PubRank

Cynthia Wolberger

Author PubWeight™ 79.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006 6.79
2 The biochemistry of sirtuins. Annu Rev Biochem 2006 4.32
3 Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 2007 4.16
4 Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation. Nat Struct Mol Biol 2006 3.71
5 Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol 2004 2.76
6 A core nucleosome surface crucial for transcriptional silencing. Nat Genet 2002 2.67
7 A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J 2003 2.37
8 Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 2005 2.31
9 Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. J Mol Biol 2006 2.22
10 Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure 2008 2.12
11 Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol 2006 2.03
12 Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol Cell 2002 2.00
13 N-lysine propionylation controls the activity of propionyl-CoA synthetase. J Biol Chem 2007 1.95
14 Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol 2009 1.82
15 Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev 2003 1.82
16 The structure and conformation of Lys63-linked tetraubiquitin. J Mol Biol 2009 1.77
17 Structural insights into the assembly and function of the SAGA deubiquitinating module. Science 2010 1.74
18 The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature 2012 1.70
19 Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure 2006 1.66
20 RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci Signal 2012 1.40
21 The structural basis of sirtuin substrate affinity. Biochemistry 2006 1.40
22 How does the histone code work? Biochem Cell Biol 2005 1.40
23 Structural basis for the mechanism and regulation of Sir2 enzymes. Mol Cell 2004 1.37
24 Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem 2008 1.29
25 Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J Biol Chem 2002 1.25
26 E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nat Struct Mol Biol 2013 1.10
27 SIR2 family of NAD(+)-dependent protein deacetylases. Methods Enzymol 2002 1.09
28 A Hoogsteen base pair embedded in undistorted B-DNA. Nucleic Acids Res 2002 1.08
29 Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera. Protein Sci 2003 1.05
30 A new chapter in the transcription SAGA. Curr Opin Struct Biol 2011 1.01
31 A conserved asparagine has a structural role in ubiquitin-conjugating enzymes. Nat Chem Biol 2013 1.01
32 Structure of Sir2Tm bound to a propionylated peptide. Protein Sci 2011 0.97
33 The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins. Protein Sci 2007 0.97
34 A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins. Anal Biochem 2011 0.92
35 Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants. J Mol Biol 2008 0.92
36 Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J Biol Chem 2013 0.91
37 Insights into nonspecific binding of homeodomains from a structure of MATalpha2 bound to DNA. Proteins 2003 0.90
38 A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity. Structure 2012 0.90
39 Getting a grip on O-acetyl-ADP-ribose. Nat Struct Mol Biol 2005 0.86
40 Structure-based mechanism of ADP-ribosylation by sirtuins. J Biol Chem 2009 0.85
41 Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5. J Mol Biol 2009 0.83
42 Arm-domain interactions can provide high binding cooperativity. Protein Sci 2004 0.83
43 Side chain specificity of ADP-ribosylation by a sirtuin. FEBS J 2009 0.83
44 Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2. Structure 2002 0.82
45 Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2. Proc Natl Acad Sci U S A 2012 0.80
46 Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Protein Sci 2014 0.78
47 A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants. J Mass Spectrom 2013 0.77
48 A new RING tossed into an old HAT. Structure 2013 0.75
49 Biochemistry: Sirtuin on a high-fat diet. Nature 2013 0.75
50 Proteins: histones and chromatin. Curr Opin Struct Biol 2011 0.75
51 A new DUB makes linear ubiquitin a party to its own destruction. Cell 2013 0.75