Published in Proc Natl Acad Sci U S A on June 05, 2006
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Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest (2003) 4.58
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Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis. J Immunol (2004) 2.95
Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts. Am J Respir Cell Mol Biol (2004) 2.82
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Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab (2011) 2.73
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Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
Lateral signaling enhances TGF-beta response complexity. Trends Cell Biol (2004) 2.38
Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A (2003) 2.37
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol (2004) 2.24
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol (2002) 2.23
An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res (2008) 2.19
Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am J Pathol (2004) 2.17
Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 2.13
Loss of Smad3 in acute T-cell lymphoblastic leukemia. N Engl J Med (2004) 2.05
Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem (2003) 1.97
Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo. J Biol Chem (2004) 1.89
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.79
Biomarkers to assess the utility of potential reduced exposure tobacco products. Nicotine Tob Res (2006) 1.75
Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta. Ann N Y Acad Sci (2003) 1.74
Cells derived from the circulation contribute to the repair of lung injury. Am J Respir Crit Care Med (2004) 1.74
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Mol Cell (2006) 1.73
Comorbidities, patient knowledge, and disease management in a national sample of patients with COPD. Am J Med (2009) 1.70
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Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity (2010) 1.68
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JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer. Breast Cancer Res (2012) 1.67
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Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol (2003) 1.64
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res (2003) 1.59
Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy. Biochem Biophys Res Commun (2003) 1.55
Proposal for a multidimensional staging system for chronic obstructive pulmonary disease. Respir Med (2005) 1.54
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Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. Am J Respir Crit Care Med (2008) 1.50
Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function. J Biol Chem (2009) 1.49
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem (2004) 1.46
Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. J Biol Chem (2003) 1.41
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta. J Cell Sci (2005) 1.39
Hypothesis: in COPD, a pound of cure may be better than an ounce of prevention. Thorax (2011) 1.38
Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res (2004) 1.38
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FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development (2009) 1.35
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Reduced miR-146a increases prostaglandin E₂in chronic obstructive pulmonary disease fibroblasts. Am J Respir Crit Care Med (2010) 1.33
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Transient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-Beta mediated mechanism in a mouse xenograft model of breast cancer. PLoS One (2010) 1.31
Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol (2005) 1.27
The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol (2009) 1.25
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res (2009) 1.24
Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice. Lab Invest (2004) 1.23
Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice. Lab Invest (2004) 1.22
Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normal. Am J Respir Cell Mol Biol (2007) 1.22
Enhancing COPD management in primary care settings. MedGenMed (2007) 1.22
Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice. Am J Pathol (2005) 1.21
A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD. Respir Med (2004) 1.21
Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Liver Int (2009) 1.21
Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics. Breast Cancer Res Treat (2009) 1.20
Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team. Am J Respir Crit Care Med (2014) 1.20
The future of chronic obstructive pulmonary disease treatment--difficulties of and barriers to drug development. Lancet (2011) 1.19
Characterization of mechanical and biochemical properties of developing embryonic tendon. Proc Natl Acad Sci U S A (2013) 1.18
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
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Conditional knockout of the Smad1 gene. Genesis (2002) 1.16
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Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts. Biochem Biophys Res Commun (2005) 1.16
TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J (2003) 1.16
Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice. Am J Physiol Cell Physiol (2007) 1.16
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Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing. Am J Pathol (2006) 1.14
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