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Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase. J Comput Aided Mol Des (2009) 1.30

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase. J Med Chem (2012) 1.14

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. J Med Chem (2011) 1.05

The role of saposin C in Gaucher disease. Mol Genet Metab (2012) 1.02

The biophysical function of pulmonary surfactant. Respir Physiol Neurobiol (2008) 1.01

The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. J Biol Chem (2009) 0.97

Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Hum Mol Genet (2009) 0.97

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators. Eur J Med Chem (2010) 0.94

A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C. Enzyme Res (2011) 0.88

Saposins utilize two strategies for lipid transfer and CD1 antigen presentation. Proc Natl Acad Sci U S A (2012) 0.84

Conformational folding and stability of the HET-C2 glycolipid transfer protein fold: does a molten globule-like state regulate activity? Biochemistry (2011) 0.84

Discovery of a novel noniminosugar acid α glucosidase chaperone series. J Med Chem (2012) 0.76

J-Spectroscopy in the presence of residual dipolar couplings: determination of one-bond coupling constants and scalable resolution. J Biomol NMR (2007) 0.75

Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature (2008) 6.38

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials (2003) 5.34

Activation of integrin function by nanopatterned adhesive interfaces. Chemphyschem (2004) 4.66

Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57

Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD. PLoS Med (2005) 3.12

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature (2010) 2.62

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis. Immunity (2006) 2.61

Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A (2003) 2.56

Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids. Annu Rev Cell Dev Biol (2005) 2.41

The epidermal barrier function is dependent on the serine protease CAP1/Prss8. J Cell Biol (2005) 2.36

[18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates. Bioconjug Chem (2004) 2.20

Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs. J Nucl Med (2004) 2.14

Combinatorial ganglioside biosynthesis. J Biol Chem (2002) 2.06

N-methylation of peptides: a new perspective in medicinal chemistry. Acc Chem Res (2008) 2.02

Sphingolipid metabolism diseases. Biochim Biophys Acta (2006) 2.01

Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man. Clin Cancer Res (2006) 1.96

Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J Biol Chem (2006) 1.94

Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly. Eur J Cell Biol (2005) 1.93

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell (2009) 1.90

Saposin C is required for lipid presentation by human CD1b. Nat Immunol (2004) 1.88

Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med Chem (2010) 1.87

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81

Impact of order and disorder in RGD nanopatterns on cell adhesion. Nano Lett (2009) 1.75

Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation. Chemistry (2003) 1.69

Asymmetric activation of the hsp90 dimer by its cochaperone aha1. Mol Cell (2010) 1.65

A conserved spider silk domain acts as a molecular switch that controls fibre assembly. Nature (2010) 1.65

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem (2005) 1.63

The N-terminal domain of p53 is natively unfolded. J Mol Biol (2003) 1.62

Ligands for mapping alphavbeta3-integrin expression in vivo. Acc Chem Res (2009) 1.60

Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem (2009) 1.58

Impact of local versus global ligand density on cellular adhesion. Nano Lett (2011) 1.58

Lysosomal degradation of membrane lipids. FEBS Lett (2009) 1.50

Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angew Chem Int Ed Engl (2008) 1.48

Carbohydrate-based mimetics in drug design: sugar amino acids and carbohydrate scaffolds. Chem Rev (2002) 1.46

Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation. Biochim Biophys Acta (2008) 1.46

Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage. J Clin Invest (2002) 1.45

Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces. Biomaterials (2007) 1.44

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc Natl Acad Sci U S A (2005) 1.43

Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Lett (2008) 1.43

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept. Proc Natl Acad Sci U S A (2006) 1.41

PET Imaging of Integrin αVβ3 Expression. Theranostics (2011) 1.41

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol (2007) 1.40

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J (2012) 1.36

Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med (2012) 1.35

Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins. J Med Chem (2002) 1.31

HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. J Mol Biol (2009) 1.28

The initial phase of fracture healing is specifically sensitive to mechanical conditions. J Orthop Res (2003) 1.28

PET imaging of CXCR4 receptors in cancer by a new optimized ligand. ChemMedChem (2011) 1.28

Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. Neuro Oncol (2009) 1.27

Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis. J Biol Chem (2006) 1.27

Lysosomal lipid storage diseases. Cold Spring Harb Perspect Biol (2011) 1.26

Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol (2002) 1.25

Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein. Biol Chem (2007) 1.25

Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase. J Biol Chem (2003) 1.24

Hsp90 is regulated by a switch point in the C-terminal domain. EMBO Rep (2009) 1.24

Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics (2002) 1.22

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J Biol Chem (2005) 1.21

Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography. Cardiovasc Res (2008) 1.21

Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. J Am Chem Soc (2010) 1.20

NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol. Chembiochem (2003) 1.20

The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR. Proc Natl Acad Sci U S A (2008) 1.20

Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine. FEBS Lett (2004) 1.19

Cooperativity in adhesion cluster formation during initial cell adhesion. Biophys J (2008) 1.18

Optimized selective N-methylation of peptides on solid support. J Pept Sci (2006) 1.18

The structures of integrins and integrin-ligand complexes: implications for drug design and signal transduction. Angew Chem Int Ed Engl (2002) 1.17

The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease. J Mol Biol (2003) 1.16

Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation. J Neurosci (2011) 1.16

First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography. Clin Cancer Res (2004) 1.15

Tumor Targeting via Integrin Ligands. Front Oncol (2013) 1.15

Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function. Mol Cell (2010) 1.14

PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. J Nucl Med (2011) 1.13

Intrinsic inhibition of the Hsp90 ATPase activity. J Biol Chem (2006) 1.13

BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. J Biol Chem (2009) 1.12

The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides. Mol Pharm (2011) 1.10

Transmembrane signal transduction of the alpha(IIb)beta(3) integrin. Protein Sci (2002) 1.10

Hexosaminidase assays. Glycoconj J (2009) 1.10

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin. J Cell Sci (2010) 1.10

In support of the BMRB. Nat Struct Mol Biol (2012) 1.09

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun (2011) 1.09

p53--a natural cancer killer: structural insights and therapeutic concepts. Angew Chem Int Ed Engl (2006) 1.08

A computational model of transmembrane integrin clustering. Structure (2004) 1.08

Cellular unbinding forces of initial adhesion processes on nanopatterned surfaces probed with magnetic tweezers. Nano Lett (2006) 1.08

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med (2014) 1.08

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum Mol Genet (2008) 1.07

Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). J Med Chem (2014) 1.07

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis. J Org Chem (2005) 1.07

Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense. J Biol Chem (2005) 1.06

The reverse activity of human acid ceramidase. J Biol Chem (2003) 1.06

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nat Struct Mol Biol (2011) 1.05

Cell interactions with hierarchically structured nano-patterned adhesive surfaces. Soft Matter (2009) 1.05

Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions. Structure (2008) 1.04

Synthesis and stereochemical assignment of DNA spore photoproduct analogues. Chemistry (2006) 1.04

Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds. Chemistry (2007) 1.03

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J (2009) 1.03

Photoswitched cell adhesion on surfaces with RGD peptides. J Am Chem Soc (2005) 1.03

N-methylation of peptides and proteins: an important element for modulating biological functions. Angew Chem Int Ed Engl (2012) 1.03