Published in Biophys J on December 01, 2015
Spindle Size Scaling Contributes to Robust Silencing of Mitotic Spindle Assembly Checkpoint. Biophys J (2016) 0.75
Dynamics robustness of cascading systems. PLoS Comput Biol (2017) 0.75
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet (2001) 9.08
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol (2003) 8.91
Studying protein dynamics in living cells. Nat Rev Mol Cell Biol (2001) 8.43
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J Cell Biol (1995) 7.59
On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer (2005) 7.53
Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J Cell Biol (1998) 6.49
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol (2009) 6.43
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J Cell Biol (1994) 6.38
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell (1997) 6.36
Dynactin increases the processivity of the cytoplasmic dynein motor. Nat Cell Biol (2000) 6.13
Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science (1996) 6.10
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev Cell (2001) 5.82
Single-molecule analysis of dynein processivity and stepping behavior. Cell (2006) 5.63
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol (2001) 5.09
Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. J Cell Biol (2001) 5.03
Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol (2008) 4.95
Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer (2002) 4.88
Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol Biol Cell (2001) 4.71
The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature (2004) 4.60
Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. J Cell Biol (1997) 4.53
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature (2007) 4.31
Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J Cell Biol (2000) 4.26
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J Cell Biol (1999) 4.15
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science (2009) 4.10
Causes and consequences of aneuploidy in cancer. Nat Rev Genet (2012) 4.08
Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol (2006) 3.99
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev (2008) 3.79
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol (2005) 3.77
Spindle checkpoint protein dynamics at kinetochores in living cells. Curr Biol (2004) 3.67
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol (2004) 3.65
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol Biol Cell (2002) 3.65
Diffusion of injected macromolecules within the cytoplasm of living cells. Proc Natl Acad Sci U S A (1981) 3.61
Processive bidirectional motion of dynein-dynactin complexes in vitro. Nat Cell Biol (2006) 3.56
Spindle assembly in Xenopus egg extracts: respective roles of centrosomes and microtubule self-organization. J Cell Biol (1997) 3.54
Molecular mobility and nucleocytoplasmic flux in hepatoma cells. J Cell Biol (1986) 3.48
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell (2010) 3.44
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36
Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin. Science (2009) 3.30
The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature (2010) 3.27
Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc Natl Acad Sci U S A (2001) 3.06
Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci (2004) 3.01
Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes. Cell (2007) 2.99
Human aneuploidy: mechanisms and new insights into an age-old problem. Nat Rev Genet (2012) 2.96
Re-evaluating centrosome function. Nat Rev Mol Cell Biol (2001) 2.96
Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes. Cell (2011) 2.89
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J Cell Sci (2001) 2.76
Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity. J Cell Biol (2009) 2.64
The size of the nucleus increases as yeast cells grow. Mol Biol Cell (2007) 2.55
Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Curr Biol (2005) 2.53
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proc Natl Acad Sci U S A (2004) 2.52
Kinetochore localization of spindle checkpoint proteins: who controls whom? Mol Biol Cell (2004) 2.50
Nuclear size control in fission yeast. J Cell Biol (2007) 2.32
Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errors. Curr Biol (2011) 2.30
Cancer chromosomal instability: therapeutic and diagnostic challenges. EMBO Rep (2012) 2.28
The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. J Cell Biol (2012) 2.18
Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein. Nat Cell Biol (2001) 2.17
Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. Nat Cell Biol (2007) 2.13
Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat Cell Biol (2008) 2.11
Evidence for an upper limit to mitotic spindle length. Curr Biol (2008) 1.94
Lack of checkpoint control at the metaphase/anaphase transition: a mechanism of meiotic nondisjunction in mammalian females. J Cell Biol (1997) 1.85
Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes. Genes Dev (2005) 1.76
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint. Curr Biol (2009) 1.76
Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. Nat Cell Biol (2010) 1.74
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res (2008) 1.73
Metaphase I arrest upon activation of the Mad2-dependent spindle checkpoint in mouse oocytes. Curr Biol (2003) 1.70
Lateral microtubule bundles promote chromosome alignment during acentrosomal oocyte meiosis. Nat Cell Biol (2009) 1.68
The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J Biol Chem (2002) 1.64
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64
Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential. J Cell Sci (2001) 1.61
Merotelic kinetochore attachment: causes and effects. Trends Cell Biol (2011) 1.60
Kinetic framework of spindle assembly checkpoint signalling. Nat Cell Biol (2013) 1.47
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice. Nat Genet (2007) 1.47
The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat Cell Biol (2013) 1.46
In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis. Curr Biol (2004) 1.42
The influence of catalysis on mad2 activation dynamics. PLoS Biol (2009) 1.40
A membranous spindle matrix orchestrates cell division. Nat Rev Mol Cell Biol (2010) 1.39
New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol (2012) 1.36
Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores. Curr Biol (2007) 1.34
One-dimensional diffusion on microtubules of particles coated with cytoplasmic dynein and immunoglobulins. Cell Struct Funct (1999) 1.34
Molecular causes of aneuploidy in mammalian eggs. Development (2013) 1.33
The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint. Nat Cell Biol (2004) 1.31
A quantitative systems view of the spindle assembly checkpoint. EMBO J (2009) 1.26
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol Cell (2010) 1.25
Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr Biol (2014) 1.25
Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc Natl Acad Sci U S A (2012) 1.23
Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase. Curr Biol (2014) 1.23
Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes. Development (2012) 1.21
Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension. Development (2012) 1.17
Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy. Cell Death Differ (2012) 1.17
Comparative analysis of follicle morphology and oocyte diameter in four mammalian species (mouse, hamster, pig, and human). J Exp Clin Assist Reprod (2006) 1.16
Lack of response to unaligned chromosomes in mammalian female gametes. Cell Cycle (2012) 1.14
Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. J Cell Biol (2008) 1.13
Evaluating putative mechanisms of the mitotic spindle checkpoint. Proc Natl Acad Sci U S A (2005) 1.12
Distribution of aneuploidy in human gametes: comparison between human sperm and oocytes. Am J Med Genet (1991) 1.09