Published in Biochemistry on September 07, 2004
Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice. Biol Open (2012) 0.90
ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex. PLoS One (2013) 0.86
Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition. BMC Struct Biol (2010) 0.83
Multifaceted Roles of ALG-2 in Ca(2+)-Regulated Membrane Trafficking. Int J Mol Sci (2016) 0.78
Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese. Genet Test Mol Biomarkers (2013) 0.75
Structural and Functional Study of Apoptosis-linked Gene-2/Heme-binding Protein 2 Interactions in HIV-1 Production. J Biol Chem (2016) 0.75
Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical squamous cell carcinoma. Fam Cancer (2015) 0.75
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature (2001) 4.99
A matter of life and death. Cancer Cell (2002) 4.07
Binding of diffusible molecules by macromolecules: rapid measurement by rate of dialysis. J Biol Chem (1969) 3.15
Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science (1996) 2.69
Calcium signaling and apoptosis. Biochem Biophys Res Commun (2003) 2.30
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem (2003) 2.19
Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. Cell Death Differ (1999) 1.99
Prognosis and treatment of disseminated uveal melanoma. Cancer (1993) 1.98
Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction. J Biol Chem (1999) 1.83
Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays (2000) 1.69
Treatment of uveal melanoma metastatic to the liver: a review of the M. D. Anderson Cancer Center experience and prognostic factors. Cancer (1995) 1.65
The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes. J Biol Chem (2000) 1.47
Structures, functions and molecular evolution of the penta-EF-hand Ca2+-binding proteins. Biochim Biophys Acta (2002) 1.39
Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem (2003) 1.19
Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. Am J Ophthalmol (1985) 1.17
Alix, a protein regulating endosomal trafficking, is involved in neuronal death. J Biol Chem (2003) 1.17
A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor. J Mol Biol (2003) 1.07
Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner. J Biol Chem (2001) 1.05
Apoptosis-linked gene product ALG-2 is a new member of the calpain small subunit subfamily of Ca2+-binding proteins. Biochemistry (1999) 1.02
Up-regulation of ALG-2 in hepatomas and lung cancer tissue. Am J Pathol (2003) 1.01
ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. Biochem Biophys Res Commun (2002) 1.00
Determination of residue specificity in the EF-hand of troponin C for Ca2+ coordination, by genetic engineering. J Biol Chem (1992) 1.00
The identification and differential expression of calcium-binding proteins associated with ocular melanoma. Biochim Biophys Acta (1998) 0.99
Structure of apoptosis-linked protein ALG-2: insights into Ca2+-induced changes in penta-EF-hand proteins. Structure (2001) 0.98
Two forms of the apoptosis-linked protein ALG-2 with different Ca(2+) affinities and target recognition. J Biol Chem (2000) 0.97
Calcium-induced exposure of a hydrophobic surface of mouse ALG-2, which is a member of the penta-EF-hand protein family. J Biochem (1998) 0.95
Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation. FEBS Lett (2002) 0.95
ALG-2: a Ca2+ -binding modulator protein involved in cell proliferation and in cell death. Biochim Biophys Acta (2002) 0.93
Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. Biochem J (1992) 0.92
Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. J Mol Biol (2000) 0.89
Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies. Cancer Res (1988) 0.89
Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions. Arch Biochem Biophys (2002) 0.87
Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma. Arch Ophthalmol (2002) 0.87
Properties of the co-chaperone protein p23 erroneously attributed to ALG-2 (apoptosis-linked gene 2). FEBS Lett (2003) 0.86
The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis. Biochim Biophys Acta (2000) 0.85
Regulation of melanogenesis by human uveal melanocytes in vitro. Exp Eye Res (1997) 0.81
Biochemical characterization of two analogues of the apoptosis-linked gene 2 protein in Dictyostelium discoideum and interaction with a physiological partner in mammals, murine Alix. J Biol Chem (2002) 0.80
Purification and primary structure of Capl, an S-100-related calcium-binding protein isolated from bovine retina. J Biol Chem (1994) 0.79
The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. FEBS Lett (2003) 0.77
Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature (2003) 5.85
Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther (2005) 4.74
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A (2006) 4.33
Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A (2005) 4.04
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol (2007) 3.86
Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem (2003) 3.16
Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol (2002) 3.13
Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci (2004) 2.72
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62
Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci (2004) 2.62
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry (2003) 2.42
Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem (2008) 2.35
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem (2007) 2.31
Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J Biol Chem (2003) 2.30
Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem (2005) 2.28
Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol (2004) 2.24
Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A (2007) 2.21
Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A (2003) 2.21
Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda) (2010) 2.18
Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem (2005) 2.15
Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem (2002) 2.11
G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol (2002) 2.08
Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol (2006) 2.03
Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci (2002) 2.03
Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry (2004) 2.03
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci U S A (2009) 2.01
Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem (2009) 2.01
Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork. J Biol Chem (2004) 2.00
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol (2007) 1.92
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci (2004) 1.92
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci (2002) 1.86
Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med (2005) 1.83
Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A (2005) 1.83
Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1. Exp Cell Res (2006) 1.82
SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci (2007) 1.77
Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci (2008) 1.76
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem (2013) 1.76
Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A (2002) 1.72
ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet (2008) 1.69
Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A (2009) 1.65
RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab (2008) 1.64
Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem (2004) 1.64
Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem (2008) 1.62
Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Proc Natl Acad Sci U S A (2006) 1.59
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem (2006) 1.58
Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem (2005) 1.58
Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express (2010) 1.58
Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem (2004) 1.57
Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem (2011) 1.55
Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem (2011) 1.55
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A (2009) 1.54
Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A (2007) 1.53
Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci (2002) 1.52
Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun (2002) 1.51
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem (2008) 1.51
Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure (2007) 1.51
Retinal pigment epithelium lipofuscin proteomics. Mol Cell Proteomics (2008) 1.50
GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J (2002) 1.49
Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. J Org Chem (2003) 1.49
Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol (2004) 1.45
Phototransduction: crystal clear. Trends Biochem Sci (2003) 1.45
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J (2010) 1.45
Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res (2003) 1.45
Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem (2002) 1.43
The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci (2010) 1.42
Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem (2003) 1.42
Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol (2008) 1.41
Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol (2011) 1.40
Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers. Mol Cell Proteomics (2009) 1.39
Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci (2006) 1.39
The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev (2011) 1.39
Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A (2006) 1.39
Functional and structural characterization of rhodopsin oligomers. J Biol Chem (2006) 1.39
Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol (2006) 1.38
Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem (2011) 1.38
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria. J Biol Chem (2004) 1.37
Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A (2013) 1.36
Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer. Mol Pharmacol (2007) 1.35
Visual rhodopsin sees the light: structure and mechanism of G protein signaling. J Biol Chem (2007) 1.35
The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem (2008) 1.33
Structure of cone photoreceptors. Prog Retin Eye Res (2009) 1.32
Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Invest Ophthalmol Vis Sci (2006) 1.32
Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival. Cancer Res (2004) 1.32
Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem (2002) 1.31
Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci (2009) 1.31
A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci (2005) 1.31
Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. J Biol Chem (2005) 1.29
Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J (2011) 1.29
Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci (2007) 1.29
Chemistry of the retinoid (visual) cycle. Chem Rev (2013) 1.28
Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta (2011) 1.28
Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol (2008) 1.28
The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annu Rev Biophys Biomol Struct (2003) 1.27
The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol (2010) 1.25
Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry (2011) 1.24
Dynamics of protein nitration in cells and mitochondria. Am J Physiol Heart Circ Physiol (2004) 1.24
Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J (2010) 1.23