Published in Proc Natl Acad Sci U S A on February 27, 2007
The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis. Front Oncol (2014) 1.33
Casein kinase I delta controls centrosome positioning during T cell activation. J Cell Biol (2011) 1.15
Protein phosphorylation in neurodegeneration: friend or foe? Front Mol Neurosci (2014) 1.15
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. Aging (Albany NY) (2009) 1.12
Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene. Transl Psychiatry (2014) 1.07
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment? BMC Neurosci (2008) 0.97
Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. Proc Natl Acad Sci U S A (2010) 0.94
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett (2013) 0.93
Combined kinase inhibition modulates parkin inactivation. Hum Mol Genet (2008) 0.92
Recent developments of protein kinase inhibitors as potential AD therapeutics. Front Cell Neurosci (2013) 0.89
Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics. Chem Rev (2015) 0.88
Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients. Int J Mol Sci (2014) 0.81
Bioactive marine drugs and marine biomaterials for brain diseases. Mar Drugs (2014) 0.81
Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. Mol Neurodegener (2010) 0.81
Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines. Biochem Biophys Res Commun (2008) 0.80
Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. PLoS One (2014) 0.79
Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action. FASEB J (2012) 0.79
Viable mouse gene ablations that robustly alter brain Aβ levels are rare. BMC Neurosci (2010) 0.79
Potential of casein kinase I in digestive cancer screening. World J Gastrointest Oncol (2009) 0.79
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun (2015) 0.78
Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice. PLoS One (2012) 0.78
Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. Biomed Res Int (2016) 0.75
Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? J Alzheimers Dis (2013) 0.75
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proc Natl Acad Sci U S A (2017) 0.75
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature (2003) 4.97
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci U S A (1996) 4.13
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev (2002) 3.80
Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci (2004) 3.05
Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell Signal (1998) 2.50
Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A (2003) 2.44
Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A (1990) 2.41
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep (2004) 2.31
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20
Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron (2001) 1.87
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci (2006) 1.80
Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem (2001) 1.74
Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. J Biol Chem (1999) 1.67
A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J Biol Chem (1989) 1.66
Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta. J Biol Chem (1995) 1.59
Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem (2000) 1.59
A prenylation motif is required for plasma membrane localization and biochemical function of casein kinase I in budding yeast. J Biol Chem (1994) 1.58
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem (2003) 1.54
Casein kinases: pleiotropic mediators of cellular regulation. Pharmacol Ther (1993) 1.53
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol (2004) 1.41
Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors. Proc Natl Acad Sci U S A (2001) 1.34
Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity. Drugs R D (2006) 1.25
Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway function. J Cell Sci (2002) 1.24
Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem (2002) 1.21
Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin. Proc Natl Acad Sci U S A (1995) 1.18
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol Cell Neurosci (2002) 1.18
A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins. J Cell Biol (1995) 1.11
Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain. Brain Res (2000) 1.07
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiol Aging (2000) 1.06
The thymus and T-cell commitment: the right niche for Notch? Nat Rev Immunol (2006) 1.02
Induced release of cell surface protein kinase yields CK1- and CK2-like enzymes in tandem. J Biol Chem (1996) 0.99
Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. J Neurochem (1998) 0.97
Amyloid beta peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin. J Biol Chem (1996) 0.96
Significance of the casein kinase system in cell growth and proliferation with emphasis on studies of the androgenic regulation of the prostate. Cell Mol Biol Res (1994) 0.91
Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms. Biochemistry (1998) 0.91
Phosphorylation of tau protein by casein kinase-1 converts it to an abnormal Alzheimer-like state. J Neurochem (1995) 0.87
Secretase as a target for Alzheimer's disease. Curr Top Med Chem (2002) 0.80
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94
Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17
A translational profiling approach for the molecular characterization of CNS cell types. Cell (2008) 8.69
Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell (2008) 7.74
Dichotomous dopaminergic control of striatal synaptic plasticity. Science (2008) 5.47
GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol (2003) 4.60
PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50
Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med (2007) 4.48
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci U S A (2004) 3.87
DARPP-32: an integrator of neurotransmission. Annu Rev Pharmacol Toxicol (2004) 3.84
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proc Natl Acad Sci U S A (2006) 3.68
Alterations in 5-HT1B receptor function by p11 in depression-like states. Science (2006) 3.55
Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Nat Neurosci (2003) 3.25
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature (2005) 3.24
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08
Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci (2004) 3.05
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature (2010) 2.80
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature (2006) 2.77
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol Dis (2005) 2.70
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol (2008) 2.62
Diverse psychotomimetics act through a common signaling pathway. Science (2003) 2.52
Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A (2003) 2.44
On the mechanism of MgATP-dependent gating of CFTR Cl- channels. J Gen Physiol (2003) 2.39
Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci U S A (2011) 2.37
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc Natl Acad Sci U S A (2010) 2.36
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron (2009) 2.26
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol (2009) 2.20
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. J Neurosci (2011) 2.15
Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. J Neurosci (2007) 2.11
Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J Biol Chem (2003) 2.10
A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature (2008) 2.10
Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Sci Transl Med (2010) 2.09
In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer. EMBO J (2006) 2.04
Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies. Neuron (2003) 2.04
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. J Gen Physiol (2003) 2.03
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell (2003) 1.98
Type 1 phosphatase, a negative regulator of cardiac function. Mol Cell Biol (2002) 1.97
MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science (2013) 1.95
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci U S A (2007) 1.93
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature (2002) 1.91
The neurobiology of dopamine signaling. Arch Neurol (2004) 1.89
Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. J Neurosci (2006) 1.88
Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci U S A (2004) 1.86
Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. Sci Signal (2009) 1.84
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A (2004) 1.84
Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci (2002) 1.82
Three-dimensional architecture of presynaptic terminal cytomatrix. J Neurosci (2007) 1.82
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A (2007) 1.77
Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice. Proc Natl Acad Sci U S A (2004) 1.72
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem (2004) 1.72
Different presynaptic roles of synapsins at excitatory and inhibitory synapses. J Neurosci (2004) 1.72
DARPP-32 mediates the actions of multiple drugs of abuse. AAPS J (2005) 1.66
Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton. Proc Natl Acad Sci U S A (2002) 1.64
Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci (2010) 1.64
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nat Neurosci (2008) 1.63
Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci (2009) 1.62
Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol Sci (2002) 1.62
Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia. Proc Natl Acad Sci U S A (2014) 1.59
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem (2005) 1.57
The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Neuron (2005) 1.57
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat Struct Mol Biol (2010) 1.56
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol (2005) 1.55
L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. J Neurochem (2009) 1.53
Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (2004) 1.52
Synaptic plasticity: one STEP at a time. Trends Neurosci (2006) 1.51
Colocalization of synapsin and actin during synaptic vesicle recycling. J Cell Biol (2003) 1.50
The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. J Neurosci (2003) 1.50
Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys. J Comp Neurol (2003) 1.49
Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J Neurosci (2008) 1.48
Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys. Cereb Cortex (2004) 1.48
Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. J Neurophysiol (2002) 1.47
Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases. J Cell Biol (2005) 1.47
Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics (2015) 1.46
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay. Ann Neurol (2005) 1.45
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A (2010) 1.42
Identification of the cortical neurons that mediate antidepressant responses. Cell (2012) 1.42