Published in J Biol Chem on July 18, 2013
New look at hemoglobin allostery. Chem Rev (2015) 0.87
Sickle Cell Hemoglobin with Mutation at αHis-50 Has Improved Solubility. J Biol Chem (2015) 0.76
Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA (2008) 8.60
The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA (2005) 6.49
The crystal structure of human deoxyhaemoglobin at 1.74 A resolution. J Mol Biol (1984) 4.49
Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry (1996) 3.36
Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol (1998) 2.35
Mapping the pathways for O2 entry into and exit from myoglobin. J Biol Chem (2000) 2.31
1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms. J Mol Biol (2006) 1.93
An enzymic reduction system for metmyoglobin and methemoglobin, and its application to functional studies of oxygen carriers. Biochim Biophys Acta (1973) 1.82
A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate. J Biol Chem (1992) 1.73
The mechanism of autooxidation of myoglobin. J Biol Chem (1993) 1.71
Equations for the spectrophotometric analysis of hemoglobin mixtures. Anal Biochem (1973) 1.67
Reactions involving superoxide and normal and unstable haemoglobins. Biochem J (1976) 1.66
Oxygen binding properties of human mutant hemoglobins synthesized in Escherichia coli. Proc Natl Acad Sci U S A (1985) 1.62
Genetic differences in hemoglobin function between highland and lowland deer mice. J Exp Biol (2010) 1.45
A human recombinant haemoglobin designed for use as a blood substitute. Nature (1992) 1.42
Production of unmodified human adult hemoglobin in Escherichia coli. Proc Natl Acad Sci U S A (1993) 1.42
Structural and functional effects of apolar mutations of the distal valine in myoglobin. J Mol Biol (1995) 1.37
Structural factors governing azide and cyanide binding to mammalian metmyoglobins. J Biol Chem (1994) 1.31
Isolation and characterization of a new hemoglobin derivative cross-linked between the alpha chains (lysine 99 alpha 1----lysine 99 alpha 2). J Biol Chem (1986) 1.30
The effects of E7 and E11 mutations on the kinetics of ligand binding to R state human hemoglobin. J Biol Chem (1989) 1.29
Mechanism of autooxidation for hemoglobins and myoglobins. Promotion of superoxide production by protons and anions. J Biol Chem (1982) 1.27
Structure of hemoglobins Zürich [His E7(63)beta replaced by Arg] and Sydney [Val E11(67)beta replaced by Ala] and role of the distal residues in ligand binding. Proc Natl Acad Sci U S A (1978) 1.25
The linkage between oxygenation and subunit dissociation in human hemoglobin. Consequences for the analysis of oxygenation curves. Biochemistry (1975) 1.25
Production of human normal adult and fetal hemoglobins in Escherichia coli. Protein Eng (1997) 1.22
Proton nuclear magnetic resonance studies on hemoglobin: cooperative interactions and partially ligated intermediates. Adv Protein Chem (1992) 1.21
Survival at extreme altitude: protective effect of increased hemoglobin-oxygen affinity. Science (1974) 1.19
Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin. J Biol Chem (2010) 1.15
Chain-selective isotopic labeling for NMR studies of large multimeric proteins: application to hemoglobin. Biophys J (2000) 1.15
Distal residues in the oxygen binding site of haemoglobin studied by protein engineering. Nature (1987) 1.13
A proton nuclear magnetic resonance study of the quaternary structure of human homoglobins in water. Biochemistry (1975) 1.06
NMR reveals hydrogen bonds between oxygen and distal histidines in oxyhemoglobin. Proc Natl Acad Sci U S A (2000) 1.01
Development of recombinant hemoglobin-based oxygen carriers. Antioxid Redox Signal (2012) 1.00
Assignment of proximal histidyl imidazole exchangeable proton NMR resonances to individual subunits in hemoglobins A, Boston, Iwate and Milwaukee. Biochem Biophys Res Commun (1980) 0.99
Polymerized pyridoxylated hemoglobin: a red cell substitute with normal oxygen capacity. Surgery (1984) 0.96
Nuclear magnetic resonance studies of hemoglobins. VII. Tertiary structure around ligand binding site in carbonmonoxyhemoglobin. Biochemistry (1972) 0.96
Proton nuclear Overhauser effect investigation of the heme pockets in ligated hemoglobin: conformational differences between oxy and carbonmonoxy forms. Biochemistry (1985) 0.95
A proton nuclear Overhauser effect investigation of the subunit interfaces in human normal adult hemoglobin. Biochim Biophys Acta (1987) 0.95
Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry (2002) 0.95
Blocking the gate to ligand entry in human hemoglobin. J Biol Chem (2010) 0.92
Modulating distal cavities in the α and β subunits of human HbA reveals the primary ligand migration pathway. Biochemistry (2011) 0.89
Biphasic nature in the autoxidation reaction of human oxyhemoglobin. Biochim Biophys Acta (1997) 0.88
The assignment of carbon monoxide association rate constants to the alpha and beta subunits in native and mutant human deoxyhemoglobin tetramers. J Biol Chem (1991) 0.88
Site-directed mutagenesis in hemoglobin: functional and structural role of inter- and intrasubunit hydrogen bonds as studied with 37 beta and 145 beta mutations. Biochemistry (1992) 0.88
A double mutant of sperm whale myoglobin mimics the structure and function of elephant myoglobin. J Biol Chem (1995) 0.88
A quantitative framework for the design of acellular hemoglobins as blood substitutes: implications of dynamic flow conditions. Biophys Chem (2007) 0.87
Properties of human hemoglobins with increased polarity in the alpha- or beta-heme pocket. Carbonmonoxy derivatives. J Biol Chem (1998) 0.86
Functional role of the distal valine (E11) residue of alpha subunits in human haemoglobin. J Mol Biol (1991) 0.85
A biophysical investigation of recombinant hemoglobins with aromatic B10 mutations in the distal heme pockets. Biochemistry (2005) 0.85
Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins. Biochemistry (2001) 0.84
An additional H-bond in the alpha 1 beta 2 interface as the structural basis for the low oxygen affinity and high cooperativity of a novel recombinant hemoglobin (beta L105W). Biochemistry (2000) 0.83
A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma. Med J Aust (2011) 0.83
A proton nuclear magnetic resonance investigation of human hemoglobin A2. Implications on the intermolecular contacts in sickle hemoglobin fibers and on the Bohr effect of human normal adult hemoglobin. Biochim Biophys Acta (1984) 0.83
Protein engineering strategies for designing more stable hemoglobin-based blood substitutes. Artif Cells Blood Substit Immobil Biotechnol (1997) 0.82
An investigation of the distal histidyl hydrogen bonds in oxyhemoglobin: effects of temperature, pH, and inositol hexaphosphate. Biochemistry (2010) 0.82
Measuring relative rates of hemoglobin oxidation and denaturation. Methods Enzymol (1994) 0.81
Recombinant hemoglobin(alpha 29leucine --> phenylalanine, alpha 96valine --> tryptophan, beta 108asparagine --> lysine) exhibits low oxygen affinity and high cooperativity combined with resistance to autoxidation. Biochemistry (1999) 0.79
Recombinant human hemoglobin: modification of the polarity of the beta-heme pocket by a valine67(E11)-->threonine mutation. Biochemistry (1993) 0.78
Interaction of haptoglobin with hemoglobin octamers based on the mutation αAsn78Cys or βGly83Cys. Am J Mol Biol (2012) 0.77
Enzymopenic hereditary methemoglobinemia. Haematologia (Budap) (1982) 0.76
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J Clin Invest (2005) 3.08
In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci U S A (2006) 3.04
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood (2005) 2.76
Noninvasive evaluation of cardiac allograft rejection by cellular and functional cardiac magnetic resonance. JACC Cardiovasc Imaging (2009) 1.79
Quaternary structure of hemoglobin in solution. Proc Natl Acad Sci U S A (2003) 1.77
Human neuroglobin functions as a redox-regulated nitrite reductase. J Biol Chem (2011) 1.70
Magnetic resonance imaging assessment of macrophage accumulation in mouse brain after experimental traumatic brain injury. J Neurotrauma (2009) 1.60
Real-time cardiac MRI without triggering, gating, or breath holding. Conf Proc IEEE Eng Med Biol Soc (2008) 1.53
Real-time cardiac MRI using prior spatial-spectral information. Conf Proc IEEE Eng Med Biol Soc (2009) 1.44
STACS: new active contour scheme for cardiac MR image segmentation. IEEE Trans Med Imaging (2005) 1.39
Longitudinal tracking of recipient macrophages in a rat chronic cardiac allograft rejection model with noninvasive magnetic resonance imaging using micrometer-sized paramagnetic iron oxide particles. Circulation (2008) 1.38
Myoglobin as a model system for designing heme protein based blood substitutes. Biophys Chem (2002) 1.36
19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells. Magn Reson Med (2011) 1.27
In vivo detection of acute rat renal allograft rejection by MRI with USPIO particles. Kidney Int (2002) 1.23
Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nat Genet (2010) 1.17
The structure--function relationship of hemoglobin in solution at atomic resolution. Chem Rev (2004) 1.17
MRI investigations of graft rejection following organ transplantation using rodent models. Methods Enzymol (2004) 1.12
High-resolution cardiac MRI using partially separable functions and weighted spatial smoothness regularization. Conf Proc IEEE Eng Med Biol Soc (2010) 1.12
Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats. J Cereb Blood Flow Metab (2008) 1.12
In support of the BMRB. Nat Struct Mol Biol (2012) 1.09
High-resolution cardiovascular MRI by integrating parallel imaging with low-rank and sparse modeling. IEEE Trans Biomed Eng (2013) 1.07
Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury. Circulation (2005) 1.05
Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein. Biochemistry (2010) 1.01
Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function. Protein J (2005) 1.01
Measurement of rate constants for reactions of O2, CO, and NO with hemoglobin. Methods Mol Med (2003) 1.01
Cerebral blood flow at one year after controlled cortical impact in rats: assessment by magnetic resonance imaging. J Neurotrauma (2002) 0.99
Four-dimensional MR cardiovascular imaging: method and applications. Conf Proc IEEE Eng Med Biol Soc (2011) 0.98
Quantitative temporal profiles of penumbra and infarction during permanent middle cerebral artery occlusion in rats. Transl Stroke Res (2010) 0.98
Quaternary structure of carbonmonoxyhemoglobins in solution: structural changes induced by the allosteric effector inositol hexaphosphate. Biochemistry (2006) 0.97
Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteine. Biochemistry (2002) 0.97
Murine orthostatic response during prolonged vertical studies: effect on cerebral blood flow measured by arterial spin-labeled MRI. Magn Reson Med (2005) 0.96
NMR investigation of the dynamics of tryptophan side-chains in hemoglobins. J Mol Biol (2002) 0.96
Superparamagnetic iron oxide particles transactivator protein-fluorescein isothiocyanate particle labeling for in vivo magnetic resonance imaging detection of cell migration: uptake and durability. Transplantation (2003) 0.95
Automatic detection of regional heart rejection in USPIO-enhanced MRI. IEEE Trans Med Imaging (2008) 0.95
Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry (2002) 0.95
MRI detection of macrophages labeled using micrometer-sized iron oxide particles. J Magn Reson Imaging (2007) 0.95
Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis. Magn Reson Imaging (2008) 0.94
Determination of the solution-bound conformation of an amino acid binding protein by NMR paramagnetic relaxation enhancement: use of a single flexible paramagnetic probe with improved estimation of its sampling space. J Am Chem Soc (2009) 0.94
A new nano-sized iron oxide particle with high sensitivity for cellular magnetic resonance imaging. Mol Imaging Biol (2011) 0.94
Hemoglobin site-mutants reveal dynamical role of interhelical H-bonds in the allosteric pathway: time-resolved UV resonance Raman evidence for intra-dimer coupling. J Mol Biol (2004) 0.94
A comparative NMR study of the polypeptide backbone dynamics of hemoglobin in the deoxy and carbonmonoxy forms. Biochemistry (2007) 0.94
Effect of inducible nitric oxide synthase on cerebral blood flow after experimental traumatic brain injury in mice. J Neurotrauma (2008) 0.93
Short planar gradient coils for MR microscopy using concentric return paths. J Magn Reson (2002) 0.92
Enhanced cellular uptake and long-term retention of chitosan-modified iron-oxide nanoparticles for MRI-based cell tracking. Int J Nanomedicine (2012) 0.91
Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome. J Cereb Blood Flow Metab (2011) 0.90
Normal and transplanted rat kidneys: diffusion MR imaging at 7 T. Radiology (2004) 0.90
Interfacial and distal-heme pocket mutations exhibit additive effects on the structure and function of hemoglobin. Biochemistry (2008) 0.89
Modulating distal cavities in the α and β subunits of human HbA reveals the primary ligand migration pathway. Biochemistry (2011) 0.89
Effector-induced structural fluctuation regulates the ligand affinity of an allosteric protein: binding of inositol hexaphosphate has distinct dynamic consequences for the T and R states of hemoglobin. Biochemistry (2008) 0.88
Dynamics of allostery in hemoglobin: roles of the penultimate tyrosine H bonds. J Mol Biol (2005) 0.88
Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid. Biochim Biophys Acta (2013) 0.87
New look at hemoglobin allostery. Chem Rev (2015) 0.87
MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice. J Cereb Blood Flow Metab (2012) 0.87
Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation. Circ Cardiovasc Imaging (2013) 0.86
A general strategy for the assignment of aliphatic side-chain resonances of uniformly 13C,15N-labeled large proteins. J Am Chem Soc (2005) 0.86
Improved subspace estimation for low-rank model-based accelerated cardiac imaging. IEEE Trans Biomed Eng (2014) 0.86
First-pass perfusion cardiac MRI using the Partially Separable Functions model with generalized support. Conf Proc IEEE Eng Med Biol Soc (2010) 0.86
Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging. J Cereb Blood Flow Metab (2005) 0.86
Tracking T-cells in vivo with a new nano-sized MRI contrast agent. Nanomedicine (2012) 0.85
A biophysical investigation of recombinant hemoglobins with aromatic B10 mutations in the distal heme pockets. Biochemistry (2005) 0.85
A synthetic receptor for asymmetric dimethyl arginine. J Am Chem Soc (2013) 0.84
Cellular and Functional Imaging of Cardiac Transplant Rejection. Curr Cardiovasc Imaging Rep (2011) 0.84
Insights into the solution structure of human deoxyhemoglobin in the absence and presence of an allosteric effector. Biochemistry (2007) 0.83
Recombinant hemoglobins with low oxygen affinity and high cooperativity. Biophys Chem (2002) 0.83
An investigation of the distal histidyl hydrogen bonds in oxyhemoglobin: effects of temperature, pH, and inositol hexaphosphate. Biochemistry (2010) 0.82
Backbone resonance assignment of human adult hemoglobin in the deoxy form. J Biomol NMR (2006) 0.82
Side-chain assignments of methyl-containing residues in a uniformly 13C-labeled hemoglobin in the carbonmonoxy form. J Biomol NMR (2004) 0.82
Molecular aspects of the high oxygen affinity of non-hypertensive hexa pegylated hemoglobin, [(SP-PEG5K)(6)-Hb]. Artif Cells Blood Substit Immobil Biotechnol (2007) 0.82
Solution structure and dynamics of human hemoglobin in the carbonmonoxy form. Biochemistry (2013) 0.81