Published in Mol Biol Cell on May 03, 2006
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins. J Cell Biol (2007) 2.24
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature (2014) 2.07
Proteostasis control by the unfolded protein response. Nat Cell Biol (2015) 1.99
Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol Cell Biol (2006) 1.60
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem (2011) 1.58
Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells. Nat Rev Cancer (2011) 1.51
Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways. Cell Microbiol (2008) 1.49
Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate. Cancer Res (2012) 1.47
Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. Biochem J (2009) 1.29
Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer (2008) 1.28
Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells. J Steroid Biochem Mol Biol (2009) 1.26
Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab (2008) 1.15
Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum. J Cell Sci (2009) 1.15
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Mol Cell Biol (2009) 1.10
ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2. Apoptosis (2012) 1.09
The role of X-box binding protein-1 in tumorigenicity. Drug News Perspect (2009) 1.09
Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein. Proc Natl Acad Sci U S A (2011) 1.07
The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem (2009) 1.05
Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis. J Gen Physiol (2006) 1.02
Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer. Horm Mol Biol Clin Investig (2011) 0.97
OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells. Endocrinology (2010) 0.97
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy. Cell Stem Cell (2015) 0.94
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A (2015) 0.93
Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise. Front Genet (2013) 0.91
Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein. J Cell Sci (2009) 0.89
Physiological roles of STIM1 and Orai1 homologs and CRAC channels in the genetic model organism Caenorhabditis elegans. Cell Calcium (2007) 0.89
Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Dis Model Mech (2014) 0.87
Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma. J Cancer Res Clin Oncol (2013) 0.87
A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis. BMC Syst Biol (2013) 0.84
Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration. J Ophthalmic Vis Res (2012) 0.84
Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies. Oncotarget (2015) 0.83
Intracellular glutathione pools are heterogeneously concentrated. Redox Biol (2013) 0.83
Role of p58IPK in Endoplasmic Reticulum Stress-associated Apoptosis and Inflammation. J Ophthalmic Vis Res (2014) 0.83
Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. Int Rev Cell Mol Biol (2015) 0.83
Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. PLoS One (2013) 0.82
Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese medaka (Oryzias latipes). Environ Sci Technol (2014) 0.81
Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart. J Mol Cell Cardiol (2013) 0.80
The non-apoptotic action of Bcl-xL: regulating Ca(2+) signaling and bioenergetics at the ER-mitochondrion interface. J Bioenerg Biomembr (2016) 0.80
Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling. Cell Cycle (2015) 0.79
Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects. PLoS One (2016) 0.77
Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta. PLoS One (2015) 0.77
Elevation of NR4A3 expression and its possible role in modulating insulin expression in the pancreatic beta cell. PLoS One (2014) 0.77
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in plants. Protoplasma (2015) 0.77
Probing endoplasmic reticulum dynamics using fluorescence imaging and photobleaching techniques. Curr Protoc Cell Biol (2013) 0.77
Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease. Curr Med Chem (2015) 0.76
Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum. J Biol Chem (2015) 0.76
Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults. J Am Heart Assoc (2016) 0.76
Unfolded protein responses with or without unfolded proteins? Cells (2012) 0.76
Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway. Br J Pharmacol (2016) 0.75
MicroRNAs meet calcium: joint venture in ER proteostasis. Sci Signal (2014) 0.75
Effects of copper sulfate-oxidized or myeloperoxidase-modified LDL on lipid loading and programmed cell death in macrophages under hypoxia. Hypoxia (Auckl) (2014) 0.75
Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response. Curr Chem Genomics (2008) 0.75
RESETing ER proteostasis: selective stress pathway hidden in the secretory route. EMBO J (2014) 0.75
IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biol (2016) 0.75
Altered activity patterns of transcription factors induced by endoplasmic reticulum stress. BMC Biochem (2016) 0.75
Dynamics of unfolded protein response in recombinant CHO cells. Cytotechnology (2014) 0.75
Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines. ACS Chem Neurosci (2015) 0.75
ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death. PLoS One (2017) 0.75
BiP: Master Regulator of the Unfolded Protein Response and Crucial Factor in Flavivirus Biology . Yale J Biol Med (2017) 0.75
Mammalian ECD protein is a novel negative regulator of the PERK arm of unfolded protein response. Mol Cell Biol (2017) 0.75
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev (1999) 13.24
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62
Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell (2001) 11.21
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell (2000) 9.13
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell (1999) 9.05
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol (2001) 7.82
A trip to the ER: coping with stress. Trends Cell Biol (2004) 7.67
ERAD: the long road to destruction. Nat Cell Biol (2005) 7.46
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell (1994) 7.10
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell (2002) 6.95
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell (1993) 6.82
Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell (1997) 6.26
Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev (1998) 5.88
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol (2000) 5.73
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol (1998) 5.66
Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell (2000) 5.56
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu Rev Cell Biol (1994) 5.54
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J (1996) 5.46
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell (2001) 5.39
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol (2001) 5.08
A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell (2003) 4.99
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell (1996) 4.12
Bypassing a kinase activity with an ATP-competitive drug. Science (2003) 3.71
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem (2000) 3.40
Structural organization of the endoplasmic reticulum. EMBO Rep (2002) 3.25
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest (2005) 3.16
ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Mol Cell Biol (2000) 2.89
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity (2003) 2.40
Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J Biol Chem (2002) 2.38
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet (2005) 2.33
Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem Biophys Res Commun (2000) 2.17
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. J Biol Chem (2002) 2.16
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J Cell Biol (2004) 2.07
The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J Biol Chem (2002) 1.63
Protein translocation across the endoplasmic reticulum: a tunnel with toll booths at entry and exit. Cell (1993) 1.41
Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. J Biol Chem (2003) 1.36
Search and destroy: ER quality control and ER-associated protein degradation. Crit Rev Biochem Mol Biol (2005) 1.29
Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. J Biol Chem (2004) 1.20
Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. J Biol Chem (2002) 1.16
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. J Biol Chem (2004) 1.14
MHC restriction in three dimensions: a view of T cell receptor/ligand interactions. Cell (1997) 1.00
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood (2010) 2.48
ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A (2012) 1.42
Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase. J Cell Biol (2011) 1.32
ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS One (2012) 1.29
A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response. J Cell Biol (2007) 1.15
A surveillance pathway monitors the fitness of the endoplasmic reticulum to control its inheritance. Cell (2010) 1.15
Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Mol Cell Biol (2009) 1.10
B- and T-cell development both involve activity of the unfolded protein response pathway. J Biol Chem (2008) 1.10
ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2. Apoptosis (2012) 1.09
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol (2014) 1.04
Late phase of the endoplasmic reticulum stress response pathway is regulated by Hog1 MAP kinase. J Biol Chem (2010) 0.90
The unfolded protein response. Curr Biol (2005) 0.75
Membrane compartments and organelles: new tricks by old dogs and new kids on the block. Curr Opin Cell Biol (2012) 0.75