Published in Mol Cell Biol on December 01, 1991
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochem J (1997) 4.31
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. J Clin Invest (2011) 2.20
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J (1994) 2.04
Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J Clin Invest (2002) 1.93
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol (1996) 1.65
A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1. J Virol (1994) 1.38
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells. Proc Natl Acad Sci U S A (2008) 1.13
Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. Clin Exp Metastasis (2003) 1.07
Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis. Mol Biol Cell (2009) 1.06
Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET. PLoS One (2012) 0.93
Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem (2012) 0.82
Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers. Br J Cancer (2000) 0.81
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A (1979) 72.18
"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem (1981) 71.15
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature (1984) 14.21
A method for isolation of intact, translationally active ribonucleic acid. DNA (1983) 13.67
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science (1991) 8.68
Growth factor receptor tyrosine kinases. Annu Rev Biochem (1988) 8.67
The molecular genetics of cancer. Science (1987) 7.64
A thousand and one protein kinases. Cell (1987) 7.61
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell (1986) 7.06
Molecular cloning and expression of human hepatocyte growth factor. Nature (1989) 6.91
Molecular themes in oncogenesis. Cell (1991) 6.73
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science (1987) 6.36
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (1987) 6.26
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (1986) 5.88
Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85
Mechanism of met oncogene activation. Cell (1986) 4.20
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci U S A (1987) 3.99
Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry (1987) 3.94
Cooperation between oncogenes. Cell (1991) 3.88
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci U S A (1987) 3.64
The human met oncogene is related to the tyrosine kinase oncogenes. Nature (1985) 3.46
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene (1991) 3.41
Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem (1989) 3.33
Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun (1989) 3.21
Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. Biochemistry (1987) 3.20
Tyrosine kinase receptor indistinguishable from the c-met protein. Nature (1989) 3.00
Signal transduction by allosteric receptor oligomerization. Trends Biochem Sci (1988) 2.82
Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res (1989) 2.59
Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. J Biol Chem (1989) 2.59
ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol Cell Biol (1987) 2.48
Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent. J Biol Chem (1988) 2.30
Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues. Proc Natl Acad Sci U S A (1990) 2.15
Using recombinant DNA techniques to study protein targeting in the eucaryotic cell. Annu Rev Cell Biol (1985) 2.07
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J (1984) 1.98
Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene (1989) 1.92
Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype. Cell (1988) 1.91
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol Cell Biol (1991) 1.90
Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J (1989) 1.76
Proteolytic processing and physiological regulation. Trends Biochem Sci (1989) 1.69
Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc Natl Acad Sci U S A (1988) 1.64
Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts. EMBO J (1988) 1.63
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene (1991) 1.58
Epidermal growth factor binding induces a conformational change in the external domain of its receptor. EMBO J (1989) 1.56
C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol Cell Biol (1991) 1.53
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. J Biol Chem (1988) 1.39
Characterization of the mouse met proto-oncogene. Oncogene (1988) 1.31
p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line. Mol Cell Biol (1988) 1.22
Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells. Mol Cell Biol (1986) 1.17
Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Mol Cell Biol (1990) 1.12
Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases. Eur J Biochem (1986) 1.09
The activated human met gene encodes a protein tyrosine kinase. FEBS Lett (1986) 1.03
Structure of the met protein and variation of met protein kinase activity among human tumour cell lines. Br J Cancer (1988) 1.01
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell (1999) 5.07
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol (1992) 5.04
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol (1995) 4.60
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell (1994) 4.10
Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp Cell Res (1985) 3.41
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene (1991) 3.41
Tyrosine kinase receptor indistinguishable from the c-met protein. Nature (1989) 3.00
Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin Cancer Res (1995) 2.84
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature (1998) 2.83
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J (1992) 2.65
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell (2001) 2.62
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol (1997) 2.51
Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene (1991) 2.44
Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell (1998) 2.39
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene (2000) 2.27
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell (1996) 2.14
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J (1996) 2.09
Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J Biol Chem (1995) 2.06
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J (1994) 2.04
Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J (1984) 1.98
Monoclonal antibodies against murine gamma interferon. Proc Natl Acad Sci U S A (1984) 1.95
The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int J Cancer (1991) 1.95
Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene (1989) 1.92
Biphasic metaplastic sarcomatoid carcinoma of the breast. Ann Oncol (2006) 1.91
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol Cell Biol (1991) 1.90
Cell surface molecules and fibronectin-mediated cell adhesion: effect of proteolytic digestion of membrane proteins. J Cell Biol (1982) 1.90
Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol (2000) 1.89
From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage. Curr Med Chem (2008) 1.88
Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin. Exp Cell Res (1985) 1.86
Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene (1994) 1.81
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene (2007) 1.79
Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF. J Cell Sci (1998) 1.75
Overexpression of the RON gene in human breast carcinoma. Oncogene (1998) 1.73
Cross-talk between the proto-oncogenes Met and Ron. Oncogene (2000) 1.71
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem (1991) 1.71
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci U S A (1992) 1.70
The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance. Neuron (2001) 1.68
The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene (1995) 1.66
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol (1996) 1.65
Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J (1997) 1.60
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene (1991) 1.58
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. Oncogene (2006) 1.56
Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene. Proc Natl Acad Sci U S A (1993) 1.56
Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br J Cancer (1993) 1.55
C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol Cell Biol (1991) 1.53
Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J Biol Chem (1993) 1.51
A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion. Immunofluorescence localization in normal and RSV-transformed fibroblasts. Exp Cell Res (1986) 1.48
Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. J Biol Chem (1991) 1.48
Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility. FASEB J (2004) 1.46
Induction of apoptosis of human primary osteoclasts treated with a transcription factor decoy mimicking a promoter region of estrogen receptor alpha. Apoptosis (2005) 1.46
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol Cell Biol (1993) 1.44
Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene (2007) 1.42
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell (1996) 1.42
HGF: a multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol (1999) 1.41
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res (1995) 1.40
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene (1995) 1.38
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro. Proc Natl Acad Sci U S A (1996) 1.37
Overexpression of the Met/HGF receptor in ovarian cancer. Int J Cancer (1994) 1.36
Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer (1996) 1.35
Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene (1997) 1.34
A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation. J Cell Biol (1997) 1.30
Antibacterial activity of pure flavonoids isolated from mosses. Phytochemistry (1999) 1.30
Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells. J Cell Biol (1986) 1.29
Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. J Biol Chem (1994) 1.26
Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas. Oncogene (1996) 1.25
The hyaluronate receptor is identical to a glycoprotein of Mr 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity. J Biol Chem (1987) 1.24
p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line. Mol Cell Biol (1988) 1.22
Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility. J Biol Chem (1996) 1.22
Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J Cell Biol (1994) 1.22
Pathway specificity for Met signalling. Nat Cell Biol (2001) 1.19
Overexpression of the met/HGF receptor in renal cell carcinomas. Int J Cancer (1996) 1.18
Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth. Cancer Res (2001) 1.18
Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells. Mol Cell Biol (1986) 1.17
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene (2000) 1.15
Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cell Mol Biol (Noisy-le-grand) (1994) 1.15
Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J Biol Chem (1994) 1.15
Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene. Cancer Genet Cytogenet (1992) 1.14
Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists. Oncogene (1999) 1.14
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. Proc Natl Acad Sci U S A (1996) 1.14
HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity. FASEB J (2000) 1.13
Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol Cell Biol (1996) 1.13
Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J Cell Biol (1994) 1.12
Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Oncogene (1997) 1.12
Epidemiologic surveillance of visceral leishmaniasis in Sicily, Italy. Am J Trop Med Hyg (1997) 1.11
Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression. Oncogene (2012) 1.11
The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1. J Biol Chem (1996) 1.11
Molecular characteristics of HGF-SF and its role in cell motility and invasion. EXS (1993) 1.10
Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals? IUBMB Life (1999) 1.10
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS). Oncogene (2006) 1.09
Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases. Eur J Biochem (1986) 1.09