Published in J Mol Biol on February 03, 2007
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell (2012) 3.39
Prevention of amyloid-like aggregation as a driving force of protein evolution. EMBO Rep (2007) 1.78
Effect of electrostatics on aggregation of prion protein Sup35 peptide. J Phys Condens Matter (2012) 0.96
The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution. Biophys J (2007) 0.95
Amyloidogenic sequences in native protein structures. Protein Sci (2010) 0.91
Crowding alone cannot account for cosolute effect on amyloid aggregation. PLoS One (2011) 0.87
Cytotoxic aggregation and amyloid formation by the myostatin precursor protein. PLoS One (2010) 0.83
Protein structure evolution in liquid DESI as revealed by selective noncovalent adduct protein probing. Int J Mass Spectrom (2012) 0.81
Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation. Prion (2012) 0.81
Misfolding and amyloid aggregation of apomyoglobin. Int J Mol Sci (2013) 0.78
Regions which are Responsible for Swapping are also Responsible for Folding and Misfolding. Open Biochem J (2011) 0.78
Monitoring insulin aggregation via capillary electrophoresis. Int J Mol Sci (2011) 0.77
Highly amyloidogenic two-chain peptide fragments are released upon partial digestion of insulin with pepsin. J Biol Chem (2015) 0.75
The impact of solubility and electrostatics on fibril formation by the H3 and H4 histones. Protein Sci (2011) 0.75
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature (2002) 10.81
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. J Mol Biol (2005) 3.18
Prediction of aggregation-prone regions in structured proteins. J Mol Biol (2008) 2.56
A causative link between the structure of aberrant protein oligomers and their toxicity. Nat Chem Biol (2010) 2.48
Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. Mol Cell (2005) 2.42
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35
Probing protein structure by limited proteolysis. Acta Biochim Pol (2004) 2.32
Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. J Mol Biol (2004) 2.14
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Prefibrillar amyloid aggregates could be generic toxins in higher organisms. J Neurosci (2006) 1.89
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J Biol Chem (2004) 1.79
Prevention of amyloid-like aggregation as a driving force of protein evolution. EMBO Rep (2007) 1.78
Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation. Structure (2005) 1.63
Insight into the structure of amyloid fibrils from the analysis of globular proteins. PLoS Comput Biol (2006) 1.55
Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships. Chem Biol (2012) 1.41
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin. Proc Natl Acad Sci U S A (2005) 1.31
A highly amyloidogenic region of hen lysozyme. J Mol Biol (2004) 1.29
Amyloid fibril formation can proceed from different conformations of a partially unfolded protein. Biophys J (2005) 1.25
The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem (2005) 1.21
The role of complex lipids in the synthesis of bioactive aldehydes of the marine diatom Skeletonema costatum. Biochim Biophys Acta (2004) 1.20
Evidence for a mechanism of amyloid formation involving molecular reorganisation within native-like precursor aggregates. J Mol Biol (2005) 1.19
Identification of the core structure of lysozyme amyloid fibrils by proteolysis. J Mol Biol (2006) 1.17
Biogenesis of 3-alkylpyridine alkaloids in the marine mollusc Haminoea orbignyana. Angew Chem Int Ed Engl (2003) 1.17
Oxidative stress by monoamine oxidases is causally involved in myofiber damage in muscular dystrophy. Hum Mol Genet (2010) 1.15
Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases. Curr Opin Struct Biol (2008) 1.14
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers. Proc Natl Acad Sci U S A (2012) 1.13
Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins. Nucleic Acids Res (2008) 1.12
Prediction of amyloid aggregation in vivo. EMBO Rep (2011) 1.11
Aggregation of the Acylphosphatase from Sulfolobus solfataricus: the folded and partially unfolded states can both be precursors for amyloid formation. J Biol Chem (2004) 1.11
Evidences for interaction of PsbS with photosynthetic complexes in maize thylakoids. Biochim Biophys Acta (2006) 1.09
Sequence and structural determinants of amyloid fibril formation. Acc Chem Res (2006) 1.07
Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase. Protein Sci (2006) 1.07
The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity. J Mol Biol (2010) 1.07
Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase. Adv Drug Deliv Rev (2007) 1.05
Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin. J Biol Chem (2013) 1.04
Amyloid formation of a protein in the absence of initial unfolding and destabilization of the native state. Biophys J (2005) 1.03
Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. J Biol Chem (2011) 1.02
Investigating the effects of mutations on protein aggregation in the cell. J Biol Chem (2004) 1.01
Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. Proc Natl Acad Sci U S A (2011) 1.01
Aggregation propensity of the human proteome. PLoS Comput Biol (2008) 1.00
Protein aggregation and amyloid fibril formation by an SH3 domain probed by limited proteolysis. J Mol Biol (2003) 1.00
Conformational properties of the aggregation precursor state of HypF-N. J Mol Biol (2008) 1.00
Structure, conformational stability, and enzymatic properties of acylphosphatase from the hyperthermophile Sulfolobus solfataricus. Proteins (2006) 0.99
Reversal of protein aggregation provides evidence for multiple aggregated States. J Mol Biol (2004) 0.99
Monitoring the process of HypF fibrillization and liposome permeabilization by protofibrils. J Mol Biol (2004) 0.99
Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes. Biochemistry (2006) 0.99
Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide. Biophys J (2010) 0.99
15S-lipoxygenase metabolism in the marine diatom Pseudo-nitzschia delicatissima. New Phytol (2009) 0.97
Relative influence of hydrophobicity and net charge in the aggregation of two homologous proteins. Biochemistry (2003) 0.97
Equilibrium collapse and the kinetic 'foldability' of proteins. Biochemistry (2002) 0.97
Kinetic analysis of amyloid formation in the presence of heparan sulfate: faster unfolding and change of pathway. J Biol Chem (2009) 0.96
The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution. Biophys J (2007) 0.95
Amyloid formation by the model protein muscle acylphosphatase is accelerated by heparin and heparan sulphate through a scaffolding-based mechanism. J Biochem (2009) 0.94
New C16 fatty-acid-based oxylipin pathway in the marine diatom Thalassiosira rotula. Org Biomol Chem (2005) 0.94
Stabilization of a native protein mediated by ligand binding inhibits amyloid formation independently of the aggregation pathway. J Med Chem (2006) 0.94
Amyloid formation from HypF-N under conditions in which the protein is initially in its native state. J Mol Biol (2005) 0.93
Conformational properties of the SDS-bound state of alpha-synuclein probed by limited proteolysis: unexpected rigidity of the acidic C-terminal tail. Biochemistry (2006) 0.93
Characterization of oligomeric species on the aggregation pathway of human lysozyme. J Mol Biol (2009) 0.93
The degree of structural protection at the edge beta-strands determines the pathway of amyloid formation in globular proteins. J Am Chem Soc (2008) 0.92
Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. FASEB J (2005) 0.92
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. ACS Chem Biol (2014) 0.92
Chloroplastic glycolipids fuel aldehyde biosynthesis in the marine diatom Thalassiosira rotula. Chembiochem (2006) 0.92
Fly cryptochrome and the visual system. Proc Natl Acad Sci U S A (2013) 0.91
Partly folded states of members of the lysozyme/lactalbumin superfamily: a comparative study by circular dichroism spectroscopy and limited proteolysis. Protein Sci (2002) 0.91
Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding. J Mol Biol (2003) 0.91
Comparison of protein fragments identified by limited proteolysis and by computational cutting of proteins. Protein Sci (2002) 0.91
The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity. FEBS J (2009) 0.91
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells. J Cell Mol Med (2011) 0.90
Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation. J Am Chem Soc (2008) 0.89
α-Lactalbumin forms with oleic acid a high molecular weight complex displaying cytotoxic activity. Biochemistry (2010) 0.89
Nerve influence on myosin light chain phosphorylation in slow and fast skeletal muscles. FEBS J (2005) 0.89
Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils. PLoS One (2011) 0.89
A model for the aggregation of the acylphosphatase from Sulfolobus solfataricus in its native-like state. Biochim Biophys Acta (2008) 0.89
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers. J Cell Sci (2012) 0.89
Dopamine quinones interact with alpha-synuclein to form unstructured adducts. Biochem Biophys Res Commun (2010) 0.88
3-Nitrotyrosine as a spectroscopic probe for investigating protein protein interactions. Protein Sci (2006) 0.88
Exploring the mechanism of formation of native-like and precursor amyloid oligomers for the native acylphosphatase from Sulfolobus solfataricus. Structure (2006) 0.88
Detection of populations of amyloid-like protofibrils with different physical properties. Biophys J (2010) 0.88