Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.

PubWeight™: 1.26‹?› | Rank: Top 10%

🔗 View Article (PMC 1430337)

Published in Mol Cell Biol on April 01, 2006

Authors

Marianna Sadagurski1, Shoshana Yakar, Galina Weingarten, Martin Holzenberger, Christopher J Rhodes, Dirk Breitkreutz, Derek Leroith, Efrat Wertheimer

Author Affiliations

1: Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Articles citing this

Emerging interactions between skin stem cells and their niches. Nat Med (2014) 1.45

Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell (2008) 1.31

MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R. PLoS One (2011) 1.15

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation. EMBO J (2008) 1.09

Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential. Toxicol Appl Pharmacol (2007) 1.03

Basement membranes in skin: unique matrix structures with diverse functions? Histochem Cell Biol (2009) 1.01

Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. Am J Pathol (2008) 1.01

A new paradigm for the role of aging in the development of skin cancer. J Invest Dermatol (2008) 1.00

Defects in skin gamma delta T cell function contribute to delayed wound repair in rapamycin-treated mice. J Immunol (2008) 0.99

Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan. Biomed Res Int (2013) 0.97

Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. Neoplasia (2010) 0.94

Gq-coupled purinergic receptors inhibit insulin-like growth factor-I/phosphoinositide 3-kinase pathway-dependent keratinocyte migration. Mol Biol Cell (2010) 0.88

PKCη promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions. Cell Death Dis (2011) 0.88

Adipocytes in skin health and disease. Cold Spring Harb Perspect Med (2014) 0.85

Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors. J Invest Dermatol (2013) 0.84

Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis. J Surg Res (2014) 0.83

The crosstalk between IL-22 signaling and miR-197 in human keratinocytes. PLoS One (2014) 0.79

Case series of dermatologic events associated with the insulin-like growth factor receptor 1 inhibitor cixutumumab. J Clin Oncol (2011) 0.79

Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation. Mol Carcinog (2010) 0.78

An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration. Dev Biol (2015) 0.78

The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma. Mol Cancer (2015) 0.77

Type I insulin-like growth factor receptor signaling in hematological malignancies. Oncotarget (2017) 0.76

Persea americana Mill. Seed: Fractionation, Characterization, and Effects on Human Keratinocytes and Fibroblasts. Evid Based Complement Alternat Med (2013) 0.76

IGF1 regulates RUNX1 expression via IRS1/2: implications for antler chondrocyte differentiation. Cell Cycle (2017) 0.75

Feedback, Lineages and Self-Organizing Morphogenesis. PLoS Comput Biol (2016) 0.75

Snail modulated miR - 493 forms a negative feedback loop with IGF1R pathway and blocks tumorigenesis. Mol Cell Biol (2016) 0.75

Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing. J Diabetes Res (2016) 0.75

A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans. Ann Dermatol (2016) 0.75

Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility. J Invest Dermatol (2016) 0.75

Articles cited by this

Wound healing--aiming for perfect skin regeneration. Science (1997) 16.08

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell (1993) 10.36

Role of insulin-like growth factors in embryonic and postnatal growth. Cell (1993) 8.22

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell (2004) 7.60

IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab (2002) 4.93

Inducible gene targeting in mice using the Cre/lox system. Methods (1998) 4.61

Getting under the skin of epidermal morphogenesis. Nat Rev Genet (2002) 4.54

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet (1999) 3.27

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol (1989) 3.21

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01

A survey of transformation markers in differentiating epidermal cell lines in culture. Cancer Res (1980) 2.53

The insulin signalling system and the IRS proteins. Diabetologia (1997) 2.44

The IGF-I receptor in cell growth, transformation and apoptosis. Biochim Biophys Acta (1997) 2.38

Identification of a major keratinocyte cell envelope protein, loricrin. Cell (1990) 2.25

Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes. Mol Cell Biol (2001) 2.14

IGF-I receptor signalling in transformation and differentiation. Mol Pathol (2001) 1.75

Insulin-like growth factor ligands, receptors, and binding proteins in cancer. J Pathol (2005) 1.73

Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem (2000) 1.67

Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. Mol Cell Biol (2001) 1.62

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes (2003) 1.51

Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem (2004) 1.44

Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J Biol Chem (2005) 1.42

Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion. Cancer Res (2000) 1.37

Mek1 alters epidermal growth and differentiation. Cancer Res (2004) 1.33

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J Invest Dermatol (2004) 1.27

Targeting the molecular target of rapamycin (mTOR). Curr Opin Oncol (2004) 1.25

Elements controlling the expression and induction of the skin hyperproliferation-associated keratin K6. J Biol Chem (1995) 1.23

Phenotypic and cytogenetic characteristics of different stages during spontaneous transformation of mouse keratinocytes in vitro. Carcinog Compr Surv (1985) 1.17

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes (2002) 1.14

The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin. Br J Dermatol (2005) 1.14

Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular. Endocrinology (2001) 1.11

Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells. J Biol Chem (2000) 1.08

Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways. Circ Res (2005) 1.07

Expression of insulin-like growth factor-1 receptor (IGF-1R) and p27Kip1 in melanocytic tumors: a potential regulatory role of IGF-1 pathway in distribution of p27Kip1 between different cyclins. Growth Factors (2000) 1.06

The regulation of skin proliferation and differentiation in the IR null mouse: implications for skin complications of diabetes. Endocrinology (2001) 1.04

Unique keratinization process in psoriasis: late differentiation markers are abolished because of the premature cell death. J Dermatol (2004) 1.01

Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes. Exp Dermatol (2000) 0.92

Differential roles of insulin receptor and insulin-like growth factor-1 receptor in differentiation of murine skin keratinocytes. J Invest Dermatol (2000) 0.91

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development. J Pediatr Endocrinol Metab (1999) 0.88

Activation of epidermal growth factor receptor promotes late terminal differentiation of cell-matrix interaction-disrupted keratinocytes. J Biol Chem (1999) 0.87

Structural biology of insulin and IGF-1 receptors. Novartis Found Symp (2004) 0.87

Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis. J Dermatol Sci (1994) 0.85

Phosphatidylinositol 3-kinase is a key regulator of early phase differentiation in keratinocytes. J Biol Chem (2002) 0.85

Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. J Biol Chem (2005) 0.85

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev (2006) 4.93

Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem (2004) 3.54

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31

Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell (2009) 2.87

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab (2005) 2.52

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A (2007) 2.48

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol (2008) 2.35

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet (2006) 2.21

Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest (2005) 2.14

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res (2010) 2.13

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab (2007) 2.02

Formation of a human β-cell population within pancreatic islets is set early in life. J Clin Endocrinol Metab (2012) 2.01

The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol (2008) 2.00

Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology (2003) 1.99

Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res (2002) 1.96

Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology (2009) 1.92

Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85

Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85

Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab (2006) 1.83

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem (2003) 1.76

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem (2002) 1.76

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. Endocrinology (2006) 1.71

Proinsulin maturation, misfolding, and proteotoxicity. Proc Natl Acad Sci U S A (2007) 1.69

Cre-mediated recombination in the skin melanocyte lineage. Genesis (2003) 1.69

Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem (2006) 1.64

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem (2006) 1.59

Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum. Diabetes Care (2013) 1.56

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem (2004) 1.54

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. J Hepatol (2013) 1.52

Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Mol Endocrinol (2007) 1.49

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes? Trends Mol Med (2002) 1.49

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab (2004) 1.49

Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem (2003) 1.46

The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes. Diabetes Metab Res Rev (2014) 1.45

Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res (2003) 1.44

Obesity, energy balance, and cancer: new opportunities for prevention. Cancer Prev Res (Phila) (2012) 1.44

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest (2003) 1.43

Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci (2010) 1.43

Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive. Endocr Rev (2013) 1.39

Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout. FASEB J (2006) 1.39

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. Cytokine Growth Factor Rev (2005) 1.37

The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol (2006) 1.37

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem (2003) 1.36

Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res (2009) 1.35

Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci (2005) 1.35

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol (2006) 1.34

Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol (2008) 1.33

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med (2011) 1.31

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem (2006) 1.31

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology (2005) 1.29

Insulin resistance in obesity as the underlying cause for the metabolic syndrome. Mt Sinai J Med (2010) 1.29

Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells. Infect Immun (2003) 1.28

Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. Diabetes (2003) 1.28

Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Diabetes (2009) 1.28

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance. Mol Cell Biol (2004) 1.28

Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome. J Clin Endocrinol Metab (2002) 1.28

Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome. Hum Gene Ther (2003) 1.28

PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene (2004) 1.27

The metabolic syndrome--from insulin resistance to obesity and diabetes. Med Clin North Am (2011) 1.25

Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol (2003) 1.23

Biology of insulin-like growth factors in development. Birth Defects Res C Embryo Today (2003) 1.23

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes (2003) 1.22

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. J Biol Chem (2005) 1.22

Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles. Nucleic Acids Res (2003) 1.21

Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice. Endocrinology (2009) 1.21

Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes (2011) 1.20

Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res (2010) 1.20

Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. J Biol Chem (2002) 1.19

Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration. Diabetes (2012) 1.18

Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes. J Clin Endocrinol Metab (2004) 1.18

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes (2009) 1.18

A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol (2010) 1.17

TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival. J Biol Chem (2004) 1.17

Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci (2010) 1.17

Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex. J Invest Dermatol (2005) 1.17

Simvastatin as a treatment for pulmonary hypertension trial. Am J Respir Crit Care Med (2010) 1.15

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Res (2006) 1.15

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice. Am J Physiol Endocrinol Metab (2006) 1.14

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes (2002) 1.14

Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences. Horm Res (2009) 1.13

Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. J Clin Invest (2011) 1.12

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes (2006) 1.12

Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1. J Bone Miner Res (2010) 1.12

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology (2004) 1.10

Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes (2010) 1.08

Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res (2008) 1.07

Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Res (2010) 1.07

A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation. Cell Metab (2007) 1.07

Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells. Mol Cell Biol (2004) 1.07

Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology (2008) 1.06

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1. J Endocrinol (2010) 1.05

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes (2002) 1.05

Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner. PLoS One (2011) 1.04

Early postnatal nutrition determines somatotropic function in mice. Endocrinology (2008) 1.04