Published in Mol Cell Biol on July 01, 2006
The structure and function of small nucleolar ribonucleoproteins. Nucleic Acids Res (2007) 2.50
The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol (2008) 1.95
A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. Mol Cell Biol (2007) 1.10
Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis. Mol Cell Biol (2009) 1.08
PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem (2012) 1.07
A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58. Mol Cell (2010) 0.97
Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. Mol Cell Biol (2006) 0.94
SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing. Nat Commun (2016) 0.92
Elucidating the role of C/D snoRNA in rRNA processing and modification in Trypanosoma brucei. Eukaryot Cell (2007) 0.91
Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control. J Cell Biol (2014) 0.89
Biochemical defects in minor spliceosome function in the developmental disorder MOPD I. RNA (2014) 0.88
A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation. RNA (2010) 0.85
Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly. Nucleic Acids Res (2013) 0.84
YAO is a nucleolar WD40-repeat protein critical for embryogenesis and gametogenesis in Arabidopsis. BMC Plant Biol (2010) 0.83
Structural and functional analysis of the U3 snoRNA binding protein Rrp9. RNA (2013) 0.81
Analysis of a critical interaction within the archaeal box C/D small ribonucleoprotein complex. J Biol Chem (2009) 0.78
Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. Development (2013) 0.78
Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms. Oncotarget (2016) 0.75
Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly. Nucleic Acids Res (2017) 0.75
Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell (1998) 10.95
The kink-turn: a new RNA secondary structure motif. EMBO J (2001) 8.58
Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell (1996) 7.92
Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions. Cell (2002) 6.62
Spliceosomal UsnRNP biogenesis, structure and function. Curr Opin Cell Biol (2001) 6.10
The expanding snoRNA world. Biochimie (2002) 6.10
A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. EMBO J (1989) 4.91
Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet (1994) 4.83
Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment. Mol Cell (2000) 4.42
A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Cell (2000) 4.33
A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J (1999) 3.80
Induced fit in RNA-protein recognition. Nat Struct Biol (2000) 3.65
Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol Cell Biol (1997) 2.95
Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA. EMBO J (1999) 2.90
Structure and function of archaeal box C/D sRNP core proteins. Nat Struct Biol (2003) 2.55
Sequence and structural elements of methylation guide snoRNAs essential for site-specific ribose methylation of pre-rRNA. EMBO J (1998) 2.52
Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability. RNA (1999) 2.48
Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea. Nucleic Acids Res (2003) 2.44
Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP. Mol Cell Biol (2002) 2.37
A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme? Nucleic Acids Res (1994) 2.37
Archaeal ribosomal protein L7 is a functional homolog of the eukaryotic 15.5kD/Snu13p snoRNP core protein. Nucleic Acids Res (2002) 2.23
Synthesis and assembly of the box C+D small nucleolar RNPs. Mol Cell Biol (2000) 2.11
In vitro reconstitution and activity of a C/D box methylation guide ribonucleoprotein complex. Proc Natl Acad Sci U S A (2002) 2.07
Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. J Biol Chem (1998) 2.06
Box C/D snoRNA-associated proteins: two pairs of evolutionarily ancient proteins and possible links to replication and transcription. RNA (2000) 1.90
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. EMBO J (2002) 1.82
RNA structure and function in C/D and H/ACA s(no)RNPs. Curr Opin Struct Biol (2004) 1.70
Exclusive interaction of the 15.5 kD protein with the terminal box C/D motif of a methylation guide snoRNP. Chem Biol (2002) 1.58
Induced fit of RNA on binding the L7Ae protein to the kink-turn motif. RNA (2005) 1.58
Site-specific cross-linking analyses reveal an asymmetric protein distribution for a box C/D snoRNP. EMBO J (2002) 1.51
The hU3-55K protein requires 15.5K binding to the box B/C motif as well as flanking RNA elements for its association with the U3 small nucleolar RNA in Vitro. J Biol Chem (2002) 1.23
Detecting protein-induced folding of the U4 snRNA kink-turn by single-molecule multiparameter FRET measurements. RNA (2005) 1.23
Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP. Mol Cell Biol (2004) 1.21
Noncoding RNA transcripts. J Appl Genet (2003) 1.06
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37
The spliceosome: design principles of a dynamic RNP machine. Cell (2009) 12.82
Identification of novel argonaute-associated proteins. Curr Biol (2005) 6.13
The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. RNA (2002) 5.73
A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. RNA (2005) 4.99
Spliceosome structure and function. Cold Spring Harb Perspect Biol (2011) 4.01
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science (2002) 3.59
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method. Proc Natl Acad Sci U S A (2002) 3.14
Isolation of an active step I spliceosome and composition of its RNP core. Nature (2008) 3.10
Macromolecular-scale resolution in biological fluorescence microscopy. Proc Natl Acad Sci U S A (2006) 3.04
GraFix: sample preparation for single-particle electron cryomicroscopy. Nat Methods (2007) 2.71
Molecular architecture of the multiprotein splicing factor SF3b. Science (2003) 2.63
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol Cell Biol (2006) 2.55
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J (2002) 2.39
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol Cell (2009) 2.39
Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP. Mol Cell Biol (2002) 2.37
Splicing of a rare class of introns by the U12-dependent spliceosome. Biol Chem (2005) 2.20
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. EMBO J (2004) 2.20
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing. EMBO J (2002) 2.11
Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. Genes Dev (2003) 2.10
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. EMBO J (2007) 2.07
Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase. RNA (2006) 2.05
Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell (2012) 2.04
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science (2011) 2.03
Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Mol Biol Cell (2006) 1.95
Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition. Cell (2008) 1.91
Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol Cell (2004) 1.89
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components. Nat Struct Mol Biol (2009) 1.89
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. RNA (2006) 1.89
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Mol Cell (2010) 1.84
Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. RNA (2006) 1.83
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. EMBO J (2002) 1.82
RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies. EMBO J (2004) 1.73
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. Nat Struct Mol Biol (2008) 1.73
Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa. Mol Cell (2007) 1.70
CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation. Nature (2011) 1.68
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA (2004) 1.67
Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein. Mol Cell (2004) 1.66
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol Cell Biol (2008) 1.64
Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science (2007) 1.64
Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation. RNA (2004) 1.63
A two-tracked approach to analyze RNA-protein crosslinking sites in native, nonlabeled small nuclear ribonucleoprotein particles. Methods (2002) 1.61
Structure and function of an RNase H domain at the heart of the spliceosome. EMBO J (2008) 1.49
Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions. Mol Cell Biol (2002) 1.49
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Mol Cell Biol (2011) 1.48
The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome. EMBO Rep (2002) 1.47
Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy. Mol Cell (2005) 1.45
Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nat Struct Mol Biol (2010) 1.45
Molecular architecture of the human Prp19/CDC5L complex. Mol Cell Biol (2010) 1.44
Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Mol Cell Biol (2002) 1.38
Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nat Struct Mol Biol (2008) 1.37
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion. Nat Commun (2012) 1.35
Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO J (2010) 1.35
Cryo-electron microscopy of spliceosomal components. Annu Rev Biophys Biomol Struct (2006) 1.33
Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy. Mol Cell (2006) 1.33
Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Mol Cell (2009) 1.32
The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes. Mol Cell (2007) 1.26
Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. EMBO J (2005) 1.26
Three-dimensional structure of a pre-catalytic human spliceosomal complex B. Nat Struct Mol Biol (2004) 1.25
Detecting protein-induced folding of the U4 snRNA kink-turn by single-molecule multiparameter FRET measurements. RNA (2005) 1.23
The snRNP 15.5K protein folds its cognate K-turn RNA: a combined theoretical and biochemical study. RNA (2005) 1.22
The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J Cell Biol (2002) 1.21
Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP. Mol Cell Biol (2004) 1.21
RNA structure and RNA-protein interactions in purified yeast U6 snRNPs. J Mol Biol (2005) 1.20
Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Anal Chem (2010) 1.20
Crystal structure of a core spliceosomal protein interface. Proc Natl Acad Sci U S A (2006) 1.20
Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes. EMBO J (2006) 1.18
U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes. Mol Cell Biol (2006) 1.18
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes Dev (2013) 1.18
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science (2013) 1.17
Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA (2012) 1.17
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes Dev (2012) 1.17
A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4. Mol Cell Biol (2009) 1.17
Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. Mol Cell Biol (2004) 1.16
Minor spliceosome components are predominantly localized in the nucleus. Proc Natl Acad Sci U S A (2008) 1.16
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA (2008) 1.16
A stochastic view of spliceosome assembly and recycling in the nucleus. PLoS Comput Biol (2007) 1.15
Direct probing of RNA structure and RNA-protein interactions in purified HeLa cell's and yeast spliceosomal U4/U6.U5 tri-snRNP particles. J Mol Biol (2002) 1.12
The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein. EMBO J (2005) 1.11
A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. Mol Cell Biol (2007) 1.10
Discriminatory RNP remodeling by the DEAD-box protein DED1. RNA (2006) 1.09
Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing. RNA (2006) 1.09
RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO J (2013) 1.08
RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoproteins. J Biol Chem (2006) 1.08
Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis. Mol Cell Biol (2009) 1.08
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc Natl Acad Sci U S A (2012) 1.08
Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. Proc Natl Acad Sci U S A (2004) 1.07
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nat Struct Mol Biol (2010) 1.06
Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure (2013) 1.05
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO J (2012) 1.04
Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP. RNA (2006) 1.04
Exon, intron and splice site locations in the spliceosomal B complex. EMBO J (2009) 1.04
Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis. Mol Cell Biol (2007) 1.03
Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry. J Biol Chem (2004) 1.03
Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing. EMBO J (2011) 1.02
The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein. Mol Cell Biol (2008) 1.02