Published in Nat Cell Biol on May 21, 2006
Differential regulation of dynein and kinesin motor proteins by tau. Science (2008) 4.29
Force-induced bidirectional stepping of cytoplasmic dynein. Cell (2007) 3.31
Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport. Curr Biol (2010) 3.16
LIS1 and NudE induce a persistent dynein force-producing state. Cell (2010) 2.88
Structure and functional role of dynein's microtubule-binding domain. Science (2008) 2.80
Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science (2014) 2.35
A cytoplasmic dynein tail mutation impairs motor processivity. Nat Cell Biol (2010) 2.20
Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. J Cell Biol (2007) 2.18
Huntingtin facilitates dynein/dynactin-mediated vesicle transport. Proc Natl Acad Sci U S A (2007) 2.16
Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proc Natl Acad Sci U S A (2009) 1.99
Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity (2009) 1.98
Dynein achieves processive motion using both stochastic and coordinated stepping. Nat Struct Mol Biol (2012) 1.98
Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol (2009) 1.94
A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J Neurosci (2009) 1.90
Local cytoskeletal and organelle interactions impact molecular-motor- driven early endosomal trafficking. Curr Biol (2013) 1.76
MTOC translocation modulates IS formation and controls sustained T cell signaling. J Cell Biol (2008) 1.75
Kinesin and dynein-dynactin at intersecting microtubules: motor density affects dynein function. Biophys J (2008) 1.70
Myosin V and Kinesin act as tethers to enhance each others' processivity. Proc Natl Acad Sci U S A (2008) 1.65
Multiple modes of cytoplasmic dynein regulation. Nat Cell Biol (2012) 1.59
Dynactin is required for transport initiation from the distal axon. Neuron (2012) 1.59
Functions and mechanics of dynein motor proteins. Nat Rev Mol Cell Biol (2013) 1.56
Axonal transport: cargo-specific mechanisms of motility and regulation. Neuron (2014) 1.55
Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J Biol Chem (2008) 1.55
Regulation of dynactin through the differential expression of p150Glued isoforms. J Biol Chem (2008) 1.54
Insights into dynein motor domain function from a 3.3-Å crystal structure. Nat Struct Mol Biol (2012) 1.51
Coordination of molecular motors: from in vitro assays to intracellular dynamics. Curr Opin Cell Biol (2010) 1.47
Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors. Proc Natl Acad Sci U S A (2012) 1.47
In vitro reconstitution of a highly processive recombinant human dynein complex. EMBO J (2014) 1.45
Mitochondrial transport and docking in axons. Exp Neurol (2009) 1.41
The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1. Neuron (2016) 1.40
MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Nat Cell Biol (2011) 1.36
CAR-associated vesicular transport of an adenovirus in motor neuron axons. PLoS Pathog (2009) 1.35
Changes in bicoid mRNA anchoring highlight conserved mechanisms during the oocyte-to-embryo transition. Curr Biol (2008) 1.31
Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis. J Cell Biol (2012) 1.31
Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe (2009) 1.30
Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends Cell Biol (2014) 1.30
Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms. Neuroscience (2010) 1.29
Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol (2009) 1.27
Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J Biol Chem (2011) 1.26
Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport. J Neurosci (2013) 1.25
Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration. Proc Natl Acad Sci U S A (2009) 1.23
Three-dimensional structure of cytoplasmic dynein bound to microtubules. Proc Natl Acad Sci U S A (2007) 1.23
Dynactin function in mitotic spindle positioning. Traffic (2008) 1.22
A nonprocessive class V myosin drives cargo processively when a kinesin- related protein is a passenger. Curr Biol (2009) 1.21
Dynactin's pointed-end complex is a cargo-targeting module. Mol Biol Cell (2012) 1.20
High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. J Cell Biol (2011) 1.19
Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Nat Cell Biol (2012) 1.17
Dynein tethers and stabilizes dynamic microtubule plus ends. Curr Biol (2012) 1.16
A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons. Mol Cell Neurosci (2008) 1.15
Reconstitution of the human cytoplasmic dynein complex. Proc Natl Acad Sci U S A (2012) 1.13
Stimulated nuclear translocation of NF-kappaB and shuttling differentially depend on dynein and the dynactin complex. Proc Natl Acad Sci U S A (2009) 1.08
Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport. Nat Cell Biol (2014) 1.06
Collective dynamics of elastically coupled myosin V motors. J Biol Chem (2012) 1.06
Can molecular motors drive distance measurements in injured neurons? PLoS Comput Biol (2009) 1.04
Drosophila katanin-60 depolymerizes and severs at microtubule defects. Biophys J (2011) 1.04
Two independent switches regulate cytoplasmic dynein's processivity and directionality. Proc Natl Acad Sci U S A (2012) 1.02
α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep (2016) 1.00
Mechanism and Regulation of Cytoplasmic Dynein. Annu Rev Cell Dev Biol (2015) 1.00
Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nat Commun (2014) 0.97
Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife (2013) 0.96
Dynactin suppresses the retrograde movement of apically localized mRNA in Drosophila blastoderm embryos. RNA (2007) 0.96
Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol (2013) 0.95
Point mutations in the stem region and the fourth AAA domain of cytoplasmic dynein heavy chain partially suppress the phenotype of NUDF/LIS1 loss in Aspergillus nidulans. Genetics (2007) 0.95
Assembly of mRNA-protein complexes for directional mRNA transport in eukaryotes--an overview. Curr Protein Pept Sci (2012) 0.95
Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. BMC Evol Biol (2012) 0.94
The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA. Elife (2014) 0.94
dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. PLoS One (2013) 0.94
Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs. J Cell Biol (2013) 0.93
Roles of dynein and dynactin in early endosome dynamics revealed using automated tracking and global analysis. PLoS One (2011) 0.91
Enhancement of single-molecule fluorescence signals by colloidal silver nanoparticles in studies of protein translation. ACS Nano (2010) 0.91
Retrograde axonal transport of VZV: kinetic studies in hESC-derived neurons. J Neurovirol (2012) 0.91
Mechanical design of translocating motor proteins. Cell Biochem Biophys (2009) 0.90
Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis. Mol Biol Cell (2013) 0.89
Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma. Front Neurosci (2014) 0.88
The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization. Mol Biol Cell (2013) 0.88
Using electrical and optical tweezers to facilitate studies of molecular motors. Phys Chem Chem Phys (2009) 0.87
Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions. Cytoskeleton (Hoboken) (2013) 0.87
Tyrosination of α-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J (2016) 0.87
The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release. Nat Struct Mol Biol (2014) 0.87
One-dimensional Brownian motion of charged nanoparticles along microtubules: a model system for weak binding interactions. Biophys J (2010) 0.86
She1-mediated inhibition of dynein motility along astral microtubules promotes polarized spindle movements. Curr Biol (2012) 0.86
Function and regulation of dynein in mitotic chromosome segregation. Chromosoma (2014) 0.84
An improved optical tweezers assay for measuring the force generation of single kinesin molecules. Methods Mol Biol (2014) 0.83
Multiscale approaches for studying energy transduction in dynein. Phys Chem Chem Phys (2009) 0.83
Intracellular spatial localization regulated by the microtubule network. PLoS One (2012) 0.83
Small peptide inhibitors disrupt a high-affinity interaction between cytoplasmic dynein and a viral cargo protein. J Virol (2010) 0.83
How Dynein Moves Along Microtubules. Trends Biochem Sci (2015) 0.83
Erroneous Silencing of the Mitotic Checkpoint by Aberrant Spindle Pole-Kinetochore Coordination. Biophys J (2015) 0.80
Structural and biomechanical basis of mitochondrial movement in eukaryotic cells. Int J Nanomedicine (2013) 0.80
The impacts of molecular motor traffic jams. Proc Natl Acad Sci U S A (2012) 0.80
Single-molecule fluorescence and in vivo optical traps: how multiple dyneins and kinesins interact. Chem Rev (2014) 0.79
Analysis of Cooperative Behavior in Multiple Kinesins Motor Protein Transport by Varying Structural and Chemical Properties. Cell Mol Bioeng (2013) 0.78
A single protofilament is sufficient to support unidirectional walking of dynein and kinesin. PLoS One (2012) 0.78
The CAP-Gly of p150: one domain, two diseases, and a function at the end. Neuron (2012) 0.78
A physical model reveals the mechanochemistry responsible for dynein's processive motion. Biophys J (2011) 0.77
RNA localization to the Balbiani body in Xenopus oocytes is regulated by the energy state of the cell and is facilitated by kinesin II. RNA (2009) 0.77
Retrograde NGF axonal transport--motor coordination in the unidirectional motility regime. Biophys J (2015) 0.77
Dynactin Deficiency in the CNS of Humans with Sporadic ALS and Mice with Genetically Determined Motor Neuron Degeneration. Neurochem Res (2013) 0.76
A numbers game underpins cytoplasmic mRNA transport. Nat Cell Biol (2012) 0.76
Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action. Elife (2017) 0.75
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization. Science (2003) 20.21
Mutant dynactin in motor neuron disease. Nat Genet (2003) 5.28
Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization. Nature (2003) 4.52
Differential regulation of dynein and kinesin motor proteins by tau. Science (2008) 4.29
Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport. Curr Biol (2010) 3.16
Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron (2002) 3.08
Axonal transport and neurodegenerative disease. Biochim Biophys Acta (2006) 3.06
Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy (polTIRFM). Cold Spring Harb Protoc (2012) 2.71
Microtubule motors at the intersection of trafficking and transport. Trends Cell Biol (2006) 2.44
The elasticity of an individual fibrin fiber in a clot. Proc Natl Acad Sci U S A (2005) 2.40
Distal spinal and bulbar muscular atrophy caused by dynactin mutation. Ann Neurol (2005) 2.34
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J Cell Biol (2012) 2.30
Defocused orientation and position imaging (DOPI) of myosin V. Proc Natl Acad Sci U S A (2006) 2.27
Myosin I can act as a molecular force sensor. Science (2008) 2.21
Huntingtin facilitates dynein/dynactin-mediated vesicle transport. Proc Natl Acad Sci U S A (2007) 2.16
Recruitment of dynein to the Jurkat immunological synapse. Proc Natl Acad Sci U S A (2006) 2.15
Microtubule plus-end tracking by CLIP-170 requires EB1. Proc Natl Acad Sci U S A (2009) 2.15
The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization. Mol Biol Cell (2003) 2.13
A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation. J Cell Biol (2006) 2.08
Retrograde axonal transport: pathways to cell death? Trends Neurosci (2010) 2.06
JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J Cell Biol (2013) 2.01
A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. J Biol Chem (2004) 1.97
Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3. J Biol Chem (2002) 1.92
Force generation in single conventional actomyosin complexes under high dynamic load. Biophys J (2005) 1.90
A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J Neurosci (2009) 1.90
Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy. Biophys J (2005) 1.88
Huntingtin as an essential integrator of intracellular vesicular trafficking. Trends Cell Biol (2009) 1.88
Local cytoskeletal and organelle interactions impact molecular-motor- driven early endosomal trafficking. Curr Biol (2013) 1.76
Protein synthesis by single ribosomes. RNA (2003) 1.74
Interleukin-1 participates in the progression from liver injury to fibrosis. Am J Physiol Gastrointest Liver Physiol (2009) 1.72
Cytoplasmic dynein nomenclature. J Cell Biol (2005) 1.71
Kinesin and dynein-dynactin at intersecting microtubules: motor density affects dynein function. Biophys J (2008) 1.70
Preparation of filamentous actin for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays. Cold Spring Harb Protoc (2012) 1.69
Single-molecule fluorescence measurements of ribosomal translocation dynamics. Mol Cell (2011) 1.65
Rotational motions of macro-molecules by single-molecule fluorescence microscopy. Acc Chem Res (2005) 1.63
Dynactin is required for transport initiation from the distal axon. Neuron (2012) 1.59
The polarized total internal reflection fluorescence microscopy (polTIRFM) processive motility assay for myosin V. Cold Spring Harb Protoc (2012) 1.56
Regulation of dynactin through the differential expression of p150Glued isoforms. J Biol Chem (2008) 1.54
Myosin VI walks "wiggly" on actin with large and variable tilting. Mol Cell (2007) 1.54
The polarized total internal reflection fluorescence microscopy (polTIRFM) twirling filament assay. Cold Spring Harb Protoc (2012) 1.54
The acquisition and analysis of polarized total internal reflection fluorescence microscopy (polTIRFM) data. Cold Spring Harb Protoc (2012) 1.51
Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome. J Biol Chem (2006) 1.49
Fluorescent labeling of myosin V for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays. Cold Spring Harb Protoc (2012) 1.48
Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors. Proc Natl Acad Sci U S A (2012) 1.47
Coordination of molecular motors: from in vitro assays to intracellular dynamics. Curr Opin Cell Biol (2010) 1.47
Polymerization of fibrin: specificity, strength, and stability of knob-hole interactions studied at the single-molecule level. Blood (2005) 1.45
Binding strength and activation state of single fibrinogen-integrin pairs on living cells. Proc Natl Acad Sci U S A (2002) 1.44
Orientation changes of the myosin light chain domain during filament sliding in active and rigor muscle. J Mol Biol (2002) 1.42
ABCA3 is critical for lamellar body biogenesis in vivo. J Biol Chem (2007) 1.41
Adaptability of myosin V studied by simultaneous detection of position and orientation. EMBO J (2006) 1.40
Dynein drives nuclear rotation during forward progression of motile fibroblasts. J Cell Sci (2008) 1.37
Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy. Biophys J (2005) 1.37
Fluorescent labeling of calmodulin with bifunctional rhodamine. Cold Spring Harb Protoc (2012) 1.33
Protein-protein unbinding induced by force: single-molecule studies. Curr Opin Struct Biol (2003) 1.33
Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells. J Cell Sci (2012) 1.32
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin. Hum Mol Genet (2008) 1.31
Single-molecule stepping and structural dynamics of myosin X. Nat Struct Mol Biol (2010) 1.31
Motor number controls cargo switching at actin-microtubule intersections in vitro. Curr Biol (2010) 1.30
The interaction of neurofilaments with the microtubule motor cytoplasmic dynein. Mol Biol Cell (2004) 1.30
Functional and structural correlations of individual alphaIIbbeta3 molecules. Blood (2004) 1.30
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J Neurosci (2014) 1.28
Single-molecule structural dynamics of EF-G--ribosome interaction during translocation. Biochemistry (2007) 1.27
Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport. J Neurosci (2013) 1.25
Construction of flow chambers for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays. Cold Spring Harb Protoc (2012) 1.25
Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons. Neuroreport (2005) 1.25
Effect of inorganic phosphate on the force and number of myosin cross-bridges during the isometric contraction of permeabilized muscle fibers from rabbit psoas. Biophys J (2008) 1.23
Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes. Mol Biol Cell (2010) 1.22
Polymerization of fibrin: Direct observation and quantification of individual B:b knob-hole interactions. Blood (2006) 1.18
Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis. Proc Natl Acad Sci U S A (2011) 1.18
Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry (2003) 1.17
Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assembly. Traffic (2007) 1.16
Mechanical studies of single ribosome/mRNA complexes. Biophys J (2005) 1.16
Dynein tethers and stabilizes dynamic microtubule plus ends. Curr Biol (2012) 1.16
Orientation of the myosin light chain region by single molecule total internal reflection fluorescence polarization microscopy. Biophys J (2005) 1.15
Twirling of actin by myosins II and V observed via polarized TIRF in a modified gliding assay. Biophys J (2008) 1.15
Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. PLoS Biol (2013) 1.15
Microtubule binding proteins CLIP-170, EB1, and p150Glued form distinct plus-end complexes. FEBS Lett (2006) 1.14
Parallax: high accuracy three-dimensional single molecule tracking using split images. Nano Lett (2009) 1.13
Dynamics of translation by single ribosomes through mRNA secondary structures. Nat Struct Mol Biol (2013) 1.13
Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons. Neuron (2011) 1.13
Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury. J Hepatol (2008) 1.13
Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. PLoS One (2010) 1.13
Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis. Neurobiol Dis (2006) 1.12
Cytoplasmic dynein/dynactin function and dysfunction in motor neurons. Int J Dev Neurosci (2006) 1.11
Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force. Biophys J (2011) 1.08
Myosin IC generates power over a range of loads via a new tension-sensing mechanism. Proc Natl Acad Sci U S A (2012) 1.08
Control of myosin-I force sensing by alternative splicing. Proc Natl Acad Sci U S A (2009) 1.08
Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophys J (2009) 1.05