Published in Genes Dev on March 01, 2006
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell (2011) 9.24
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest (2007) 2.09
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
Physical interaction between TBX5 and MEF2C is required for early heart development. Mol Cell Biol (2009) 1.71
MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genet (2013) 1.42
Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling. Oncogene (2012) 1.27
Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics (2007) 1.19
Regulation of skeletal myogenesis by Notch. Exp Cell Res (2010) 1.08
RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels. Mol Cell Biol (2014) 1.07
Notch signaling in CD4 and CD8 T cell development. Curr Opin Immunol (2008) 1.06
Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. EMBO J (2012) 1.05
Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age. PLoS One (2013) 1.05
The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Res (2009) 1.04
Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc Natl Acad Sci U S A (2007) 1.01
Multiple upstream modules regulate zebrafish myf5 expression. BMC Dev Biol (2007) 0.98
Notch signaling as a therapeutic target for breast cancer treatment? Breast Cancer Res (2011) 0.97
A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1. Biochem J (2007) 0.95
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development. Blood (2007) 0.95
Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity. Development (2013) 0.93
GSK3beta is a negative regulator of the transcriptional coactivator MAML1. Nucleic Acids Res (2009) 0.91
Notch signaling in differentiation and function of dendritic cells. Immunol Res (2008) 0.91
The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival. J Biol Chem (2010) 0.90
The transient expression of miR-203 and its inhibiting effects on skeletal muscle cell proliferation and differentiation. Cell Death Dis (2014) 0.88
Comprehensive analysis of alternative splicing and functionality in neuronal differentiation of P19 cells. PLoS One (2011) 0.88
Notch: a mastermind of vascular morphogenesis. J Clin Invest (2007) 0.87
MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer. PLoS One (2012) 0.87
Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem (2013) 0.85
Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins. Int Immunol (2012) 0.83
Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle. Cell Mol Life Sci (2013) 0.83
Notch signaling regulates myogenic regenerative capacity of murine and human mesoangioblasts. Cell Death Dis (2014) 0.82
NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Cancer Res (2014) 0.81
CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement. Proc Natl Acad Sci U S A (2014) 0.81
Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage. BMB Rep (2015) 0.80
Long Non-coding RNAs in the Cytoplasm. Genomics Proteomics Bioinformatics (2016) 0.79
Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS. PLoS One (2011) 0.78
MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes Dev (2016) 0.78
Non-coding RNAs in muscle differentiation and musculoskeletal disease. J Clin Invest (2016) 0.77
G9a inhibits MEF2C activity to control sarcomere assembly. Sci Rep (2016) 0.76
Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity. Stem Cell Reports (2017) 0.76
Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling. PLoS One (2015) 0.75
Olfactory Sensory Neurons Control Dendritic Complexity of Mitral Cells via Notch Signaling. PLoS Genet (2016) 0.75
PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells. Biomed Res Int (2017) 0.75
A rapid one-generation genetic screen in a Drosophila model to capture rhabdomyosarcoma effectors and therapeutic targets. G3 (Bethesda) (2014) 0.75
Antagonistic regulation of cell cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors. J Biol Chem (2017) 0.75
Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation. J Exp Med (2017) 0.75
Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway. Cell Death Dis (2017) 0.75
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol (1963) 29.15
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Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell (1995) 6.24
Notch-mediated restoration of regenerative potential to aged muscle. Science (2003) 5.99
The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Dev Cell (2002) 5.70
Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science (1997) 5.54
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The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development (1994) 3.99
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci U S A (2001) 3.96
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Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol (1997) 3.62
Jagged: a mammalian ligand that activates Notch1. Cell (1995) 3.51
Control of muscle development by dueling HATs and HDACs. Curr Opin Genet Dev (2001) 3.17
Biological control through regulated transcriptional coactivators. Cell (2004) 3.05
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development (1996) 2.92
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood (2004) 2.90
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Looking back to the embryo: defining transcriptional networks in adult myogenesis. Nat Rev Genet (2003) 2.70
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev (2002) 2.64
Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J Cell Sci (2000) 2.57
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development (1999) 2.55
Separable regulatory elements governing myogenin transcription in mouse embryogenesis. Science (1993) 2.36
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol (1999) 2.36
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The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. J Biol Chem (2001) 1.62
Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol (1999) 1.61
The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev (1990) 1.61
The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev (2000) 1.59
The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis. Semin Cell Dev Biol (2005) 1.50
TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J (2004) 1.42
Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. J Biol Chem (2002) 1.36
A Notch feeling of somite segmentation and beyond. Dev Biol (2004) 1.28
Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev (2002) 1.25
Modulation of notch signaling during somitogenesis. Annu Rev Cell Dev Biol (2003) 1.15
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev (2005) 1.13
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The origin of skeletal muscle stem cells in the embryo and the adult. Curr Opin Cell Biol (2001) 1.05
Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. Gene (2004) 0.83
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell (2005) 17.41
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med (2003) 11.17
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med (2006) 8.26
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell (2005) 7.99
Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med (2013) 7.52
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
The roles of FLT3 in hematopoiesis and leukemia. Blood (2002) 6.14
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell (2007) 6.06
The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res (2005) 5.93
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell (2010) 5.02
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A (2008) 4.79
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res (2009) 4.32
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. N Engl J Med (2012) 4.26
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Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat Med (2010) 4.00
The interplay between MYC and HIF in cancer. Nat Rev Cancer (2008) 3.97
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood (2004) 3.84
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Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A (2004) 3.74
Striated muscle cytoarchitecture: an intricate web of form and function. Annu Rev Cell Dev Biol (2002) 3.66
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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol (2007) 3.51
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell (2004) 3.46
c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res (2003) 3.39
Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat Rev Cancer (2007) 3.36
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia. Blood (2008) 3.30
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. Cancer Cell (2007) 3.23
Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins. Mol Ther (2011) 3.10
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell (2002) 3.09
Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature (2010) 3.03
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab (2006) 2.82
PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease. Cancer Cell (2003) 2.70
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2009) 2.54
Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc Natl Acad Sci U S A (2012) 2.53
Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression. Cancer Res (2005) 2.49
Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int (2005) 2.42
Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell (2002) 2.42
Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics (2011) 2.31
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet (2003) 2.30
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A (2002) 2.28
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature (2003) 2.28
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The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood (2011) 2.23
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The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol (2003) 2.12
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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc Natl Acad Sci U S A (2008) 1.98
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Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study. Blood (2007) 1.85
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Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood (2006) 1.83
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Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood (2004) 1.81
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol (2002) 1.81
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci U S A (2004) 1.81
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia. Cancer Res (2004) 1.79
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The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab (2005) 1.72
Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial Transplant (2005) 1.71
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Diagnosis of bladder cancer with microelectromechanical systems-based cystoscopic optical coherence tomography. Urology (2009) 1.69
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AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia. Clin Cancer Res (2005) 1.61
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Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells. Cancer Biol Ther (2006) 1.60
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Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood (2005) 1.58
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PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol (2003) 1.55