Published in Nature on February 23, 2006
A large-scale full-length cDNA analysis to explore the budding yeast transcriptome. Proc Natl Acad Sci U S A (2006) 5.24
The yeast actin cytoskeleton: from cellular function to biochemical mechanism. Microbiol Mol Biol Rev (2006) 2.55
Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies. Genes Dev (2006) 2.26
TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol Biol Cell (2009) 2.23
Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster. J Cell Biol (2010) 1.83
Membrane potential governs lateral segregation of plasma membrane proteins and lipids in yeast. EMBO J (2006) 1.83
Plasma membrane microdomains regulate turnover of transport proteins in yeast. J Cell Biol (2008) 1.77
Clathrin-mediated endocytosis in budding yeast. Trends Cell Biol (2011) 1.63
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol (2012) 1.58
A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol (2009) 1.54
Pkh-kinases control eisosome assembly and organization. EMBO J (2007) 1.52
A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A (2009) 1.50
Distinct roles for Arp2/3 regulators in actin assembly and endocytosis. PLoS Biol (2008) 1.50
TOR1 and TOR2 have distinct locations in live cells. Eukaryot Cell (2008) 1.46
Patchwork organization of the yeast plasma membrane into numerous coexisting domains. Nat Cell Biol (2012) 1.46
The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover. J Biol Chem (2008) 1.45
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol (2010) 1.44
Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. PLoS One (2015) 1.43
A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics (2009) 1.42
Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae. Mol Biol Cell (2007) 1.41
Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. J Cell Biol (2008) 1.33
Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochim Biophys Acta (2006) 1.28
Mechanisms of spindle positioning. J Cell Biol (2013) 1.27
The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans. Mol Biol Cell (2008) 1.24
Eisosome proteins assemble into a membrane scaffold. J Cell Biol (2011) 1.24
The eisosome core is composed of BAR domain proteins. Mol Biol Cell (2011) 1.22
HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog (2011) 1.16
Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination. Mol Biol Cell (2007) 1.16
Eisosome-driven plasma membrane organization is mediated by BAR domains. Nat Struct Mol Biol (2011) 1.16
The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell (2009) 1.12
Sterol-rich plasma membrane domains in fungi. Eukaryot Cell (2007) 1.12
Roles for sphingolipids in Saccharomyces cerevisiae. Adv Exp Med Biol (2010) 1.08
Pil1 controls eisosome biogenesis. Mol Biol Cell (2008) 1.08
Existence of a novel clathrin-independent endocytic pathway in yeast that depends on Rho1 and formin. J Cell Biol (2011) 1.07
The filament-forming protein Pil1 assembles linear eisosomes in fission yeast. Mol Biol Cell (2011) 1.07
Membrane-sculpting BAR domains generate stable lipid microdomains. Cell Rep (2013) 1.04
Endocytosis and early endosome motility in filamentous fungi. Curr Opin Microbiol (2014) 1.04
Spatiotemporal activation of Rac1 for engulfment of apoptotic cells. Proc Natl Acad Sci U S A (2008) 1.03
Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2. Mol Cell Biol (2014) 1.02
Endocytosis is crucial for cell polarity and apical membrane recycling in the filamentous fungus Aspergillus oryzae. Eukaryot Cell (2008) 1.02
Actin organization and dynamics in filamentous fungi. Nat Rev Microbiol (2011) 1.01
A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum. J Cell Sci (2008) 1.01
Reconstitution and protein composition analysis of endocytic actin patches. Curr Biol (2010) 1.01
SNAP-, CLIP- and Halo-tag labelling of budding yeast cells. PLoS One (2013) 1.00
Unifying fluorescence microscopy and mass spectrometry for studying protein complexes in cells. Mol Cell Proteomics (2009) 0.98
Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J Proteome Res (2009) 0.96
Membrane protein Rim21 plays a central role in sensing ambient pH in Saccharomyces cerevisiae. J Biol Chem (2012) 0.95
Eisosome organization in the filamentous ascomycete Aspergillus nidulans. Eukaryot Cell (2010) 0.95
Seg1 controls eisosome assembly and shape. J Cell Biol (2012) 0.95
Distribution of cortical endoplasmic reticulum determines positioning of endocytic events in yeast plasma membrane. PLoS One (2012) 0.95
TOR complex 2-Ypk1 signaling maintains sphingolipid homeostasis by sensing and regulating ROS accumulation. Cell Rep (2014) 0.94
Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis. J Cell Sci (2011) 0.93
Candida albicans SUR7 contributes to secretion, biofilm formation, and macrophage killing. BMC Microbiol (2010) 0.93
Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters. Mol Cell Biol (2007) 0.92
Toxicity mechanisms of amphotericin B and its neutralization by conjugation with arabinogalactan. Antimicrob Agents Chemother (2012) 0.92
Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions. Proc Natl Acad Sci U S A (2014) 0.92
Preformed cell structure and cell heredity. Prion (2008) 0.92
Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan. Eukaryot Cell (2007) 0.92
Temporal and spatial regulation of gene expression during asexual development of Neurospora crassa. Genetics (2010) 0.92
A Pil1-Sle1-Syj1-Tax4 functional pathway links eisosomes with PI(4,5)P2 regulation. J Cell Sci (2014) 0.91
C terminus of Nce102 determines the structure and function of microdomains in the Saccharomyces cerevisiae plasma membrane. Eukaryot Cell (2010) 0.91
Yeast Ist2 recruits the endoplasmic reticulum to the plasma membrane and creates a ribosome-free membrane microcompartment. PLoS One (2012) 0.90
The SpoMBe pathway drives membrane bending necessary for cytokinesis and spore formation in yeast meiosis. EMBO J (2008) 0.90
Lipid raft involvement in yeast cell growth and death. Front Oncol (2012) 0.90
Global analysis of condition-specific subcellular protein distribution and abundance. Mol Cell Proteomics (2013) 0.89
Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components. Mol Cell Proteomics (2012) 0.88
A role for eisosomes in maintenance of plasma membrane phosphoinositide levels. Mol Biol Cell (2014) 0.88
Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane. Membranes (Basel) (2011) 0.88
The Candida albicans Sur7 protein is needed for proper synthesis of the fibrillar component of the cell wall that confers strength. Eukaryot Cell (2010) 0.88
RNA-seq analyses of gene expression in the microsclerotia of Verticillium dahliae. BMC Genomics (2013) 0.88
Eisosomes and plasma membrane organization. Mol Genet Genomics (2012) 0.86
Protein-induced membrane curvature alters local membrane tension. Biophys J (2014) 0.85
Overview of a surface-ripened cheese community functioning by meta-omics analyses. PLoS One (2015) 0.85
ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae. J Membr Biol (2009) 0.83
Yeast and fungal morphogenesis from an evolutionary perspective. Semin Cell Dev Biol (2008) 0.83
Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast. J Biol Chem (2013) 0.83
Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. PLoS Genet (2011) 0.82
Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes. Virology (2014) 0.82
Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK. PLoS One (2013) 0.81
Eisosome Ultrastructure and Evolution in Fungi, Microalgae, and Lichens. Eukaryot Cell (2015) 0.81
The Sur7 protein resides in punctate membrane subdomains and mediates spatial regulation of cell wall synthesis in Candida albicans. Commun Integr Biol (2009) 0.81
The effect of natamycin on the transcriptome of conidia of Aspergillus niger. Stud Mycol (2012) 0.81
The MARVEL domain protein Nce102 regulates actin organization and invasive growth of Candida albicans. MBio (2013) 0.81
The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis. EMBO J (2012) 0.80
Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis. Mol Biol Cell (2011) 0.80
An expanded view of the eukaryotic cytoskeleton. Mol Biol Cell (2013) 0.80
Rapid response of the yeast plasma membrane proteome to salt stress. Mol Cell Proteomics (2011) 0.80
Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae. Cell Cycle (2012) 0.80
Vesicle trafficking from a lipid perspective: Lipid regulation of exocytosis in Saccharomyces cerevisiae. Cell Logist (2012) 0.79
Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta (2015) 0.79
Ultrastructural imaging of endocytic sites in Saccharomyces cerevisiae by transmission electron microscopy and immunolabeling. Microsc Microanal (2013) 0.79
Eisosomes and membrane compartments in the ascomycetes: A view from Aspergillus nidulans. Commun Integr Biol (2011) 0.78
Plasma Membrane Proteolipid 3 Protein Modulates Amphotericin B Resistance through Sphingolipid Biosynthetic Pathway. Sci Rep (2015) 0.78
Amyloid cannot resist identification. Prion (2013) 0.78
Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase. Biochim Biophys Acta (2012) 0.78
Pun1p is a metal ion-inducible, calcineurin/Crz1p-regulated plasma membrane protein required for cell wall integrity. Biochim Biophys Acta (2011) 0.78
Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans. PLoS One (2012) 0.78
The yeast BDF1 regulates endocytosis via LSP1 under salt stress. Curr Microbiol (2015) 0.77
A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast. PLoS Genet (2014) 0.77
Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06
IRE1 signaling affects cell fate during the unfolded protein response. Science (2007) 9.01
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol (2006) 6.47
An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science (2009) 6.14
Painful publishing. Science (2008) 5.17
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature (2008) 4.70
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science (2009) 4.58
Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol (2006) 4.55
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A (2007) 4.21
Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol (2008) 4.10
The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87
Bypassing a kinase activity with an ATP-competitive drug. Science (2003) 3.71
Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature (2002) 3.68
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science (2011) 3.19
H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. PLoS Biol (2007) 3.18
Gene recruitment of the activated INO1 locus to the nuclear membrane. PLoS Biol (2004) 3.09
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature (2008) 2.94
Substrate twinning activates the signal recognition particle and its receptor. Nature (2004) 2.91
Bioinformatics Training Network (BTN): a community resource for bioinformatics trainers. Brief Bioinform (2011) 2.79
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol (2009) 2.35
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLoS Biol (2010) 2.35
Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One (2009) 2.30
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci U S A (2010) 2.23
Does surgical experience have an effect on the success of retinal detachment surgery? Retina (2012) 2.22
ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy (2007) 2.21
Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol (2005) 2.18
DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery. Nat Cell Biol (2010) 2.03
Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol (2013) 2.02
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife (2013) 1.85
The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A (2011) 1.75
Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. PLoS Biol (2004) 1.73
Mechanism of association and reciprocal activation of two GTPases. PLoS Biol (2004) 1.72
Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol Cell (2010) 1.71
A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol (2009) 1.54
ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife (2013) 1.52
Pkh-kinases control eisosome assembly and organization. EMBO J (2007) 1.52
Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J Cell Biol (2011) 1.50
Structural basis of FFAT motif-mediated ER targeting. Structure (2005) 1.49
Co-translational protein targeting by the signal recognition particle. FEBS Lett (2005) 1.47
Optical control of metabotropic glutamate receptors. Nat Neurosci (2013) 1.45
Signal sequences activate the catalytic switch of SRP RNA. Science (2009) 1.44
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol (2010) 1.44
Mechanism of membrane fluidity optimization: isothermal control of the Bacillus subtilis acyl-lipid desaturase. Mol Microbiol (2002) 1.43
ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology. J Cell Sci (2010) 1.43
Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol (2010) 1.37
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev (2006) 1.34
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J (2005) 1.34
Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation. J Cell Biol (2007) 1.32
IRE1-independent gain control of the unfolded protein response. PLoS Biol (2004) 1.31
Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol (2012) 1.31
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. Proc Natl Acad Sci U S A (2004) 1.30
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife (2012) 1.29
Fundus near infrared fluorescence correlates with fundus near infrared reflectance. Invest Ophthalmol Vis Sci (2006) 1.29
Induced nucleotide specificity in a GTPase. Proc Natl Acad Sci U S A (2003) 1.29
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease. Genome Biol (2004) 1.28
A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory. PLoS Biol (2013) 1.27
Cohesinopathy mutations disrupt the subnuclear organization of chromatin. J Cell Biol (2009) 1.26
Gene positioning and expression. Curr Opin Cell Biol (2011) 1.26
Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. J Biol Chem (2013) 1.25
Transcription factor binding to a DNA zip code controls interchromosomal clustering at the nuclear periphery. Dev Cell (2012) 1.24
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Breast Cancer Res (2014) 1.23
The eisosome core is composed of BAR domain proteins. Mol Biol Cell (2011) 1.22
A CHOP-regulated microRNA controls rhodopsin expression. J Cell Biol (2011) 1.22
Detection of acute hepatopancreatic necrosis disease (AHPND) in Mexico. Dis Aquat Organ (2014) 1.22
Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial. Invest Ophthalmol Vis Sci (2009) 1.21
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. EMBO J (2011) 1.21
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol (2002) 1.21
Macular translocation with 360 degrees retinotomy for exudative age-related macular degeneration. Arch Ophthalmol (2002) 1.18
The unfolded protein response during prostate cancer development. Cancer Metastasis Rev (2009) 1.18
The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating. Mol Biol Cell (2006) 1.17
SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol (2008) 1.16
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol (2011) 1.14
Regulation and epigenetic control of transcription at the nuclear periphery. Trends Genet (2007) 1.12
Structural and functional basis for RNA cleavage by Ire1. BMC Biol (2011) 1.12
Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. J Oncol (2011) 1.11
Cdk phosphorylation of a nucleoporin controls localization of active genes through the cell cycle. Mol Biol Cell (2010) 1.10
Accuracy of intraocular lens power calculation using partial coherence interferometry in patients with high myopia. Ophthalmic Physiol Opt (2012) 1.08
Pil1 controls eisosome biogenesis. Mol Biol Cell (2008) 1.08
Visual resolution with retinal implants estimated from recordings in cat visual cortex. Vision Res (2006) 1.07
Role of dopamine in the physiology of T-cells and dendritic cells. J Neuroimmunol (2009) 1.06
Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate (2013) 1.05
Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease. J Immunol (2013) 1.05
A method and technical equipment for an acute human trial to evaluate retinal implant technology. J Neural Eng (2005) 1.04
The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting. Mol Biol Cell (2007) 1.04
Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins. Mol Biol Cell (2004) 1.02
Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. J Pharmacol Exp Ther (2010) 1.02
Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines. J Cell Biol (2008) 1.00
Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Immunol (2012) 0.99
Compartmentalization of the nucleus. Trends Cell Biol (2011) 0.99
Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. Proc Natl Acad Sci U S A (2010) 0.99