Published in EMBO J on July 15, 2003
A nucleator arms race: cellular control of actin assembly. Nat Rev Mol Cell Biol (2010) 5.33
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J (2004) 3.31
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26
Invadopodia: specialized cell structures for cancer invasion. Clin Exp Metastasis (2006) 3.05
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Cell (2008) 2.71
Human subtelomeric WASH genes encode a new subclass of the WASP family. PLoS Genet (2007) 2.43
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr Biol (2006) 2.20
Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem J (2004) 2.08
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol (2008) 1.88
Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell Stem Cell (2014) 1.88
Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60
Regulation of WASP/WAVE proteins: making a long story short. J Cell Biol (2004) 1.50
Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J Cell Biol (2006) 1.50
The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion. J Biol Chem (2009) 1.49
Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells. Am J Pathol (2007) 1.46
Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. Mol Cell Biol (2004) 1.38
Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. PLoS One (2011) 1.34
N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Mol Biol Cell (2006) 1.31
DISTORTED3/SCAR2 is a putative arabidopsis WAVE complex subunit that activates the Arp2/3 complex and is required for epidermal morphogenesis. Plant Cell (2005) 1.30
WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade. Int J Cancer (2011) 1.24
WASP and SCAR/WAVE proteins: the drivers of actin assembly. J Cell Sci (2009) 1.23
Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2. BMC Cell Biol (2005) 1.16
Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity. J Cell Sci (2007) 1.11
Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One (2008) 1.09
The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines. Transl Psychiatry (2014) 1.09
mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation. J Biol Chem (2011) 1.06
Arabidopsis SCARs function interchangeably to meet actin-related protein 2/3 activation thresholds during morphogenesis. Plant Cell (2008) 1.05
Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A (2011) 1.04
WAVE2 is regulated by multiple phosphorylation events within its VCA domain. Cell Motil Cytoskeleton (2009) 1.02
Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol (2013) 1.02
Phosphoregulation of the WAVE regulatory complex and signal integration. Semin Cell Dev Biol (2013) 0.96
A major role for Scar/WAVE-1 downstream of GPVI in platelets. J Thromb Haemost (2007) 0.94
Self-organization of protrusions and polarity during eukaryotic chemotaxis. Curr Opin Cell Biol (2014) 0.94
The actin nucleation factor JMY is a negative regulator of neuritogenesis. Mol Biol Cell (2011) 0.93
Immune pathology associated with altered actin cytoskeleton regulation. Autoimmunity (2010) 0.92
Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins. Dev Dyn (2012) 0.92
Endothelial cells use dynamic actin to facilitate lymphocyte transendothelial migration and maintain the monolayer barrier. Mol Biol Cell (2014) 0.92
Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. Cell Microbiol (2012) 0.91
Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging. J Cell Sci (2012) 0.90
Actin cytoskeletal defects in immunodeficiency. Immunol Rev (2013) 0.90
Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling. FEBS Lett (2012) 0.89
The N-terminus of Dictyostelium Scar interacts with Abi and HSPC300 and is essential for proper regulation and function. Mol Biol Cell (2007) 0.89
Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein. BMC Cell Biol (2009) 0.88
Surfing the big WAVE: Insights into the role of WAVE3 as a driving force in cancer progression and metastasis. Semin Cell Dev Biol (2012) 0.85
Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. Mol Biol Cell (2011) 0.83
Nucleation promoting factors regulate the expression and localization of Arp2/3 complex during meiosis of mouse oocytes. PLoS One (2012) 0.82
WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient. Mol Biol Cell (2006) 0.81
Molecular analysis of Arp2/3 complex activation in cells. Biophys J (2012) 0.81
Actin engine in immunological synapse. Immune Netw (2012) 0.81
Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol (2016) 0.79
Function and regulation of the Arp2/3 complex during cell migration in diverse environments. Curr Opin Cell Biol (2016) 0.78
Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation. Genetics (2015) 0.78
ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor. PLoS One (2015) 0.77
WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. PLoS One (2013) 0.77
Effects of dimethyl sulfoxide on asymmetric division and cytokinesis in mouse oocytes. BMC Dev Biol (2014) 0.76
High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1. PLoS One (2011) 0.76
A conformational change within the WAVE2 complex regulates its degradation following cellular activation. Sci Rep (2017) 0.75
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α. Sci Rep (2015) 0.75
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct (2000) 10.11
Rho GTPases and their effector proteins. Biochem J (2000) 8.89
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Curr Biol (1999) 6.24
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A (1999) 5.62
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature (1998) 4.95
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature (2000) 4.51
WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J (1998) 4.46
Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am J Pathol (1996) 4.25
WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J Cell Sci (2001) 3.74
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature (2000) 3.56
Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity (1997) 3.35
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol (2001) 2.91
Rac1 is required for the formation of three germ layers during gastrulation. Oncogene (1998) 2.61
A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry (1996) 2.39
SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. J Cell Biol (1998) 2.32
SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila. J Cell Biol (2002) 2.31
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol (2000) 2.19
Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. EMBO J (2000) 2.13
Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge. J Cell Sci (2002) 2.11
Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities. Curr Biol (2001) 2.06
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Biochem Biophys Res Commun (1999) 2.01
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J Cell Sci (1998) 1.99
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A (2003) 1.86
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol (2002) 1.77
Human papillomavirus type 16 E7 alleviates a proliferation block in early passage human mammary epithelial cells. Oncogene (1996) 1.71
Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. J Biol Chem (2001) 1.70
Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem (2002) 1.40
Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone. J Cell Sci (2003) 1.31
Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions. J Virol (1994) 1.30
Rab5 induces Rac-independent lamellipodia formation and cell migration. Mol Biol Cell (1999) 1.28
Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling. J Biol Chem (1999) 1.16
Cell motility: braking WAVEs. Nature (2002) 1.14
N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia. J Cell Sci (2001) 1.14
EGF-stimulated lamellipod extension in adenocarcinoma cells. Ultramicroscopy (2001) 1.13
The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex. J Biol Chem (2002) 1.11
The WASp-like protein scar regulates macropinocytosis, phagocytosis and endosomal membrane flow in Dictyostelium. J Cell Sci (2001) 1.08
Cell motility: insights from the backstage. Nat Cell Biol (2002) 1.03
The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia. FEBS Lett (2002) 0.88
Characterization and expression analyses of the mouse Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar. Gene (2002) 0.79
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A (2014) 14.78
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell (2010) 6.00
The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res (2005) 5.93
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol (2012) 5.66
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
DNA repair, genome stability, and aging. Cell (2005) 5.52
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 5.07
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature (2004) 4.68
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell (2005) 4.14
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A (2004) 3.74
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature (2004) 3.62
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood (2002) 3.59
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell (2004) 3.46
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature (2003) 3.25
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins. Mol Ther (2011) 3.10
Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat Genet (2007) 3.08
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature (2010) 3.03
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Science (2004) 2.93
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell (2006) 2.91
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab (2006) 2.82
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72
The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc Natl Acad Sci U S A (2004) 2.69
Using buoyant mass to measure the growth of single cells. Nat Methods (2010) 2.67
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev (2004) 2.56
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell (2002) 2.49
Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (2006) 2.49
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest (2005) 2.45
The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
The influence of transcriptional orientation on endogenous switch region function. Nat Immunol (2003) 2.38
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36