Published in Behav Brain Res on May 09, 2006
Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther (2009) 1.67
DARPP-32, Jack of All Trades… Master of Which? Front Behav Neurosci (2011) 1.09
Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex. Neuropsychopharmacology (2011) 1.06
Dopamine receptor signaling and current and future antipsychotic drugs. Handb Exp Pharmacol (2012) 1.04
Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacol Ther (2010) 1.02
Impaired object recognition following prolonged withdrawal from extended-access cocaine self-administration. Neuroscience (2008) 0.92
DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families. Behav Brain Funct (2012) 0.88
Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex. Psychopharmacology (Berl) (2011) 0.84
Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex. Neuroscience (2010) 0.82
A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat. PLoS One (2012) 0.81
Increased particulate phosphodiesterase 4 in the prefrontal cortex supports 5-HT4 receptor-induced improvement of object recognition memory in the rat. Psychopharmacology (Berl) (2008) 0.81
Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex. PLoS One (2012) 0.80
Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence. PLoS One (2013) 0.78
Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex. Eur Neuropsychopharmacol (2015) 0.77
Memory retrieval of inhibitory avoidance requires histamine H1 receptor activation in the hippocampus. Proc Natl Acad Sci U S A (2016) 0.77
Synergistic effects between CA1 mu opioid and dopamine D1-like receptors in impaired passive avoidance performance induced by hepatic encephalopathy in mice. Psychopharmacology (Berl) (2013) 0.77
Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load. J Cogn Neurosci (2013) 0.75
Effects of chronic REM sleep restriction on D1 receptor and related signal pathways in rat prefrontal cortex. Biomed Res Int (2015) 0.75
Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17
PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci U S A (2004) 3.87
DARPP-32: an integrator of neurotransmission. Annu Rev Pharmacol Toxicol (2004) 3.84
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proc Natl Acad Sci U S A (2006) 3.68
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature (2005) 3.24
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature (2006) 2.77
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol (2008) 2.62
The prefrontal cortex as a key target of the maladaptive response to stress. J Neurosci (2007) 2.51
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov (2012) 2.44
On the mechanism of MgATP-dependent gating of CFTR Cl- channels. J Gen Physiol (2003) 2.39
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol (2009) 2.20
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature (2008) 2.10
In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer. EMBO J (2006) 2.04
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. J Gen Physiol (2003) 2.03
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell (2003) 1.98
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci U S A (2007) 1.93
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature (2002) 1.91
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A (2004) 1.84
DARPP-32 mediates the actions of multiple drugs of abuse. AAPS J (2005) 1.66
Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci (2010) 1.64
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem (2005) 1.57
The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron (2005) 1.57
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat Struct Mol Biol (2010) 1.56
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol (2005) 1.55
Synaptic plasticity: one STEP at a time. Trends Neurosci (2006) 1.51
Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav Brain Res (2009) 1.51
Case scenario: postoperative delirium in elderly surgical patients. Anesthesiology (2010) 1.49
Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases. J Cell Biol (2005) 1.47
Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics (2015) 1.46
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A (2010) 1.42
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J (2006) 1.40
Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol (2014) 1.39
FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nat Neurosci (2008) 1.36
Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A. J Neurochem (2002) 1.32
Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. Proc Natl Acad Sci U S A (2009) 1.29
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Proc Natl Acad Sci U S A (2008) 1.28
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci (2014) 1.28
Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc Natl Acad Sci U S A (2005) 1.26
Structural basis for protein phosphatase 1 regulation and specificity. FEBS J (2012) 1.26
A direct test of the reductionist approach to structural studies of calmodulin activity: relevance of peptide models of target proteins. J Biol Chem (2002) 1.25
Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle. J Gen Physiol (2006) 1.24
Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg (2008) 1.24
Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action. Neuropsychopharmacology (2006) 1.24
Phosphorylation of spinophilin modulates its interaction with actin filaments. J Biol Chem (2002) 1.23
Recent advances in quantitative neuroproteomics. Methods (2013) 1.23
Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants. Cereb Cortex (2004) 1.22
Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA. J Gen Physiol (2005) 1.22
TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol Endocrinol Metab (2002) 1.22
The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. Proc Natl Acad Sci U S A (2007) 1.21
Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem (2002) 1.21
Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci U S A (2005) 1.21
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem (2007) 1.20
Quantitative analysis of protein phosphorylation in mouse brain by hypothesis-driven multistage mass spectrometry. Anal Chem (2005) 1.20
The hippocampal-prefrontal pathway: the weak link in psychiatric disorders? Eur Neuropsychopharmacol (2013) 1.20
Structural domains involved in the regulation of transmitter release by synapsins. J Neurosci (2005) 1.19
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals. J Pharmacol Exp Ther (2003) 1.19
Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. J Neurochem (2006) 1.18
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol Cell Neurosci (2002) 1.18
PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. J Biol Chem (2003) 1.17
Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease. Biochem Pharmacol (2011) 1.16
Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain. J Gen Physiol (2004) 1.16
A novel cAMP-stimulated pathway in protein phosphatase 2A activation. J Pharmacol Exp Ther (2002) 1.15
Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. Aging Cell (2008) 1.15
Detailed structural characterization of unbound protein phosphatase 1 inhibitors. Biochemistry (2008) 1.14
Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Mol Pharmacol (2003) 1.13
Neurotoxicity of general anesthetics: cause for concern? Anesthesiology (2009) 1.13
Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: evidence from experiments in the non-human primate. Ann N Y Acad Sci (2007) 1.12
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry (2002) 1.10
Isoform-selective effects of isoflurane on voltage-gated Na+ channels. Anesthesiology (2007) 1.09
Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I. Proc Natl Acad Sci U S A (2007) 1.09
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol (2012) 1.09
Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Proc Natl Acad Sci U S A (2003) 1.08
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release. J Pharmacol Exp Ther (2005) 1.08
Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation. Neuropharmacology (2008) 1.08
Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines. Proc Natl Acad Sci U S A (2006) 1.08
Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. J Biol Chem (2009) 1.07
cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3. J Biol Chem (2010) 1.07
Spinophilin is phosphorylated by Ca2+/calmodulin-dependent protein kinase II resulting in regulation of its binding to F-actin. J Neurochem (2004) 1.06
Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). Proc Natl Acad Sci U S A (2005) 1.05
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. EMBO J (2010) 1.05
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc Natl Acad Sci U S A (2003) 1.04
Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. Proc Natl Acad Sci U S A (2009) 1.04
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc Natl Acad Sci U S A (2008) 1.04
Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci (2010) 1.04
Assessment of cognitive function in the heterozygous reeler mouse. Psychopharmacology (Berl) (2006) 1.03
Protein phosphatases and Alzheimer's disease. Prog Mol Biol Transl Sci (2012) 1.03
A mathematical tool for exploring the dynamics of biological networks. Proc Natl Acad Sci U S A (2007) 1.02
Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status. Behav Brain Res (2010) 1.01
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo. Eur J Neurosci (2003) 1.01
Proteomic analysis of activity-dependent synaptic plasticity in hippocampal neurons. J Proteome Res (2007) 1.01
Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel. J Pharmacol Exp Ther (2007) 1.01
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release. J Pharmacol Exp Ther (2005) 1.01
General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology (2007) 1.00
Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. J Biol Chem (2007) 0.99