Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 3502009)

Published in Nat Struct Mol Biol on May 06, 2012

Authors

Ajay Ummat1, Olga Rechkoblit, Rinku Jain, Jayati Roy Choudhury, Robert E Johnson, Timothy D Silverstein, Angeliki Buku, Samer Lone, Louise Prakash, Satya Prakash, Aneel K Aggarwal

Author Affiliations

1: Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, USA.

Articles citing this

An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η. Biochemistry (2014) 1.23

Translesion DNA synthesis and mutagenesis in eukaryotes. Cold Spring Harb Perspect Biol (2013) 1.09

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η. Proc Natl Acad Sci U S A (2013) 1.00

Biochemical analysis of active site mutations of human polymerase η. Mutat Res (2013) 0.89

Laser microbeam-induced DNA damage inhibits cell division in fertilized eggs and early embryos. Cell Cycle (2013) 0.88

Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis. J Clin Invest (2016) 0.86

Cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase-η. Nucleic Acids Res (2016) 0.83

Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ. Genes Dev (2015) 0.81

Structural basis for the inefficient nucleotide incorporation opposite cisplatin-DNA lesion by human DNA polymerase β. J Biol Chem (2014) 0.80

Comparative Molecular Dynamics Studies of Human DNA Polymerase η. J Chem Inf Model (2015) 0.79

Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNA. Environ Mol Mutagen (2013) 0.79

Relative Binding Free Energies of Adenine and Guanine to Damaged and Undamaged DNA in Human DNA Polymerase η: Clues for Fidelity and Overall Efficiency. J Am Chem Soc (2015) 0.79

The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta. Nucleic Acids Res (2015) 0.75

Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels. Chem Commun (Camb) (2017) 0.75

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity. Nucleic Acids Res (2017) 0.75

Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells. Mutagenesis (2015) 0.75

Translesion synthesis past guanine(C8)-thymine(N3) intrastrand cross-links catalyzed by selected A- and Y-family polymerases. Mol Biosyst (2016) 0.75

Effects of Active Site Mutations on Specificity of Nucleobase Binding in Human DNA Polymerase η. J Phys Chem B (2016) 0.75

Articles cited by this

Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res (2007) 37.31

Likelihood-enhanced fast translation functions. Acta Crystallogr D Biol Crystallogr (2005) 29.38

The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer (2007) 12.38

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature (1999) 10.87

Macromolecular TLS refinement in REFMAC at moderate resolutions. Methods Enzymol (2003) 9.69

Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov (2005) 9.47

Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem (2005) 8.13

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science (1999) 7.20

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Nature (2000) 5.48

The DNA damage response and cancer therapy. Nature (2012) 5.25

Mechanisms of resistance to cisplatin. Mutat Res (2001) 3.51

Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69

Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell (2007) 2.46

Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science (2005) 2.37

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science (2007) 1.94

Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta. Biochemistry (2000) 1.75

Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature (2010) 1.73

A role for polymerase eta in the cellular tolerance to cisplatin-induced damage. Cancer Res (2005) 1.58

NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin. Biochemistry (1998) 1.48

A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents. Mol Cancer Res (2006) 1.36

Yeast and human translesion DNA synthesis polymerases: expression, purification, and biochemical characterization. Methods Enzymol (2006) 1.34

Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res (2009) 1.05

Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro. Biochemistry (2003) 1.01

Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. EMBO J (2010) 0.98

Articles by these authors

Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem (2005) 8.13

The break-even point: when medical advances are less important than improving the fidelity with which they are delivered. Ann Fam Med (2005) 3.84

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature (2003) 3.72

Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature (2004) 3.57

Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression. Mol Cell (2007) 3.51

Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell (2007) 3.34

Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase. Mol Cell (2002) 3.28

Gonorrhea and chlamydia in the United States among persons 14 to 39 years of age, 1999 to 2002. Ann Intern Med (2007) 3.20

Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair. Genes Dev (2002) 3.04

Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science (2010) 2.98

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91

Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae. Mol Cell Biol (2004) 2.49

Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell (2007) 2.46

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta. Nat Struct Mol Biol (2009) 2.44

Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae. Mol Cell Biol (2002) 2.37

Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science (2005) 2.37

Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol Cell Biol (2002) 2.15

Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. Proc Natl Acad Sci U S A (2006) 2.06

The health impact of resolving racial disparities: an analysis of US mortality data. Am J Public Health (2004) 1.98

Population-based genetic and evolutionary analysis of Chlamydia trachomatis urogenital strain variation in the United States. J Bacteriol (2004) 1.94

Risk factors for Plantar fasciitis: a matched case-control study. J Bone Joint Surg Am (2003) 1.92

Giving everyone the health of the educated: an examination of whether social change would save more lives than medical advances. Am J Public Health (2007) 1.90

Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis. Proc Natl Acad Sci U S A (2006) 1.86

Yeast Rev1 protein is a G template-specific DNA polymerase. J Biol Chem (2002) 1.86

Head-to-head multicenter comparison of DNA probe and nucleic acid amplification tests for Chlamydia trachomatis infection in women performed with an improved reference standard. J Clin Microbiol (2002) 1.85

Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair. Structure (2005) 1.80

Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature (2010) 1.73

Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase. Structure (2008) 1.72

Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988-1994. J Infect Dis (2002) 1.72

Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2008) 1.71

The relative importance of patient-reported barriers to colorectal cancer screening. Am J Prev Med (2010) 1.68

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Proc Natl Acad Sci U S A (2008) 1.66

Crystal structure of PU.1/IRF-4/DNA ternary complex. Mol Cell (2002) 1.64

Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol (2004) 1.64

BstYI bound to noncognate DNA reveals a "hemispecific" complex: implications for DNA scanning. Structure (2007) 1.63

Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucleic Acids Res (2002) 1.63

Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells. Proc Natl Acad Sci U S A (2009) 1.62

Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions. Mol Cell Biol (2006) 1.61

Mms2-Ubc13-dependent and -independent roles of Rad5 ubiquitin ligase in postreplication repair and translesion DNA synthesis in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.61

Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini. Proc Natl Acad Sci U S A (2002) 1.59

Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat Struct Mol Biol (2006) 1.58

Crystal structure of the SF3 helicase from adeno-associated virus type 2. Structure (2003) 1.56

Title VII funding and physician practice in rural or low-income areas. J Rural Health (2005) 1.54

Role of human DNA polymerase kappa as an extender in translesion synthesis. Proc Natl Acad Sci U S A (2002) 1.51

Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ. Proc Natl Acad Sci U S A (2012) 1.50

Interactive preventive health record to enhance delivery of recommended care: a randomized trial. Ann Fam Med (2012) 1.49

Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol. Genes Dev (2003) 1.48

Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. Proc Natl Acad Sci U S A (2008) 1.47