1.51

Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals. J Neurochem (1990) 1.51

Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder. J Clin Psychopharmacol (1999) 1.50

Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2. Genomics (1992) 1.49

Effect of noxious tail pinch on the discharge rate of mesocortical and mesolimbic dopamine neurons: selective activation of the mesocortical system. Brain Res (1989) 1.45

An NMDA intervention strategy in schizophrenia with "low-dose" milacemide. Clin Neuropharmacol (1991) 1.41

Hedonic valence, dopamine and motivation. Mol Psychiatry (1996) 1.39

Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am J Psychiatry (1997) 1.39

Anti-hyperactivity medication: methylphenidate and amphetamine. Mol Psychiatry (1998) 1.35

Effects of catecholamine uptake blockers in the caudate-putamen and subregions of the medial prefrontal cortex of the rat. Brain Res (2002) 1.33

Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia. Neuropsychopharmacology (2003) 1.30

Pharmacology of mesocortical dopamine neurons. Pharmacol Rev (1983) 1.27

Enhancement by an ampakine of memory encoding in humans. Exp Neurol (1997) 1.24

Cloning, expression and structure of catechol-O-methyltransferase. Biochim Biophys Acta (1995) 1.24

The effects of prefrontal lesions on working memory performance and theory. Cogn Affect Behav Neurosci (2004) 1.24

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form. Proc Natl Acad Sci U S A (1991) 1.23

The anatomy of dopamine in monkey and human prefrontal cortex. J Neural Transm Suppl (1992) 1.23

Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience (1984) 1.22

Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia. Psychopharmacology (Berl) (2004) 1.22

Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. Eur J Pharmacol (1990) 1.20

A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J Pharmacol Exp Ther (1982) 1.18

Dextroamphetamine enhances "neural network-specific" physiological signals: a positron-emission tomography rCBF study. J Neurosci (1996) 1.18

The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. Neuropsychopharmacology (1999) 1.17

Interaction between diffusion and Michaelis-Menten uptake of dopamine after iontophoresis in striatum. Biophys J (1995) 1.17

The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia. J Neurosci (1991) 1.17

Evoked extracellular dopamine in vivo in the medial prefrontal cortex. J Neurochem (1993) 1.15

Molecular cloning and characterization of rat liver catechol-O-methyltransferase. Gene (1990) 1.14

Probing prefrontal function in schizophrenia with neuropsychological paradigms. Schizophr Bull (1988) 1.13

Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am J Psychiatry (1995) 1.13

Effects of pergolide on intravenous cocaine self-administration in men and women. Psychopharmacology (Berl) (1998) 1.12

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Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats. Neuroreport (2001) 1.11

Attenuated frontal activation during a verbal fluency task in patients with schizophrenia. Am J Psychiatry (1998) 1.10

Genetics of red cell COMT activity: analysis of thermal stability and family data. Am J Med Genet (1981) 1.09

Catechol-O-methyltransferase activity: a determinant of levodopa response. Clin Pharmacol Ther (1980) 1.07

Cognitive improvement during Tolcapone treatment in Parkinson's disease. J Neural Transm (Vienna) (1997) 1.07

Microdomains for dopamine volume neurotransmission in primate prefrontal cortex. J Neurosci (2004) 1.05

The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. Clin Neuropharmacol (1993) 1.05

Catecholamine release and uptake in the mouse prefrontal cortex. J Neurochem (2001) 1.04

Neuropsychiatric dynamics: the study of mental illness using functional magnetic resonance imaging. Eur J Radiol (1999) 1.04

Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues. J Neural Transm Suppl (1990) 1.04

A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients. Psychopharmacology (Berl) (2004) 1.01

Cloning and characterization of human placental catechol-O-methyltransferase cDNA. DNA Cell Biol (1991) 0.99

First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice. Neuroreport (2001) 0.99

Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging (1991) 0.98

Idiopathic hypersomnia. Psychiatry Clin Neurosci (1998) 0.98

Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav Brain Res (1997) 0.97

The catecholaminergic innervation of primate prefrontal cortex. J Neural Transm Suppl (1992) 0.96

Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. J Neurosci (2001) 0.96

Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia. Arch Gen Psychiatry (1992) 0.95

Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat. Brain Res (1992) 0.95

Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo. Synapse (1995) 0.93

18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease. Synapse (2002) 0.92

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