Published in J Cell Physiol on May 01, 1993
A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr Eye Res (2005) 1.97
Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun (1997) 1.84
Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc Natl Acad Sci U S A (1999) 1.79
Antimicrobial defensin peptides of the human ocular surface. Br J Ophthalmol (1999) 1.44
Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology (2002) 1.41
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci (2003) 1.39
Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir Res (2006) 1.18
CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition. J Virol (2003) 1.17
Immunohistochemical localization of defensin in human coronary vessels. Am J Pathol (1997) 1.11
Host defense peptides in wound healing. Mol Med (2008) 1.10
Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation. Am J Pathol (2002) 1.10
Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease. Invest Ophthalmol Vis Sci (2003) 1.09
Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance? Int J Mol Sci (2009) 1.08
Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf (2004) 1.00
Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells. Exp Eye Res (2010) 1.00
Identification, characterization, and evolution of a primate beta-defensin gene cluster. Genes Immun (2005) 1.00
Anti-microbial properties of histone H2A from skin secretions of rainbow trout, Oncorhynchus mykiss. Biochem J (2002) 0.99
Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution. J Biol Chem (2010) 0.92
Antimicrobial functionalized genetically engineered spider silk. Biomaterials (2011) 0.91
Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells. Histochem Cell Biol (2010) 0.90
The use of antimicrobial peptides in ophthalmology: an experimental study in corneal preservation and the management of bacterial keratitis. Trans Am Ophthalmol Soc (2002) 0.90
Antimicrobial peptides and induced membrane curvature: geometry, coordination chemistry, and molecular engineering. Curr Opin Solid State Mater Sci (2013) 0.89
In vitro activity of human beta-defensin 2 against Pseudomonas aeruginosa in the presence of tear fluid. Antimicrob Agents Chemother (2007) 0.88
Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome. Am J Transplant (2013) 0.88
Induction of a rat enteric defensin gene by hemorrhagic shock. Infect Immun (1999) 0.84
Human antimicrobial proteins in ear wax. Eur J Clin Microbiol Infect Dis (2011) 0.81
The in vitro activity of selected defensins against an isolate of Pseudomonas in the presence of human tears. Br J Ophthalmol (2006) 0.80
Increased human defensine levels hint at an inflammatory etiology of bisphosphonate-associated osteonecrosis of the jaw: an immunohistological study. J Transl Med (2011) 0.80
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells. PLoS One (2012) 0.80
Biological responses to spider silk-antibiotic fusion protein. J Tissue Eng Regen Med (2011) 0.77
Expression of natural peptide antibiotics in human articular cartilage and synovial membrane. Clin Diagn Lab Immunol (2001) 0.77
Low concentrations of human neutrophil peptide ameliorate experimental murine colitis. Int J Mol Med (2016) 0.75
Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest (1985) 8.63
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol (2000) 6.62
Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes. Infect Immun (1984) 5.30
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest (1989) 5.21
A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science (1999) 3.90
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A (1990) 3.90
Primary structures of three human neutrophil defensins. J Clin Invest (1985) 3.70
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J Biol Chem (1985) 3.58
Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J Biol Chem (1983) 3.00
Direct inactivation of viruses by human granulocyte defensins. J Virol (1986) 3.00
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res (2000) 2.89
Defensins. Eur J Haematol (1990) 2.88
Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science (1991) 2.71
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci U S A (1997) 2.53
Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest (1989) 2.50
Defensins: endogenous antibiotic peptides of animal cells. Cell (1991) 2.45
Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci (1994) 2.43
Structure, function, and membrane integration of defensins. Curr Opin Struct Biol (1995) 2.40
Pathologic progression of autochthonous prostate cancer in the TRAMP model. Prostate Cancer Prostatic Dis (1999) 2.37
Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages. Infect Immun (1983) 2.33
Refined structure of alkaline phosphatase from Escherichia coli at 2.8 A resolution. J Mol Biol (1985) 2.31
Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J Virol (1985) 2.31
Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium. Infect Immun (1990) 2.25
Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells. Arch Ophthalmol (2001) 2.24
Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest (1988) 2.18
Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin. Infect Immun (1987) 2.16
Characteristics of an established cell line of retinoblastoma. J Natl Cancer Inst (1974) 2.05
Activity of rabbit leukocyte peptides against Candida albicans. Infect Immun (1985) 2.05
Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J (1996) 2.03
In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood (1986) 2.01
The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol (1998) 1.98
Purification and in vitro activities of rabbit platelet microbicidal proteins. Infect Immun (1997) 1.96
Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun (1994) 1.93
Neutrophils and host defense. Ann Intern Med (1988) 1.92
Intraocular lens power calculation after laser in situ keratomileusis for myopia and hyperopia: a standardized approach. Cornea (2001) 1.90
Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity. Infect Immun (1985) 1.89
In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. J Infect Dis (1986) 1.84
Is donor age an important determinant of graft survival? Cornea (1999) 1.79
Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect Immun (1994) 1.78
Sizing membrane pores in lipid vesicles by leakage of co-encapsulated markers: pore formation by melittin. Biophys J (1997) 1.76
Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids. Biophys J (1997) 1.68
Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. J Immunol (1988) 1.64
Structure and diversity of the murine cryptdin gene family. Genomics (1994) 1.62
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. Proc Natl Acad Sci U S A (1999) 1.61
The effect of trabeculectomy on corneal topography. Ophthalmic Surg (1992) 1.60
Defensin-rich dense granules of human neutrophils. Blood (1987) 1.59
The TRAMP mouse as a model for prostate cancer. Curr Protoc Immunol (2001) 1.57
P53 expression in altered limbal basal cells of pingueculae, pterygia, and limbal tumors. Curr Eye Res (1997) 1.53
Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant. Infect Immun (1981) 1.52
Antimicrobial activity of phagocyte granule proteins. Semin Respir Infect (1986) 1.49
Purification and antimicrobial properties of three defensins from rat neutrophils. Infect Immun (1989) 1.46
Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors. J Androl (1993) 1.44
Defensins promote fusion and lysis of negatively charged membranes. Protein Sci (1993) 1.43
The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Cancer Res (1999) 1.42
Purification and primary structure of murine cryptdin-1, a Paneth cell defensin. FEBS Lett (1992) 1.42
Human neutrophil-mediated nonoxidative antifungal activity against Cryptococcus neoformans. Infect Immun (2000) 1.38
p53 expression and relation to human papillomavirus infection in pingueculae, pterygia, and limbal tumors. Arch Ophthalmol (1999) 1.34
Single culture media in infectious keratitis. Cornea (1999) 1.32
The science of pterygia. Br J Ophthalmol (2009) 1.31
Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins. J Biol Chem (1997) 1.26
Penetrating keratoplasty for keratoconus. Cornea (2000) 1.21
Oxygen-independent bactericidal systems. Mechanisms and disorders. Hematol Oncol Clin North Am (1988) 1.21
Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells. Curr Eye Res (1994) 1.20
CD spectra of indolicidin antimicrobial peptides suggest turns, not polyproline helix. Biochemistry (1999) 1.19
Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2. Am Rev Respir Dis (1985) 1.17
Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes. Infect Immun (1999) 1.16
Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils. J Leukoc Biol (1998) 1.15
Lysozyme: primary bactericidin in human plasma serum active against Bacillus subtilis. Infect Immun (1978) 1.15
Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry (1995) 1.14
Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle. Acta Anat (Basel) (1996) 1.14
In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins. Infect Immun (1990) 1.13
Purification and characterization of human T-lymphocyte-derived erythroid-potentiating activity. J Biol Chem (1984) 1.11
Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils. J Biol Chem (1993) 1.11
Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity. Biochim Biophys Acta (1995) 1.10
Solution structures of the rabbit neutrophil defensin NP-5. J Mol Biol (1988) 1.09
Smooth muscle-epithelial interactions in normal and neoplastic prostatic development. Acta Anat (Basel) (1996) 1.09
Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci U S A (1997) 1.08
Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the cornea. J Cell Physiol (1996) 1.07
Cryptdin gene expression in developing mouse small intestine. Am J Physiol (1997) 1.07
NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1. Biochemistry (1992) 1.07
Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer. J Biol Chem (2000) 1.07
Acanthamoeba sclerokeratitis. Determining diagnostic criteria. Arch Ophthalmol (1986) 1.06
Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer. Cancer Res (2001) 1.06
Characterization of two crystal forms of neutrophil cationic protein NP2, a naturally occurring broad-spectrum antimicrobial agent from leukocytes. J Mol Biol (1984) 1.05
Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. J Immunol (1995) 1.05
Spontaneous chronic corneal epithelial defects (SCCED) in dogs: clinical features, innervation, and effect of topical SP, with or without IGF-1. Invest Ophthalmol Vis Sci (2001) 1.04
Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat. Acta Anat (Basel) (1996) 1.03
Interactions of monomeric rabbit neutrophil defensins with bilayers: comparison with dimeric human defensin HNP-2. Biochemistry (1996) 1.03
In vitro effect of phagocyte cationic peptides on Coccidioides immitis. J Infect Dis (1985) 1.03
Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochem Pharmacol (1988) 1.02
Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum. Infect Immun (2000) 1.02
Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides. J Pept Res (2003) 1.02
Surface keratopathy after penetrating keratoplasty. Trans Am Ophthalmol Soc (2001) 1.02
Aerobic bacterial conjunctival flora in diabetic patients. Cornea (2004) 1.01
Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools. FASEB J (2009) 1.01
Two-dimensional NMR studies of the antimicrobial peptide NP-5. Biochemistry (1987) 1.01
Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins. Cell Immunol (1988) 1.00
Opsonic activity of MCP-1 and MCP-2, cationic peptides from rabbit alveolar macrophages. Diagn Microbiol Infect Dis (1985) 1.00
Synthesis and characterization of indolicidin, a tryptophan-rich antimicrobial peptide from bovine neutrophils. Int J Pept Protein Res (1995) 1.00