Published in J Immunol on March 01, 2006
PI3 kinase signals BCR-dependent mature B cell survival. Cell (2009) 4.43
Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity (2008) 2.56
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat Immunol (2008) 2.52
Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses. Proc Natl Acad Sci U S A (2007) 1.38
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood (2006) 1.33
STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors. J Biol Chem (2011) 1.22
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A (2012) 1.19
Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal (2010) 1.08
Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages. BMC Genomics (2008) 1.02
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem (2012) 0.97
Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution. Int Immunol (2009) 0.93
Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Mol Med (2007) 0.93
Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol (2012) 0.92
Foxo1 regulates marginal zone B-cell development. Eur J Immunol (2010) 0.86
Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. J Exp Clin Cancer Res (2015) 0.80
Arsenic trioxide-induced growth arrest of breast cancer MCF-7 cells involving FOXO3a and IκB kinase β expression and localization. Cancer Biother Radiopharm (2012) 0.80
Glucocorticoid (GC)-mediated down-regulation of urokinase plasminogen activator expression via the serum and GC regulated kinase-1/forkhead box O3a pathway. Endocrinology (2008) 0.79
Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One (2014) 0.78
Disruptive chemicals, senescence and immortality. Carcinogenesis (2015) 0.78
Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer. Oncotarget (2017) 0.75
Disrupted cooperation between transcription factors across diverse cancer types. BMC Genomics (2016) 0.75
Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival. Cell Cycle (2016) 0.75
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med (2010) 3.26
Retracted Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem (2003) 3.06
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One (2011) 2.92
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest (2002) 2.65
Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol (2004) 2.59
Regulation of quiescence in lymphocytes. Trends Immunol (2003) 2.58
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol (2002) 2.42
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity (2012) 2.19
FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol (2008) 1.97
Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Mol Cell Biol (2005) 1.94
Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol (2013) 1.71
SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J Immunol (2007) 1.68
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem J (2011) 1.59
Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol (2007) 1.56
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem J (2012) 1.56
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest (2008) 1.56
Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors. Blood (2004) 1.54
ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res (2005) 1.50
Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses. Eur J Immunol (2004) 1.49
Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol (2004) 1.39
KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood (2006) 1.33
Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur J Immunol (2007) 1.23
Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol (2004) 1.22
Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood (2004) 1.22
T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase. J Immunol (2008) 1.21
Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require phosphatidylinositol 3-kinase. J Virol (2003) 1.21
Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function. Proc Natl Acad Sci U S A (2013) 1.19
Akt and mTOR in B Cell Activation and Differentiation. Front Immunol (2012) 1.16
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment. Blood (2012) 1.14
PI3Ks in lymphocyte signaling and development. Curr Top Microbiol Immunol (2010) 1.12
Target of rapamycin signaling in leukemia and lymphoma. Clin Cancer Res (2010) 1.11
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc Natl Acad Sci U S A (2006) 1.10
KLF4 is a FOXO target gene that suppresses B cell proliferation. Int Immunol (2008) 1.08
Targeting TOR dependence in cancer. Oncotarget (2010) 1.07
A novel blood test for the early detection of Alzheimer's disease. J Alzheimers Dis (2011) 1.04
PI3K signaling controls cell fate at many points in B lymphocyte development and activation. Semin Cell Dev Biol (2004) 1.02
Immune regulation by rapamycin: moving beyond T cells. Sci Signal (2009) 1.01
Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J Immunol (2003) 1.01
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood (2007) 1.00
Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function. J Biol Chem (2012) 0.94
Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha. Int Immunol (2004) 0.90
S6 kinase 2 potentiates interleukin-3-driven cell proliferation. J Leukoc Biol (2005) 0.89
p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function. Blood (2009) 0.87
Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha. J Biol Chem (2002) 0.87
Foxo1 regulates marginal zone B-cell development. Eur J Immunol (2010) 0.86
Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. J Biol Chem (2006) 0.86
Cell signaling. New mTOR targets Grb attention. Science (2011) 0.86
DNA-scaffolded multivalent ligands to modulate cell function. Chembiochem (2014) 0.86
A polyvalent aptamer system for targeted drug delivery. Biomaterials (2013) 0.85
The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells. Autoimmunity (2009) 0.83
Achieving cancer cell death with PI3K/mTOR-targeted therapies. Ann N Y Acad Sci (2013) 0.82
Genetics. Can cancer drugs treat immunodeficiency? Science (2013) 0.81
Role of phosphoinositide 3-kinase signaling in autoimmunity. Autoimmunity (2007) 0.81
B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR. Mol Endocrinol (2011) 0.81
The in vivo evaluation of active-site TOR inhibitors in models of BCR-ABL+ leukemia. Methods Mol Biol (2012) 0.80
Measuring phosphorylated Akt and other phosphoinositide 3-kinase-regulated phosphoproteins in primary lymphocytes. Methods Enzymol (2007) 0.78
A lipid kinase cousin cooperates to promote cancer. Cancer Cell (2011) 0.78
B cell receptor signaling: picky about PI3Ks. Sci Signal (2010) 0.75
Too much of a good thing: immunodeficiency due to hyperactive PI3K signaling. J Clin Invest (2014) 0.75
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest (2017) 0.75
Signal transduction and autoimmunity: introduction. Autoimmunity (2007) 0.75
Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem (2017) 0.75