Mitophagy in neurodegeneration and aging.

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. EMBO Rep (2015) 1.20

Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders. Am J Neurodegener Dis (2013) 1.08

Receptor-mediated mitophagy in yeast and mammalian systems. Cell Res (2014) 1.07

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy (2014) 0.92

Parkinson's disease as a result of aging. Aging Cell (2015) 0.92

Neuronal inputs and outputs of aging and longevity. Front Genet (2013) 0.90

The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms. Biomed Res Int (2014) 0.84

Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease. Cell Biochem Biophys (2014) 0.82

LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. Free Radic Res (2015) 0.82

The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging. Front Neuroanat (2014) 0.80

Mitophagy in neurodegeneration and aging. Neurochem Int (2017) 0.78

The regulation of autophagy during exercise in skeletal muscle. J Appl Physiol (1985) (2015) 0.77

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. J Neurosci (2016) 0.76

From theories of aging to anti-aging interventions. Front Genet (2014) 0.75

Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND. Brain Sci (2017) 0.75

Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy. Aging Cell (2017) 0.75

PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation. Autophagy (2017) 0.75

Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD. Int J Biochem Cell Biol (2016) 0.75

PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila. Cell Death Dis (2016) 0.75

A multimethod computational simulation approach for investigating mitochondrial dynamics and dysfunction in degenerative aging. Aging Cell (2017) 0.75

Machine learning for predicting lifespan-extending chemical compounds. Aging (Albany NY) (2017) 0.75

Phylogenetic and Molecular Evolutionary Analysis of Mitophagy Receptors under Hypoxic Conditions. Front Physiol (2017) 0.75

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature (1998) 21.49

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81

Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89

Mitochondrial membrane permeabilization in cell death. Physiol Rev (2007) 12.72

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 11.81

Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol (2007) 10.79

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science (2004) 8.71

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A (2003) 7.57

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet (2004) 7.45

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat Genet (2000) 7.20

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet (2006) 6.52

Essential role for Nix in autophagic maturation of erythroid cells. Nature (2008) 6.49

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell (2011) 5.98

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol (2010) 5.94

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85

Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77

Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep (2009) 5.52

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nat Cell Biol (2008) 5.50

A lethal defect of mitochondrial and peroxisomal fission. N Engl J Med (2007) 5.27

NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14

Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet (2006) 4.61

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet (2011) 4.41

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci (2010) 4.22

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet (2010) 3.77

Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res (2005) 3.54

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A (2011) 3.49

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell Metab (2006) 3.38

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One (2010) 3.16

Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science (2011) 3.10

Autophagy and aging: keeping that old broom working. Trends Genet (2008) 3.09

Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem (2004) 3.07

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem (2011) 2.99

Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta (2008) 2.56

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell (2012) 2.52

Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science (2011) 2.46

Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32

Taking a "good" look at free radicals in the aging process. Trends Cell Biol (2011) 2.21

ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy (2007) 2.21

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep (2012) 2.08

How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) (2008) 2.08

The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal (2011) 2.05

A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet (2010) 1.99

Pexophagy: autophagic degradation of peroxisomes. Biochim Biophys Acta (2006) 1.93

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem (2011) 1.93

Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Autophagy (2009) 1.90

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy (2010) 1.83

Mitochondrial quality control: a matter of life and death for neurons. EMBO J (2012) 1.83

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci U S A (2011) 1.82

Mitochondrial alterations in Alzheimer's disease. J Alzheimers Dis (2006) 1.65

Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons. Curr Biol (2012) 1.64

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One (2011) 1.62

Mutant huntingtin and mitochondrial dysfunction. Trends Neurosci (2008) 1.59

The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol (2010) 1.51

Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging. Am J Physiol Regul Integr Comp Physiol (2004) 1.37

Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol (2011) 1.37

Selective autophagy in the maintenance of cellular homeostasis in aging organisms. Biogerontology (2011) 1.25

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging. Neurobiol Dis (2010) 1.15

Shaping the role of mitochondria in the pathogenesis of Huntington's disease. EMBO J (2012) 1.11

Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol Dis (2002) 1.10

Aup1-mediated regulation of Rtg3 during mitophagy. J Biol Chem (2009) 1.05

A landmark protein essential for mitophagy: Atg32 recruits the autophagic machinery to mitochondria. Autophagy (2009) 0.96

Mitochondrial pathology in Parkinson's disease. Mt Sinai J Med (2011) 0.93

The intricacy of nuclear membrane dynamics during nucleophagy. Nucleus (2010) 0.92

Huntington's disease: pathogenesis, diagnosis and treatment. J Psychiatry Neurosci (1994) 0.83

Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family. Antioxid Redox Signal (2009) 0.82

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

The Genomes On Line Database (GOLD) in 2007: status of genomic and metagenomic projects and their associated metadata. Nucleic Acids Res (2007) 11.24

The Genomes On Line Database (GOLD) in 2009: status of genomic and metagenomic projects and their associated metadata. Nucleic Acids Res (2009) 9.98

The Genomes On Line Database (GOLD) v.2: a monitor of genome projects worldwide. Nucleic Acids Res (2006) 6.79

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature (2007) 3.07

Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta (2013) 2.61

Can autophagy promote longevity? Nat Cell Biol (2010) 2.55

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23

Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol (2007) 2.11

Small heat-shock proteins protect from heat-stroke-associated neurodegeneration. Nature (2012) 1.98

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature (2002) 1.97

A dual role of p53 in the control of autophagy. Autophagy (2008) 1.88

Caenorhabditis elegans: a versatile platform for drug discovery. Biotechnol J (2006) 1.72

Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J (2011) 1.66

Genetic models of mechanotransduction: the nematode Caenorhabditis elegans. Physiol Rev (2004) 1.66

Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature (2009) 1.62

Prohibitin and mitochondrial biology. Trends Endocrinol Metab (2009) 1.54

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging (Albany NY) (2009) 1.48

The NemaGENETAG initiative: large scale transposon insertion gene-tagging in Caenorhabditis elegans. Genetica (2009) 1.42

Nemo: a computational tool for analyzing nematode locomotion. BMC Neurosci (2007) 1.31

The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol (2005) 1.31

Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans. J Cell Biol (2006) 1.30

Necrosis in yeast. Apoptosis (2010) 1.21

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol (2013) 1.18

A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling. EMBO J (2008) 1.15

Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep (2002) 1.14

The biochemistry of neuronal necrosis: rogue biology? Nat Rev Neurosci (2003) 1.13

Modeling human diseases in Caenorhabditis elegans. Biotechnol J (2010) 1.11

Proteolytic mechanisms in necrotic cell death and neurodegeneration. FEBS Lett (2005) 1.06

The life span-prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy (2010) 1.05

Spermidine protects against α-synuclein neurotoxicity. Cell Cycle (2014) 1.02

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J (2013) 1.02

Microscopic optical projection tomography in vivo. PLoS One (2011) 0.97

Transgenesis in Caenorhabditis elegans. Methods Mol Biol (2009) 0.97

Protein synthesis is a novel determinant of aging in Caenorhabditis elegans. Ann N Y Acad Sci (2007) 0.97

Correction for specimen movement and rotation errors for in-vivo Optical Projection Tomography. Biomed Opt Express (2010) 0.95

Mechanisms of aging and energy metabolism in Caenorhabditis elegans. IUBMB Life (2008) 0.95

SUMOylation and cell signalling. Biotechnol J (2009) 0.94

Cell-specific monitoring of protein synthesis in vivo. PLoS One (2009) 0.92

Induction of RNA interference in Caenorhabditis elegans by RNAs derived from plants exhibiting post-transcriptional gene silencing. Nucleic Acids Res (2002) 0.92

KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro. J Cell Physiol (2011) 0.91

Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol (2012) 0.90

Spermidine promotes mating and fertilization efficiency in model organisms. Cell Cycle (2012) 0.89

Autophagy and ageing: insights from invertebrate model organisms. Ageing Res Rev (2012) 0.88

The role of synaptic ion channels in synaptic plasticity. EMBO Rep (2006) 0.87

Opposing function of mitochondrial prohibitin in aging. Aging (Albany NY) (2010) 0.87

Calcium homeostasis in aging neurons. Front Genet (2012) 0.86

Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J (2011) 0.86

Non-developmentally programmed cell death in Caenorhabditis elegans. Semin Cancer Biol (2006) 0.86

Downregulation of lung mitochondrial prohibitin in COPD. Respir Med (2012) 0.86

Coupling mitogenesis and mitophagy for longevity. Autophagy (2015) 0.84

Non-apoptotic cell death in Caenorhabditis elegans. Dev Dyn (2010) 0.84

Oxidative stress and mitochondrial protein quality control in aging. J Proteomics (2013) 0.83

Signaling pathways regulating protein synthesis during ageing. Exp Gerontol (2006) 0.83

Longevity-relevant regulation of autophagy at the level of the acetylproteome. Autophagy (2011) 0.83

Automated motion correction for in vivo optical projection tomography. IEEE Trans Med Imaging (2012) 0.82

Metabolic control by target of rapamycin and autophagy during ageing - a mini-review. Gerontology (2013) 0.82

Novel inducers of BECN1-independent autophagy: cis-unsaturated fatty acids. Autophagy (2015) 0.82

Autophagy and cell death in Caenorhabditis elegans. Curr Pharm Des (2008) 0.82

The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Cell Mol Life Sci (2013) 0.81

GPA-14, a Gα(i) subunit mediates dopaminergic behavioral plasticity in C. elegans. Behav Brain Funct (2013) 0.81

Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans. Ageing Res Rev (2003) 0.80

Molecular modeling of mechanosensory ion channel structural and functional features. PLoS One (2010) 0.80

Roles for SUMO modification during senescence. Adv Exp Med Biol (2010) 0.79

Embryonic and induced pluripotent stem cell differentiation as a tool in neurobiology. Biotechnol J (2012) 0.79

The role of autophagy in genetic pathways influencing ageing. Biogerontology (2011) 0.78

The second international conference "genetics of aging and longevity". Aging (Albany NY) (2012) 0.77

High-throughput and longitudinal analysis of aging and senescent decline in Caenorhabditis elegans. Methods Mol Biol (2013) 0.77

Cell tracking in live Caenorhabditis elegans embryos via third harmonic generation imaging microscopy measurements. J Biomed Opt (2011) 0.77

Heat shock response and ionstasis: axis against neurodegeneration. Aging (Albany NY) (2012) 0.77

The contactin RIG-6 mediates neuronal and non-neuronal cell migration in Caenorhabditis elegans. Dev Biol (2012) 0.77

First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Biol Chem (2006) 0.77

Neurodegenerative conditions associated with ageing: a molecular interplay? Mech Ageing Dev (2005) 0.77

Imaging of Caenorhabditis elegans neurons by second-harmonic generation and two-photon excitation fluorescence. J Biomed Opt (2005) 0.77

Necrotic cell death and neurodegeneration: The involvement of endocytosis and intracellular trafficking. Worm (2012) 0.76

Stress responses during ageing: molecular pathways regulating protein homeostasis. Methods Mol Biol (2015) 0.76

Assessing aging and senescent decline in Caenorhabditis elegans: cohort survival analysis. Methods Mol Biol (2013) 0.76

Protein metabolism and homeostasis in aging. Preface. Adv Exp Med Biol (2010) 0.76

Mitochondrial biogenesis and dynamics in neurodegeneration: a causative relationship. Neurochem Res (2013) 0.76

Autophagy in Caenorhabditis elegans. Biochim Biophys Acta (2008) 0.75

Identification of the M541L sequence variation of the transmembrane KIT domain in Merkel cell carcinoma. Anticancer Res (2011) 0.75

Editorial: brain matters. Biotechnol J (2008) 0.75

Editorial: diseases of the brain--neuronal function and dysfunction. Biotechnol J (2007) 0.75