Published in Mol Cell Biol on February 01, 2002
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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov (2011) 4.78
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol Cell Biol (2005) 3.09
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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest (2008) 2.77
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest (2002) 2.65
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The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J Cell Biol (2005) 2.04
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Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab (2010) 1.05
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FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nat Cell Biol (2013) 1.04
Elevated PI3K signaling drives multiple breast cancer subtypes. Oncotarget (2011) 1.03
Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Mol Cell Endocrinol (2008) 1.00
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Hepatitis C virus infection and type 1 and type 2 diabetes mellitus. World J Diabetes (2014) 0.98
BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metab (2014) 0.97
PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol (2011) 0.96
Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding. Nutr Metab (Lond) (2009) 0.95
p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene (2010) 0.95
Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem (2011) 0.93
p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway. J Biol Chem (2011) 0.91
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The intricate role of growth hormone in metabolism. Front Endocrinol (Lausanne) (2011) 0.89
Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression. Cell Mol Life Sci (2010) 0.87
Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha. J Biol Chem (2002) 0.87
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The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy. Ann Surg (2006) 0.84
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Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open (2014) 0.82
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p85α is a microRNA target and affects chemosensitivity in pancreatic cancer. J Surg Res (2015) 0.81
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice. Trans Am Clin Climatol Assoc (2003) 0.80
Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. PLoS One (2010) 0.80
PI3K at the crossroads of tumor angiogenesis signaling pathways. Mol Cell Oncol (2015) 0.78
p85α promotes nucleolin transcription and subsequently enhances EGFR mRNA stability and EGF-induced malignant cellular transformation. Oncotarget (2016) 0.78
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Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment. Pharmacogenomics (2016) 0.77
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Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle. Diabetes (2010) 0.76
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proc Natl Acad Sci U S A (2016) 0.75
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Pro-apoptotic effects of rHSG on C6 glioma cells. Int J Mol Med (2016) 0.75
Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma. Oncotarget (2016) 0.75
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