Published in Nature on April 16, 2006
Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell (2008) 3.73
EMDataBank.org: unified data resource for CryoEM. Nucleic Acids Res (2010) 3.32
Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions. J Struct Biol (2010) 2.48
Cargo transport: molecular motors navigate a complex cytoskeleton. Curr Opin Cell Biol (2008) 2.39
Myosin Va maneuvers through actin intersections and diffuses along microtubules. Proc Natl Acad Sci U S A (2007) 2.14
Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells. J Cell Biol (2007) 2.08
Walking to work: roles for class V myosins as cargo transporters. Nat Rev Mol Cell Biol (2011) 1.93
Myosin V from head to tail. Cell Mol Life Sci (2008) 1.76
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features. Proc Natl Acad Sci U S A (2006) 1.63
Intact flagellar motor of Borrelia burgdorferi revealed by cryo-electron tomography: evidence for stator ring curvature and rotor/C-ring assembly flexion. J Bacteriol (2009) 1.61
How are the cellular functions of myosin VI regulated within the cell? Biochem Biophys Res Commun (2007) 1.58
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule level. Curr Biol (2009) 1.53
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells. J Cell Biol (2007) 1.51
Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Dev Cell (2011) 1.50
Truncated myosin XI tail fusions inhibit peroxisome, Golgi, and mitochondrial movement in tobacco leaf epidermal cells: a genetic tool for the next generation. J Exp Bot (2008) 1.41
Rapid glucose depletion immobilizes active myosin V on stabilized actin cables. Curr Biol (2014) 1.41
The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va. Proc Natl Acad Sci U S A (2008) 1.31
Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography. J Mol Biol (2008) 1.29
Tomographic subvolume alignment and subvolume classification applied to myosin V and SIV envelope spikes. J Struct Biol (2008) 1.24
Load and Pi control flux through the branched kinetic cycle of myosin V. J Biol Chem (2008) 1.24
Electrostatic origin of the unidirectionality of walking myosin V motors. Proc Natl Acad Sci U S A (2013) 1.24
Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography. J Mol Biol (2010) 1.22
Marker-free image registration of electron tomography tilt-series. BMC Bioinformatics (2009) 1.18
The structure of the Myo4p globular tail and its function in ASH1 mRNA localization. J Cell Biol (2010) 1.17
The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery. J Mol Biol (2007) 1.15
Plasmodesmata viewed as specialised membrane adhesion sites. Protoplasma (2010) 1.09
Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function. Dev Cell (2012) 1.08
Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes. Proc Natl Acad Sci U S A (2007) 1.05
Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics. Nat Rev Neurosci (2013) 0.97
Mechanochemical model for myosin V. Proc Natl Acad Sci U S A (2009) 0.97
Electron crystallography of proteins in membranes. Curr Opin Struct Biol (2008) 0.97
Antiparallel coiled-coil-mediated dimerization of myosin X. Proc Natl Acad Sci U S A (2012) 0.96
Identification and characterization of multiple novel Rab-myosin Va interactions. Mol Biol Cell (2013) 0.94
Structural basis of myosin V Rab GTPase-dependent cargo recognition. Proc Natl Acad Sci U S A (2013) 0.91
Calcium-activated Myosin V closes the Drosophila pupil. Curr Biol (2008) 0.90
Structural insights into functional overlapping and differentiation among myosin V motors. J Biol Chem (2013) 0.90
Mechanical design of translocating motor proteins. Cell Biochem Biophys (2009) 0.90
On the freezing and identification of lipid monolayer 2-D arrays for cryoelectron microscopy. J Struct Biol (2007) 0.90
3D visualization of HIV virions by cryoelectron tomography. Methods Enzymol (2010) 0.89
Flexible light-chain and helical structure of F-actin explain the movement and step size of myosin-VI. Biophys J (2006) 0.88
More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va. J Biol Chem (2013) 0.88
Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy. Elife (2015) 0.88
Switching of myosin-V motion between the lever-arm swing and brownian search-and-catch. Nat Commun (2012) 0.87
Motor proteins and molecular motors: how to operate machines at the nanoscale. J Phys Condens Matter (2013) 0.87
7A projection map of the S-layer protein sbpA obtained with trehalose-embedded monolayer crystals. J Struct Biol (2007) 0.86
Lever-arm mechanics of processive myosins. Biophys J (2011) 0.85
Structure and Regulation of the Movement of Human Myosin VIIA. J Biol Chem (2015) 0.85
Full-length myosin Va exhibits altered gating during processive movement on actin. Proc Natl Acad Sci U S A (2012) 0.84
Calcium can mobilize and activate myosin-VI. Proc Natl Acad Sci U S A (2016) 0.84
Extensibility of the extended tail domain of processive and nonprocessive myosin V molecules. Biophys J (2009) 0.84
Force-producing ADP state of myosin bound to actin. Proc Natl Acad Sci U S A (2016) 0.84
Various Themes of Myosin Regulation. J Mol Biol (2016) 0.83
Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis. J Mol Biol (2016) 0.83
Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c. PLoS One (2013) 0.83
Nucleotide-dependent shape changes in the reverse direction motor, myosin VI. Biophys J (2010) 0.83
Structural and functional insights on the Myosin superfamily. Bioinform Biol Insights (2012) 0.83
Head-to-tail regulation is critical for the in vivo function of myosin V. J Cell Biol (2015) 0.83
Slip sliding away with myosin V. Proc Natl Acad Sci U S A (2007) 0.81
Calcium-induced mechanical change in the neck domain alters the activity of plant myosin XI. J Biol Chem (2012) 0.81
Limiting factors in single particle cryo electron tomography. Comput Struct Biotechnol J (2012) 0.81
The SH3 domain of a M7 interacts with its C-terminal proline-rich region. Protein Sci (2006) 0.79
Plant-Specific Myosin XI, a Molecular Perspective. Front Plant Sci (2012) 0.79
Kinetic Adaptations of Myosins for Their Diverse Cellular Functions. Traffic (2016) 0.79
The Globular Tail Domain of Myosin-5a Functions as a Dimer in Regulating the Motor Activity. J Biol Chem (2016) 0.78
Coarse-grained simulation of myosin-V movement. Comput Math Methods Med (2012) 0.78
Strain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor Activity. PLoS Comput Biol (2016) 0.77
Olfactomedin-1 Has a V-shaped Disulfide-linked Tetrameric Structure. J Biol Chem (2015) 0.77
Myosin light chains: Teaching old dogs new tricks. Bioarchitecture (2014) 0.77
Three-dimensional structure of the KdpFABC complex of Escherichia coli by electron tomography of two-dimensional crystals. J Struct Biol (2007) 0.76
Quantum dot labeling strategies to characterize single-molecular motors. Methods Mol Biol (2011) 0.76
The path to visualization of walking myosin V by high-speed atomic force microscopy. Biophys Rev (2014) 0.76
Myosin V is a biological Brownian machine. Biophysics (Nagoya-shi) (2014) 0.75
Detecting stoichiometry of macromolecular complexes in live cells using FRET. Nat Commun (2016) 0.75
Flexural Stiffness of Myosin Va Subdomains as Measured from Tethered Particle Motion. J Biophys (2015) 0.75
Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro. Proc Natl Acad Sci U S A (2017) 0.75
The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss. Open Biol (2014) 0.75
Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. Elife (2016) 0.75
Loss of cargo binding in the human myosin VI deafness mutant (R1166X) leads to increased actin filament binding. Biochem J (2016) 0.75
Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature (2006) 6.78
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc Natl Acad Sci U S A (2003) 3.02
Myosin V processivity: multiple kinetic pathways for head-to-head coordination. Proc Natl Acad Sci U S A (2004) 2.49
Recreation of the terminal events in physiological integrin activation. J Cell Biol (2010) 2.48
Myosin V: regulation by calcium, calmodulin, and the tail domain. J Cell Biol (2004) 2.40
Differential labeling of myosin V heads with quantum dots allows direct visualization of hand-over-hand processivity. Biophys J (2005) 2.31
Accurate marker-free alignment with simultaneous geometry determination and reconstruction of tilt series in electron tomography. Ultramicroscopy (2005) 2.25
Structural organization of the actin cytoskeleton at sites of clathrin-mediated endocytosis. Curr Biol (2011) 2.18
Myosin Va maneuvers through actin intersections and diffuses along microtubules. Proc Natl Acad Sci U S A (2007) 2.14
Tropomyosin is essential for processive movement of a class V myosin from budding yeast. Curr Biol (2012) 1.84
The structural basis of myosin V processive movement as revealed by electron cryomicroscopy. Mol Cell (2005) 1.82
Myosin V and Kinesin act as tethers to enhance each others' processivity. Proc Natl Acad Sci U S A (2008) 1.65
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features. Proc Natl Acad Sci U S A (2006) 1.63
Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states. J Biol Chem (2006) 1.62
Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro. J Mol Cell Cardiol (2009) 1.57
AIDS virus envelope spike structure. Curr Opin Struct Biol (2007) 1.54
Structural comparison of HIV-1 envelope spikes with and without the V1/V2 loop. J Virol (2010) 1.39
Random walk of processive, quantum dot-labeled myosin Va molecules within the actin cortex of COS-7 cells. Biophys J (2009) 1.37
Cryoelectron tomography of HIV-1 envelope spikes: further evidence for tripod-like legs. PLoS Pathog (2008) 1.29
Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography. J Mol Biol (2008) 1.29
A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region. J Mol Biol (2004) 1.29
A mutant heterodimeric myosin with one inactive head generates maximal displacement. J Cell Biol (2003) 1.26
Engineering the processive run length of Myosin V. J Biol Chem (2007) 1.25
Tomographic subvolume alignment and subvolume classification applied to myosin V and SIV envelope spikes. J Struct Biol (2008) 1.24
Load and Pi control flux through the branched kinetic cycle of myosin V. J Biol Chem (2008) 1.24
Adeno-associated virus-2 and its primary cellular receptor--Cryo-EM structure of a heparin complex. Virology (2009) 1.23
Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport. Proc Natl Acad Sci U S A (2011) 1.23
Alpha-cardiac actin mutations produce atrial septal defects. Hum Mol Genet (2007) 1.21
A nonprocessive class V myosin drives cargo processively when a kinesin- related protein is a passenger. Curr Biol (2009) 1.21
The requirement for mechanical coupling between head and S2 domains in smooth muscle myosin ATPase regulation and its implications for dimeric motor function. J Mol Biol (2005) 1.17
Does the myosin V neck region act as a lever? J Muscle Res Cell Motil (2004) 1.16
Mutation of a conserved glycine in the SH1-SH2 helix affects the load-dependent kinetics of myosin. Biophys J (2006) 1.15
She3p binds to the rod of yeast myosin V and prevents it from dimerizing, forming a single-headed motor complex. J Biol Chem (2008) 1.13
Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. PLoS One (2010) 1.13
Effect of calcium on calmodulin bound to the IQ motifs of myosin V. J Biol Chem (2007) 1.10
Structure of AAV-DJ, a retargeted gene therapy vector: cryo-electron microscopy at 4.5 Å resolution. Structure (2012) 1.10
Myosin isoforms show unique conformations in the actin-bound state. Proc Natl Acad Sci U S A (2003) 1.10
Regulation of myosin V processivity by calcium at the single molecule level. J Biol Chem (2006) 1.10
Novel structures for alpha-actinin:F-actin interactions and their implications for actin-membrane attachment and tension sensing in the cytoskeleton. J Mol Biol (2007) 1.09
Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20. Virology (2012) 1.09
Focus gradient correction applied to tilt series image data used in electron tomography. J Struct Biol (2003) 1.09
Common structural motifs for the regulation of divergent class II myosins. J Biol Chem (2010) 1.08
Collective dynamics of elastically coupled myosin V motors. J Biol Chem (2012) 1.06
In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport. Proc Natl Acad Sci U S A (2013) 1.05
Expression of a nonpolymerizable actin mutant in Sf9 cells. Biochemistry (2004) 1.05
Structure of the alpha-actinin-vinculin head domain complex determined by cryo-electron microscopy. J Mol Biol (2006) 1.05
Ca2+ sensitivity of regulated cardiac thin filament sliding does not depend on myosin isoform. J Physiol (2006) 1.04
A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin. J Biol Chem (2013) 1.04
Molecular modeling of averaged rigor crossbridges from tomograms of insect flight muscle. J Struct Biol (2002) 1.04
Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle. Biophys J (2004) 1.04
Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complex. J Cell Biol (2011) 1.03
Functional consequences of a mutation in an expressed human alpha-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy. J Biol Chem (2006) 1.02
Electron tomography of fast frozen, stretched rigor fibers reveals elastic distortions in the myosin crossbridges. J Struct Biol (2004) 1.01
Processivity of chimeric class V myosins. J Biol Chem (2005) 1.01
Single-molecule reconstitution of mRNA transport by a class V myosin. Nat Struct Mol Biol (2013) 1.01
Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc Natl Acad Sci U S A (2010) 1.00
Methods for identifying and averaging variable molecular conformations in tomograms of actively contracting insect flight muscle. J Struct Biol (2009) 0.99
Electron tomography of swollen rigor fibers of insect flight muscle reveals a short and variably angled S2 domain. J Mol Biol (2006) 0.98
Identification of the beta1-integrin binding site on alpha-actinin by cryoelectron microscopy. J Struct Biol (2005) 0.97
Smooth muscle heavy meromyosin phosphorylated on one of its two heads supports force and motion. J Biol Chem (2009) 0.97
Addition of lysines to the 50/20 kDa junction of myosin strengthens weak binding to actin without affecting the maximum ATPase activity. Biochemistry (2003) 0.97
Phosphorylation of a single head of smooth muscle myosin activates the whole molecule. Biochemistry (2006) 0.97
Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy. J Struct Biol (2007) 0.96
The carboxyl-terminal isoforms of smooth muscle myosin heavy chain determine thick filament assembly properties. J Cell Biol (2002) 0.96
Fission yeast tropomyosin specifies directed transport of myosin-V along actin cables. Mol Biol Cell (2013) 0.96
Diffusive movement of processive kinesin-1 on microtubules. Traffic (2009) 0.95
Crystal structures of monomeric actin bound to cytochalasin D. J Mol Biol (2008) 0.95
The 3D structure of villin as an unusual F-Actin crosslinker. Structure (2008) 0.92
Simultaneous observation of tail and head movements of myosin V during processive motion. J Biol Chem (2010) 0.91
The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface. PLoS One (2007) 0.90
On the freezing and identification of lipid monolayer 2-D arrays for cryoelectron microscopy. J Struct Biol (2007) 0.90
Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation. J Mol Biol (2011) 0.89
Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences. J Biol Chem (2013) 0.89
Two-dimensional crystallization of herpes simplex virus type 1 single-stranded DNA-binding protein, ICP8, on a lipid monolayer. Biochim Biophys Acta (2004) 0.88
More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va. J Biol Chem (2013) 0.88
Essential features of the class V myosin from budding yeast for ASH1 mRNA transport. Mol Biol Cell (2009) 0.86
Motor domain phosphorylation modulates kinesin-1 transport. J Biol Chem (2013) 0.85
Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection. Traffic (2012) 0.85
Delineating cooperative responses of processive motors in living cells. Proc Natl Acad Sci U S A (2014) 0.85
Full-length myosin Va exhibits altered gating during processive movement on actin. Proc Natl Acad Sci U S A (2012) 0.84
Structural changes in isometrically contracting insect flight muscle trapped following a mechanical perturbation. PLoS One (2012) 0.83