Published in Cancer Cell on April 01, 2005
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p53 mutations in cancer. Nat Cell Biol (2013) 5.18
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
Mutant p53: one name, many proteins. Genes Dev (2012) 4.33
Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06
Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol (2010) 3.65
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev (2008) 3.17
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res (2008) 2.67
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
p63 and p73, the ancestors of p53. Cold Spring Harb Perspect Biol (2010) 2.16
20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins. Cell Death Differ (2009) 1.93
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
The molecular pathogenesis of head and neck squamous cell carcinoma. J Clin Invest (2012) 1.86
The p53 family and programmed cell death. Oncogene (2008) 1.81
Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. Proc Natl Acad Sci U S A (2006) 1.80
Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol (2007) 1.78
TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
Aberrant regulation and function of microRNAs in cancer. Curr Biol (2014) 1.72
IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature (2014) 1.66
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest (2007) 1.64
TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol (2013) 1.61
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J (2009) 1.54
ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation. Cancer Res (2011) 1.52
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A (2006) 1.48
p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genet (2009) 1.41
Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol (2011) 1.39
p53 Isoforms: An Intracellular Microprocessor? Genes Cancer (2011) 1.37
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A (2008) 1.36
DeltaNp73 regulates neuronal survival in vivo. Proc Natl Acad Sci U S A (2009) 1.35
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. Nat Genet (2015) 1.34
p53 Family and Cellular Stress Responses in Cancer. Front Oncol (2014) 1.33
Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer (2011) 1.33
p73 in Cancer. Genes Cancer (2011) 1.33
Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology (2008) 1.33
Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. Onco Targets Ther (2013) 1.27
Targeting p53 for Novel Anticancer Therapy. Transl Oncol (2010) 1.26
p53 Family: Role of Protein Isoforms in Human Cancer. J Nucleic Acids (2011) 1.26
MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol (2006) 1.23
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53. Cell Death Dis (2010) 1.20
Identification and functional characterization of two new transcriptional variants of the human p63 gene. Nucleic Acids Res (2009) 1.19
ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol (2014) 1.19
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Leukemia (2011) 1.15
p53 and the pathogenesis of skin cancer. Toxicol Appl Pharmacol (2006) 1.13
Mechanisms of transcriptional repression of cell-cycle G2/M promoters by p63. Nucleic Acids Res (2006) 1.13
The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene (2009) 1.11
A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Proc Natl Acad Sci U S A (2010) 1.11
C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity. Nucleic Acids Res (2008) 1.10
EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Sci Rep (2012) 1.10
p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. Mol Cell Biol (2012) 1.10
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. Proc Natl Acad Sci U S A (2011) 1.08
TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation. Proc Natl Acad Sci U S A (2014) 1.08
The C-terminus of p63 contains multiple regulatory elements with different functions. Cell Death Dis (2010) 1.07
Measles virus V protein inhibits p53 family member p73. J Virol (2006) 1.06
hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage. Mol Cell Biol (2009) 1.06
Ubiquitin and ubiquitin-like modifications of the p53 family. Neoplasia (2006) 1.05
p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology (2013) 1.05
Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax. Nucleic Acids Res (2008) 1.03
DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem (2011) 1.03
Smoking, p53 mutation, and lung cancer. Mol Cancer Res (2014) 1.03
p53: the attractive tumor suppressor in the cancer research field. J Biomed Biotechnol (2010) 1.02
p73 poses a barrier to malignant transformation by limiting anchorage-independent growth. EMBO J (2008) 1.01
p53/p63/p73 in the epidermis in health and disease. Cold Spring Harb Perspect Med (2014) 1.01
The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. J Biol Chem (2011) 0.99
Cell cycle regulation in the developing lens. Semin Cell Dev Biol (2006) 0.97
UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation. Cell Cycle (2011) 0.97
Structure of p73 DNA-binding domain tetramer modulates p73 transactivation. Proc Natl Acad Sci U S A (2012) 0.96
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. J Clin Invest (2012) 0.96
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage. J Biol Chem (2013) 0.96
1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model. Mol Cancer Ther (2008) 0.96
Tumor suppression by p53: making cells senescent. Histol Histopathol (2010) 0.96
BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD). Cell Death Differ (2010) 0.95
Regulatory feedback loop between TP73 and TRIM32. Cell Death Dis (2013) 0.95
Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5. Proc Natl Acad Sci U S A (2016) 0.94
Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis. Cell Rep (2014) 0.94
Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73. Cancer Biol Ther (2008) 0.93
Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J Invest Dermatol (2012) 0.93
TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S. Nucleic Acids Res (2008) 0.93
p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGFβ signaling. Cell Death Differ (2015) 0.93
Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy. FEBS Lett (2012) 0.92
Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B. Aging (Albany NY) (2009) 0.92
Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinoma. Am J Pathol (2010) 0.92
Role of p63 in Development, Tumorigenesis and Cancer Progression. Cancer Microenviron (2012) 0.91
TAp73 is a central transcriptional regulator of airway multiciliogenesis. Genes Dev (2016) 0.91
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. J Clin Invest (2010) 0.90
p73 as a pharmaceutical target for cancer therapy. Curr Pharm Des (2011) 0.90
Crosstalk between c-Jun and TAp73alpha/beta contributes to the apoptosis-survival balance. Nucleic Acids Res (2011) 0.90
c-Abl phosphorylation of ΔNp63α is critical for cell viability. Cell Death Dis (2010) 0.90
Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity. FEBS J (2014) 0.90
Cascades of transcription regulation during liver regeneration. Int J Biochem Cell Biol (2010) 0.89
14-3-3σ and p63 play opposing roles in epidermal tumorigenesis. Carcinogenesis (2011) 0.89
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36
Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet (2007) 15.46
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06
Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature (2009) 11.46
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. Nat Genet (2004) 10.92
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 8.48
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
MicroRNAs and cancer: short RNAs go a long way. Cell (2009) 7.25
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A (2008) 6.89
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell (2009) 6.55
p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature (2003) 6.01
The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res (2005) 5.93
Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev (2009) 5.21
Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha. Proc Natl Acad Sci U S A (2004) 5.15
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med (2004) 4.98
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature (2009) 4.93
Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev (2008) 4.77
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell (2009) 4.71
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature (2002) 4.56
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell (2006) 4.51
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc (2009) 4.50
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
p63 protects the female germ line during meiotic arrest. Nature (2006) 3.98
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 3.94
Expression of tumour-specific antigens underlies cancer immunoediting. Nature (2012) 3.89
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A (2004) 3.74
On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet (2002) 3.57
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity. J Virol (2005) 3.54
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature (2012) 3.51
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. J Clin Invest (2004) 3.47
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell (2004) 3.46
Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res (2004) 3.43
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell (2009) 3.37
Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell (2011) 3.36
Treating metastatic cancer with nanotechnology. Nat Rev Cancer (2011) 3.30
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell (2002) 3.29
Suppression of lung adenocarcinoma progression by Nkx2-1. Nature (2011) 3.27
Cancer modeling in the modern era: progress and challenges. Cell (2002) 3.12
Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins. Mol Ther (2011) 3.10
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature (2002) 3.05
Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature (2010) 3.03
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev (2013) 2.90
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab (2006) 2.82
Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72
An atmospheric perspective on North American carbon dioxide exchange: CarbonTracker. Proc Natl Acad Sci U S A (2007) 2.40
The increase in international medical graduates in family practice residency programs. Fam Med (2002) 2.40
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell (2013) 2.38
Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration. Am J Ophthalmol (2013) 2.32
Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev (2011) 2.29
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A (2002) 2.28
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature (2003) 2.28
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A (2002) 2.24
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell (2003) 2.23
Cell type-specific effects of Rb deletion in the murine retina. Genes Dev (2004) 2.18
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A (2007) 2.18
The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol (2003) 2.17
An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell (2011) 2.14
Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (2004) 2.14
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A (2009) 2.13
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (2009) 2.11
Anthropogenic emissions of methane in the United States. Proc Natl Acad Sci U S A (2013) 2.09
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J (2008) 2.08
Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med (2005) 2.08