Published in J Cell Biol on November 01, 2004
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59
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Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration. Exp Eye Res (2014) 1.14
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Negative feedback by IRE1β optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A (2013) 1.00
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Quercetin affects Hsp70/IRE1α mediated protection from death induced by endoplasmic reticulum stress. Oxid Med Cell Longev (2015) 0.76
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A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med (2003) 4.08
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Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA. Mol Cell (2009) 2.17
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Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A (2009) 2.00
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The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. Arterioscler Thromb Vasc Biol (2010) 1.56
Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins. Exp Cell Res (2009) 1.55
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Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem (2002) 1.43
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Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways. Mol Biol Cell (2011) 1.27
Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function. J Neurosci (2003) 1.27
Protective role of macrophages in noninflammatory lung injury caused by selective ablation of alveolar epithelial type II Cells. J Immunol (2007) 1.26
Is an entertainment robot useful in the care of elderly people with severe dementia? J Gerontol A Biol Sci Med Sci (2004) 1.22
IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level. PLoS One (2010) 1.21
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Increased cytotoxicity of soluble Fas ligand by fusing isoleucine zipper motif. Biochem Biophys Res Commun (2004) 1.18
JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs. J Biol Chem (2002) 1.17
Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1. J Cell Sci (2007) 1.16
Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation. Neuron (2012) 1.14
Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins. Genes Cells (2006) 1.13
Isolation and characterization of a putative transducer of endoplasmic reticulum stress in Oryza sativa. Plant Cell Physiol (2002) 1.12
An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1. Biochem J (2005) 1.12
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A genetic link between the unfolded protein response and vesicle formation from the endoplasmic reticulum. Biochem Biophys Res Commun (2002) 1.05
Conditional ablation of mature olfactory sensory neurons mediated by diphtheria toxin receptor. J Neurocytol (2005) 1.03
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Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy. Gastroenterology (2003) 1.01
Negative feedback by IRE1β optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A (2013) 1.00
Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice. Biochem Biophys Res Commun (2007) 0.98
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Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST. J Biol Chem (2013) 0.97
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Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice. Endocr J (2009) 0.96
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Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins. FEBS Lett (2010) 0.86
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Saccharomyces cerevisiae Rot1 is an essential molecular chaperone in the endoplasmic reticulum. Mol Biol Cell (2008) 0.82
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Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding. J Biochem (2006) 0.80
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F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1. Cell Struct Funct (2013) 0.78
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A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations. Int J Cancer (2013) 0.77
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Morphological analysis of the upper eyelid tarsus in Asians. Ann Plast Surg (2011) 0.77
Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms. Biosci Biotechnol Biochem (2013) 0.77
Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue. Biochem Biophys Res Commun (2013) 0.77
Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout. Biochem Biophys Res Commun (2013) 0.76
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