Published in Structure on June 01, 2006
Amyloid formation by globular proteins under native conditions. Nat Chem Biol (2009) 3.72
Defined DNA sequences promote the assembly of a bacterial protein into distinct amyloid nanostructures. Proc Natl Acad Sci U S A (2007) 1.01
Structural and dynamics characteristics of acylphosphatase from Sulfolobus solfataricus in the monomeric state and in the initial native-like aggregates. J Biol Chem (2010) 0.84
Characterizing intermolecular interactions that initiate native-like protein aggregation. Biophys J (2012) 0.84
Deletional protein engineering based on stable fold. PLoS One (2012) 0.77
Misfolding of amyloidogenic proteins and their interactions with membranes. Biomolecules (2013) 0.77
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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature (2002) 10.81
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. J Mol Biol (2005) 3.18
Prediction of aggregation-prone regions in structured proteins. J Mol Biol (2008) 2.56
A causative link between the structure of aberrant protein oligomers and their toxicity. Nat Chem Biol (2010) 2.48
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. J Mol Biol (2004) 2.14
Italian cross-cultural adaptation and validation of the Oxford Shoulder Score. J Shoulder Elbow Surg (2009) 2.02
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Prefibrillar amyloid aggregates could be generic toxins in higher organisms. J Neurosci (2006) 1.89
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J Biol Chem (2004) 1.79
Prevention of amyloid-like aggregation as a driving force of protein evolution. EMBO Rep (2007) 1.78
Generation of high-quality protein extracts from formalin-fixed, paraffin-embedded tissues. Proteomics (2009) 1.70
Novel binding partners of Ldb1 are required for haematopoietic development. Development (2006) 1.63
Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation. Structure (2005) 1.63
Insight into the structure of amyloid fibrils from the analysis of globular proteins. PLoS Comput Biol (2006) 1.55
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. Hum Mol Genet (2008) 1.43
Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships. Chem Biol (2012) 1.41
Comparison of detergent-based sample preparation workflows for LTQ-Orbitrap analysis of the Escherichia coli proteome. Proteomics (2013) 1.40
Hb Southern Italy: coexistence of two missence mutations (the Hb Sun Prairie alpha2 130 Ala --> Pro and Hb Caserta alpha2 26 Ala --> Thr) in a single HBA2 gene. Br J Haematol (2008) 1.39
Expression and purification of the recombinant subunits of toluene/o-xylene monooxygenase and reconstitution of the active complex. Eur J Biochem (2002) 1.39
Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. FEBS Lett (2005) 1.32
Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation. Biochemistry (2006) 1.32
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin. Proc Natl Acad Sci U S A (2005) 1.31
Phenol hydroxylase and toluene/o-xylene monooxygenase from Pseudomonas stutzeri OX1: interplay between two enzymes. Appl Environ Microbiol (2004) 1.26
Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Cancer Res (2009) 1.25
Amyloid fibril formation can proceed from different conformations of a partially unfolded protein. Biophys J (2005) 1.25
Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. Cancer Res (2010) 1.20
Evidence for a mechanism of amyloid formation involving molecular reorganisation within native-like precursor aggregates. J Mol Biol (2005) 1.19
Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. PLoS Biol (2010) 1.18
Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases. Curr Opin Struct Biol (2008) 1.14
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers. Proc Natl Acad Sci U S A (2012) 1.13
Prediction of amyloid aggregation in vivo. EMBO Rep (2011) 1.11
Aggregation of the Acylphosphatase from Sulfolobus solfataricus: the folded and partially unfolded states can both be precursors for amyloid formation. J Biol Chem (2004) 1.11
Liquid chromatography-tandem mass spectrometric ion-switching determination of chlorantraniliprole and flubendiamide in fruits and vegetables. J Agric Food Chem (2008) 1.10
Sequence and structural determinants of amyloid fibril formation. Acc Chem Res (2006) 1.07
Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase. Protein Sci (2006) 1.07
The role of the conserved residues His-246, His-199, and Tyr-255 in the catalysis of catechol 2,3-dioxygenase from Pseudomonas stutzeri OX1. J Biol Chem (2004) 1.06
Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin. J Biol Chem (2013) 1.04
Amyloid formation of a protein in the absence of initial unfolding and destabilization of the native state. Biophys J (2005) 1.03
Investigating the effects of mutations on protein aggregation in the cell. J Biol Chem (2004) 1.01
Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. Proc Natl Acad Sci U S A (2011) 1.01
Aggregation propensity of the human proteome. PLoS Comput Biol (2008) 1.00
Conformational properties of the aggregation precursor state of HypF-N. J Mol Biol (2008) 1.00
Protein aggregation and amyloid fibril formation by an SH3 domain probed by limited proteolysis. J Mol Biol (2003) 1.00
Thermal stability and aggregation of sulfolobus solfataricus beta-glycosidase are dependent upon the N-epsilon-methylation of specific lysyl residues: critical role of in vivo post-translational modifications. J Biol Chem (2003) 0.99
Structure, conformational stability, and enzymatic properties of acylphosphatase from the hyperthermophile Sulfolobus solfataricus. Proteins (2006) 0.99
Monitoring the process of HypF fibrillization and liposome permeabilization by protofibrils. J Mol Biol (2004) 0.99
Reversal of protein aggregation provides evidence for multiple aggregated States. J Mol Biol (2004) 0.99
2-D PAGE and MS analysis of proteins from formalin-fixed, paraffin-embedded tissues. Proteomics (2009) 0.99
Setting proteins free: progresses and achievements in proteomics of formalin-fixed, paraffin-embedded tissues. Proteomics Clin Appl (2011) 0.99
Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide. Biophys J (2010) 0.99
Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes. Biochemistry (2006) 0.99
Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. Nature (2013) 0.98
Amyloid fibril formation and disaggregation of fragment 1-29 of apomyoglobin: insights into the effect of pH on protein fibrillogenesis. J Mol Biol (2007) 0.97
Relative influence of hydrophobicity and net charge in the aggregation of two homologous proteins. Biochemistry (2003) 0.97
Equilibrium collapse and the kinetic 'foldability' of proteins. Biochemistry (2002) 0.97
Sulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulum. EMBO J (2007) 0.97
Kinetic analysis of amyloid formation in the presence of heparan sulfate: faster unfolding and change of pathway. J Biol Chem (2009) 0.96
The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution. Biophys J (2007) 0.95
Amyloid formation by the model protein muscle acylphosphatase is accelerated by heparin and heparan sulphate through a scaffolding-based mechanism. J Biochem (2009) 0.94
Stabilization of a native protein mediated by ligand binding inhibits amyloid formation independently of the aggregation pathway. J Med Chem (2006) 0.94
The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP. Nucleic Acids Res (2003) 0.93
Amyloid formation from HypF-N under conditions in which the protein is initially in its native state. J Mol Biol (2005) 0.93
Pancreatic cancer-derived S-100A8 N-terminal peptide: a diabetes cause? Clin Chim Acta (2006) 0.92
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. ACS Chem Biol (2014) 0.92
The degree of structural protection at the edge beta-strands determines the pathway of amyloid formation in globular proteins. J Am Chem Soc (2008) 0.92
Biological properties of a human compact anti-ErbB2 antibody. Carcinogenesis (2005) 0.92
Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding. J Mol Biol (2003) 0.91
A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. EMBO Mol Med (2012) 0.91
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells. J Cell Mol Med (2011) 0.90
Effects of the known pathogenic mutations on the aggregation pathway of the amyloidogenic peptide of apolipoprotein A-I. J Mol Biol (2011) 0.90
Bidimensional tandem mass spectrometry for selective identification of nitration sites in proteins. Anal Chem (2007) 0.90
The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS One (2012) 0.90
Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation. J Am Chem Soc (2008) 0.89
A model for the aggregation of the acylphosphatase from Sulfolobus solfataricus in its native-like state. Biochim Biophys Acta (2008) 0.89
Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils. PLoS One (2011) 0.89
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers. J Cell Sci (2012) 0.89
Topological investigation of amyloid fibrils obtained from beta2-microglobulin. Protein Sci (2002) 0.89
Hb Foggia or alpha 117(GH5)Phe -> Ser: a new alpha 2 globin allele affecting the alpha Hb-AHSP interaction. Haematologica (2008) 0.88
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro. Biochim Biophys Acta (2013) 0.88
Proteomics of beta2-microglobulin amyloid fibrils. Biochim Biophys Acta (2005) 0.88
"Native-like aggregation" of the acylphosphatase from Sulfolobus solfataricus and its biological implications. FEBS Lett (2009) 0.88
Detection of populations of amyloid-like protofibrils with different physical properties. Biophys J (2010) 0.88