Published in J Invest Dermatol on September 01, 2004
Epithelial stem cells, wound healing and cancer. Nat Rev Cancer (2012) 2.23
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol (2010) 1.92
Tracing the cellular origin of cancer. Nat Cell Biol (2013) 1.75
Dynamic expression of epidermal caspase 8 simulates a wound healing response. Nature (2009) 1.71
Psoriasis: what we have learned from mouse models. Nat Rev Rheumatol (2010) 1.61
CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ. J Invest Dermatol (2012) 1.49
Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med (2009) 1.45
Cell-extracellular matrix interactions in normal and diseased skin. Cold Spring Harb Perspect Biol (2011) 1.37
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. Blood (2008) 1.33
Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell (2008) 1.31
Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol (2006) 1.26
Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc Natl Acad Sci U S A (2010) 1.22
Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J Virol (2008) 1.18
Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A (2013) 1.16
Role of LIM kinases in normal and psoriatic human epidermis. Mol Biol Cell (2006) 1.14
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A (2011) 1.13
Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin. J Invest Dermatol (2010) 1.11
MEK genomics in development and disease. Brief Funct Genomics (2012) 1.04
PPARgamma and MEK Interactions in Cancer. PPAR Res (2008) 1.02
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. BMC Cancer (2008) 1.01
Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivo. Mol Cell Biol (2006) 0.97
An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors. Cancer Res (2009) 0.96
Innate sensing of microbial products promotes wound-induced skin cancer. Nat Commun (2015) 0.89
Modeling cutaneous squamous carcinoma development in the mouse. Cold Spring Harb Perspect Med (2014) 0.78
Cells of origin and tumor-initiating cells for nonmelanoma skin cancers. Cancer Lett (2012) 0.77
Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis. Cancer Res (2016) 0.76
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
A specialized vascular niche for adult neural stem cells. Cell Stem Cell (2008) 5.53
Extracellular-matrix tethering regulates stem-cell fate. Nat Mater (2012) 3.94
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84
Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell (2011) 3.55
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol (2010) 3.33
Stem cell depletion through epidermal deletion of Rac1. Science (2005) 3.26
Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development (2004) 3.24
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc Natl Acad Sci U S A (2006) 2.91
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82
Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development (2002) 2.79
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77
Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71
Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer (2003) 2.69
Lineage tracing. Cell (2012) 2.67
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci U S A (2009) 2.28
Epithelial stem cells, wound healing and cancer. Nat Rev Cancer (2012) 2.23
Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development (2003) 2.23
Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development (2006) 2.06
The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development (2006) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Sic transit gloria: farewell to the epidermal transit amplifying cell? Cell Stem Cell (2007) 1.91
The basement membrane of hair follicle stem cells is a muscle cell niche. Cell (2011) 1.88
Epidermal stem cells: an update. Curr Opin Genet Dev (2006) 1.87
Defining dermal adipose tissue. Exp Dermatol (2014) 1.84
Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Nat Cell Biol (2008) 1.79
New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer (2006) 1.75
Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat Protoc (2010) 1.72
Hair follicle dermal papilla cells at a glance. J Cell Sci (2011) 1.72
The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Curr Biol (2006) 1.71
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1. J Cell Biol (2006) 1.65
Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol (2002) 1.59
Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr Biol (2003) 1.54
The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. PLoS One (2008) 1.53
Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet (2005) 1.51
The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet (2011) 1.48
Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial. Arch Dermatol (2004) 1.46
Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. PLoS One (2007) 1.45
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin. Development (2011) 1.43
Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Development (2003) 1.42
Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med (2006) 1.40
Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling. J Cell Sci (2003) 1.37
Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J Cell Sci (2003) 1.37
Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell (2008) 1.31
Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo. J Invest Dermatol (2011) 1.30
Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol (2004) 1.30
Diverse epigenetic strategies interact to control epidermal differentiation. Nat Cell Biol (2012) 1.29
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt. J Cell Sci (2004) 1.22
Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc Natl Acad Sci U S A (2010) 1.22
Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin. Stem Cells (2008) 1.22
Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol (2007) 1.22
What is the point of large-scale collections of human induced pluripotent stem cells? Nat Biotechnol (2013) 1.20
Epidermal label-retaining cells: background and recent applications. J Investig Dermatol Symp Proc (2004) 1.20
The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1. Stem Cell Reports (2013) 1.20
Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. Dev Biol (2008) 1.19
A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control. J Cell Biol (2003) 1.18
A year in the life of eLife. Elife (2013) 1.14
Role of LIM kinases in normal and psoriatic human epidermis. Mol Biol Cell (2006) 1.14
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A (2011) 1.13
Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J Invest Dermatol (2007) 1.11
Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type. Cancer Res (2007) 1.09
Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture. J Cell Sci (2007) 1.08
Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev Biol (2010) 1.06
Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP. J Invest Dermatol (2009) 1.05
Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease. J Biol Chem (2003) 1.05
Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials (2010) 1.04
Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development (2013) 1.04
Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol (2013) 1.03
Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation. EMBO Mol Med (2010) 1.02
Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. J Cell Biol (2004) 1.02
A stem cell gene expression profile of human squamous cell carcinomas. Cancer Lett (2008) 1.01
Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication. J Invest Dermatol (2005) 1.01
Interaction of periplakin and envoplakin with intermediate filaments. J Cell Sci (2002) 1.01
Necl2 regulates epidermal adhesion and wound repair. Development (2009) 1.01
Expression of Notch pathway genes in mammalian epidermis and modulation by beta-catenin. Dev Dyn (2007) 0.99
FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis. Cancer Res (2012) 0.97
c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis. Cell Rep (2013) 0.97
An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors. Cancer Res (2009) 0.96
Pirfenidone in idiopathic pulmonary fibrosis: expert panel discussion on the management of drug-related adverse events. Adv Ther (2014) 0.94
Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1. Development (2010) 0.93
Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation. J Cell Sci (2008) 0.93
LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development. J Pathol (2013) 0.92
β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol (2012) 0.92
Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors. Proc Natl Acad Sci U S A (2014) 0.91
NKT cell subsets in infection and inflammation. Immunol Lett (2003) 0.91
KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules. J Cell Sci (2009) 0.91
Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer. Cancer Lett (2009) 0.91
False-positive hepatitis B serology following IVIG therapy: forgotten but not gone!! J Am Acad Dermatol (2012) 0.90
Sensitive and specific assays for routine serological diagnosis of epidermolysis bullosa acquisita. J Am Acad Dermatol (2012) 0.89
Immunofluorescence antigen mapping for hereditary epidermolysis bullosa. Indian J Dermatol Venereol Leprol (2012) 0.89
Suprabasal alpha 5 beta1 integrin expression stimulates formation of epidermal squamous cell carcinomas without disrupting TGFbeta signaling or inducing spindle cell tumors. Mol Carcinog (2005) 0.89
PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation. Cell Res (2009) 0.88
An individual with Muir-Torre syndrome found to have a pathogenic MSH6 gene mutation. Fam Cancer (2007) 0.88
Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One (2011) 0.88
Non-profit publishing: open access and the end of copyright transfer. J Cell Sci (2004) 0.88