PubRank

Krzysztof Palczewski

Author PubWeight™ 317.51‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature 2003 5.85
2 Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther 2005 4.74
3 Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A 2006 4.33
4 Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A 2005 4.04
5 Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol 2007 3.86
6 Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem 2003 3.16
7 Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci 2004 2.72
8 International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev 2007 2.62
9 Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci 2004 2.62
10 Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem 2007 2.59
11 Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry 2003 2.42
12 Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem 2008 2.35
13 The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem 2007 2.31
14 Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem 2005 2.28
15 Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol 2004 2.24
16 Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A 2007 2.21
17 Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A 2003 2.21
18 Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda) 2010 2.18
19 Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem 2005 2.15
20 Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem 2002 2.11
21 G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol 2002 2.08
22 Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol 2006 2.03
23 Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry 2004 2.03
24 Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci U S A 2009 2.01
25 Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem 2009 2.01
26 Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol 2007 1.92
27 A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci 2004 1.92
28 Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci 2002 1.86
29 Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med 2005 1.83
30 Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A 2005 1.83
31 Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci 2008 1.76
32 Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem 2013 1.76
33 Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A 2002 1.72
34 ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet 2008 1.69
35 Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A 2009 1.65
36 RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab 2008 1.64
37 Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem 2004 1.64
38 Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem 2008 1.62
39 Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem 2006 1.58
40 Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem 2005 1.58
41 Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express 2010 1.58
42 Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem 2004 1.57
43 Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem 2011 1.55
44 Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem 2011 1.55
45 Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A 2009 1.54
46 Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A 2007 1.53
47 Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci 2002 1.52
48 Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun 2002 1.51
49 Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem 2008 1.51
50 Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure 2007 1.51
51 GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J 2002 1.49
52 Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol 2004 1.45
53 Phototransduction: crystal clear. Trends Biochem Sci 2003 1.45
54 A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J 2010 1.45
55 Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res 2003 1.45
56 Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem 2002 1.43
57 The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci 2010 1.42
58 Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem 2003 1.42
59 Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol 2008 1.41
60 Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol 2011 1.40
61 Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci 2006 1.39
62 The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev 2011 1.39
63 Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A 2006 1.39
64 Functional and structural characterization of rhodopsin oligomers. J Biol Chem 2006 1.39
65 Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol 2006 1.38
66 Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem 2011 1.38
67 Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A 2013 1.36
68 Visual rhodopsin sees the light: structure and mechanism of G protein signaling. J Biol Chem 2007 1.35
69 The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem 2008 1.33
70 Structure of cone photoreceptors. Prog Retin Eye Res 2009 1.32
71 Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci 2009 1.31
72 A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci 2005 1.31
73 Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. J Biol Chem 2005 1.29
74 Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J 2011 1.29
75 Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci 2007 1.29
76 Chemistry of the retinoid (visual) cycle. Chem Rev 2013 1.28
77 Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta 2011 1.28
78 Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol 2008 1.28
79 The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annu Rev Biophys Biomol Struct 2003 1.27
80 The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol 2010 1.25
81 Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry 2011 1.24
82 Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J 2010 1.23
83 The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol 2005 1.23
84 Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem 2013 1.22
85 Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. J Struct Biol 2006 1.20
86 Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J Biol Chem 2010 1.20
87 Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci 2005 1.20
88 A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration. Invest Ophthalmol Vis Sci 2004 1.19
89 Diversifying the repertoire of G protein-coupled receptors through oligomerization. Proc Natl Acad Sci U S A 2005 1.19
90 A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. J Biol Chem 2004 1.19
91 Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem 2007 1.18
92 Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med 2010 1.18
93 Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet 2009 1.17
94 Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels. J Biol Chem 2005 1.17
95 Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. J Biol Chem 2012 1.16
96 ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J 2010 1.16
97 Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Res 2003 1.14
98 Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev 2008 1.14
99 Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res 2010 1.14
100 Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem 2008 1.13
101 A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Invest Ophthalmol Vis Sci 2005 1.12
102 A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res 2008 1.12
103 Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem 2010 1.12
104 Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med 2006 1.11
105 The retinoid cycle and retina disease. Vision Res 2003 1.11
106 Detecting molecular interactions that stabilize native bovine rhodopsin. J Mol Biol 2006 1.11
107 Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem 2004 1.10
108 Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem 2010 1.10
109 GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics 2010 1.09
110 Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A 2006 1.09
111 Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vision Res 2007 1.08
112 Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J 2013 1.08
113 Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem 2011 1.08
114 Inflammatory priming predisposes mice to age-related retinal degeneration. J Clin Invest 2012 1.07
115 Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. Structure 2012 1.07
116 Melanopsin is highly resistant to light and chemical bleaching in vivo. J Biol Chem 2012 1.06
117 Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet 2009 1.06
118 Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest 2013 1.06
119 The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol 2006 1.06
120 Nonvisual photoreception in the chick iris. Science 2004 1.05
121 Ca2+ -dependent regulation of phototransduction. Photochem Photobiol 2008 1.05
122 Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J Struct Biol 2011 1.05
123 In vivo two-photon imaging of the mouse retina. Biomed Opt Express 2013 1.05
124 Stabilizing effect of Zn2+ in native bovine rhodopsin. J Biol Chem 2007 1.05
125 Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem 2008 1.04
126 Topology and membrane association of lecithin: retinol acyltransferase. J Biol Chem 2006 1.04
127 Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics 2007 1.04
128 Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc Natl Acad Sci U S A 2014 1.03
129 Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry 2008 1.03
130 Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. J Biol Chem 2009 1.03
131 Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod 2010 1.03
132 Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry 2011 1.03
133 Crystal packing analysis of Rhodopsin crystals. J Struct Biol 2007 1.02
134 Delivery of retinoid-based therapies to target tissues. Biochemistry 2007 1.02
135 Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry 2009 1.02
136 Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry 2006 1.02
137 Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. J Biol Chem 2013 1.01
138 Imaging of protein crystals with two-photon microscopy. Biochemistry 2012 1.01
139 Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem 2011 1.00
140 Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. J Biol Chem 2006 1.00
141 Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol 2002 1.00
142 Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A 2012 0.99
143 Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function. Langmuir 2008 0.99
144 Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A 2010 0.99
145 Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol 2014 0.99
146 Comparative analysis of GPCR crystal structures. Photochem Photobiol 2009 0.98
147 The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci 2012 0.98
148 Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry 2008 0.98
149 Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation. J Biol Chem 2005 0.97
150 Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. J Struct Biol 2012 0.97
151 Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Invest Ophthalmol Vis Sci 2006 0.97
152 The rhodopsin-transducin complex houses two distinct rhodopsin molecules. J Struct Biol 2013 0.96
153 Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem 2011 0.96
154 Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J 2008 0.96
155 Metabolism and transactivation activity of 13,14-dihydroretinoic acid. J Biol Chem 2005 0.95
156 Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 2012 0.95
157 Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. FASEB J 2011 0.95
158 Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res 2011 0.95
159 Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys 2013 0.94
160 P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet 2013 0.93
161 Arrestin interaction with rhodopsin: conceptual models. Cell Biochem Biophys 2006 0.93
162 Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry 2009 0.93
163 Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry 2005 0.92
164 Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry 2010 0.92
165 Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry 2011 0.92
166 Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry 2010 0.92
167 Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Invest Ophthalmol Vis Sci 2009 0.91
168 Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. J Biol Chem 2013 0.91
169 Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc 2008 0.91
170 Photoreceptor phagocytosis is mediated by phosphoinositide signaling. FASEB J 2013 0.91
171 Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Biochemistry 2007 0.91
172 An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem 2010 0.91
173 A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem 2009 0.91
174 Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem 2012 0.91
175 Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry 2005 0.91
176 G protein-coupled receptors--recent advances. Acta Biochim Pol 2012 0.90
177 Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem 2002 0.90
178 Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. Invest Ophthalmol Vis Sci 2009 0.90
179 Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem 2006 0.89
180 Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. FASEB J 2011 0.89
181 Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res 2009 0.89
182 Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol 2010 0.89
183 Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure 2013 0.89
184 Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.88
185 Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem 2012 0.88
186 Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun 2004 0.88
187 Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry 2008 0.88
188 QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Invest Ophthalmol Vis Sci 2013 0.88
189 Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis. Mol Pharmacol 2011 0.87
190 Increased adiposity in the retinol saturase-knockout mouse. FASEB J 2009 0.87
191 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. Microscopy (Oxf) 2012 0.87
192 Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. J Neurochem 2012 0.87
193 Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci 2008 0.86
194 Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. J Biol Chem 2013 0.86
195 Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS One 2010 0.86
196 Inherent instability of the retinitis pigmentosa P23H mutant opsin. J Biol Chem 2014 0.85
197 Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure 2010 0.85
198 Evolutionarily conserved long intergenic non-coding RNAs in the eye. Hum Mol Genet 2013 0.85
199 Chemokine receptors and other G protein-coupled receptors. Curr Opin HIV AIDS 2009 0.85
200 Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab 2009 0.85
201 Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. Biochemistry 2004 0.85
202 Reliable determination of site-specific in vivo protein N-glycosylation based on collision-induced MS/MS and chromatographic retention time. J Am Soc Mass Spectrom 2014 0.85
203 Time-resolved fluorescence spectroscopy measures clustering and mobility of a G protein-coupled receptor opsin in live cell membranes. J Am Chem Soc 2014 0.84
204 Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Vision Res 2003 0.83
205 Activation of retinoic acid receptors by dihydroretinoids. Mol Pharmacol 2009 0.83
206 Visualization of retinoid storage and trafficking by two-photon microscopy. Methods Mol Biol 2010 0.83
207 Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.83
208 Reprint of "Crystal packing analysis of Rhodopsin crystals" [J. Struct. Biol. 158 (2007) 455-462]. J Struct Biol 2007 0.83
209 Rhodopsin: a structural primer for G-protein coupled receptors. Arch Pharm (Weinheim) 2005 0.83
210 HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. J Biol Chem 2012 0.82
211 Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem 2014 0.82
212 R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthalmol Vis Sci 2014 0.82
213 Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol 2002 0.82
214 Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry 2011 0.81
215 Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys 2013 0.81
216 A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics 2013 0.81
217 Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry 2002 0.81
218 Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry 2007 0.81
219 High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules. Protein Sci 2014 0.81
220 A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. Invest Ophthalmol Vis Sci 2012 0.80
221 Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice. Biomacromolecules 2014 0.80
222 Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol 2010 0.80
223 Crystallization of G protein-coupled receptors. Methods Cell Biol 2013 0.80
224 Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer. FEBS Lett 2003 0.80
225 Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol 2010 0.79
226 Heterogeneous N-terminal acylation of retinal proteins results from the retina's unusual lipid metabolism. Biochemistry 2011 0.79
227 Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest 2015 0.79
228 Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. ACS Nano 2013 0.79
229 Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1). Biochemistry 2012 0.79
230 Rhodopsin and its kinase. Methods Enzymol 2002 0.78
231 Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods 2011 0.78
232 The G protein-coupled receptor rhodopsin: a historical perspective. Methods Mol Biol 2015 0.78
233 Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem 2010 0.78
234 Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry 2011 0.78
235 Argonaute high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation reveals a snapshot of miRNA gene regulation in the mammalian retina. Biochemistry 2014 0.78
236 Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes. Retina 2003 0.77
237 Photoreceptor guanylate cyclase variants: cGMP production under control. Acta Biochim Pol 2003 0.77
238 Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology 2010 0.77
239 Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods Enzymol 2013 0.77
240 The role of the 11-cis-retinal ring methyl substituents in visual pigment formation. Chembiochem 2006 0.77
241 Imaging G protein-coupled receptor islands. Nat Chem Biol 2005 0.76
242 Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. PLoS One 2013 0.76
243 Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity. J Am Chem Soc 2013 0.75
244 Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes. Curr Protoc Mouse Biol 2014 0.75
245 Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates. J Phys Chem B 2013 0.75