Published in J Biol Chem on March 25, 2010
In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament. Circ Res (2011) 1.81
Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor. Circ Res (2012) 1.69
Signaling to myosin regulatory light chain in sarcomeres. J Biol Chem (2011) 1.33
Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle. Arch Biochem Biophys (2011) 1.16
A molecular model of phosphorylation-based activation and potentiation of tarantula muscle thick filaments. J Mol Biol (2011) 1.00
Signaling through myosin light chain kinase in smooth muscles. J Biol Chem (2013) 0.98
Coiled-coil response to mechanical force: global stability and local cracking. Biophys J (2013) 0.98
Proteomic analysis of the enterocyte brush border. Am J Physiol Gastrointest Liver Physiol (2011) 0.98
Visualizing key hinges and a potential major source of compliance in the lever arm of myosin. Proc Natl Acad Sci U S A (2010) 0.96
Characterizations of myosin essential light chain's N-terminal truncation mutant Δ43 in transgenic mouse papillary muscles by using tension transients in response to sinusoidal length alterations. J Muscle Res Cell Motil (2013) 0.89
Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a. J Biol Chem (2012) 0.88
Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. J Biol Chem (2014) 0.87
Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58Q. J Mol Cell Cardiol (2013) 0.86
Modification of interface between regulatory and essential light chains hampers phosphorylation-dependent activation of smooth muscle myosin. J Biol Chem (2012) 0.85
Regulation of the actin-activated MgATPase activity of Acanthamoeba myosin II by phosphorylation of serine 639 in motor domain loop 2. Proc Natl Acad Sci U S A (2012) 0.82
Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle. J Physiol (2014) 0.80
Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections. Arterioscler Thromb Vasc Biol (2016) 0.78
Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis. PLoS One (2013) 0.76
Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle. Physiol Rep (2015) 0.76
Force transmission in epithelial tissues. Dev Dyn (2016) 0.75
A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila. J Mol Biol (2016) 0.75
Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington's Disease. PLoS One (2016) 0.75
Physiological versus pharmacological signalling to myosin phosphorylation in airway smooth muscle. J Physiol (2017) 0.75
Multiscale and Multiaxial Mechanics of Vascular Smooth Muscle. Biophys J (2017) 0.75
Three-dimensional structure of myosin subfragment-1: a molecular motor. Science (1993) 14.90
Structure of the actin-myosin complex and its implications for muscle contraction. Science (1993) 11.30
A robust algorithm for the reconstruction of helical filaments using single-particle methods. Ultramicroscopy (2000) 5.01
Regulation and kinetics of the actin-myosin-ATP interaction. Annu Rev Biochem (1980) 4.57
Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2. Proc Natl Acad Sci U S A (2001) 2.93
Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function. Am J Physiol (1993) 2.81
Phosphorylation of platelet myosin increases actin-activated myosin ATPase activity. Nature (1975) 2.79
Structure of the regulatory domain of scallop myosin at 2.8 A resolution. Nature (1994) 2.78
Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin molecules. Nature (1983) 2.73
A bent monomeric conformation of myosin from smooth muscle. Proc Natl Acad Sci U S A (1982) 2.51
Atomic model of a myosin filament in the relaxed state. Nature (2005) 2.49
Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation. Structure (1996) 2.45
Three-dimensional structure of vertebrate cardiac muscle myosin filaments. Proc Natl Acad Sci U S A (2008) 2.39
Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart. Circ Res (2006) 2.36
Conformational states of smooth muscle myosin. Effects of light chain phosphorylation and ionic strength. J Biol Chem (1984) 2.29
Spare the rod, spoil the regulation: necessity for a myosin rod. Proc Natl Acad Sci U S A (1997) 1.94
Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filaments. Biophys J (1996) 1.75
Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells. Mol Biol Cell (2008) 1.70
Electron microscopic studies of myosin molecules from chicken gizzard muscle I: the formation of the intramolecular loop in the myosin tail. J Biochem (1982) 1.58
Two heads are required for phosphorylation-dependent regulation of smooth muscle myosin. J Biol Chem (1995) 1.52
Structures of smooth muscle myosin and heavy meromyosin in the folded, shutdown state. J Mol Biol (2007) 1.48
Visualization of an unstable coiled coil from the scallop myosin rod. Nature (2003) 1.45
Refined model of the 10S conformation of smooth muscle myosin by cryo-electron microscopy 3D image reconstruction. J Mol Biol (2003) 1.41
Regulation of expressed truncated smooth muscle myosins. Role of the essential light chain and tail length. J Biol Chem (1994) 1.35
Arrangement of the heads of myosin in relaxed thick filaments from tarantula muscle. J Mol Biol (1985) 1.33
Visualization of head-head interactions in the inhibited state of smooth muscle myosin. J Cell Biol (1999) 1.31
ATP-linked monomer-polymer equilibrium of smooth muscle myosin: the free folded monomer traps ADP.Pi. EMBO J (1986) 1.29
Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution. Proc Natl Acad Sci U S A (2008) 1.28
Molecular dynamics simulations reveal a disorder-to-order transition on phosphorylation of smooth muscle myosin. Biophys J (2007) 1.27
Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment. Proc Natl Acad Sci U S A (2006) 1.26
Myosin filament assembly in an ever-changing myofilament lattice of smooth muscle. Am J Physiol Cell Physiol (2005) 1.25
Active site trapping of nucleotide by smooth and non-muscle myosins. J Mol Biol (1988) 1.25
Site-directed spin labeling reveals a conformational switch in the phosphorylation domain of smooth muscle myosin. Proc Natl Acad Sci U S A (2005) 1.20
Function of the NH2-terminal domain of the regulatory light chain on the regulation of smooth muscle myosin. J Biol Chem (1994) 1.19
The requirement for mechanical coupling between head and S2 domains in smooth muscle myosin ATPase regulation and its implications for dimeric motor function. J Mol Biol (2005) 1.17
Head-head interaction characterizes the relaxed state of Limulus muscle myosin filaments. J Mol Biol (2008) 1.16
Myosin filament 3D structure in mammalian cardiac muscle. J Struct Biol (2008) 1.03
Structure and function of the 10 S conformation of smooth muscle myosin. J Biol Chem (1996) 1.00
The 7-stranded structure of relaxed scallop muscle myosin filaments: support for a common head configuration in myosin-regulated muscles. J Struct Biol (2009) 0.99
Structural model of the regulatory domain of smooth muscle heavy meromyosin. J Biol Chem (2002) 0.97
Myosin subunit interactions. Properties of the 19,000-dalton light chain-deficient myosin. J Biol Chem (1986) 0.95
Coiled-coil unwinding at the smooth muscle myosin head-rod junction is required for optimal mechanical performance. Biophys J (2001) 0.90
Role of skeletal and smooth muscle myosin light chains. Biophys J (1995) 0.84
Myosin V processivity: multiple kinetic pathways for head-to-head coordination. Proc Natl Acad Sci U S A (2004) 2.49
Myosin V: regulation by calcium, calmodulin, and the tail domain. J Cell Biol (2004) 2.40
Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography. Nature (2006) 2.39
Differential labeling of myosin V heads with quantum dots allows direct visualization of hand-over-hand processivity. Biophys J (2005) 2.31
Myosin Va maneuvers through actin intersections and diffuses along microtubules. Proc Natl Acad Sci U S A (2007) 2.14
Tropomyosin is essential for processive movement of a class V myosin from budding yeast. Curr Biol (2012) 1.84
The structural basis of myosin V processive movement as revealed by electron cryomicroscopy. Mol Cell (2005) 1.82
Myosin V and Kinesin act as tethers to enhance each others' processivity. Proc Natl Acad Sci U S A (2008) 1.65
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features. Proc Natl Acad Sci U S A (2006) 1.63
Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states. J Biol Chem (2006) 1.62
Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro. J Mol Cell Cardiol (2009) 1.57
Random walk of processive, quantum dot-labeled myosin Va molecules within the actin cortex of COS-7 cells. Biophys J (2009) 1.37
A mutant heterodimeric myosin with one inactive head generates maximal displacement. J Cell Biol (2003) 1.26
Engineering the processive run length of Myosin V. J Biol Chem (2007) 1.25
Load and Pi control flux through the branched kinetic cycle of myosin V. J Biol Chem (2008) 1.24
Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport. Proc Natl Acad Sci U S A (2011) 1.23
A nonprocessive class V myosin drives cargo processively when a kinesin- related protein is a passenger. Curr Biol (2009) 1.21
Alpha-cardiac actin mutations produce atrial septal defects. Hum Mol Genet (2007) 1.21
Does the myosin V neck region act as a lever? J Muscle Res Cell Motil (2004) 1.16
Mutation of a conserved glycine in the SH1-SH2 helix affects the load-dependent kinetics of myosin. Biophys J (2006) 1.15
She3p binds to the rod of yeast myosin V and prevents it from dimerizing, forming a single-headed motor complex. J Biol Chem (2008) 1.13
Regulation of myosin V processivity by calcium at the single molecule level. J Biol Chem (2006) 1.10
Myosin isoforms show unique conformations in the actin-bound state. Proc Natl Acad Sci U S A (2003) 1.10
Collective dynamics of elastically coupled myosin V motors. J Biol Chem (2012) 1.06
In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport. Proc Natl Acad Sci U S A (2013) 1.05
Expression of a nonpolymerizable actin mutant in Sf9 cells. Biochemistry (2004) 1.05
A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin. J Biol Chem (2013) 1.04
Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complex. J Cell Biol (2011) 1.03
Functional consequences of a mutation in an expressed human alpha-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy. J Biol Chem (2006) 1.02
Processivity of chimeric class V myosins. J Biol Chem (2005) 1.01
Single-molecule reconstitution of mRNA transport by a class V myosin. Nat Struct Mol Biol (2013) 1.01
Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc Natl Acad Sci U S A (2010) 1.00
Phosphorylation of a single head of smooth muscle myosin activates the whole molecule. Biochemistry (2006) 0.97
Smooth muscle heavy meromyosin phosphorylated on one of its two heads supports force and motion. J Biol Chem (2009) 0.97
Addition of lysines to the 50/20 kDa junction of myosin strengthens weak binding to actin without affecting the maximum ATPase activity. Biochemistry (2003) 0.97
Fission yeast tropomyosin specifies directed transport of myosin-V along actin cables. Mol Biol Cell (2013) 0.96
The carboxyl-terminal isoforms of smooth muscle myosin heavy chain determine thick filament assembly properties. J Cell Biol (2002) 0.96
Crystal structures of monomeric actin bound to cytochalasin D. J Mol Biol (2008) 0.95
Diffusive movement of processive kinesin-1 on microtubules. Traffic (2009) 0.95
Simultaneous observation of tail and head movements of myosin V during processive motion. J Biol Chem (2010) 0.91
The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface. PLoS One (2007) 0.90
Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation. J Mol Biol (2011) 0.89
Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences. J Biol Chem (2013) 0.89
More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va. J Biol Chem (2013) 0.88
Essential features of the class V myosin from budding yeast for ASH1 mRNA transport. Mol Biol Cell (2009) 0.86
Motor domain phosphorylation modulates kinesin-1 transport. J Biol Chem (2013) 0.85
Delineating cooperative responses of processive motors in living cells. Proc Natl Acad Sci U S A (2014) 0.85
Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection. Traffic (2012) 0.85
Full-length myosin Va exhibits altered gating during processive movement on actin. Proc Natl Acad Sci U S A (2012) 0.84
The two heads of smooth muscle myosin are enzymatically independent but mechanically interactive. J Biol Chem (2003) 0.82
Functional effects of nemaline myopathy mutations on human skeletal alpha-actin. J Biol Chem (2008) 0.81
No strain, no gain. Nat Cell Biol (2005) 0.80
Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly. Proc Natl Acad Sci U S A (2011) 0.80
A single molecule approach to mRNA transport by a class V myosin. RNA Biol (2014) 0.77