Published in Hum Mol Genet on September 02, 2004
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci (2008) 5.12
Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol (2006) 4.60
The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet (2005) 4.02
BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell (2006) 2.11
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science (2009) 1.87
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Mol Biol Cell (2006) 1.64
The dystrobrevin-binding protein 1 gene: features and networks. Mol Psychiatry (2008) 1.47
The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. Mol Psychiatry (2009) 1.44
DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J Cell Biol (2008) 1.42
Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain (2008) 1.35
Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophr Res (2007) 1.35
AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biol Psychiatry (2007) 1.30
Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia. Am J Hum Genet (2006) 1.30
Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background. Genes Brain Behav (2009) 1.29
Finding schizophrenia genes. J Clin Invest (2005) 1.28
Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology (2009) 1.27
Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein. Biochem J (2006) 1.27
Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc Natl Acad Sci U S A (2009) 1.26
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev (2010) 1.24
Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron (2009) 1.24
DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res (2006) 1.20
Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance. Biol Psychiatry (2010) 1.16
Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia. Proc Natl Acad Sci U S A (2011) 1.15
Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications. Handb Exp Pharmacol (2012) 1.12
NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia. Front Cell Neurosci (2013) 1.12
Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behav Brain Funct (2007) 1.06
A genome wide association study for backfat thickness in Italian Large White pigs highlights new regions affecting fat deposition including neuronal genes. BMC Genomics (2012) 1.05
Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene. Mol Neurobiol (2011) 1.04
Comparing genes and phenomenology in the major psychoses: schizophrenia and bipolar 1 disorder. Schizophr Bull (2008) 1.03
Emerging links between homeostatic synaptic plasticity and neurological disease. Front Cell Neurosci (2013) 1.03
Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J Neural Transm (Vienna) (2006) 1.03
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS One (2011) 0.99
Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression. Brain Behav Immun (2013) 0.98
Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade. ASN Neuro (2011) 0.97
The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample. Schizophr Res (2009) 0.95
Gene expression in the etiology of schizophrenia. Schizophr Bull (2008) 0.93
DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene. Hum Hered (2007) 0.93
Snapin is critical for presynaptic homeostatic plasticity. J Neurosci (2012) 0.92
What happens in the brain of schizophrenia patients?: an investigation from the viewpoint of neuropathology. Nagoya J Med Sci (2013) 0.92
Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus (2010) 0.92
Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. J Biomed Biotechnol (2009) 0.89
DTNBP1 is associated with imaging phenotypes in schizophrenia. Hum Brain Mapp (2009) 0.89
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders. Curr Mol Med (2015) 0.89
Dysbindin-1 genotype effects on emotional working memory. Mol Psychiatry (2009) 0.89
Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness. Behav Brain Res (2011) 0.87
Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner. PLoS One (2009) 0.87
Deletions in chromosome 6p22.3-p24.3, including ATXN1, are associated with developmental delay and autism spectrum disorders. Mol Cytogenet (2012) 0.87
Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain. PLoS One (2010) 0.86
Molecular mechanisms driving homeostatic plasticity of neurotransmitter release. Front Cell Neurosci (2013) 0.85
Atypical anti-schizophrenic drugs prevent changes in cortical N-methyl-D-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups. Pharmacol Biochem Behav (2008) 0.85
Which perspectives can endophenotypes and biological markers offer in the early recognition of schizophrenia? J Neural Transm (Vienna) (2007) 0.84
Dysbindin and Schizophrenia: it's dopamine and glutamate all over again. Biol Psychiatry (2011) 0.83
Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. J Biol Chem (2010) 0.82
Nature and nurture in neuropsychiatric genetics: where do we stand? Dialogues Clin Neurosci (2010) 0.82
Association study of DTNBP1 with schizophrenia in a US sample. Psychiatr Genet (2009) 0.82
Dysbindin gene (DTNBP1) and schizophrenia in Korean population. Eur Arch Psychiatry Clin Neurosci (2009) 0.82
Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice. Schizophr Res (2013) 0.82
The effects of a DTNBP1 gene variant on attention networks: an fMRI study. Behav Brain Funct (2010) 0.81
Association study of SNAP25 and schizophrenia in Irish family and case-control samples. Am J Med Genet B Neuropsychiatr Genet (2010) 0.81
Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia. Behav Brain Funct (2007) 0.81
Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication. Psychopharmacology (Berl) (2006) 0.81
Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse. PLoS One (2011) 0.81
Correlated alterations in serotonergic and dopaminergic modulations at the hippocampal mossy fiber synapse in mice lacking dysbindin. PLoS One (2011) 0.81
Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia. Neuropsychopharmacology (2010) 0.81
Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning. Hippocampus (2013) 0.80
The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. J Neurosci (2015) 0.79
Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy. J Cell Biol (2013) 0.79
6p22.3 deletion: report of a patient with autism, severe intellectual disability and electroencephalographic anomalies. Mol Cytogenet (2013) 0.78
The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenet Genomics (2009) 0.78
Genetic association of single nucleotide polymorphisms in dystrobrevin binding protein 1 gene with schizophrenia in a Malaysian population. Genet Mol Biol (2015) 0.78
Loss of dysbindin-1 in mice impairs reward-based operant learning by increasing impulsive and compulsive behavior. Behav Brain Res (2012) 0.78
The Gem interacting protein (GMIP) gene is associated with major depressive disorder. Neurogenetics (2005) 0.77
Animal Models of Psychosis: Current State and Future Directions. Curr Behav Neurosci Rep (2014) 0.76
The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse. J Neurosci (2016) 0.76
The Schizophrenia-Related Protein Dysbindin-1A Is Degraded and Facilitates NF-Kappa B Activity in the Nucleus. PLoS One (2015) 0.76
Association study of serine racemase gene with methamphetamine psychosis. Curr Neuropharmacol (2011) 0.76
Behavioral characterization of mice overexpressing human dysbindin-1. Mol Brain (2014) 0.76
Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes. Neuropsychopharmacology (2016) 0.75
The BLOC-1 Subunit Pallidin Facilitates Activity-Dependent Synaptic Vesicle Recycling. eNeuro (2017) 0.75
The effect of deficient muscarinic signaling on commonly reported biochemical effects in schizophrenia and convergence with genetic susceptibility loci in explaining symptom dimensions of psychosis. Front Pharmacol (2014) 0.75
Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation. Cell Discov (2015) 0.75
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet (2008) 10.52
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci (2005) 10.13
Serotonin transporter genetic variation and the response of the human amygdala. Science (2002) 9.31
Spatio-temporal transcriptome of the human brain. Nature (2011) 9.19
The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry (2008) 9.00
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet (2003) 6.63
Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry (2005) 6.27
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet (2004) 5.70
Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci (2006) 5.70
Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci (2008) 5.19
Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci (2003) 5.11
Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature (2011) 5.01
The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci (2004) 4.84
Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry (2004) 4.46
A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry (2005) 4.33
Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A (2003) 4.21
The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage (2002) 3.70
Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A (2006) 3.58
Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am J Psychiatry (2003) 3.52
Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry (2003) 3.43
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet (2008) 3.33
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry (2006) 3.24
DNA methylation signatures in development and aging of the human prefrontal cortex. Am J Hum Genet (2012) 3.17
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A (2002) 3.11
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. Brain (2009) 3.03
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry (2003) 2.82
Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Arch Gen Psychiatry (2005) 2.78
Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. Proc Natl Acad Sci U S A (2005) 2.73
Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A (2006) 2.71
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A (2005) 2.68
A validated network of effective amygdala connectivity. Neuroimage (2007) 2.58
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain (2008) 2.55
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends Neurosci (2004) 2.50
Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry (2003) 2.47
Imaging genomics. Br Med Bull (2003) 2.39
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat Neurosci (2005) 2.39
Effect of catechol-O-methyltransferase val158met genotype on attentional control. J Neurosci (2005) 2.37
Efficient physical embedding of topologically complex information processing networks in brains and computer circuits. PLoS Comput Biol (2010) 2.37
A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med (2009) 2.37
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A (2004) 2.36
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat Neurosci (2002) 2.32
Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry (2006) 2.29
Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch Gen Psychiatry (2010) 2.28
Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet (2006) 2.21
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc Natl Acad Sci U S A (2010) 2.16
Prenatal expression patterns of genes associated with neuropsychiatric disorders. Am J Psychiatry (2014) 2.14
Variation in dopamine genes influences responsivity of the human reward system. Proc Natl Acad Sci U S A (2008) 2.13
Age-related alterations in default mode network: impact on working memory performance. Neurobiol Aging (2008) 2.11
Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice. J Neurosci (2008) 2.08
Cognitive fitness of cost-efficient brain functional networks. Proc Natl Acad Sci U S A (2009) 2.07
Neurophysiological correlates of age-related changes in working memory capacity. Neurosci Lett (2005) 2.06
Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science (2013) 2.04
BDNF function and intracellular signaling in neurons. Histol Histopathol (2010) 1.99
Genes and the parsing of cognitive processes. Trends Cogn Sci (2004) 1.97
Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry (2006) 1.94
Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry (2010) 1.89
Dopaminergic modulation of cortical function in patients with Parkinson's disease. Ann Neurol (2002) 1.87
Reliability and validity of Japanese version of the Mini-International Neuropsychiatric Interview. Psychiatry Clin Neurosci (2005) 1.87
Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain. J Neurosci (2006) 1.85
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet (2006) 1.82
Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry (2004) 1.82
Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci (2003) 1.82
Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. J Neurosci (2007) 1.81
DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Proc Natl Acad Sci U S A (2009) 1.76
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res (2002) 1.76
Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Arch Gen Psychiatry (2009) 1.75
Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest (2007) 1.74
Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings. Biol Psychiatry (2007) 1.73
Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry (2008) 1.72
Tolcapone improves cognition and cortical information processing in normal human subjects. Neuropsychopharmacology (2006) 1.71
Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. Biol Psychiatry (2006) 1.71
The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. Eur Arch Psychiatry Clin Neurosci (2012) 1.70
Dysfunctional prefrontal regional specialization and compensation in schizophrenia. Am J Psychiatry (2006) 1.69
Quantifying incoherence in speech: an automated methodology and novel application to schizophrenia. Schizophr Res (2007) 1.68
Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. Eur J Neurosci (2008) 1.67
False positives in imaging genetics. Neuroimage (2007) 1.65