Published in J Cell Biol on April 24, 2006
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol (2014) 4.28
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis (2010) 2.69
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal (2010) 2.27
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration. Nature (2012) 1.98
Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol (2011) 1.50
APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability. Am J Physiol Renal Physiol (2014) 1.23
Genetic control of necrosis - another type of programmed cell death. Curr Opin Cell Biol (2010) 1.16
Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. PLoS One (2009) 1.14
GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death. J Cell Sci (2010) 1.12
Autophagy protects against hypoxic injury in C. elegans. Autophagy (2008) 1.07
Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat. Cell Mol Neurobiol (2009) 0.94
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol (2011) 0.93
Cell-specific monitoring of protein synthesis in vivo. PLoS One (2009) 0.92
A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. Elife (2013) 0.91
Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94. Biotechnol J (2007) 0.89
Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J (2011) 0.86
Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget (2016) 0.83
Vacuolar H+-ATPase (V-ATPase) promotes vacuolar membrane permeabilization and nonapoptotic death in stressed yeast. J Biol Chem (2012) 0.83
Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages. Respir Res (2010) 0.81
Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1). PLoS Pathog (2016) 0.81
Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells. J Exp Clin Cancer Res (2015) 0.80
Aging and cell death in the other yeasts, Schizosaccharomyces pombe and Candida albicans. FEMS Yeast Res (2013) 0.80
Protease signaling in animal and plant-regulated cell death. FEBS J (2015) 0.78
Target of rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death. Epigenetics Chromatin (2013) 0.78
Development of high content imaging methods for cell death detection in human pluripotent stem cell-derived cardiomyocytes. J Cardiovasc Transl Res (2012) 0.77
Necrosis in C. elegans. Methods Mol Biol (2013) 0.77
Necrotic cell death and neurodegeneration: The involvement of endocytosis and intracellular trafficking. Worm (2012) 0.76
Noncanonical cell death in the nematode Caenorhabditis elegans. Methods Enzymol (2014) 0.76
Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans. Sci Rep (2017) 0.75
Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3'-oxime (7BIO). Cancer Cell Int (2015) 0.75
Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans. Nanotoxicology (2015) 0.75
C. elegans midbodies are released, phagocytosed and undergo LC3-dependent degradation independent of macroautophagy. J Cell Sci (2016) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
The calpain system. Physiol Rev (2003) 9.95
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol (2000) 9.01
Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J Cell Biol (1997) 6.57
Lysosomes and autophagy in cell death control. Nat Rev Cancer (2005) 5.47
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans. Gene (1990) 5.27
Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane. J Biol Chem (1989) 5.15
Organelle-specific initiation of cell death pathways. Nat Cell Biol (2001) 5.03
At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol (2003) 3.26
Calreticulin: one protein, one gene, many functions. Biochem J (1999) 3.16
Calcium signaling: a tale for all seasons. Proc Natl Acad Sci U S A (2002) 2.92
The changing landscape of ischaemic brain injury mechanisms. Nature (1999) 2.91
Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science (2002) 2.71
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans. Mol Biol Cell (2005) 2.44
Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum Mol Genet (2004) 2.33
Patterns of cell death. Methods Achiev Exp Pathol (1988) 2.30
Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis. Proc Natl Acad Sci U S A (2004) 2.28
Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog. Nat Genet (2001) 2.23
Lysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein. J Cell Biol (1986) 2.18
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature (2002) 1.97
Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci (2000) 1.91
Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron (2001) 1.90
Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med (Berl) (2000) 1.63
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types. Proc Natl Acad Sci U S A (2002) 1.62
Neuropathology of degenerative cell death in Caenorhabditis elegans. J Neurosci (1997) 1.48
Processing and activation of lysosomal proteinases. Biol Chem (2002) 1.44
Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol (2000) 1.43
Neuronal cell death in nervous system development, disease, and injury (Review). Int J Mol Med (2001) 1.32
The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol (2005) 1.31
Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell Calcium (2004) 1.30
The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit. J Biol Chem (2000) 1.30
Neuronal cell death: a demise with different shapes. Trends Pharmacol Sci (1999) 1.28
The NHX family of Na+-H+ exchangers in Caenorhabditis elegans. J Biol Chem (2002) 1.27
Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states. Cell Calcium (2001) 1.24
Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans. J Cell Sci (2000) 1.21
Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur J Neurosci (1998) 1.19
Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus (2003) 1.15
Homotypic fusion between aggregated lysosomes triggered by elevated [Ca2+]i in fibroblasts. J Cell Sci (1997) 1.14
Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep (2002) 1.14
The biochemistry of neuronal necrosis: rogue biology? Nat Rev Neurosci (2003) 1.13
Calcium, free radicals and excitotoxins in neuronal apoptosis. Cell Calcium (1998) 1.08
Proteolytic mechanisms in necrotic cell death and neurodegeneration. FEBS Lett (2005) 1.06
Murine cell surface glycoproteins. Identification, purification, and characterization of a major glycosylated component of 110,000 daltons by use of a monoclonal antibody. J Biol Chem (1982) 1.05
Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans. J Biol Chem (2000) 1.00
The ABC transporter PGP-2 from Caenorhabditis elegans is expressed in the sensory neuron pair AWA and contributes to lysosome formation and lipid storage within the intestine. Biochem Biophys Res Commun (2005) 0.94
The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death. Cell (2003) 0.93
Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition. Acta Neuropathol (2002) 0.86
Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans. Genetics (1988) 0.85
Protection of ischemic rat heart by dantrolene, an antagonist of the sarcoplasmic reticulum calcium release channel. Basic Res Cardiol (2000) 0.85
Lysosome destabilization by cytosolic extracts, putative involvement of Ca(2+)/phospholipase C. FEBS Lett (2005) 0.82
Calreticulin comes of age. Trends Cell Biol (2000) 0.79
Excitotoxic neuron death, acidotic endangerment, and the paradox of acidotic protection. Adv Neurol (1996) 0.78
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
The Genomes On Line Database (GOLD) in 2007: status of genomic and metagenomic projects and their associated metadata. Nucleic Acids Res (2007) 11.24
The Genomes On Line Database (GOLD) in 2009: status of genomic and metagenomic projects and their associated metadata. Nucleic Acids Res (2009) 9.98
The Genomes On Line Database (GOLD) v.2: a monitor of genome projects worldwide. Nucleic Acids Res (2006) 6.79
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature (2007) 3.07
Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta (2013) 2.61
Can autophagy promote longevity? Nat Cell Biol (2010) 2.55
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23
Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol (2007) 2.11
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration. Nature (2012) 1.98
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature (2002) 1.97
A dual role of p53 in the control of autophagy. Autophagy (2008) 1.88
Caenorhabditis elegans: a versatile platform for drug discovery. Biotechnol J (2006) 1.72
Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J (2011) 1.66
Genetic models of mechanotransduction: the nematode Caenorhabditis elegans. Physiol Rev (2004) 1.66
Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature (2009) 1.62
Prohibitin and mitochondrial biology. Trends Endocrinol Metab (2009) 1.54
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging (Albany NY) (2009) 1.48
The NemaGENETAG initiative: large scale transposon insertion gene-tagging in Caenorhabditis elegans. Genetica (2009) 1.42
The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol (2005) 1.31
Nemo: a computational tool for analyzing nematode locomotion. BMC Neurosci (2007) 1.31
Necrosis in yeast. Apoptosis (2010) 1.21
Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol (2013) 1.18
A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling. EMBO J (2008) 1.15
Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep (2002) 1.14
The biochemistry of neuronal necrosis: rogue biology? Nat Rev Neurosci (2003) 1.13
Modeling human diseases in Caenorhabditis elegans. Biotechnol J (2010) 1.11
Proteolytic mechanisms in necrotic cell death and neurodegeneration. FEBS Lett (2005) 1.06
The life span-prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy (2010) 1.05
Spermidine protects against α-synuclein neurotoxicity. Cell Cycle (2014) 1.02
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J (2013) 1.02
Transgenesis in Caenorhabditis elegans. Methods Mol Biol (2009) 0.97
Microscopic optical projection tomography in vivo. PLoS One (2011) 0.97
Protein synthesis is a novel determinant of aging in Caenorhabditis elegans. Ann N Y Acad Sci (2007) 0.97
The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Aging Cell (2013) 0.96
Correction for specimen movement and rotation errors for in-vivo Optical Projection Tomography. Biomed Opt Express (2010) 0.95
Mitophagy in neurodegeneration and aging. Front Genet (2012) 0.95
Mechanisms of aging and energy metabolism in Caenorhabditis elegans. IUBMB Life (2008) 0.95
SUMOylation and cell signalling. Biotechnol J (2009) 0.94
Cell-specific monitoring of protein synthesis in vivo. PLoS One (2009) 0.92
Induction of RNA interference in Caenorhabditis elegans by RNAs derived from plants exhibiting post-transcriptional gene silencing. Nucleic Acids Res (2002) 0.92
KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro. J Cell Physiol (2011) 0.91
Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol (2012) 0.90
Spermidine promotes mating and fertilization efficiency in model organisms. Cell Cycle (2012) 0.89
Autophagy and ageing: insights from invertebrate model organisms. Ageing Res Rev (2012) 0.88
The role of synaptic ion channels in synaptic plasticity. EMBO Rep (2006) 0.87
Opposing function of mitochondrial prohibitin in aging. Aging (Albany NY) (2010) 0.87
Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J (2011) 0.86
Non-developmentally programmed cell death in Caenorhabditis elegans. Semin Cancer Biol (2006) 0.86
Calcium homeostasis in aging neurons. Front Genet (2012) 0.86
Downregulation of lung mitochondrial prohibitin in COPD. Respir Med (2012) 0.86
Coupling mitogenesis and mitophagy for longevity. Autophagy (2015) 0.84
Non-apoptotic cell death in Caenorhabditis elegans. Dev Dyn (2010) 0.84
Oxidative stress and mitochondrial protein quality control in aging. J Proteomics (2013) 0.83
Signaling pathways regulating protein synthesis during ageing. Exp Gerontol (2006) 0.83
Longevity-relevant regulation of autophagy at the level of the acetylproteome. Autophagy (2011) 0.83
Automated motion correction for in vivo optical projection tomography. IEEE Trans Med Imaging (2012) 0.82
Metabolic control by target of rapamycin and autophagy during ageing - a mini-review. Gerontology (2013) 0.82
Autophagy and cell death in Caenorhabditis elegans. Curr Pharm Des (2008) 0.82
Novel inducers of BECN1-independent autophagy: cis-unsaturated fatty acids. Autophagy (2015) 0.82
High-throughput in vivo genetic and drug screening using femtosecond laser nano-surgery, and microfluidics. Conf Proc IEEE Eng Med Biol Soc (2008) 0.82
The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Cell Mol Life Sci (2013) 0.81
GPA-14, a Gα(i) subunit mediates dopaminergic behavioral plasticity in C. elegans. Behav Brain Funct (2013) 0.81
Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans. Ageing Res Rev (2003) 0.80
Molecular modeling of mechanosensory ion channel structural and functional features. PLoS One (2010) 0.80
Effects of Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici on the nematode Caenorhabditis elegans include possible antitumor activity. Appl Microbiol Biotechnol (2012) 0.80
Roles for SUMO modification during senescence. Adv Exp Med Biol (2010) 0.79
Embryonic and induced pluripotent stem cell differentiation as a tool in neurobiology. Biotechnol J (2012) 0.79
The role of autophagy in genetic pathways influencing ageing. Biogerontology (2011) 0.78
Cell tracking in live Caenorhabditis elegans embryos via third harmonic generation imaging microscopy measurements. J Biomed Opt (2011) 0.77
High-throughput and longitudinal analysis of aging and senescent decline in Caenorhabditis elegans. Methods Mol Biol (2013) 0.77
The second international conference "genetics of aging and longevity". Aging (Albany NY) (2012) 0.77
First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Biol Chem (2006) 0.77
Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration. Conf Proc IEEE Eng Med Biol Soc (2009) 0.77
Imaging of Caenorhabditis elegans neurons by second-harmonic generation and two-photon excitation fluorescence. J Biomed Opt (2005) 0.77
Neurodegenerative conditions associated with ageing: a molecular interplay? Mech Ageing Dev (2005) 0.77
Heat shock response and ionstasis: axis against neurodegeneration. Aging (Albany NY) (2012) 0.77
The contactin RIG-6 mediates neuronal and non-neuronal cell migration in Caenorhabditis elegans. Dev Biol (2012) 0.77
Stress responses during ageing: molecular pathways regulating protein homeostasis. Methods Mol Biol (2015) 0.76
Protein metabolism and homeostasis in aging. Preface. Adv Exp Med Biol (2010) 0.76
Necrotic cell death and neurodegeneration: The involvement of endocytosis and intracellular trafficking. Worm (2012) 0.76
GCN2 and TOR converge on aging. Aging (Albany NY) (2013) 0.76
Assessing aging and senescent decline in Caenorhabditis elegans: cohort survival analysis. Methods Mol Biol (2013) 0.76
Mitochondrial biogenesis and dynamics in neurodegeneration: a causative relationship. Neurochem Res (2013) 0.76
Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception. Nat Genet (2015) 0.75
Autophagy in Caenorhabditis elegans. Biochim Biophys Acta (2008) 0.75
Editorial: diseases of the brain--neuronal function and dysfunction. Biotechnol J (2007) 0.75
Identification of the M541L sequence variation of the transmembrane KIT domain in Merkel cell carcinoma. Anticancer Res (2011) 0.75
Response of Caenorhabditis elegans to wireless devices radiation exposure. Int J Radiat Biol (2015) 0.75
Editorial: brain matters. Biotechnol J (2008) 0.75