Published in Nucleic Acids Res on March 31, 2006
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease. Nucleic Acids Res (2008) 1.44
Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res (2010) 1.35
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. J Biol Chem (2008) 1.27
The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J Biol Chem (2009) 1.27
FEN1 ensures telomere stability by facilitating replication fork re-initiation. J Biol Chem (2010) 1.14
Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways. J Mol Biol (2007) 1.05
Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair. Mol Cell Biol (2008) 1.02
Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates. Nucleic Acids Res (2009) 0.97
Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease. J Mol Biol (2007) 0.97
PCNA stimulates catalysis by structure-specific nucleases using two distinct mechanisms: substrate targeting and catalytic step. Nucleic Acids Res (2008) 0.90
Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily. Mech Ageing Dev (2012) 0.90
A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. PLoS One (2013) 0.84
Human replication factor C stimulates flap endonuclease 1. J Biol Chem (2009) 0.84
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. Oncogene (2014) 0.83
Direct observation of DNA threading in flap endonuclease complexes. Nat Struct Mol Biol (2016) 0.80
Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae. Nucleic Acids Res (2008) 0.79
Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1. PLoS One (2013) 0.78
Comprehensive classification of the PIN domain-like superfamily. Nucleic Acids Res (2017) 0.75
Function and structure relationships in DNA polymerases. Annu Rev Biochem (1994) 5.66
A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell (1997) 5.49
The characterization of a mammalian DNA structure-specific endonuclease. EMBO J (1994) 3.85
Reconstitution of complete SV40 DNA replication with purified replication factors. J Biol Chem (1994) 3.81
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell (2004) 3.33
Expansion and length-dependent fragility of CTG repeats in yeast. Science (1998) 3.25
Flap endonuclease 1: a central component of DNA metabolism. Annu Rev Biochem (2004) 3.16
Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene. J Bacteriol (1995) 3.05
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell (1998) 2.67
Calf 5' to 3' exo/endonuclease must slide from a 5' end of the substrate to perform structure-specific cleavage. J Biol Chem (1995) 2.62
Structural basis for recruitment of human flap endonuclease 1 to PCNA. EMBO J (2004) 2.57
The crystal structure of flap endonuclease-1 from Methanococcus jannaschii. Nat Struct Biol (1998) 2.37
Conditional lethality of null mutations in RTH1 that encodes the yeast counterpart of a mammalian 5'- to 3'-exonuclease required for lagging strand DNA synthesis in reconstituted systems. J Biol Chem (1995) 2.23
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J (2001) 2.21
Enzymatic completion of mammalian lagging-strand DNA replication. Proc Natl Acad Sci U S A (1994) 2.11
Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1. J Biol Chem (2000) 1.97
Triplet repeats form secondary structures that escape DNA repair in yeast. Proc Natl Acad Sci U S A (1999) 1.83
Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats. Mol Cell (1999) 1.83
Repeat expansion--all in a flap? Nat Genet (1997) 1.80
Involvement of flap endonuclease 1 in base excision DNA repair. J Biol Chem (1998) 1.73
PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins. Nucleic Acids Res (2005) 1.71
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Mol Cell (2001) 1.70
Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases. Bioessays (2005) 1.69
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events. Proc Natl Acad Sci U S A (1999) 1.59
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep (2005) 1.56
Characterization of the human and mouse WRN 3'-->5' exonuclease. Nucleic Acids Res (2000) 1.46
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J (2003) 1.45
Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Mol Cell Biol (2003) 1.41
Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Mol Cell Biol (2004) 1.22
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet (2004) 1.21
The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast. Genetics (2000) 1.20
Effect of flap modifications on human FEN1 cleavage. Biochemistry (1999) 1.19
In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding. J Biol Chem (2000) 1.18
Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol (2005) 1.09
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Res (2005) 1.08
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J Biol Chem (2005) 1.05
The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity. Nucleic Acids Res (2004) 1.05
Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth. Biochemistry (2001) 1.03
Human flap endonuclease-1: conformational change upon binding to the flap DNA substrate and location of the Mg2+ binding site. Biochemistry (2001) 1.01
Novel function of Rad27 (FEN-1) in restricting short-sequence recombination. Mol Cell Biol (2001) 1.00
Fen1 is induced p53 dependently and involved in the recovery from UV-light-induced replication inhibition. Oncogene (2005) 0.98
Modeling of flap endonuclease interactions with DNA substrate. J Mol Biol (2003) 0.98
Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure. J Biol Chem (2004) 0.98
Mechanism of tracking and cleavage of adduct-damaged DNA substrates by the mammalian 5'- to 3'-exonuclease/endonuclease RAD2 homologue 1 or flap endonuclease 1. J Biol Chem (1996) 0.93
Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1. J Biol Chem (1998) 0.92
Triplet repeat expansion generated by DNA slippage is suppressed by human flap endonuclease 1. J Biol Chem (2004) 0.91
Interaction interface of human flap endonuclease-1 with its DNA substrates. J Biol Chem (2004) 0.85
The endonuclease Hje catalyses rapid, multiple turnover resolution of Holliday junctions. J Mol Biol (2005) 0.81
The TIGR Rice Genome Annotation Resource: improvements and new features. Nucleic Acids Res (2006) 8.26
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell (2004) 3.33
Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). Pain (2006) 2.87
Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med (2007) 2.48
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily. Cell (2011) 2.44
Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc Natl Acad Sci U S A (2003) 2.18
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle (2011) 2.15
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol Cell (2008) 2.12
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion. Cancer Res (2011) 1.80
Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression. Mol Cell (2012) 1.76
Global regulation of gene expression by ArlRS, a two-component signal transduction regulatory system of Staphylococcus aureus. J Bacteriol (2005) 1.72
Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases. Bioessays (2005) 1.69
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell (2012) 1.63
MST12 regulates infectious growth but not appressorium formation in the rice blast fungus Magnaporthe grisea. Mol Plant Microbe Interact (2002) 1.57
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep (2005) 1.56
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin. J Biol Chem (2004) 1.53
Refinement of light-responsive transcript lists using rice oligonucleotide arrays: evaluation of gene-redundancy. PLoS One (2008) 1.53
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J (2003) 1.45
Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells (2006) 1.43
Okazaki fragment maturation: nucleases take centre stage. J Mol Cell Biol (2011) 1.42
Two novel fungal virulence genes specifically expressed in appressoria of the rice blast fungus. Plant Cell (2002) 1.41
Large-scale gene discovery in the oomycete Phytophthora infestans reveals likely components of phytopathogenicity shared with true fungi. Mol Plant Microbe Interact (2005) 1.38
Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice. Mol Cell Biol (2007) 1.37
Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res (2010) 1.35
A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp. Stem Cells (2008) 1.32
PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans. Biochem Biophys Res Commun (2003) 1.30
The diagnostic accuracy of pleural effusion and plasma samples versus tumour tissue for detection of EGFR mutation in patients with advanced non-small cell lung cancer: comparison of methodologies. J Clin Pathol (2013) 1.30
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. Nat Chem Biol (2010) 1.29
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. J Biol Chem (2008) 1.27
The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J Biol Chem (2009) 1.27
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J (2013) 1.25
Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis. Differentiation (2007) 1.22
Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer. Cancer Res (2011) 1.20
Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease. J Mol Biol (2005) 1.19
Regeneration of dental pulp after pulpotomy by transplantation of CD31(-)/CD146(-) side population cells from a canine tooth. Regen Med (2009) 1.15
The TIGR Maize Database. Nucleic Acids Res (2006) 1.12
Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models. J Transl Med (2012) 1.11
Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers. Mol Cancer Res (2008) 1.10
Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk. Hum Mutat (2009) 1.08
Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes. Cancer Res (2002) 1.08
Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends. Nucleic Acids Res (2012) 1.06
Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target. J Mol Biol (2004) 1.06
A chronic ulcerative colitis model in rats. World J Gastroenterol (2000) 1.06
Comparative analysis of 87,000 expressed sequence tags from the fumonisin-producing fungus Fusarium verticillioides. Fungal Genet Biol (2005) 1.06
Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability. Am J Hum Genet (2013) 1.05
Analysis of major alkaloids in Rhizoma coptidis by capillary electrophoresis-electrospray-time of flight mass spectrometry with different background electrolytes. Electrophoresis (2008) 1.05
Expressed sequence tags from loblolly pine embryos reveal similarities with angiosperm embryogenesis. Plant Mol Biol (2006) 1.05
Identification of a novel essential two-component signal transduction system, YhcSR, in Staphylococcus aureus. J Bacteriol (2005) 1.05
Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways. J Mol Biol (2007) 1.05
Distinct roles of two Mg2+ binding sites in regulation of murine flap endonuclease-1 activities. Biochemistry (2002) 1.03
Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases. Trends Biochem Sci (2011) 1.02
Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair. Mol Cell Biol (2008) 1.02
A novel onco-miR-365 induces cutaneous squamous cell carcinoma. Carcinogenesis (2013) 1.01
Mechanism of dissolution enhancement and bioavailability of poorly water soluble celecoxib by preparing stable amorphous nanoparticles. J Pharm Pharm Sci (2010) 1.00
Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans. DNA Repair (Amst) (2006) 1.00
YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA. RNA (2003) 1.00
Marinobacter nanhaiticus sp. nov., polycyclic aromatic hydrocarbon-degrading bacterium isolated from the sediment of the South China Sea. Antonie Van Leeuwenhoek (2012) 0.99
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell Res (2011) 0.98
Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element. Nucleic Acids Res (2006) 0.98
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One (2009) 0.98
Deinococcus radiodurans PprI switches on DNA damage response and cellular survival networks after radiation damage. Mol Cell Proteomics (2008) 0.98
Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Nucleic Acids Res (2009) 0.98
DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation. Cancer Sci (2009) 0.98
DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. Biochem Biophys Res Commun (2006) 0.98
Search for apoptotic nucleases in yeast: role of Tat-D nuclease in apoptotic DNA degradation. J Biol Chem (2005) 0.97
Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies. J Transl Med (2013) 0.97
Increased neural responses to unfairness in a loss context. Neuroimage (2013) 0.96
Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues. Biochemistry (2005) 0.96
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nat Commun (2012) 0.95
Expression of Deinococcus radiodurans PprI enhances the radioresistance of Escherichia coli. DNA Repair (Amst) (2003) 0.95
Evidence for and characterization of Ca2+ binding to the catalytic region of Arabidopsis thaliana phospholipase Dbeta. J Biol Chem (2004) 0.93
Plasmodium yoelii: distinct CD4(+)CD25(+) regulatory T cell responses during the early stages of infection in susceptible and resistant mice. Exp Parasitol (2006) 0.93
Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance. J Biol Chem (2008) 0.93
Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. Cancer Res (2002) 0.92
Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation. Biochemistry (2003) 0.92
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA Repair (Amst) (2012) 0.92