Published in Curr Opin Struct Biol on October 18, 2011
Towards the identification of protein complexes and functional modules by integrating PPI network and gene expression data. BMC Bioinformatics (2012) 1.10
Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias. Cerebellum (2014) 1.03
Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex. EMBO J (2014) 1.00
Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev (2015) 0.95
Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci (2013) 0.94
Global SUMO Proteome Responses Guide Gene Regulation, mRNA Biogenesis, and Plant Stress Responses. Front Plant Sci (2012) 0.89
A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLoS One (2013) 0.88
Functions of SAGA in development and disease. Epigenomics (2014) 0.85
Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module. Mol Cell Biol (2015) 0.83
The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J (2015) 0.82
SAGA complex components and acetate repression in Aspergillus nidulans. G3 (Bethesda) (2012) 0.80
Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe. G3 (Bethesda) (2014) 0.79
Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex in Plants: Genome Wide Identification, Evolutionary Conservation and Functional Determination. PLoS One (2015) 0.78
Mechanisms for regulating deubiquitinating enzymes. Protein Sci (2014) 0.78
Proteins: histones and chromatin. Curr Opin Struct Biol (2011) 0.75
The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain. PLoS One (2015) 0.75
Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA. Nucleic Acids Res (2017) 0.75
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell (1996) 9.86
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev (2001) 6.28
Transcription of eukaryotic protein-coding genes. Annu Rev Genet (2000) 6.12
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J (2001) 5.34
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature (2005) 5.15
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p. EMBO J (2000) 4.82
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Transcriptional coactivator complexes. Annu Rev Biochem (2001) 3.97
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell (2008) 3.60
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell (2008) 3.42
Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell (2004) 3.16
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion. Nat Genet (1997) 2.77
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Mol Cell (2007) 2.71
Inducible gene expression: diverse regulatory mechanisms. Nat Rev Genet (2010) 2.53
Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation. J Biol Chem (2001) 2.50
Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide. Nature (1999) 2.50
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. J Biol Chem (2003) 2.48
H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell (2007) 2.32
Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell (2009) 2.29
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export. Nat Cell Biol (2008) 2.27
Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol Cell (2009) 2.25
The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene (2007) 2.04
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. Proc Natl Acad Sci U S A (1999) 1.99
Structural insights into the assembly and function of the SAGA deubiquitinating module. Science (2010) 1.74
Multiple faces of the SAGA complex. Curr Opin Cell Biol (2010) 1.67
Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module. Cell (2010) 1.66
Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). J Biol Chem (2006) 1.59
Insights into SAGA function during gene expression. EMBO Rep (2009) 1.58
SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system. EMBO J (2008) 1.54
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J (2011) 1.52
Dissection of USP catalytic domains reveals five common insertion points. Mol Biosyst (2009) 1.47
Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2. Genes Dev (2008) 1.39
Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Mol Syst Biol (2011) 1.29
Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes. Epigenetics Chromatin (2009) 1.27
Zinc-finger UBPs: regulators of deubiquitylation. Trends Biochem Sci (2008) 1.19
Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1. J Biol Chem (2009) 1.00
The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties. EMBO Rep (2010) 0.93
Solution NMR characterization of Sgf73(1-104) indicates that Zn ion is required to stabilize zinc finger motif. Biochem Biophys Res Commun (2010) 0.80
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
The biochemistry of sirtuins. Annu Rev Biochem (2006) 4.32
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab (2007) 4.16
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation. Nat Struct Mol Biol (2006) 3.71
Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol (2004) 2.76
A core nucleosome surface crucial for transcriptional silencing. Nat Genet (2002) 2.67
A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J (2003) 2.37
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell (2005) 2.31
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. J Mol Biol (2006) 2.22
Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure (2008) 2.12
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol (2006) 2.03
Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol Cell (2002) 2.00
N-lysine propionylation controls the activity of propionyl-CoA synthetase. J Biol Chem (2007) 1.95
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82
Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev (2003) 1.82
The structure and conformation of Lys63-linked tetraubiquitin. J Mol Biol (2009) 1.77
Structural insights into the assembly and function of the SAGA deubiquitinating module. Science (2010) 1.74
The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature (2012) 1.70
Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure (2006) 1.66
RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci Signal (2012) 1.40
How does the histone code work? Biochem Cell Biol (2005) 1.40
The structural basis of sirtuin substrate affinity. Biochemistry (2006) 1.40
Structural basis for the mechanism and regulation of Sir2 enzymes. Mol Cell (2004) 1.37
Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem (2008) 1.29
Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J Biol Chem (2002) 1.25
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nat Struct Mol Biol (2013) 1.10
SIR2 family of NAD(+)-dependent protein deacetylases. Methods Enzymol (2002) 1.09
A Hoogsteen base pair embedded in undistorted B-DNA. Nucleic Acids Res (2002) 1.08
Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera. Protein Sci (2003) 1.05
A conserved asparagine has a structural role in ubiquitin-conjugating enzymes. Nat Chem Biol (2013) 1.01
Structure of Sir2Tm bound to a propionylated peptide. Protein Sci (2011) 0.97
The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins. Protein Sci (2007) 0.97
A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins. Anal Biochem (2011) 0.92
Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants. J Mol Biol (2008) 0.92
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J Biol Chem (2013) 0.91
Insights into nonspecific binding of homeodomains from a structure of MATalpha2 bound to DNA. Proteins (2003) 0.90
A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity. Structure (2012) 0.90
Getting a grip on O-acetyl-ADP-ribose. Nat Struct Mol Biol (2005) 0.86
Structure-based mechanism of ADP-ribosylation by sirtuins. J Biol Chem (2009) 0.85
Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5. J Mol Biol (2009) 0.83
Side chain specificity of ADP-ribosylation by a sirtuin. FEBS J (2009) 0.83
Arm-domain interactions can provide high binding cooperativity. Protein Sci (2004) 0.83
Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2. Structure (2002) 0.82
Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2. Proc Natl Acad Sci U S A (2012) 0.80
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Protein Sci (2014) 0.78
A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants. J Mass Spectrom (2013) 0.77
Proteins: histones and chromatin. Curr Opin Struct Biol (2011) 0.75
A new DUB makes linear ubiquitin a party to its own destruction. Cell (2013) 0.75
Biochemistry: Sirtuin on a high-fat diet. Nature (2013) 0.75
A new RING tossed into an old HAT. Structure (2013) 0.75