Crystal structures of gamma-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 1458908)

Published in Proc Natl Acad Sci U S A on April 17, 2006

Authors

Toshihiro Okada1, Hideyuki Suzuki, Kei Wada, Hidehiko Kumagai, Keiichi Fukuyama

Author Affiliations

1: Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Articles citing this

Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res (2007) 1.92

The human gamma-glutamyltransferase gene family. Hum Genet (2008) 1.08

Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin. Mol Microbiol (2008) 1.06

A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase. J Biol Chem (2009) 1.03

The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket. Proc Natl Acad Sci U S A (2009) 1.02

Histoplasma capsulatum secreted gamma-glutamyltransferase reduces iron by generating an efficient ferric reductant. Mol Microbiol (2008) 0.98

Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue. J Biol Chem (2010) 0.98

Novel insights into eukaryotic γ-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem (2013) 0.93

Crystal structure of Bacillus anthracis transpeptidase enzyme CapD. J Biol Chem (2009) 0.88

Crystal structure of acivicin-inhibited gamma-glutamyltranspeptidase reveals critical roles for its C-terminus in autoprocessing and catalysis. Biochemistry (2009) 0.88

Gamma-glutamyl transpeptidase: redox regulation and drug resistance. Adv Cancer Res (2014) 0.88

Evidence for conserved function of γ-glutamyltranspeptidase in Helicobacter genus. PLoS One (2012) 0.87

Three-dimensional structure of nylon hydrolase and mechanism of nylon-6 hydrolysis. J Biol Chem (2011) 0.86

Emerging regulatory paradigms in glutathione metabolism. Adv Cancer Res (2014) 0.85

A hydrolytic γ-glutamyl transpeptidase from thermo-acidophilic archaeon Picrophilus torridus: binding pocket mutagenesis and transpeptidation. Extremophiles (2012) 0.82

Divergent effects of compounds on the hydrolysis and transpeptidation reactions of γ-glutamyl transpeptidase. J Enzyme Inhib Med Chem (2011) 0.82

N-acetylglucosamine deacetylases modulate the anchoring of the gamma-glutamyl capsule to the cell wall of Bacillus anthracis. Microb Drug Resist (2014) 0.80

Structure of Bacillus subtilis γ-glutamyltranspeptidase in complex with acivicin: diversity of the binding mode of a classical and electrophilic active-site-directed glutamate analogue. Acta Crystallogr D Biol Crystallogr (2014) 0.80

Gene cloning and protein expression of γ-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: comparison of molecular and structural properties with mesophilic counterparts. Extremophiles (2011) 0.79

Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling. Antioxid Redox Signal (2013) 0.79

Role of the conserved Thr399 and Thr417 residues of Bacillus licheniformis gamma-Glutamyltranspeptidase as evaluated by mutational analysis. Curr Microbiol (2009) 0.79

Human γ-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem (2015) 0.78

Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1. Histochem Cell Biol (2014) 0.76

Unfolding analysis of the mature and unprocessed forms of Bacillus licheniformis γ-glutamyltranspeptidase. J Biol Phys (2011) 0.76

Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway. Acta Crystallogr D Struct Biol (2016) 0.76

Improvement of the glutaryl-7-aminocephalosporanic acid acylase activity of a bacterial gamma-glutamyltranspeptidase. Appl Environ Microbiol (2008) 0.76

"Phylogenetic and evolutionary analysis of functional divergence among Gamma glutamyl transpeptidase (GGT) subfamilies". Biol Direct (2015) 0.76

Garlic γ-glutamyl transpeptidases that catalyze deglutamylation of biosynthetic intermediate of alliin. Front Plant Sci (2015) 0.75

Preclinical Evaluation of a Potential GSH Ester Based PET/SPECT Imaging Probe DT(GSHMe)₂ to Detect Gamma Glutamyl Transferase Over Expressing Tumors. PLoS One (2015) 0.75

Experimental evidence for the involvement of amino acid residue Glu398 in the autocatalytic processing of Bacillus licheniformis γ-glutamyltranspeptidase. FEBS Open Bio (2012) 0.75

Heterogeneous nucleation helps the search for initial crystallization conditions of γ-glutamyl transpeptidase from Bacillus licheniformis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.75

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight. J Biol Chem (2017) 0.75

Articles cited by this

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47

The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88

Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers (1983) 99.69

Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet (1984) 32.58

Automated protein model building combined with iterative structure refinement. Nat Struct Biol (1999) 27.52

ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics (1999) 21.85

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation. Nature (1995) 3.30

Penicillin acylase has a single-amino-acid catalytic centre. Nature (1995) 2.18

gamma-Glutamyl transpeptidase: catalytic, structural and functional aspects. Mol Cell Biochem (1981) 1.98

Essential role of Helicobacter pylori gamma-glutamyltranspeptidase for the colonization of the gastric mucosa of mice. Mol Microbiol (1999) 1.91

gamma-Glutamyltranspeptidase from Escherichia coli K-12: purification and properties. J Bacteriol (1986) 1.71

Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase. Biochemistry (1993) 1.57

Three-dimensional structure of human lysosomal aspartylglucosaminidase. Nat Struct Biol (1995) 1.56

TOPS: an enhanced database of protein structural topology. Nucleic Acids Res (2004) 1.55

Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids. Proc Natl Acad Sci U S A (1982) 1.52

LAFIRE: software for automating the refinement process of protein-structure analysis. Acta Crystallogr D Biol Crystallogr (2006) 1.43

gamma-Glutamyltranspeptidase from Escherichia coli K-12: formation and localization. J Bacteriol (1986) 1.37

DNA sequence of the Escherichia coli K-12 gamma-glutamyltranspeptidase gene, ggt. J Bacteriol (1989) 1.36

Glutathionuria: inborn error of metabolism due to tissue deficiency of gamma-glutamyl transpeptidase. Biochem Biophys Res Commun (1975) 1.35

Escherichia coli K-12 can utilize an exogenous gamma-glutamyl peptide as an amino acid source, for which gamma-glutamyltranspeptidase is essential. J Bacteriol (1993) 1.28

Autocatalytic processing of gamma-glutamyltranspeptidase. J Biol Chem (2002) 1.21

An important role for glutathione and gamma-glutamyltranspeptidase in the supply of growth requirements during nitrogen starvation of the yeast Saccharomyces cerevisiae. Microbiology (1997) 1.17

Glutathionuria: gamma-glutamyl transpeptidase deficiency. J Inherit Metab Dis (1980) 1.10

Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. J Biol Chem (1997) 1.10

Identification of catalytic nucleophile of Escherichia coli gamma-glutamyltranspeptidase by gamma-monofluorophosphono derivative of glutamic acid: N-terminal thr-391 in small subunit is the nucleophile. Biochemistry (2000) 1.07

Molecular cloning of Escherichia coli K-12 ggt and rapid isolation of gamma-glutamyltranspeptidase. Biochem Biophys Res Commun (1988) 1.02

gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression. Adv Enzymol Relat Areas Mol Biol (1998) 1.01

Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis. J Biol Chem (1993) 0.94

Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase. J Biol Chem (1995) 0.94

Effect of site-directed mutations on processing and activity of gamma-glutamyltranspeptidase of Escherichia coli K-12. J Biochem (1995) 0.93

Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit. J Biol Chem (1995) 0.93

Comparison of the size and physical properties of gamma-glutamyltranspeptidase purified from rat kidney following solubilization with papain or with Triton X-100. J Biol Chem (1976) 0.82

Crystallization and preliminary X-ray analysis of gamma-glutamyltranspeptidase from Escherichia coli K-12. J Mol Biol (1993) 0.80

Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase. J Biochem (1996) 0.78

Articles by these authors

MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom (2010) 6.16

Omics-based identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis. Proc Natl Acad Sci U S A (2007) 4.13

Elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics. J Biol Chem (2005) 2.98

12-oxo-phytodienoic acid triggers expression of a distinct set of genes and plays a role in wound-induced gene expression in Arabidopsis. Plant Physiol (2005) 2.72

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT). J Gastroenterol (2011) 2.07

Metabolite annotations based on the integration of mass spectral information. Plant J (2008) 1.97

Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis. Plant J (2005) 1.97

Characterization of the ABA-regulated global responses to dehydration in Arabidopsis by metabolomics. Plant J (2008) 1.91

KaPPA-view: a web-based analysis tool for integration of transcript and metabolite data on plant metabolic pathway maps. Plant Physiol (2005) 1.90

Microbial production of plant benzylisoquinoline alkaloids. Proc Natl Acad Sci U S A (2008) 1.89

Molecular cloning and characterization of Bifidobacterium bifidum 1,2-alpha-L-fucosidase (AfcA), a novel inverting glycosidase (glycoside hydrolase family 95). J Bacteriol (2004) 1.72

Solvent tuning of electrochemical potentials in the active sites of HiPIP versus ferredoxin. Science (2007) 1.63

Metabolic pathways involved in cold acclimation identified by integrated analysis of metabolites and transcripts regulated by DREB1A and DREB2A. Plant Physiol (2009) 1.60

An extracellular aspartic protease functions in Arabidopsis disease resistance signaling. EMBO J (2004) 1.58

Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure. Appl Environ Microbiol (2008) 1.52

Identification and molecular cloning of a novel glycoside hydrolase family of core 1 type O-glycan-specific endo-alpha-N-acetylgalactosaminidase from Bifidobacterium longum. J Biol Chem (2005) 1.51

A bacterial platform for fermentative production of plant alkaloids. Nat Commun (2011) 1.48

The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. Proc Natl Acad Sci U S A (2002) 1.44

A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. J Biol Chem (2004) 1.42

The asymmetric trimeric architecture of [2Fe-2S] IscU: implications for its scaffolding during iron-sulfur cluster biosynthesis. J Mol Biol (2008) 1.40

A shift from colon- to ileum-predominant bacteria in ileal-pouch feces following total proctocolectomy. Dig Dis Sci (2012) 1.40

Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. Eukaryot Cell (2004) 1.40

Interchangeability and distinct properties of bacterial Fe-S cluster assembly systems: functional replacement of the isc and suf operons in Escherichia coli with the nifSU-like operon from Helicobacter pylori. J Biochem (2004) 1.39

Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates. Glycobiology (2009) 1.37

Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria. J Biol Chem (2011) 1.36

CoP: a database for characterizing co-expressed gene modules with biological information in plants. Bioinformatics (2010) 1.32

Characterization of heterotrimeric G protein complexes in rice plasma membrane. Plant J (2004) 1.29

LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. J Biol Chem (2007) 1.21

Autocatalytic processing of gamma-glutamyltranspeptidase. J Biol Chem (2002) 1.21

gamma-Glutamylputrescine synthetase in the putrescine utilization pathway of Escherichia coli K-12. J Biol Chem (2008) 1.20

Novel plant immune-priming compounds identified via high-throughput chemical screening target salicylic acid glucosyltransferases in Arabidopsis. Plant Cell (2012) 1.18

The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette. J Bacteriol (2005) 1.18

Structural and thermodynamic analyses of solute-binding Protein from Bifidobacterium longum specific for core 1 disaccharide and lacto-N-biose I. J Biol Chem (2008) 1.17

Effective production of 3,4-dihydroxyphenyl-L-alanine (L-DOPA) with Erwinia herbicola cells carrying a mutant transcriptional regulator TyrR. J Biotechnol (2005) 1.15

Crystal structure of chondroitin polymerase from Escherichia coli K4. Biochem Biophys Res Commun (2008) 1.13

Autoprocessing of Helicobacter pylori gamma-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad. J Biol Chem (2006) 1.12

Clarification of pathway-specific inhibition by Fourier transform ion cyclotron resonance/mass spectrometry-based metabolic phenotyping studies. Plant Physiol (2006) 1.11

Theory of hybrid dynamical systems and its applications to biological and medical systems. Philos Trans A Math Phys Eng Sci (2010) 1.11

A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germ-line mutations. Cancer Res (2003) 1.10

Role of a PA14 domain in determining substrate specificity of a glycoside hydrolase family 3 β-glucosidase from Kluyveromyces marxianus. Biochem J (2010) 1.09

Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. Plant Cell (2006) 1.07

DNA methylation of colon mucosa in ulcerative colitis patients: correlation with inflammatory status. Inflamm Bowel Dis (2011) 1.06

Construction of thermotolerant yeast expressing thermostable cellulase genes. J Biotechnol (2007) 1.06

Characterizing global evolutions of complex systems via intermediate network representations. Sci Rep (2012) 1.05

Identification of an endo-beta-N-acetylglucosaminidase gene in Caenorhabditis elegans and its expression in Escherichia coli. Glycobiology (2002) 1.05

Bifidobacterium longum subsp. infantis uses two different β-galactosidases for selectively degrading type-1 and type-2 human milk oligosaccharides. Glycobiology (2011) 1.05

Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. Oncol Rep (2006) 1.04

Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12. FEMS Microbiol Lett (2006) 1.04

Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers. Oncogene (2004) 1.04

Crystal structure of the gamma-glutamyltranspeptidase precursor protein from Escherichia coli. Structural changes upon autocatalytic processing and implications for the maturation mechanism. J Biol Chem (2006) 1.04

Identification and characterization of ANAC042, a transcription factor family gene involved in the regulation of camalexin biosynthesis in Arabidopsis. Mol Plant Microbe Interact (2012) 1.02

A putrescine-inducible pathway comprising PuuE-YneI in which gamma-aminobutyrate is degraded into succinate in Escherichia coli K-12. J Bacteriol (2010) 1.01

Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses. J Nippon Med Sch (2012) 1.01

Characterization and crystallization of an IscU-type scaffold protein with bound [2Fe-2S] cluster from the hyperthermophile, aquifex aeolicus. J Biochem (2007) 1.01

Crystal structures of ferrous and CO-, CN(-)-, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1. Biochemistry (2003) 1.00

Identification of the LIV-I/LS system as the third phenylalanine transporter in Escherichia coli K-12. J Bacteriol (2004) 1.00

Cloning and functional expression of thermostable beta-glucosidase gene from Thermoascus aurantiacus. Appl Microbiol Biotechnol (2006) 0.99

The putrescine Importer PuuP of Escherichia coli K-12. J Bacteriol (2009) 0.99

Superluminescent variants of marine luciferases for bioassays. Anal Chem (2011) 0.98

Crystal structure of Escherichia coli SufA involved in biosynthesis of iron-sulfur clusters: implications for a functional dimer. FEBS Lett (2005) 0.98

Enzymatic synthesis of gamma-glutamylvaline to improve the bitter taste of valine. J Agric Food Chem (2004) 0.98

Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms. Biochemistry (2002) 0.98

Improvement of the bitter taste of amino acids through the transpeptidation reaction of bacterial gamma-glutamyltranspeptidase. J Agric Food Chem (2002) 0.97

T tube drainage for spontaneous perforation of the extrahepatic bile duct. Med Sci Monit (2011) 0.97

Pathway engineering of Brassica napus seeds using multiple key enzyme genes involved in ketocarotenoid formation. J Exp Bot (2009) 0.97

Integrated analysis of the effects of cold and dehydration on rice metabolites, phytohormones, and gene transcripts. Plant Physiol (2014) 0.97

Purification, crystallization and preliminary X-ray analysis of the galacto-N-biose-/lacto-N-biose I-binding protein (GL-BP) of the ABC transporter from Bifidobacterium longum JCM1217. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.97

Crystal structure of rat heme oxygenase-1 in complex with heme bound to azide. Implication for regiospecific hydroxylation of heme at the alpha-meso carbon. J Biol Chem (2002) 0.97

Crystal structure of Escherichia coli SufC, an ABC-type ATPase component of the SUF iron-sulfur cluster assembly machinery. FEBS Lett (2005) 0.96

KaPPA-View4: a metabolic pathway database for representation and analysis of correlation networks of gene co-expression and metabolite co-accumulation and omics data. Nucleic Acids Res (2010) 0.96

Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasis. Int J Oncol (2006) 0.96

Safety-information-driven human mobility patterns with metapopulation epidemic dynamics. Sci Rep (2012) 0.95

Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme. Eur J Biochem (2004) 0.95

Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. J Biol Chem (2004) 0.94

Bench-top fermentative production of plant benzylisoquinoline alkaloids using a bacterial platform. Bioeng Bugs (2012) 0.94

Advantages of using thin endoscope-assisted endoscopic submucosal dissection technique for large colorectal tumors. Dig Endosc (2010) 0.93

Crystal structure of phycocyanobilin:ferredoxin oxidoreductase in complex with biliverdin IXalpha, a key enzyme in the biosynthesis of phycocyanobilin. Proc Natl Acad Sci U S A (2005) 0.93

Structural basis for thermostability of endo-1,5-alpha-L-arabinanase from Bacillus thermodenitrificans TS-3. J Biochem (2005) 0.93

Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes. Plant Cell Physiol (2006) 0.93

Amino acid taste receptor regulates insulin secretion in pancreatic β-cell line MIN6 cells. Genes Cells (2011) 0.92

Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists. J Mol Biol (2008) 0.92

1,2-alpha-l-Fucosynthase: a glycosynthase derived from an inverting alpha-glycosidase with an unusual reaction mechanism. FEBS Lett (2008) 0.91

Changes in microbiota population during fermentation of narezushi as revealed by pyrosequencing analysis. Biosci Biotechnol Biochem (2012) 0.91