Published in Mol Cell Biol on June 23, 2008
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol (2011) 2.08
K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway. J Cell Biol (2009) 1.90
The ubiquitin proteasome system in neuropathology. Acta Neuropathol (2009) 1.65
Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains. Traffic (2009) 1.39
Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis. Mol Cell Biol (2011) 1.37
The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective. Cardiovasc Res (2009) 1.36
Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles. Mol Biol Cell (2009) 1.29
Regulation of Akt signaling activation by ubiquitination. Cell Cycle (2010) 1.28
Masking of a nuclear signal motif by monoubiquitination leads to mislocalization and degradation of the regulatory enzyme cytidylyltransferase. Mol Cell Biol (2009) 1.27
A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Mol Cell Proteomics (2011) 1.25
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene (2010) 1.21
Endosomal transport via ubiquitination. Trends Cell Biol (2011) 1.12
Contribution of lysine 11-linked ubiquitination to MIR2-mediated major histocompatibility complex class I internalization. J Biol Chem (2010) 1.09
Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. J Biol Chem (2009) 1.07
Impaired turnover of prolactin receptor contributes to transformation of human breast cells. Cancer Res (2009) 1.06
Molecular mechanisms of prolactin and its receptor. Endocr Rev (2012) 1.04
Quality control for unfolded proteins at the plasma membrane. J Cell Biol (2010) 0.96
Ubiquitination-dependent regulation of signaling receptors in cancer. Genes Cancer (2010) 0.94
Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor. J Lipid Res (2013) 0.92
c-Cbl-mediated selective virus-receptor translocations into lipid rafts regulate productive Kaposi's sarcoma-associated herpesvirus infection in endothelial cells. J Virol (2011) 0.92
Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis. J Biol Chem (2012) 0.89
Lysine 48-linked polyubiquitination of organic anion transporter-1 is essential for its protein kinase C-regulated endocytosis. Mol Pharmacol (2012) 0.89
Versatile roles of k63-linked ubiquitin chains in trafficking. Cells (2014) 0.88
Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor. J Biol Chem (2010) 0.85
A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling. Mol Cell Biol (2012) 0.85
The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Mol Biol Cell (2012) 0.85
Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling. J Biol Chem (2011) 0.84
Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation. Mol Endocrinol (2010) 0.82
Three ubiquitination sites of organic anion transporter-1 synergistically mediate protein kinase C-dependent endocytosis of the transporter. Mol Pharmacol (2013) 0.82
Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation. Am J Physiol Renal Physiol (2013) 0.82
Increased expression of the prolactin receptor is associated with malignant laryngeal tumors. Exp Ther Med (2012) 0.82
Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression. J Immunol (2010) 0.82
Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport. Biol Open (2012) 0.81
Prolactin (PRL)-stimulated ubiquitination of ZnT2 mediates a transient increase in zinc secretion followed by ZnT2 degradation in mammary epithelial cells. J Biol Chem (2014) 0.79
SERS nanosensors that report pH of endocytic compartments during FcεRI transit. Anal Bioanal Chem (2010) 0.77
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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol (2003) 5.43
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol (2006) 4.25
A role for ubiquitin ligase recruitment in retrovirus release. Proc Natl Acad Sci U S A (2000) 4.19
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Adaptors for clathrin coats: structure and function. Annu Rev Cell Dev Biol (2004) 3.41
Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci (2003) 3.37
The role of prolactin in mammary carcinoma. Endocr Rev (2003) 2.95
The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene (2004) 2.94
Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation. J Biol Chem (2003) 2.77
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. Immunity (2006) 2.66
Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature (2006) 2.64
Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol Cell (2005) 2.52
Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules. EMBO J (2006) 2.39
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Nature (2007) 2.36
Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol (2007) 2.07
Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival. Mol Cell Biol (2002) 1.98
Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells. Traffic (2006) 1.96
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol (2007) 1.90
Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem (2004) 1.87
The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Mol Biol Cell (2007) 1.83
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Rep (2006) 1.72
Both proteasomes and lysosomes degrade the activated erythropoietin receptor. Blood (2004) 1.60
E1-L2 activates both ubiquitin and FAT10. Mol Cell (2007) 1.60
Inhibition of MHC class II expression and immune responses by c-MIR. J Immunol (2006) 1.60
Endocytosis and degradation of the growth hormone receptor are proteasome-dependent. J Biol Chem (2000) 1.55
Endosomal dynamics of Met determine signaling output. Mol Biol Cell (2003) 1.55
Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery. Mol Biol Cell (2007) 1.37
Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase. Mol Cell Biol (2004) 1.34
Dissecting the ubiquitin pathway by mass spectrometry. Biochim Biophys Acta (2006) 1.32
beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation. Blood (2007) 1.25
Development and potential clinical uses of human prolactin receptor antagonists. Endocr Rev (2005) 1.24
Cell cycle, proteolysis and cancer. Curr Opin Cell Biol (2004) 1.22
The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor. J Biol Chem (2007) 1.17
Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells. Cancer Res (2005) 1.16
Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints. Oncogene (2005) 1.15
Development of pure prolactin receptor antagonists. J Biol Chem (2003) 1.11
Regulation of prolactin receptor levels and activity in breast cancer. J Mammary Gland Biol Neoplasia (2008) 1.07
The ubiquitin system: from basic mechanisms to the patient bed. IUBMB Life (2004) 1.06
Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta (2005) 1.04
Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2. J Endocrinol (2008) 0.98
Stabilization of prolactin receptor in breast cancer cells. Oncogene (2006) 0.94
Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways. Mol Endocrinol (2002) 0.90
Proteasomes mediate prolactin-induced receptor down-regulation and fragment generation in breast cancer cells. J Biol Chem (2005) 0.85
Membrane traffic: catching the lysosome express. Curr Biol (2006) 0.78
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science (2004) 5.64
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell (2008) 4.51
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. J Clin Invest (2005) 4.19
Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Mol Cell Proteomics (2006) 3.56
Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer. J Clin Oncol (2012) 3.51
The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR. Nat Struct Mol Biol (2004) 3.16
Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: a randomized, double-blind trial. Arch Intern Med (2011) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell (2006) 3.08
Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science (2010) 2.92
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells (2010) 2.89
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J (2006) 2.84
Comparative impact of trastuzumab and cyclophosphamide on HER-2-positive human breast cancer xenografts. Clin Cancer Res (2009) 2.79
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem (2010) 2.72
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature (2008) 2.51
Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer (2011) 2.42
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science (2004) 2.39
Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res (2007) 2.35
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Nature (2006) 2.35
A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone. Nat Genet (2004) 2.30
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem (2003) 2.25
Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. J Biol Chem (2005) 2.24
Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column. Anal Chem (2002) 2.22
Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron (2003) 2.19
SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J (2003) 2.16
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09
Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol (2007) 2.07
C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science (2009) 2.04
Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines. Cell (2010) 2.02
Development of a preclinical model of spontaneous human melanoma central nervous system metastasis. Cancer Res (2008) 1.99
Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells. Traffic (2006) 1.96
Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell (2008) 1.94
Enhanced 2,3-butanediol production by Klebsiella pneumoniae SDM. Appl Microbiol Biotechnol (2008) 1.92
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90
Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem (2004) 1.87
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest (2012) 1.85
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. J Biol Chem (2008) 1.83
Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology (2008) 1.83
Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth. Cancer Res (2008) 1.78
Mechanism-based corrector combination restores ΔF508-CFTR folding and function. Nat Chem Biol (2013) 1.76
Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res (2003) 1.75
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell (2010) 1.73
Acetoin metabolism in bacteria. Crit Rev Microbiol (2007) 1.73
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function. Cell (2012) 1.73
Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell (2006) 1.69
Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. EMBO J (2006) 1.67
Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase. EMBO J (2006) 1.64
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. Proc Natl Acad Sci U S A (2010) 1.62
Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci (2008) 1.60
Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection. J Biol Chem (2004) 1.58
Quantum teleportation and entanglement distribution over 100-kilometre free-space channels. Nature (2012) 1.56
The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis. J Biol Chem (2010) 1.55
N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic. J Cell Biol (2009) 1.54
Activated expression of an Arabidopsis HD-START protein confers drought tolerance with improved root system and reduced stomatal density. Plant Cell (2008) 1.53
Systematical optimization of reverse-phase chromatography for shotgun proteomics. J Proteome Res (2009) 1.53
Solution structure of human prolactin. J Mol Biol (2005) 1.52
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. J Neurochem (2008) 1.51
Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J Exp Med (2002) 1.51
Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor. Blood (2011) 1.49
Racial ethnic differences in rates and determinants of deceased donor kidney transplantation. J Am Soc Nephrol (2011) 1.48
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease. J Biol Chem (2011) 1.48
Systematic approach for validating the ubiquitinated proteome. Anal Chem (2008) 1.47
Non-sterilized fermentative production of polymer-grade L-lactic acid by a newly isolated thermophilic strain Bacillus sp. 2-6. PLoS One (2009) 1.46
The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell (2013) 1.46
Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe (2009) 1.46
Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression. Am J Physiol Endocrinol Metab (2011) 1.45
Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs. J Cell Sci (2007) 1.44
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol (2008) 1.44
Application of new homologous in vitro bioassays for human lactogens to assess the actual bioactivity of human prolactin isoforms in hyperprolactinaemic patients. Clin Endocrinol (Oxf) (2006) 1.44
Physicochemical properties of cross-linked poly-gamma-glutamic acid and its flocculating activity against kaolin suspension. J Biosci Bioeng (2005) 1.43
Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. J Natl Cancer Inst (2004) 1.41
The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome. J Biol Chem (2009) 1.39
Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains. Traffic (2009) 1.39
TYK2 activity promotes ligand-induced IFNAR1 proteolysis. Biochem J (2006) 1.39
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci (2008) 1.39
Evening versus morning dosing regimen drug therapy for hypertension. Cochrane Database Syst Rev (2011) 1.38
A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16. Appl Environ Microbiol (2008) 1.38
The subcellular localization of MEK and ERK--a novel nuclear translocation signal (NTS) paves a way to the nucleus. Mol Cell Endocrinol (2009) 1.37