Published in Mol Cancer Res on April 01, 2006
Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol Mol Biol Rev (2009) 3.62
What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci U S A (2007) 3.32
Unlocking the sugar "steric gate" of DNA polymerases. Biochemistry (2011) 1.56
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol (2009) 1.54
Advances in understanding the complex mechanisms of DNA interstrand cross-link repair. Cold Spring Harb Perspect Biol (2013) 1.45
Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A (2012) 1.44
Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. Nat Struct Mol Biol (2012) 1.02
Translesion DNA polymerases and cancer. Front Genet (2012) 1.01
Human DNA polymerase eta activity and translocation is regulated by phosphorylation. Proc Natl Acad Sci U S A (2008) 1.00
Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases. Nucleic Acids Res (2011) 0.98
ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. Genes Dev (2013) 0.98
Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells. Proc Natl Acad Sci U S A (2015) 0.98
DNA polymerase eta reduces the gamma-H2AX response to psoralen interstrand crosslinks in human cells. Exp Cell Res (2007) 0.94
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity. Proc Natl Acad Sci U S A (2013) 0.94
Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link. EMBO J (2015) 0.93
Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer. Antioxid Redox Signal (2012) 0.89
DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents. Mol Pharmacol (2012) 0.88
Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J Biol Chem (2015) 0.88
DNA polymerase eta and chemotherapeutic agents. Antioxid Redox Signal (2011) 0.86
3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain. Mar Drugs (2009) 0.85
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin. Nat Commun (2014) 0.83
Translesion DNA synthesis in the context of cancer research. Cancer Cell Int (2011) 0.82
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol (2013) 0.82
Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy. PLoS One (2013) 0.81
Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. Proc Natl Acad Sci U S A (2015) 0.80
Polymerase η suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Res (2014) 0.80
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta. Carcinogenesis (2012) 0.80
Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival. Oncotarget (2016) 0.78
Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy. Mol Cell Oncol (2015) 0.76
Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η. J Biol Chem (2016) 0.76
The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η. Nucleic Acids Res (2016) 0.76
A founder large deletion mutation in Xeroderma pigmentosum-Variant form in Tunisia: implication for molecular diagnosis and therapy. Biomed Res Int (2014) 0.76
The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers. Front Genet (2016) 0.76
RAD18 polymorphisms are associated with platinum-based chemotherapy toxicity in Chinese patients with non-small cell lung cancer. Acta Pharmacol Sin (2016) 0.75
DNA lesion bypass polymerases and 4'-thio-β-Darabinofuranosylcytosine (T-araC). Int J Biochem Mol Biol (2011) 0.75
The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta. Nucleic Acids Res (2015) 0.75
Synthetic nucleotides as probes of DNA polymerase specificity. J Nucleic Acids (2012) 0.75
Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity. Nucleic Acids Res (2017) 0.75
DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia. Biochemistry (2017) 0.75
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell (2005) 3.85
Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition. Mol Cell (2003) 3.66
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J (2003) 2.89
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell (2005) 2.88
H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci U S A (2006) 2.85
Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69
Temporal dissection of tumorigenesis in primary cancers. Cancer Discov (2011) 2.40
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Nature (2004) 2.40
Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin. Mol Cell (2005) 2.32
Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science (2005) 2.31
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. J Exp Med (2003) 2.26
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Cell (2011) 2.16
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Mol Cell (2006) 2.13
Crystal structure of thymine DNA glycosylase conjugated to SUMO-1. Nature (2005) 2.11
Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes. DNA Repair (Amst) (2008) 2.01
Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells (2004) 2.00
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Mol Cell Biol (2004) 1.85
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc Natl Acad Sci U S A (2001) 1.83
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med (2005) 1.80
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks. Proc Natl Acad Sci U S A (2010) 1.77
Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. Biochemistry (2002) 1.71
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Proc Natl Acad Sci U S A (2005) 1.67
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc Natl Acad Sci U S A (2002) 1.63
Rad54 dissociates homologous recombination intermediates by branch migration. Nat Struct Mol Biol (2007) 1.61
DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A (2004) 1.60
Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Mol Cell Biol (2005) 1.58
Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions. J Biol Chem (2004) 1.53
A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst) (2002) 1.53
Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene. Proc Natl Acad Sci U S A (2002) 1.46
Search for a prion-specific nucleic acid. J Virol (2005) 1.44
Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc Natl Acad Sci U S A (2012) 1.44
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J Biol Chem (2007) 1.44
Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J Biol Chem (2002) 1.43
Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B. J Biol Chem (2003) 1.40
Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol Cell (2009) 1.37
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Mol Cell Biol (2006) 1.34
Structure of the human GINS complex and its assembly and functional interface in replication initiation. Nat Struct Mol Biol (2007) 1.33
Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients. J Invest Dermatol (2002) 1.32
Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc Natl Acad Sci U S A (2009) 1.29
Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci U S A (2006) 1.27
The XPC-HR23B complex displays high affinity and specificity for damaged DNA in a true-equilibrium fluorescence assay. Biochemistry (2002) 1.26
Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates. EMBO J (2003) 1.25
Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res (2005) 1.24
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J Biol Chem (2004) 1.23
DNA bending by the human damage recognition complex XPC-HR23B. DNA Repair (Amst) (2003) 1.20
Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. J Biol Chem (2002) 1.20
Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Mol Cell Biol (2002) 1.20
The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH. DNA Repair (Amst) (2002) 1.18
Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin. J Biol Chem (2003) 1.18
Cells have long experience of dealing with UVC light. Nature (2006) 1.17
Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis. Genes Cells (2003) 1.15
Analysis of the role of Aurora B on the chromosomal targeting of condensin I. Nucleic Acids Res (2007) 1.14
Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents. Proc Natl Acad Sci U S A (2011) 1.12
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Nat Struct Mol Biol (2009) 1.12
Xeroderma pigmentosum group C in an isolated region of Guatemala. J Invest Dermatol (2006) 1.11
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. Genes Cells (2008) 1.11
Rescue of Xrcc1 knockout mouse embryo lethality by transgene-complementation. DNA Repair (Amst) (2003) 1.10
Crystal structure of SUMO-3-modified thymine-DNA glycosylase. J Mol Biol (2006) 1.09
Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts. J Biol Chem (2002) 1.09
A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Genes Cells (2006) 1.08
Localization of human Mcm10 is spatially and temporally regulated during the S phase. J Biol Chem (2004) 1.07
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep (2003) 1.06
In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation. Mol Cell Biol (2007) 1.06
Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. PLoS Genet (2010) 1.06
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. EMBO J (2003) 1.05
A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation. Genes Cells (2007) 1.05
UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells. DNA Repair (Amst) (2009) 1.05
A role for DNA polymerase beta in mutagenic UV lesion bypass. J Biol Chem (2002) 1.04
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. DNA Repair (Amst) (2006) 1.03
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota. DNA Repair (Amst) (2003) 1.03
Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex. DNA Repair (Amst) (2004) 1.02
Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. DNA Repair (Amst) (2009) 1.01
The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells. Mol Cell (2010) 1.01
Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro. Biochemistry (2003) 1.01
Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η. Proc Natl Acad Sci U S A (2013) 1.00
Human DNA polymerase eta activity and translocation is regulated by phosphorylation. Proc Natl Acad Sci U S A (2008) 1.00
Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. J Mol Biol (2008) 1.00
Dicer-related drh-3 gene functions in germ-line development by maintenance of chromosomal integrity in Caenorhabditis elegans. Genes Cells (2007) 0.99
DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis. Genes Cells (2004) 0.99
Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development. J Biol Chem (2005) 0.98
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis. Mol Cell (2011) 0.98
A novel zinc finger structure in the large subunit of human general transcription factor TFIIE. J Biol Chem (2004) 0.97
Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha. Mol Cell Biol (2005) 0.97
Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells. FEBS J (2006) 0.96
The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site. J Biol Chem (2012) 0.96
Novel DNA microarray system for analysis of nascent mRNAs. DNA Res (2008) 0.96
Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity. Mutagenesis (2008) 0.96
Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins. J Biol Chem (2010) 0.96
Translesion synthesis past equine estrogen-derived 2'-deoxycytidine DNA adducts by human DNA polymerases eta and kappa. Biochemistry (2004) 0.95
Is head and neck melanoma different from trunk and extremity melanomas with respect to sentinel lymph node status and clinical outcome? Ann Surg Oncol (2013) 0.94
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. Nucleic Acids Res (2004) 0.94
Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks. Cell Cycle (2011) 0.92
Negative regulation of condensin I by CK2-mediated phosphorylation. EMBO J (2006) 0.91
Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides. Nucleic Acids Res (2009) 0.91
Translesion synthesis by human DNA polymerase eta across oxidative products of guanine. Nucleic Acids Symp Ser (Oxf) (2004) 0.90
Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells. J Biol Chem (2003) 0.90
Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex. DNA Repair (Amst) (2005) 0.90
Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts. DNA Repair (Amst) (2005) 0.90
Mutagenic properties of 3-(deoxyguanosin-N2-yl)-2-acetylaminofluorene, a persistent acetylaminofluorene-derived DNA adduct in mammalian cells. Biochemistry (2004) 0.89