Published in Arch Gen Psychiatry on September 01, 2003
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet (2004) 5.70
Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol (2006) 4.60
Individual differences in executive functions are almost entirely genetic in origin. J Exp Psychol Gen (2008) 3.76
The endophenotype concept in psychiatric genetics. Psychol Med (2006) 2.49
Cognitive fitness of cost-efficient brain functional networks. Proc Natl Acad Sci U S A (2009) 2.07
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Hum Mol Genet (2009) 1.71
Genetic approaches to addiction: genes and alcohol. Addiction (2008) 1.70
Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry (2006) 1.59
Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proc Natl Acad Sci U S A (2007) 1.53
Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension. Neuropsychology (2009) 1.48
Neurogenetics and pharmacology of learning, motivation, and cognition. Neuropsychopharmacology (2010) 1.45
Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment. Brain Cogn (2009) 1.44
Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. Mol Psychiatry (2008) 1.43
Genes, cognition and brain through a COMT lens. Neuroscience (2009) 1.43
Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls. Biol Psychiatry (2007) 1.41
Neurobehavioral evidence for changes in dopamine system activity during adolescence. Neurosci Biobehav Rev (2009) 1.41
DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. Neuropsychopharmacology (2010) 1.40
Gene-environment interplay between cannabis and psychosis. Schizophr Bull (2008) 1.34
Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Hum Genet (2006) 1.29
Vive les differences! Individual variation in neural mechanisms of executive control. Curr Opin Neurobiol (2010) 1.23
Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem. Schizophr Bull (2008) 1.21
The genetic basis of addictive disorders. Psychiatr Clin North Am (2012) 1.20
Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms. Front Hum Neurosci (2008) 1.19
A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome). Am J Med Genet B Neuropsychiatr Genet (2006) 1.19
Cannabis and cognitive dysfunction: parallels with endophenotypes of schizophrenia? J Psychiatry Neurosci (2007) 1.18
COMT val158met genotype affects recruitment of neural mechanisms supporting fluid intelligence. Cereb Cortex (2008) 1.16
COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition. Biol Psychiatry (2012) 1.16
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proc Natl Acad Sci U S A (2009) 1.15
The effect of polymorphism at the serotonin transporter gene on decision-making, memory and executive function in ecstasy users and controls. Psychopharmacology (Berl) (2006) 1.10
Early life adversity reduces stress reactivity and enhances impulsive behavior: implications for health behaviors. Int J Psychophysiol (2012) 1.09
From an executive network to executive control: a computational model of the n-back task. J Cogn Neurosci (2011) 1.04
Normal genetic variation, cognition, and aging. Behav Cogn Neurosci Rev (2003) 1.04
Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa. PLoS One (2013) 1.02
COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. Cereb Cortex (2009) 1.01
Control of working memory content in schizophrenia. Schizophr Res (2011) 1.01
COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults. J Int Neuropsychol Soc (2010) 1.01
COMT genotype, gender and cognition in community-dwelling, older adults. Neurosci Lett (2006) 1.01
Specificity of the effect of a nicotinic receptor polymorphism on individual differences in visuospatial attention. J Cogn Neurosci (2005) 1.00
Intermediate phenotypes in schizophrenia: a selective review. Dialogues Clin Neurosci (2005) 0.99
Genetic bases for endophenotypes in psychiatric disorders. Dialogues Clin Neurosci (2005) 0.98
Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiol Aging (2009) 0.98
Lack of association between COMT and working memory in a population-based cohort of healthy young adults. Neuropsychopharmacology (2013) 0.98
Cross-species assessments of motor and exploratory behavior related to bipolar disorder. Neurosci Biobehav Rev (2010) 0.97
Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. J Abnorm Psychol (2008) 0.97
Genetics of emotion. Trends Cogn Sci (2011) 0.97
The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. Exp Brain Res (2005) 0.95
Pharmacological manipulation of human working memory. Psychopharmacology (Berl) (2004) 0.94
COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits. Genes Brain Behav (2009) 0.94
COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation. J Psychiatry Neurosci (2013) 0.93
Functional significance of central D1 receptors in cognition: beyond working memory. J Cereb Blood Flow Metab (2012) 0.93
Linking neurogenetics and individual differences in language learning: the dopamine hypothesis. Cortex (2012) 0.92
Gonadectomy and hormone replacement affects in vivo basal extracellular dopamine levels in the prefrontal cortex but not motor cortex of adult male rats. Cereb Cortex (2010) 0.92
Dopamine and psychosis: theory, pathomechanisms and intermediate phenotypes. Neurosci Biobehav Rev (2009) 0.91
The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders. AIDS Behav (2008) 0.91
Impairment in functional capacity as an endophenotype candidate in severe mental illness. Schizophr Bull (2011) 0.91
Convergent approaches for defining functional imaging endophenotypes in schizophrenia. Front Hum Neurosci (2009) 0.91
COMT genotype affects prefrontal white matter pathways in children and adolescents. Neuroimage (2010) 0.90
Executive attention in schizophrenic males and the impact of COMT Val108/158Met genotype on performance on the attention network test. Schizophr Bull (2008) 0.90
Effects of sex and COMT genotype on environmentally modulated cognitive control in mice. Proc Natl Acad Sci U S A (2012) 0.90
Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning. Eur Arch Psychiatry Clin Neurosci (2012) 0.89
The role of prefrontal catecholamines in attention and working memory. Front Neural Circuits (2014) 0.89
Differential dopaminergic modulation of executive control in healthy subjects. Psychopharmacology (Berl) (2004) 0.89
Dopamine, cognitive function, and gamma oscillations: role of D4 receptors. Front Cell Neurosci (2013) 0.89
Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults. J Clin Exp Neuropsychol (2011) 0.88
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. PLoS One (2010) 0.88
Improving executive function using transcranial infrared laser stimulation. J Neuropsychol (2015) 0.87
Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood. J Toxicol Environ Health A (2009) 0.87
Recent advances in treating cognitive impairment in schizophrenia. Psychopharmacology (Berl) (2008) 0.87
Cortical mapping of genotype-phenotype relationships in schizophrenia. Hum Brain Mapp (2007) 0.87
Imaging genomics and response to treatment with antipsychotics in schizophrenia. NeuroRx (2006) 0.87
Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness. Behav Brain Res (2011) 0.87
Developmental imaging genetics: linking dopamine function to adolescent behavior. Brain Cogn (2013) 0.87
WORKING MEMORY IMPAIRMENT AS AN ENDOPHENOTYPIC MARKER OF A SCHIZOPHRENIA DIATHESIS. Schizophr Res Cogn (2014) 0.86
Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder. J Neural Transm (Vienna) (2011) 0.86
Handedness, heritability, neurocognition and brain asymmetry in schizophrenia. Brain (2010) 0.85
Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder. J Acquir Immune Defic Syndr (2014) 0.85
The ethics of elective psychopharmacology. Int J Neuropsychopharmacol (2011) 0.85
Cognitive effects of nicotine: genetic moderators. Addict Biol (2010) 0.85
Distinguishing neurocognitive functions in schizophrenia using partially ordered classification models. Schizophr Bull (2006) 0.85
Polymorphisms in genes modulating the dopamine system: do they inf luence outcome and response to medication after traumatic brain injury? J Head Trauma Rehabil (2009) 0.85
The longitudinal and interactive effects of HIV status, stimulant use, and host genotype upon neurocognitive functioning. J Neurovirol (2014) 0.85
Which perspectives can endophenotypes and biological markers offer in the early recognition of schizophrenia? J Neural Transm (Vienna) (2007) 0.84
No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study. BMC Psychiatry (2004) 0.84
Prefrontal dopamine and the dynamic control of human long-term memory. Transl Psychiatry (2011) 0.84
COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination. Behav Brain Funct (2010) 0.84
A hotspot of inactivation: The A22S and V108M polymorphisms individually destabilize the active site structure of catechol O-methyltransferase. Biochemistry (2009) 0.84
Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics. NeuroRx (2006) 0.84
The role of executive functions in the control of aggressive behavior. Front Psychol (2011) 0.83
Variation in genes involved in dopamine clearance influence the startle response in older adults. J Neural Transm (Vienna) (2011) 0.83
Does COMT genotype influence the effects of d-amphetamine on executive functioning? Genes Brain Behav (2012) 0.83
Impaired passive maintenance and spared manipulation of internal representations in patients with schizophrenia. Schizophr Bull (2010) 0.83
RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sample. Schizophr Bull (2009) 0.82
Executive functions and selective attention are favored in middle-aged healthy women carriers of the Val/Val genotype of the catechol-o-methyltransferase gene: a behavioral genetic study. Behav Brain Funct (2010) 0.82
The structural biology of oestrogen metabolism. J Steroid Biochem Mol Biol (2013) 0.82
Attention Deficit Hyperactivity Disorder comorbid oppositional defiant disorder and its predominately inattentive type: evidence for an association with COMT but not MAOA in a Chinese sample. Behav Brain Funct (2009) 0.82
COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory. PLoS One (2013) 0.82
Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. Lipids Health Dis (2009) 0.82
Genetic predictor of working memory and prefrontal function in women with HIV. J Neurovirol (2014) 0.81
Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia. Schizophr Bull (2008) 0.81
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci (2005) 10.13
Serotonin transporter genetic variation and the response of the human amygdala. Science (2002) 9.31
Spatio-temporal transcriptome of the human brain. Nature (2011) 9.19
The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry (2008) 9.00
Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry (2005) 6.27
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27
Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet (2004) 5.87
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet (2004) 5.70
Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci (2006) 5.70
Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci (2008) 5.19
Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci (2003) 5.11
Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature (2011) 5.01
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry (2008) 4.91
The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci (2004) 4.84
COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science (2003) 4.72
Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry (2004) 4.46
A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry (2005) 4.33
Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A (2003) 4.21
An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res (2005) 3.94
The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage (2002) 3.70
Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A (2006) 3.58
Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry (2003) 3.52
Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44
Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry (2003) 3.43
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet (2008) 3.33
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry (2006) 3.24
DNA methylation signatures in development and aging of the human prefrontal cortex. Am J Hum Genet (2012) 3.17
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol (2008) 3.13
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A (2002) 3.11
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. Brain (2009) 3.03
Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Arch Gen Psychiatry (2005) 2.78
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain (2006) 2.75
Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. Proc Natl Acad Sci U S A (2005) 2.73
Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A (2006) 2.71
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A (2005) 2.68
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
A validated network of effective amygdala connectivity. Neuroimage (2007) 2.58
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry (2002) 2.51
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends Neurosci (2004) 2.50
Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry (2004) 2.49
Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry (2003) 2.47
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
Imaging genomics. Br Med Bull (2003) 2.39
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat Neurosci (2005) 2.39
Effect of catechol-O-methyltransferase val158met genotype on attentional control. J Neurosci (2005) 2.37
Efficient physical embedding of topologically complex information processing networks in brains and computer circuits. PLoS Comput Biol (2010) 2.37
A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med (2009) 2.37
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A (2004) 2.36
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat Neurosci (2002) 2.32
Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry (2006) 2.31
Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry (2006) 2.29
Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch Gen Psychiatry (2010) 2.28
Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet (2006) 2.21
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med (2009) 2.20
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain (2004) 2.17
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc Natl Acad Sci U S A (2010) 2.16
Prenatal expression patterns of genes associated with neuropsychiatric disorders. Am J Psychiatry (2014) 2.14
Variation in dopamine genes influences responsivity of the human reward system. Proc Natl Acad Sci U S A (2008) 2.13
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry (2004) 2.12
Age-related alterations in default mode network: impact on working memory performance. Neurobiol Aging (2008) 2.11
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry (2006) 2.09
Neuronal avalanches in the resting MEG of the human brain. J Neurosci (2013) 2.08
Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice. J Neurosci (2008) 2.08
Cognitive fitness of cost-efficient brain functional networks. Proc Natl Acad Sci U S A (2009) 2.07
Neurophysiological correlates of age-related changes in working memory capacity. Neurosci Lett (2005) 2.06
Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine. Biol Psychiatry (2008) 2.05
Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci (2005) 2.04
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature (2010) 2.00
Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol (2006) 1.98
Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry (2004) 1.98
Genes and the parsing of cognitive processes. Trends Cogn Sci (2004) 1.97
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet (2004) 1.95